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{
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"name":"Ascaroside 5 exchange",
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"lower_bound":-0.0,
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"gene_reaction_rule":"",
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"annotation":{
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}
},
{
"id":"TCE5369",
"name":"Sulfite transport",
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"na1_e":1.0,
"so3_c":-1.0,
"so3_e":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
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"subsystem":"Transport",
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}
},
{
"id":"TCE5368",
"name":"3-Hydroxypropanoate transport",
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"3hpp_c":-1.0,
"3hpp_e":1.0
},
"lower_bound":-1000.0,
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"gene_reaction_rule":"",
"subsystem":"Transport",
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"sbo":"SBO:0000185"
}
},
{
"id":"TCE5361",
"name":"5-Oxoproline transport",
"metabolites":{
"5oxpro_c":1.0,
"5oxpro_e":-1.0,
"na1_c":2.0,
"na1_e":-2.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
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"sbo":"SBO:0000185"
}
},
{
"id":"TCE5360",
"name":"5,6-Dihydrothymine transport",
"metabolites":{
"56dthm_c":-1.0,
"56dthm_e":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE5363",
"name":"5,6-dihydrouracil transport",
"metabolites":{
"56dura_c":-1.0,
"56dura_e":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE5362",
"name":"3-Methyl-2-oxobutanoate transport",
"metabolites":{
"3mob_c":1.0,
"3mob_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RM01360",
"name":"(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase (acetyl-CoA-forming)",
"metabolites":{
"acac_m":1.0,
"accoa_m":1.0,
"hmgcoa_m":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00022150",
"subsystem":"Synthesis and degradation of ketone bodies",
"annotation":{
"ec-code":"4.1.3.4",
"kegg.reaction":"R01360",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE5364",
"name":"3-Hydroxy-2-methylpropanoate transport",
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"3hmp_c":-1.0,
"3hmp_e":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE5367",
"name":"D-Glyceraldehyde transport",
"metabolites":{
"glyald_c":1.0,
"glyald_e":-1.0,
"na1_c":1.0,
"na1_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE5366",
"name":"Succinic semialdehyde transport",
"metabolites":{
"sucsal_c":-1.0,
"sucsal_e":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"EX02512",
"name":"beta cyanoalanine exchange",
"metabolites":{
"cyanala_e":-1.0
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RC02493",
"name":"ATP:pyridoxamine 5-phosphotransferase",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"h_c":1.0,
"pyam5p_c":1.0,
"pydam_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00019008",
"subsystem":"Vitamin B6 metabolism",
"annotation":{
"ec-code":"2.7.1.35",
"kegg.reaction":"R02493",
"sbo":"SBO:0000176"
}
},
{
"id":"RC02497",
"name":"dihydrotestosterone:NADP+ delta4-oxidoreductase",
"metabolites":{
"5adtststerone_c":1.0,
"h_c":-1.0,
"nadp_c":1.0,
"nadph_c":-1.0,
"tststerone_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00007102 or WBGene00009635",
"subsystem":"Steroid hormone biosynthesis",
"annotation":{
"ec-code":"1.3.1.22",
"kegg.reaction":"R02497",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE0424",
"name":"D-Mannose transport",
"metabolites":{
"man_c":1.0,
"man_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC02543",
"name":"Acyl-CoA:sphingosylphosphorylcholine N-acyltransferase",
"metabolites":{
"Rtotalcoa_c":-1.0,
"coa_c":1.0,
"h_c":1.0,
"spc_ce_c":-1.0,
"sphmyln_ce_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00002043 or WBGene00002044 or WBGene00006505",
"subsystem":"Sphingolipid metabolism",
"annotation":{
"ec-code":"2.3.1.24",
"kegg.reaction":"R02543",
"sbo":"SBO:0000176"
}
},
{
"id":"RC02017",
"name":"2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase",
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"dadp_c":1.0,
"h2o_c":1.0,
"trdox_c":1.0,
"trdrd_c":-1.0
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00004391 and WBGene00004392 and (WBGene00017610 or WBGene00019055)",
"subsystem":"Purine metabolism",
"annotation":{
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"kegg.reaction":"R02017",
"sbo":"SBO:0000176"
}
},
{
"id":"RC02016",
"name":"NADPH:oxidized-thioredoxin oxidoreductase",
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"trdrd_c":1.0
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"lower_bound":-0.0,
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"gene_reaction_rule":"WBGene00015553",
"subsystem":"Pyrimidine metabolism",
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"kegg.reaction":"R02016",
"sbo":"SBO:0000176"
}
},
{
"id":"RC05916",
"name":"UDP-N-acetyl-D-glucosamine:phosphatidylinositol N-acetyl-D-glucosaminyltransferase",
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"h_c":1.0,
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"uacgam_c":-1.0,
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"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00008504 or WBGene00011860 or WBGene00008431",
"subsystem":"Glycosylphosphatidylinositol(GPI)-anchor biosynthesis",
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"kegg.reaction":"R05916",
"sbo":"SBO:0000176"
}
},
{
"id":"RC02019",
"name":"2-Deoxyguanosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase",
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"subsystem":"Purine metabolism",
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"kegg.reaction":"R02019",
"sbo":"SBO:0000176"
}
},
{
"id":"RC02018",
"name":"2-Deoxyuridine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase",
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"h2o_c":1.0,
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"gene_reaction_rule":"WBGene00004391 and WBGene00004392 and (WBGene00017610 or WBGene00019055)",
"subsystem":"Pyrimidine metabolism",
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"kegg.reaction":"R02018",
"sbo":"SBO:0000176"
}
},
{
"id":"RC03542",
"name":"alpha-Aminopropiononitrile aminohydrolase",
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"aprop_c":-1.0,
"h2o_c":-2.0,
"nh4_c":1.0
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"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00014206",
"subsystem":"Cyanoamino acid metabolism",
"annotation":{
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"kegg.reaction":"R03542",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00899",
"name":"L-cysteinylglycine dipeptidase",
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"cys-L_c":1.0,
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"h2o_c":-1.0
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"3.4.11.2"
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"kegg.reaction":"R00899",
"sbo":"SBO:0000176"
}
},
{
"id":"RC03660",
"name":"L-Phenylalanine:tRNA(Ala) ligase (AMP-forming)",
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"gene_reaction_rule":"WBGene00001497 and WBGene00001498",
"subsystem":"Aminoacyl-tRNA biosynthesis",
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"kegg.reaction":"R03660",
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},
{
"id":"RC00893",
"name":"L-Cysteine:oxygen oxidoreductase",
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"subsystem":"Cysteine and methionine metabolism",
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"kegg.reaction":"R00893",
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},
{
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"name":"O3-acetyl-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase",
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},
{
"id":"RC00895",
"name":"L-Cysteine:2-oxoglutarate aminotransferase",
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"cys-L_c":-1.0,
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"kegg.reaction":"R00895",
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},
{
"id":"RC00894",
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"kegg.reaction":"R00894",
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},
{
"id":"RC07209",
"name":"oxysterol 7alpha-hydroxylase (acting on 25-hydroxycholesterol)",
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"xol25oh_c":-1.0,
"xoltri25_c":1.0
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"lower_bound":-0.0,
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"gene_reaction_rule":"",
"subsystem":"Primary bile acid biosynthesis",
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"kegg.reaction":"R07209",
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},
{
"id":"RM03856",
"name":"trans-Dodec-2-enoyl-CoA reductase",
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"gene_reaction_rule":"WBGene00012375 or WBGene00012970",
"subsystem":"Fatty acid elongation",
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"kegg.reaction":"R03856",
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},
{
"id":"RM03857",
"name":"Lauroyl-CoA:(acceptor) 2,3-oxidoreductase",
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"ddcacoa_m":-1.0,
"etfox_m":-1.0,
"etfrd_m":1.0
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"lower_bound":-1000.0,
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"gene_reaction_rule":"(WBGene00020812 or WBGene00019406 or WBGene00020366)",
"subsystem":"Fatty acid metabolism",
"annotation":{
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"kegg.reaction":"R03857",
"sbo":"SBO:0000176"
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},
{
"id":"RM03858",
"name":"Lauroyl-CoA:acetyl-CoA C-acyltransferase",
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"coa_m":-1.0,
"ddcacoa_m":1.0
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"gene_reaction_rule":"WBGene00015125 or WBGene00009952",
"subsystem":"Fatty acid elongation",
"annotation":{
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"kegg.reaction":"R03858",
"sbo":"SBO:0000176"
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},
{
"id":"RM03524",
"name":"L-cysteine hydrogen-sulfide-lyase (adding HCN)",
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"cys-L_m":-1.0,
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"h_m":1.0
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"lower_bound":-1000.0,
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"gene_reaction_rule":"WBGene00010759",
"subsystem":"Cyanoamino acid metabolism",
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"kegg.reaction":"R03524",
"sbo":"SBO:0000176"
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},
{
"id":"RC00945",
"name":"5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase",
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"h2o_c":1.0,
"mlthf_c":1.0,
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"thf_c":-1.0
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"gene_reaction_rule":"WBGene00003214",
"subsystem":"Glycine, serine and threonine metabolism",
"annotation":{
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"kegg.reaction":"R00945",
"sbo":"SBO:0000176"
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},
{
"id":"RC00946",
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"thf_c":1.0
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},
{
"id":"RC00941",
"name":"10-formyltetrahydrofolate:NADP+ oxidoreductase",
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"h2o_c":-1.0,
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"thf_c":1.0
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},
{
"id":"RC00943",
"name":"Formate:tetrahydrofolate ligase (ADP-forming)",
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"kegg.reaction":"R00943",
"sbo":"SBO:0000176"
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},
{
"id":"EX00486",
"name":"Bilirubin exchange",
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
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},
{
"id":"TCE0333",
"name":"Adenine transport",
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"ade_e":-1.0
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"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
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},
{
"id":"TCE0332",
"name":"Maltose transport",
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"malt_e":-1.0
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},
{
"id":"RC03302",
"name":"3,4-Dihydroxyphenylacetaldehyde:NADP+ oxidoreductase",
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"34dhpha_c":1.0,
"h2o_c":-1.0,
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"gene_reaction_rule":"WBGene00000111",
"subsystem":"Tyrosine metabolism",
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"kegg.reaction":"R03302",
"sbo":"SBO:0000176"
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},
{
"id":"RC04463",
"name":"5-Phosphoribosylformylglycinamide:L-glutamine amido-ligase (ADP-forming)",
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"atp_c":-1.0,
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"subsystem":"Purine metabolism",
"annotation":{
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"kegg.reaction":"R04463",
"sbo":"SBO:0000176"
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},
{
"id":"RC03300",
"name":"3,4-Dihydroxyphenylacetaldehyde:NAD+ oxidoreductase",
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"34dhpha_c":1.0,
"h2o_c":-1.0,
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"nadh_c":1.0
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"subsystem":"Tyrosine metabolism",
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"kegg.reaction":"R03300",
"sbo":"SBO:0000176"
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},
{
"id":"TCE0338",
"name":"D-Galactose transport",
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"gal_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC00939",
"name":"5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase",
"metabolites":{
"dhf_c":-1.0,
"h_c":-1.0,
"nadp_c":1.0,
"nadph_c":-1.0,
"thf_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00007974",
"subsystem":"One carbon pool by folate",
"annotation":{
"ec-code":"1.5.1.3",
"kegg.reaction":"R00939",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00306",
"name":"cellobiose glucohydrolase",
"metabolites":{
"clb_c":-1.0,
"glc-D_c":2.0,
"h2o_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00016848 or WBGene00017103",
"subsystem":"Starch and sucrose metabolism",
"annotation":{
"ec-code":"3.2.1.21",
"kegg.reaction":"R00306",
"sbo":"SBO:0000176"
}
},
{
"id":"EX04598",
"name":"Platelet-activating factor exchange",
"metabolites":{
"paf_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RC04311",
"name":"1-Acyl-glycerone-3-phosphate:long-chain-alcohol O-3-phospho-2-oxopropanyltransferase",
"metabolites":{
"Rtotal_c":1.0,
"adhap_c":-1.0,
"akdhap_c":1.0,
"alkylR1oh_c":-1.0,
"h_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000081",
"subsystem":"Ether lipid metabolism",
"annotation":{
"ec-code":"2.5.1.26",
"kegg.reaction":"R04311",
"sbo":"SBO:0000176"
}
},
{
"id":"RC03665",
"name":"L-Valine:tRNAVal ligase (AMP-forming)",
"metabolites":{
"amp_c":1.0,
"atp_c":-1.0,
"ppi_c":1.0,
"trnaval_c":-1.0,
"val-L_c":-1.0,
"valtrna_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00006936",
"subsystem":"Aminoacyl-tRNA biosynthesis",
"annotation":{
"ec-code":"6.1.1.9",
"kegg.reaction":"R03665",
"sbo":"SBO:0000176"
}
},
{
"id":"RC04313",
"name":"Protein lysine peptidase",
"metabolites":{
"h2o_c":-1.0,
"pepX_c":1.0,
"peptmelys_c":-1.0,
"tmlys_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Carnitine biosynthesis",
"annotation":{
"ec-code":"3.4.-.-",
"kegg.reaction":"R04313",
"sbo":"SBO:0000176"
}
},
{
"id":"RM03293",
"name":"trans-4-Hydroxy-L-proline:NADP+ 5-oxidoreductase",
"metabolites":{
"1p3h5c_m":1.0,
"4hpro-LT_m":-1.0,
"h_m":2.0,
"nadp_m":-1.0,
"nadph_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00010924 or WBGene00018904",
"subsystem":"Arginine and proline metabolism",
"annotation":{
"ec-code":"1.5.1.2",
"kegg.reaction":"R03293",
"sbo":"SBO:0000176"
}
},
{
"id":"RM03291",
"name":"trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase",
"metabolites":{
"1p3h5c_m":1.0,
"4hpro-LT_m":-1.0,
"h_m":2.0,
"nad_m":-1.0,
"nadh_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00010924 or WBGene00018904",
"subsystem":"Arginine and proline metabolism",
"annotation":{
"ec-code":"1.5.1.2",
"kegg.reaction":"R03291",
"sbo":"SBO:0000176"
}
},
{
"id":"RC03161",
"name":"ATP:6-deoxy-L-galactose 1-phosphotransferase",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"fuc-L_c":-1.0,
"fuc1p-L_c":1.0,
"h_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00007745",
"subsystem":"Fructose and mannose metabolism",
"annotation":{
"ec-code":"2.7.1.52",
"kegg.reaction":"R03161",
"sbo":"SBO:0000176"
}
},
{
"id":"RM03989",
"name":"trans-Tetradec-2-enoyl-CoA reductase",
"metabolites":{
"h_m":-1.0,
"nadp_m":1.0,
"nadph_m":-1.0,
"td2coa_m":-1.0,
"tdcoa_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00012375 or WBGene00012970",
"subsystem":"Fatty acid elongation",
"annotation":{
"ec-code":"1.3.1.38",
"kegg.reaction":"R03989",
"sbo":"SBO:0000176"
}
},
{
"id":"RC03664",
"name":"L-Tryptophan -tRNA(Trp) ligase (AMP-forming)",
"metabolites":{
"amp_c":1.0,
"atp_c":-1.0,
"ppi_c":1.0,
"trnatrp_c":-1.0,
"trp-L_c":-1.0,
"trptrna_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00006945",
"subsystem":"Aminoacyl-tRNA biosynthesis",
"annotation":{
"ec-code":"6.1.1.2",
"kegg.reaction":"R03664",
"sbo":"SBO:0000176"
}
},
{
"id":"RM03451",
"name":"trimethyllysine dioxygenase",
"metabolites":{
"3htmelys_m":1.0,
"akg_m":-1.0,
"co2_m":1.0,
"o2_m":-1.0,
"succ_m":1.0,
"tmlys_m":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00001523",
"subsystem":"Carnitine biosynthesis",
"annotation":{
"ec-code":"1.14.11.8",
"kegg.reaction":"R03451",
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0102",
"name":"fatty-acid--CoA ligase (fa17p0iso)",
"metabolites":{
"amp_c":1.0,
"atp_c":-1.0,
"coa_c":-1.0,
"fa17p0iso_c":-1.0,
"fa17p0isocoa_c":1.0,
"ppi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00009221 or WBGene00020343 or WBGene00018152 or WBGene00013575 or WBGene00022037 or WBGene00019920 or WBGene00016716 or WBGene00011173",
"subsystem":"Fatty acid metabolism",
"annotation":{
"ec-code":"6.2.1.3",
"kegg.reaction":"R00390",
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0103",
"name":"Beta oxidation of fa17p0iso (peroxisomal)",
"metabolites":{
"accoa_c":1.0,
"coa_c":-1.0,
"fa15p0isocoa_c":1.0,
"fa17p0isocoa_c":-1.0,
"h2o2_c":1.0,
"h2o_c":-1.0,
"h_c":1.0,
"nad_c":-1.0,
"nadh_c":1.0,
"o2_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00008167 or WBGene00008564 or WBGene00008565 or WBGene00008566 or WBGene00008567 or WBGene00019060 or WBGene00010336) and (WBGene00000991 or WBGene00017123) and WBGene00013284",
"subsystem":"Peroxisomal fatty acid beta oxidation",
"annotation":{
"ec-code":[
"1.3.3.6",
"4.2.1.17",
"1.1.1.211",
"1.1.1.35",
"2.3.1.16"
],
"kegg.reaction":[
"R00388",
"R02685",
"R01778",
"R00391"
],
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0101",
"name":"fatty-acid--CoA ligase (fa15p0iso)",
"metabolites":{
"amp_c":1.0,
"atp_c":-1.0,
"coa_c":-1.0,
"fa15p0iso_c":-1.0,
"fa15p0isocoa_c":1.0,
"ppi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00009221 or WBGene00020343 or WBGene00018152 or WBGene00013575 or WBGene00022037 or WBGene00019920 or WBGene00016716 or WBGene00011173",
"subsystem":"Fatty acid metabolism",
"annotation":{
"ec-code":"6.2.1.3",
"kegg.reaction":"R00390",
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0106",
"name":"Beta oxidation of fa19c11 (peroxisomal)",
"metabolites":{
"accoa_c":1.0,
"coa_c":-1.0,
"fa17c9coa_c":1.0,
"fa19c11coa_c":-1.0,
"h2o2_c":1.0,
"h2o_c":-1.0,
"h_c":1.0,
"nad_c":-1.0,
"nadh_c":1.0,
"o2_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00008167 or WBGene00008564 or WBGene00008565 or WBGene00008566 or WBGene00008567 or WBGene00019060 or WBGene00010336) and (WBGene00000991 or WBGene00017123) and WBGene00013284",
"subsystem":"Peroxisomal fatty acid beta oxidation",
"annotation":{
"ec-code":[
"1.3.3.6",
"4.2.1.17",
"1.1.1.211",
"1.1.1.35",
"2.3.1.16"
],
"kegg.reaction":[
"R00388",
"R02685",
"R01778",
"R00391"
],
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0107",
"name":"Beta oxidation of fa17c9 (peroxisomal)",
"metabolites":{
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"coa_c":-3.0,
"fa11c3coa_c":1.0,
"fa17c9coa_c":-1.0,
"h2o2_c":3.0,
"h2o_c":-3.0,
"h_c":3.0,
"nad_c":-3.0,
"nadh_c":3.0,
"o2_c":-3.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00008167 or WBGene00008564 or WBGene00008565 or WBGene00008566 or WBGene00008567 or WBGene00019060 or WBGene00010336) and (WBGene00000991 or WBGene00017123) and WBGene00013284",
"subsystem":"Peroxisomal fatty acid beta oxidation",
"annotation":{
"ec-code":[
"1.3.3.6",
"4.2.1.17",
"1.1.1.211",
"1.1.1.35",
"2.3.1.16"
],
"kegg.reaction":[
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"R02685",
"R01778",
"R00391"
],
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0104",
"name":"Beta oxidation of fa15p0iso (peroxisomal)",
"metabolites":{
"accoa_c":3.0,
"coa_c":-3.0,
"fa15p0isocoa_c":-1.0,
"fa9p0isocoa_c":1.0,
"h2o2_c":3.0,
"h2o_c":-3.0,
"h_c":3.0,
"nad_c":-3.0,
"nadh_c":3.0,
"o2_c":-3.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00008167 or WBGene00008564 or WBGene00008565 or WBGene00008566 or WBGene00008567 or WBGene00019060 or WBGene00010336) and (WBGene00000991 or WBGene00017123) and WBGene00013284",
"subsystem":"Peroxisomal fatty acid beta oxidation",
"annotation":{
"ec-code":[
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"4.2.1.17",
"1.1.1.211",
"1.1.1.35",
"2.3.1.16"
],
"kegg.reaction":[
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"R02685",
"R01778",
"R00391"
],
"sbo":"SBO:0000176"
}
},
{
"id":"RC01121",
"name":"ATP:(R)-5-diphosphomevalonate carboxy-lyase",
"metabolites":{
"5dpmev_c":-1.0,
"adp_c":1.0,
"atp_c":-1.0,
"co2_c":1.0,
"ipdp_c":1.0,
"pi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00012984",
"subsystem":"Terpenoid backbone biosynthesis",
"annotation":{
"ec-code":"4.1.1.33",
"kegg.reaction":"R01121",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01920",
"name":"S-adenosylmethioninamine:putrescine 3-aminopropyltransferase",
"metabolites":{
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"ametam_c":-1.0,
"h_c":1.0,
"ptrc_c":-1.0,
"spmd_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00012909",
"subsystem":"Cysteine and methionine metabolism",
"annotation":{
"ec-code":"2.5.1.16",
"kegg.reaction":"R01920",
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0108",
"name":"Acyl-CoA:L-carnitine O-acyltransferase I (vaccenyl CoA)",
"metabolites":{
"coa_c":1.0,
"crn_c":-1.0,
"vacccoa_c":-1.0,
"vacccrn_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00012907 or WBGene00021703 or WBGene00019644 or WBGene00008629 or WBGene00020911",
"subsystem":"Carnitine shuttle",
"annotation":{
"ec-code":"2.3.1.21",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01923",
"name":"Palmitoyl-CoA:L-carnitine O-palmitoyltransferase I",
"metabolites":{
"coa_c":1.0,
"crn_c":-1.0,
"pmtcoa_c":-1.0,
"pmtcrn_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00012907 or WBGene00021703 or WBGene00019644 or WBGene00008629 or WBGene00020911",
"subsystem":"Fatty acid metabolism",
"annotation":{
"ec-code":"2.3.1.21",
"kegg.reaction":"R01923",
"sbo":"SBO:0000176"
}
},
{
"id":"RC05052",
"name":"L-erythro-4-hydroxyglutamate:2-oxoglutarate aminotransferase",
"metabolites":{
"4h2oglt_c":1.0,
"akg_c":-1.0,
"e4hglu_c":-1.0,
"glu-L_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00020146",
"subsystem":"Arginine and proline metabolism",
"annotation":{
"ec-code":"2.6.1.1",
"kegg.reaction":"R05052",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01926",
"name":"sphingosine kinase",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"h_c":1.0,
"sphings_ce_c":-1.0,
"sphs1p_ce_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00007918",
"subsystem":"Sphingolipid metabolism",
"annotation":{
"ec-code":"2.7.1.91",
"kegg.reaction":"R01926",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00417",
"name":"protein N-acetylglucosaminyltransferase",
"metabolites":{
"h_c":1.0,
"pepasn_c":-1.0,
"pepasp_acgamam_c":1.0,
"uacgam_c":-1.0,
"udp_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Protein modification by hydroxylation",
"annotation":{
"ec-code":"2.4.1.94",
"kegg.reaction":"R00417",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00416",
"name":"UTP:N-acetyl-alpha-D-glucosamine-1-phosphate uridylyltransferase",
"metabolites":{
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"h_c":-1.0,
"ppi_c":1.0,
"uacgam_c":1.0,
"utp_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00007965",
"subsystem":"Amino sugar and nucleotide sugar metabolism",
"annotation":{
"ec-code":"2.7.7.23",
"kegg.reaction":"R00416",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01126",
"name":"Inosine 5-monophosphate phosphohydrolase",
"metabolites":{
"h2o_c":-1.0,
"imp_c":-1.0,
"ins_c":1.0,
"pi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00017775 or WBGene00012423 or WBGene00022201",
"subsystem":"Purine metabolism",
"annotation":{
"ec-code":"3.1.3.5",
"kegg.reaction":"R01126",
"sbo":"SBO:0000176"
}
},
{
"id":"RM02300",
"name":"S-Aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming)",
"metabolites":{
"5fthf_m":1.0,
"h2o_m":-1.0,
"h_m":1.0,
"methf_m":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00017765",
"subsystem":"One carbon pool by folate",
"annotation":{
"ec-code":"2.1.2.10",
"kegg.reaction":"R02300",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00093",
"name":"L-Glutamate:NAD+ oxidoreductase (transaminating)",
"metabolites":{
"akg_c":-1.0,
"gln-L_c":-1.0,
"glu-L_c":2.0,
"h_c":-1.0,
"nad_c":1.0,
"nadh_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00012326",
"subsystem":"Alanine, aspartate and glutamate metabolism",
"annotation":{
"ec-code":"1.4.1.14",
"kegg.reaction":"R00093",
"sbo":"SBO:0000176"
}
},
{
"id":"DMN0032",
"name":"fa19c11 drain",
"metabolites":{
"fa19c11_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Fatty acid metabolism",
"annotation":{
"sbo":"SBO:0000628"
}
},
{
"id":"DMN0031",
"name":"fa17c9 drain",
"metabolites":{
"fa17c9_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Fatty acid metabolism",
"annotation":{
"sbo":"SBO:0000628"
}
},
{
"id":"DMN0030",
"name":"fa16p1n7 drain",
"metabolites":{
"fa16p1n7_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Fatty acid metabolism",
"annotation":{
"sbo":"SBO:0000628"
}
},
{
"id":"RCC0213",
"name":"ascr5 synthesis",
"metabolites":{
"27ascfa27p0coa_c":-1.0,
"accoa_c":12.0,
"ascr5coa_c":1.0,
"coa_c":-12.0,
"h2o2_c":12.0,
"h2o_c":-12.0,
"h_c":12.0,
"nad_c":-12.0,
"nadh_c":12.0,
"o2_c":-12.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00008564 or WBGene00008565) and WBGene00017123 and WBGene00000991 and WBGene00013284",
"subsystem":"Ascaroside biosynthesis",
"annotation":{
"sbo":"SBO:0000176"
}
},
{
"id":"DMN0035",
"name":"spermine demand",
"metabolites":{
"sprm_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Cysteine and methionine metabolism",
"annotation":{
"sbo":"SBO:0000628"
}
},
{
"id":"DMN0034",
"name":"spermidine demand",
"metabolites":{
"spmd_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Cysteine and methionine metabolism",
"annotation":{
"sbo":"SBO:0000628"
}
},
{
"id":"DMN0039",
"name":"ubiquinone demand",
"metabolites":{
"q_m":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Ubiquinone and other terpenoid-quinone biosynthesis",
"annotation":{
"sbo":"SBO:0000628"
}
},
{
"id":"DMN0038",
"name":"vitamin C demand",
"metabolites":{
"ascb-L_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Miscellaneous",
"annotation":{
"sbo":"SBO:0000628"
}
},
{
"id":"RCC0218",
"name":"ascr18 synthesis",
"metabolites":{
"26ascfa27p0coa_c":-1.0,
"accoa_c":8.0,
"ascr18coa_c":1.0,
"coa_c":-8.0,
"h2o2_c":8.0,
"h2o_c":-8.0,
"h_c":8.0,
"nad_c":-8.0,
"nadh_c":8.0,
"o2_c":-8.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00008564 or WBGene00019060) and WBGene00017123 and WBGene00000991 and WBGene00013284",
"subsystem":"Ascaroside biosynthesis",
"annotation":{
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0219",
"name":"ascr7 synthesis",
"metabolites":{
"ascr1coa_c":-1.0,
"ascr7coa_c":1.0,
"h2o2_c":1.0,
"o2_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00008564 or WBGene00008566",
"subsystem":"Ascaroside biosynthesis",
"annotation":{
"sbo":"SBO:0000176"
}
},
{
"id":"RC01855",
"name":"2-Deoxyguanosine 5-triphosphate diphosphohydrolase",
"metabolites":{
"dgmp_c":1.0,
"dgtp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"ppi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00001823",
"subsystem":"Purine metabolism",
"annotation":{
"ec-code":"3.6.1.19",
"kegg.reaction":"R01855",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01321",
"name":"CDP-choline:1,2-diacyl-sn-glycerol cholinephosphotransferase",
"metabolites":{
"cdpchol_c":-1.0,
"cmp_c":1.0,
"dag_pl_c":-1.0,
"h_c":1.0,
"pchol_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00013024",
"subsystem":"Glycerophospholipid metabolism",
"annotation":{
"ec-code":"2.7.8.2",
"kegg.reaction":"R01321",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01326",
"name":"ATP:D-mannose 6-phosphotransferase",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"h_c":1.0,
"man6p_c":1.0,
"man_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00008780 or WBGene00010416 or WBGene00022306",
"subsystem":"Fructose and mannose metabolism",
"annotation":{
"ec-code":"2.7.1.1",
"kegg.reaction":"R01326",
"sbo":"SBO:0000176"
}
},
{
"id":"EX00001",
"name":"H2O exchange",
"metabolites":{
"h2o_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RCC0078",
"name":"Prostaglandin G/H synthase",
"metabolites":{
"arachd_c":-1.0,
"h2o_c":1.0,
"h_c":-1.0,
"nadp_c":1.0,
"nadph_c":-1.0,
"o2_c":-2.0,
"prostgh2_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Arachidonic acid metabolism",
"annotation":{
"ec-code":"1.14.99.1",
"kegg.reaction":[
"R01590",
"R00073"
],
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0079",
"name":"acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase (acting on Rtotal4 group)",
"metabolites":{
"Rtotal4coa_c":-1.0,
"alpa_tag_c":1.0,
"coa_c":1.0,
"glyc3p_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00017261 or (WBGene00018657 or WBGene00011106)",
"subsystem":"Glycerolipid metabolism",
"annotation":{
"ec-code":"2.3.1.15",
"kegg.reaction":"R00851",
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0076",
"name":"heme protein synthesis",
"metabolites":{
"apohemeprotein_c":-1.0,
"hemeprotein_c":1.0,
"pheme_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Iron metabolism",
"annotation":{
"sbo":"SBO:0000176"
}
},
{
"id":"EX00344",
"name":"phosphatidylglycerol  exchange",
"metabolites":{
"pglyc_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RCC0074",
"name":"sulfinic acid oxidation",
"metabolites":{
"3sala_c":-1.0,
"Lcyst_c":1.0,
"h2o2_c":-1.0,
"h2o_c":1.0,
"h_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Taurine and hypotaurine metabolism",
"annotation":{
"sbo":"SBO:0000176"
}
},
{
"id":"EX00346",
"name":"Ethanolamine phosphate exchange",
"metabolites":{
"ethamp_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RCC0072",
"name":"long chain fatty acid elongation (C13:iso to C15:iso)",
"metabolites":{
"co2_c":1.0,
"coa_c":1.0,
"fa13p0iso_c":-1.0,
"fa15p0iso_c":1.0,
"h2o_c":1.0,
"h_c":-3.0,
"malcoa_c":-1.0,
"nadp_c":2.0,
"nadph_c":-2.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00001243 and WBGene00002891 and WBGene00020517 and WBGene00000198",
"subsystem":"Monomethyl branched chain fatty acid synthesis",
"annotation":{
"ec-code":[
"2.3.1.199",
"1.1.1.330",
"4.2.1.134",
"1.3.1.93"
],
"kegg.reaction":[
"R09419",
"R10826",
"R10827",
"R10828"
],
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0073",
"name":"long chain fatty acid elongation (C15:iso to C17:iso)",
"metabolites":{
"co2_c":1.0,
"coa_c":1.0,
"fa15p0iso_c":-1.0,
"fa17p0iso_c":1.0,
"h2o_c":1.0,
"h_c":-3.0,
"malcoa_c":-1.0,
"nadp_c":2.0,
"nadph_c":-2.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00001243 or WBGene00001244) and WBGene00002891 and WBGene00020517 and WBGene00000198",
"subsystem":"Monomethyl branched chain fatty acid synthesis",
"annotation":{
"ec-code":[
"2.3.1.199",
"1.1.1.330",
"4.2.1.134",
"1.3.1.93"
],
"kegg.reaction":[
"R09419",
"R10826",
"R10827",
"R10828"
],
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0070",
"name":"long chain fatty acid elongation (Palmitoleyl-coA to Vaccenyl-coA)",
"metabolites":{
"co2_c":1.0,
"coa_c":1.0,
"fa16p1n7coa_c":-1.0,
"h2o_c":1.0,
"h_c":-3.0,
"malcoa_c":-1.0,
"nadp_c":2.0,
"nadph_c":-2.0,
"vacccoa_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00001239 or WBGene00001240 or WBGene00001241 or WBGene00001242 or WBGene00001243 or WBGene00001244 or WBGene00001245 or WBGene00001247) and WBGene00002891 and WBGene00020517 and WBGene00000198",
"subsystem":"Biosynthesis of unsaturated fatty acids",
"annotation":{
"ec-code":[
"2.3.1.199",
"1.1.1.330",
"4.2.1.134",
"1.3.1.93"
],
"kegg.reaction":[
"R09419",
"R10826",
"R10827",
"R10828"
],
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0071",
"name":"branched-chain fatty acid synthase",
"metabolites":{
"co2_c":4.0,
"coa_c":5.0,
"fa13p0iso_c":1.0,
"h2o_c":3.0,
"h_c":-11.0,
"ivcoa_c":-1.0,
"malcoa_c":-4.0,
"nadp_c":8.0,
"nadph_c":-8.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00009342",
"subsystem":"Monomethyl branched chain fatty acid synthesis",
"annotation":{
"ec-code":"2.3.1.85",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00529",
"name":"ATP:sulfate adenylyltransferase",
"metabolites":{
"aps_c":1.0,
"atp_c":-1.0,
"h_c":-1.0,
"ppi_c":1.0,
"so4_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00004091",
"subsystem":"Purine metabolism",
"annotation":{
"ec-code":"2.7.7.4",
"kegg.reaction":"R00529",
"sbo":"SBO:0000176"
}
},
{
"id":"TCM0144",
"name":"Aminoacetone transport",
"metabolites":{
"aact_c":1.0,
"aact_m":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE5365",
"name":"2-Oxobutanoate transport",
"metabolites":{
"2obut_c":1.0,
"2obut_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC00527",
"name":"S-Formylglutathione hydrolase",
"metabolites":{
"Sfglutth_c":-1.0,
"for_c":1.0,
"gthrd_c":1.0,
"h2o_c":-1.0,
"h_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00013018",
"subsystem":"Methane metabolism",
"annotation":{
"ec-code":"3.1.2.12",
"kegg.reaction":"R00527",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00525",
"name":"N-formylglutamate deformylase",
"metabolites":{
"Nforglu_c":-1.0,
"for_c":1.0,
"glu-L_c":1.0,
"h2o_c":-1.0,
"h_c":2.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Histidine metabolism",
"annotation":{
"ec-code":"3.5.1.68",
"kegg.reaction":"R00525",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE0795",
"name":"taurocholic acid transport",
"metabolites":{
"tchola_c":1.0,
"tchola_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"DGR0017",
"name":"Bacterial outer LPS (except for the first two monomers embedded in lipa) degradation",
"metabolites":{
"etha_c":2.0,
"glc-D-A_c":9.0,
"h2o_c":-10.0,
"h_c":-4.0,
"nad_c":2.0,
"nadh_c":-2.0,
"outerlps_BAC_c":-1.0,
"pyr_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Bacterial digestion",
"annotation":{
"sbo":"SBO:0000176"
}
},
{
"id":"DGR0016",
"name":"Bacterial lipa (inner LPS and first two monomers of outer section) degradation",
"metabolites":{
"ddca_c":1.0,
"gam_c":2.0,
"h2o_c":-5.0,
"lipa_BAC_c":-1.0,
"nad_c":4.0,
"nadh_c":-4.0,
"pyr_c":2.0,
"r5p_c":2.0,
"ttdca_c":5.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Bacterial digestion",
"annotation":{
"sbo":"SBO:0000176"
}
},
{
"id":"DGR0015",
"name":"Bacterial outer LPS (except for the first two monomers embedded in lipa) uptake",
"metabolites":{
"outerlps_BAC_c":1.0,
"outerlps_BAC_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Bacterial digestion",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"DGR0014",
"name":"Bacterial lipa (inner LPS and first two monomers of outer section) uptake",
"metabolites":{
"lipa_BAC_c":1.0,
"lipa_BAC_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Bacterial digestion",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"DGR0013",
"name":"Bacterial LPS degradation into lipa (inner LPS plus first two outer monomers) and outerlps_BAC (the rest of LPS)",
"metabolites":{
"lipa_BAC_e":1.0,
"lps_BAC_e":-1.0,
"outerlps_BAC_e":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Bacterial digestion",
"annotation":{
"sbo":"SBO:0000176"
}
},
{
"id":"DGR0012",
"name":"Bacterial peptidoglycan degradation",
"metabolites":{
"acgam_c":2.0,
"ala-L_c":3.0,
"co2_c":1.0,
"glu-L_c":1.0,
"h2o_c":-8.0,
"h_c":-1.0,
"lac-D_c":1.0,
"lys-L_c":1.0,
"peptido_BAC_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Bacterial digestion",
"annotation":{
"sbo":"SBO:0000176"
}
},
{
"id":"DGR0011",
"name":"Bacterial peptidoglycan uptake",
"metabolites":{
"peptido_BAC_c":1.0,
"peptido_BAC_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Bacterial digestion",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"DGR0010",
"name":"Bacterial DNA uptake",
"metabolites":{
"dna_BAC_c":1.0,
"dna_BAC_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Bacterial digestion",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC06259",
"name":"dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (6man to 7man)",
"metabolites":{
"dolmanp_c":-1.0,
"dolp_c":1.0,
"h_c":1.0,
"m5mpdol_c":-1.0,
"m6mpdol_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00007556",
"subsystem":"N-Glycan biosynthesis",
"annotation":{
"ec-code":"2.4.1.259",
"kegg.reaction":"R06259",
"sbo":"SBO:0000176"
}
},
{
"id":"RC06258",
"name":"dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (5man to 6man)",
"metabolites":{
"dolmanp_c":-1.0,
"dolp_c":1.0,
"h_c":1.0,
"m4mpdol_c":-1.0,
"m5mpdol_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00010720",
"subsystem":"N-Glycan biosynthesis",
"annotation":{
"ec-code":"2.4.1.258",
"kegg.reaction":"R06258",
"sbo":"SBO:0000176"
}
},
{
"id":"DGR0019",
"name":"Bacterial phosphatidylethanolamine degradation",
"metabolites":{
"Rtotal_BAC_c":2.0,
"g3pe_c":1.0,
"h2o_c":-2.0,
"h_c":2.0,
"pe_BAC_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00019747 or WBGene00009801 or WBGene00012319 or WBGene00017026 or WBGene00019229 or WBGene00022233 or WBGene00011423 or WBGene00007419 or WBGene00044468",
"subsystem":"Bacterial digestion",
"annotation":{
"ec-code":"3.1.1.4",
"kegg.reaction":"R02053",
"sbo":"SBO:0000176"
}
},
{
"id":"DGR0018",
"name":"Bacterial phosphatidylethanolamine uptake",
"metabolites":{
"pe_BAC_c":1.0,
"pe_BAC_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Bacterial digestion",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC01218",
"name":"5,10-methylenetetrahydrofolate:NAD+ oxidoreductase",
"metabolites":{
"methf_c":1.0,
"mlthf_c":-1.0,
"nad_c":-1.0,
"nadh_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000929",
"subsystem":"One carbon pool by folate",
"annotation":{
"ec-code":"1.5.1.15",
"kegg.reaction":"R01218",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE6001",
"name":"testosterone transport",
"metabolites":{
"tststerone_c":-1.0,
"tststerone_e":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE6002",
"name":"N-acetylgalactosamine transport",
"metabolites":{
"acgal_c":-1.0,
"acgal_e":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM0212",
"name":"Thiosulfate and L-Malate transport",
"metabolites":{
"mal-L_c":-1.0,
"mal-L_m":1.0,
"tsul_c":1.0,
"tsul_m":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RM00216",
"name":"(S)-Malate:NADP+ oxidoreductase(oxaloacetate-decarboxylating)",
"metabolites":{
"co2_m":1.0,
"mal-L_m":-1.0,
"nadp_m":-1.0,
"nadph_m":1.0,
"pyr_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00012983",
"subsystem":"Pyruvate metabolism",
"annotation":{
"ec-code":"1.1.1.40",
"kegg.reaction":"R00216",
"sbo":"SBO:0000176"
}
},
{
"id":"TCM0210",
"name":"Octanoyl-CoA (n-C8:0CoA) transport",
"metabolites":{
"occoa_c":-1.0,
"occoa_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM0216",
"name":"dATP and ATP transport",
"metabolites":{
"atp_c":1.0,
"atp_m":-1.0,
"datp_c":-1.0,
"datp_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM0217",
"name":"Sulfite and L-Malate transport",
"metabolites":{
"mal-L_c":-1.0,
"mal-L_m":1.0,
"so3_c":1.0,
"so3_m":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC00631",
"name":"aldehyde:NAD+ oxidoreductase",
"metabolites":{
"Rtotal7_c":1.0,
"fattyald_c":-1.0,
"h2o_c":-1.0,
"h_c":2.0,
"nad_c":-1.0,
"nadh_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00000108 or WBGene00000110) or (WBGene00000117 or WBGene00000118)",
"subsystem":"Degradation of alkylacylglycerolipids",
"annotation":{
"ec-code":"1.2.1.3",
"kegg.reaction":"R00631",
"sbo":"SBO:0000176"
}
},
{
"id":"TCM0215",
"name":"dADP and ADP transport",
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},
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"lower_bound":-0.0,
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},
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"lower_bound":-0.0,
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},
{
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"name":"Orotate exchange",
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"lower_bound":-0.0,
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},
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"lower_bound":-0.0,
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},
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"name":"D-Glyceraldehyde exchange",
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"lower_bound":-0.0,
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"RNA_c":-0.188823,
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"lower_bound":-0.0,
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},
{
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"lower_bound":-0.0,
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},
{
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"lower_bound":-0.0,
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},
{
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"lower_bound":-0.0,
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},
{
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"lower_bound":-0.0,
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},
{
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"gene_reaction_rule":"",
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},
{
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"gly_m":-1.0
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"lower_bound":-1000.0,
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}
},
{
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"lower_bound":-0.0,
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},
{
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{
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},
{
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},
{
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},
{
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{
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},
{
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"name":"cAMP exchange",
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{
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},
{
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},
{
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},
{
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},
{
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},
{
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},
{
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},
{
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},
{
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{
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"lower_bound":-1000.0,
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},
{
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},
{
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},
{
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},
{
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"name":"Aminoacetone transport",
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},
{
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},
{
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},
{
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},
{
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},
{
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"lower_bound":-1000.0,
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},
{
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"name":"L-Arabinose transport",
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},
{
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"name":"Glycerol transport",
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},
{
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"name":"L-Carnitine transport",
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"lower_bound":-1000.0,
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"gene_reaction_rule":"",
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},
{
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"name":"Glycine transport",
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"lower_bound":-1000.0,
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"gene_reaction_rule":"",
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},
{
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"name":"Xylitol transport",
"metabolites":{
"xylt_c":1.0,
"xylt_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE1304",
"name":"L-Lactate transport",
"metabolites":{
"lac-L_c":1.0,
"lac-L_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE1303",
"name":"L-Proline transport",
"metabolites":{
"pro-L_c":1.0,
"pro-L_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RM00199",
"name":"ATP:pyruvate,water phosphotransferase",
"metabolites":{
"amp_m":1.0,
"atp_m":-1.0,
"h2o_m":-1.0,
"h_m":2.0,
"pep_m":1.0,
"pi_m":1.0,
"pyr_m":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00011893",
"subsystem":"Pyruvate metabolism",
"annotation":{
"ec-code":"2.7.9.2",
"kegg.reaction":"R00199",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE1301",
"name":"O2 transport",
"metabolites":{
"o2_c":1.0,
"o2_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE1300",
"name":"Ethanol transport",
"metabolites":{
"etoh_c":1.0,
"etoh_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"EX06001",
"name":"3-Hydroxy-2-methylpropanoate exchange",
"metabolites":{
"3hmp_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX02076",
"name":"sedoheptulose exchange",
"metabolites":{
"sedh_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RC02173",
"name":"Tryptamine:oxygen oxidoreductase (deaminating)",
"metabolites":{
"h2o2_c":1.0,
"h2o_c":-1.0,
"id3acald_c":1.0,
"nh4_c":1.0,
"o2_c":-1.0,
"trypta_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000138",
"subsystem":"Tryptophan metabolism",
"annotation":{
"ec-code":"1.4.3.4",
"kegg.reaction":"R02173",
"sbo":"SBO:0000176"
}
},
{
"id":"RC02484",
"name":"deoxyuridine:orthophosphate 2-deoxy-D-ribosyltransferase",
"metabolites":{
"2dr1p_c":1.0,
"duri_c":-1.0,
"pi_c":-1.0,
"ura_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00019298 or WBGene00022817",
"subsystem":"Pyrimidine metabolism",
"annotation":{
"ec-code":[
"2.4.2.1",
"2.4.2.3"
],
"kegg.reaction":"R02484",
"sbo":"SBO:0000176"
}
},
{
"id":"RC02485",
"name":"Deoxycytidine aminohydrolase",
"metabolites":{
"dcyt_c":-1.0,
"duri_c":1.0,
"h2o_c":-1.0,
"h_c":-1.0,
"nh4_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000391 or WBGene00000392",
"subsystem":"Pyrimidine metabolism",
"annotation":{
"ec-code":"3.5.4.5",
"kegg.reaction":"R02485",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE0430",
"name":"Pyridoxine transport",
"metabolites":{
"pydxn_c":1.0,
"pydxn_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RM08505",
"name":"cholesterol 26-hydroxylase",
"metabolites":{
"chsterol_m":-1.0,
"h2o_m":1.0,
"h_m":-1.0,
"nadp_m":1.0,
"nadph_m":-1.0,
"o2_m":-1.0,
"xol27oh_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000905",
"subsystem":"Primary bile acid biosynthesis",
"annotation":{
"ec-code":"1.14.13.15",
"kegg.reaction":"R08505",
"sbo":"SBO:0000176"
}
},
{
"id":"RMC0058",
"name":"Acyl-CoA:L-carnitine O-acyltransferase II (Dodecanoyl-CoA )",
"metabolites":{
"coa_m":-1.0,
"crn_m":1.0,
"ddcacoa_m":1.0,
"ddcrn_m":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00011122",
"subsystem":"Carnitine shuttle",
"annotation":{
"ec-code":"2.3.1.21",
"sbo":"SBO:0000176"
}
},
{
"id":"RMC0054",
"name":"Sulfite:ferricytochrome-c oxidoreductase",
"metabolites":{
"ficytC_m":-2.0,
"focytC_m":2.0,
"h2o_c":-1.0,
"h_c":2.0,
"so3_c":-1.0,
"so4_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00010397 and (WBGene00017121 or WBGene00013854)",
"subsystem":"Sulfur metabolism",
"annotation":{
"ec-code":"1.8.3.1",
"sbo":"SBO:0000176"
}
},
{
"id":"RC03018",
"name":"ATP:pantothenate 4-phosphotransferase",
"metabolites":{
"4ppan_c":1.0,
"adp_c":1.0,
"atp_c":-1.0,
"h_c":1.0,
"pnto-R_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00004068 or WBGene00006862",
"subsystem":"Pantothenate and CoA biosynthesis",
"annotation":{
"ec-code":"2.7.1.33",
"kegg.reaction":"R03018",
"sbo":"SBO:0000176"
}
},
{
"id":"RC02003",
"name":"Geranyl-diphosphate:isopentenyl-diphosphate geranyltrans-transferase",
"metabolites":{
"frdp_c":1.0,
"grdp_c":-1.0,
"ipdp_c":-1.0,
"ppi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00011058",
"subsystem":"Terpenoid backbone biosynthesis",
"annotation":{
"ec-code":"2.5.1.10",
"kegg.reaction":"R02003",
"sbo":"SBO:0000176"
}
},
{
"id":"RM04742",
"name":"Decanoyl-CoA:acetyl-CoA C-acyltransferase",
"metabolites":{
"3oddcoa_m":-1.0,
"accoa_m":1.0,
"coa_m":-1.0,
"dcacoa_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00015125 or WBGene00009952",
"subsystem":"Fatty acid elongation",
"annotation":{
"ec-code":"2.3.1.16",
"kegg.reaction":"R04742",
"sbo":"SBO:0000176"
}
},
{
"id":"RC02556",
"name":"Deoxyadenosine aminohydrolase",
"metabolites":{
"dad-2_c":-1.0,
"din_c":1.0,
"h2o_c":-1.0,
"h_c":-1.0,
"nh4_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00015551 or WBGene00016632",
"subsystem":"Purine metabolism",
"annotation":{
"ec-code":"3.5.4.4",
"kegg.reaction":"R02556",
"sbo":"SBO:0000176"
}
},
{
"id":"RC02557",
"name":"Deoxyadenosine:orthophosphate ribosyltransferase",
"metabolites":{
"2dr1p_c":1.0,
"ade_c":1.0,
"dad-2_c":-1.0,
"pi_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00019298",
"subsystem":"Purine metabolism",
"annotation":{
"ec-code":"2.4.2.1",
"kegg.reaction":"R02557",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00888",
"name":"GDP-mannose 4,6-hydro-lyase (GDP-4-dehydro-6-deoxy-D-mannose-forming)",
"metabolites":{
"gdpddman_c":1.0,
"gdpmann_c":-1.0,
"h2o_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000266 or WBGene00010166",
"subsystem":"Fructose and mannose metabolism",
"annotation":{
"ec-code":"4.2.1.47",
"kegg.reaction":"R00888",
"sbo":"SBO:0000176"
}
},
{
"id":"RM01648",
"name":"4-aminobutanoate:2-oxoglutarate aminotransferase",
"metabolites":{
"4abut_m":-1.0,
"akg_m":-1.0,
"glu-L_m":1.0,
"sucsal_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00001794",
"subsystem":"Alanine, aspartate and glutamate metabolism",
"annotation":{
"ec-code":"2.6.1.19",
"kegg.reaction":"R01648",
"sbo":"SBO:0000176"
}
},
{
"id":"RC03755",
"name":"Acyl-CoA:2-acylglycerol O-acyltransferase",
"metabolites":{
"Rtotal5coa_c":-1.0,
"coa_c":1.0,
"dag_tag_c":1.0,
"mag_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"((WBGene00019464 or WBGene00021818) or WBGene00020910) or WBGene00010296",
"subsystem":"Glycerolipid metabolism",
"annotation":{
"ec-code":"2.3.1.22",
"kegg.reaction":"R03755",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE5069",
"name":"Selenocysteine transport",
"metabolites":{
"selcys_c":-1.0,
"selcys_e":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC00885",
"name":"GTP:alpha-D-mannose-1-phosphate guanylyltransferase",
"metabolites":{
"gdpmann_c":1.0,
"gtp_c":-1.0,
"h_c":-1.0,
"man1p_c":-1.0,
"ppi_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00016583 or WBGene00021628",
"subsystem":"Fructose and mannose metabolism",
"annotation":{
"ec-code":"2.7.7.13",
"kegg.reaction":"R00885",
"sbo":"SBO:0000176"
}
},
{
"id":"RC07218",
"name":"Cholesterol 25-hydroxylase",
"metabolites":{
"chsterol_c":-1.0,
"h2o_c":1.0,
"h_c":-1.0,
"nadp_c":1.0,
"nadph_c":-1.0,
"o2_c":-1.0,
"xol25oh_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00018036",
"subsystem":"Primary bile acid biosynthesis",
"annotation":{
"ec-code":"1.14.99.38",
"kegg.reaction":"R07218",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE5066",
"name":"selenite transport",
"metabolites":{
"selnt_c":-1.0,
"selnt_e":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"EX02679",
"name":"Dodecanoate (n-C12:0) exchange",
"metabolites":{
"ddca_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RC07211",
"name":"L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating) (First step)",
"metabolites":{
"o2_c":-1.0,
"phe-L_c":-1.0,
"thbpt4acam_c":1.0,
"thbpt_c":-1.0,
"tyr-L_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000240",
"subsystem":"Phenylalanine metabolism",
"annotation":{
"ec-code":"1.14.16.1",
"kegg.reaction":"R07211",
"sbo":"SBO:0000176"
}
},
{
"id":"RC07212",
"name":"L-Tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating) (4a-Hydroxytetrahydrobiopterin forming)",
"metabolites":{
"34dhphe_c":1.0,
"o2_c":-1.0,
"thbpt4acam_c":1.0,
"thbpt_c":-1.0,
"tyr-L_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000296",
"subsystem":"Isoquinoline alkaloid biosynthesis",
"annotation":{
"ec-code":"1.14.16.2",
"kegg.reaction":"R07212",
"sbo":"SBO:0000176"
}
},
{
"id":"RC07213",
"name":"L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating) (4a-Hydroxytetrahydrobiopterin forming)",
"metabolites":{
"5htrp_c":1.0,
"o2_c":-1.0,
"thbpt4acam_c":1.0,
"thbpt_c":-1.0,
"trp-L_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00006600",
"subsystem":"Tryptophan metabolism",
"annotation":{
"ec-code":"1.14.16.4",
"kegg.reaction":"R07213",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE0544",
"name":"Hypoxanthine transport",
"metabolites":{
"hxan_c":1.0,
"hxan_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC05577",
"name":"L-Aspartate:tRNA(Asp) ligase (AMP-forming)",
"metabolites":{
"amp_c":1.0,
"asp-L_c":-1.0,
"asptrna_c":1.0,
"atp_c":-1.0,
"ppi_c":1.0,
"trnaasp_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00001094",
"subsystem":"Aminoacyl-tRNA biosynthesis",
"annotation":{
"ec-code":"6.1.1.12",
"kegg.reaction":"R05577",
"sbo":"SBO:0000176"
}
},
{
"id":"RC03681",
"name":"glycogenin; glycogen synthase",
"metabolites":{
"h_c":1.0,
"nbglycogen_c":1.0,
"udp_c":1.0,
"udpg_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00006863 or WBGene00012020) and WBGene00001793",
"subsystem":"Starch and sucrose metabolism",
"annotation":{
"ec-code":[
"2.4.1.186",
"2.4.1.11"
],
"kegg.reaction":[
"R03681",
"R00292"
],
"sbo":"SBO:0000176"
}
},
{
"id":"RC00959",
"name":"alpha-D-Glucose 1-phosphate 1,6-phosphomutase",
"metabolites":{
"g1p_c":-1.0,
"g6p-A_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00019890 or WBGene00012803",
"subsystem":"Glycolysis / Gluconeogenesis",
"annotation":{
"ec-code":"5.4.2.2",
"kegg.reaction":"R00959",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE1137",
"name":"L-Serine transport",
"metabolites":{
"ser-L_c":1.0,
"ser-L_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"EX04853",
"name":"w-hydroxyl leukotriene B4 exchange",
"metabolites":{
"leuktrB4woh_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RC07387",
"name":"Plasmanylcholine 2-acylhydrolase",
"metabolites":{
"Rtotal6_c":1.0,
"ak2lgchol_c":1.0,
"akac2gchol_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00019747 or WBGene00009801 or WBGene00012319 or WBGene00017026 or WBGene00019229 or WBGene00022233 or WBGene00011423 or WBGene00007419 or WBGene00044468",
"subsystem":"Ether lipid metabolism",
"annotation":{
"ec-code":"3.1.1.4",
"kegg.reaction":"R07387",
"sbo":"SBO:0000176"
}
},
{
"id":"RC03376",
"name":"Protein lysine,2-oxoglutarate:oxygen oxidoreductase (5-hydroxylating)",
"metabolites":{
"akg_c":-1.0,
"co2_c":1.0,
"o2_c":-1.0,
"pcollg5hlys_c":1.0,
"pcollglys_c":-1.0,
"succ_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00002497",
"subsystem":"Collagen biosynthesis",
"annotation":{
"ec-code":"1.14.11.4",
"kegg.reaction":"R03376",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE0329",
"name":"Hexadecanoate (n-C16:0) transport",
"metabolites":{
"hdca_c":1.0,
"hdca_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"EX00208",
"name":"Maltose exchange",
"metabolites":{
"malt_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RC04262",
"name":"3beta-hydroxy-Delta5-C27-steroid oxidoreductase",
"metabolites":{
"h_c":1.0,
"nad_c":-1.0,
"nadh_c":1.0,
"xol7a_c":-1.0,
"xol7aone_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00012394 or WBGene00022498 or WBGene00022616",
"subsystem":"Primary bile acid biosynthesis",
"annotation":{
"ec-code":"1.1.1.181",
"kegg.reaction":"R04263",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01054",
"name":"ADP-ribose ribophosphohydrolase",
"metabolites":{
"adprib_c":-1.0,
"amp_c":1.0,
"h2o_c":-1.0,
"h_c":2.0,
"r5p_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00003579 or WBGene00003583",
"subsystem":"Purine metabolism",
"annotation":{
"ec-code":"3.6.1.13",
"kegg.reaction":"R01054",
"sbo":"SBO:0000176"
}
},
{
"id":"EX04722",
"name":"\"3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate\" exchange",
"metabolites":{
"thcholstoic_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RC08539",
"name":"NADPH:ferricytochrome-b5 oxidoreductase",
"metabolites":{
"ficytb_c":-2.0,
"focytb_c":2.0,
"h_c":-1.0,
"nadp_c":1.0,
"nadph_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00001262",
"subsystem":"Miscellaneous",
"annotation":{
"ec-code":"1.6.2.4",
"kegg.reaction":"R08539",
"sbo":"SBO:0000176"
}
},
{
"id":"RC04321",
"name":"CDP-choline:1-alkyl-2-acetylglycerol cholinephosphotransferase",
"metabolites":{
"acakg_c":-1.0,
"cdpchol_c":-1.0,
"cmp_c":1.0,
"h_c":1.0,
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},
{
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}
},
{
"id":"RC04325",
"name":"10-Formyltetrahydrofolate:5-phosphoribosylglycinamide formyltransferase",
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"fgam_c":1.0,
"gar_c":-1.0,
"h_c":1.0,
"thf_c":1.0
},
"lower_bound":-1000.0,
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},
{
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"name":"5'-Phosphoribosyl-N-formylglycinamide formation by 5,10-Methenyltetrahydrofolate",
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}
},
{
"id":"RM00261",
"name":"L-glutamate 1-carboxy-lyase (4-aminobutanoate-forming)",
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"co2_m":1.0,
"glu-L_m":-1.0,
"h_m":-1.0
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"lower_bound":-0.0,
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"annotation":{
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"kegg.reaction":"R00261",
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}
},
{
"id":"RC01051",
"name":"ATP:D-ribose 5-phosphotransferase",
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"h_c":1.0,
"r5p_c":1.0,
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"subsystem":"Pentose phosphate pathway",
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}
},
{
"id":"EX05455",
"name":"7alpha-Hydroxycholest-4-en-3-one exchange",
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},
{
"id":"RC01132",
"name":"IMP:diphosphate phospho-D-ribosyltransferase",
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"lower_bound":-0.0,
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},
{
"id":"RC01130",
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}
},
{
"id":"RC01137",
"name":"ATP:dADP phosphotransferase",
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},
{
"id":"EX00178",
"name":"Thymine exchange",
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"lower_bound":-0.0,
"upper_bound":1000.0,
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}
},
{
"id":"RC01135",
"name":"IMP:L-aspartate ligase (GDP-forming)",
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},
{
"id":"RC01134",
"name":"inosine-5-phosphate:NADP+ oxidoreductase (aminating)",
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},
{
"id":"RC01138",
"name":"dATP:pyruvate 2-O-phosphotransferase",
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}
},
{
"id":"RC04742",
"name":"Decanoyl-CoA:acetyl-CoA C-acyltransferase",
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"coa_c":-1.0,
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"lower_bound":-0.0,
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},
{
"id":"RC05692",
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"lower_bound":-1000.0,
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"subsystem":"Fructose and mannose metabolism",
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"sbo":"SBO:0000176"
}
},
{
"id":"RM03646",
"name":"L-Arginine:tRNA(Arg) ligase (AMP-forming)",
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"ppi_m":1.0,
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"lower_bound":-0.0,
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"sbo":"SBO:0000176"
}
},
{
"id":"RC03991",
"name":"myristoyl-CoA:acetylCoA C-myristoyltransferase",
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"coa_c":-1.0,
"tdcoa_c":1.0
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"lower_bound":-0.0,
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"subsystem":"Peroxisomal fatty acid beta oxidation",
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},
{
"id":"RM03648",
"name":"L-Asparagine:tRNA(Asn) ligase (AMP-forming)",
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},
{
"id":"DMN0020",
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"lower_bound":-0.0,
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},
{
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},
{
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"lower_bound":-0.0,
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},
{
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},
{
"id":"DMN0024",
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
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"annotation":{
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},
{
"id":"DMN0025",
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
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},
{
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},
{
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},
{
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"subsystem":"Purine metabolism",
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},
{
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},
{
"id":"RC01863",
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},
{
"id":"RC09085",
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"kegg.reaction":"R09085",
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},
{
"id":"RC01681",
"name":"Hypotaurine oxidase",
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},
{
"id":"RC01682",
"name":"3-Sulfo-L-alanine carboxy-lyase (taurine-forming)",
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},
{
"id":"RCC0009",
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},
{
"id":"RC01049",
"name":"ATP:D-ribose-5-phosphate diphosphotransferase",
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"subsystem":"Pentose phosphate pathway",
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},
{
"id":"EX00352",
"name":"D-Glucosamine 6-phosphate exchange",
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"subsystem":"Exchange with the environment",
"annotation":{
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},
{
"id":"RCC0001",
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"icit_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000040",
"subsystem":"Citrate cycle (TCA cycle)",
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},
{
"id":"RC01041",
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"subsystem":"Glycerolipid metabolism",
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},
{
"id":"EX00355",
"name":"\"3,4-Dihydroxy-L-phenylalanine\" exchange",
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},
{
"id":"TCE1297",
"name":"L-Alanine transport",
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"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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},
{
"id":"RM00513",
"name":"ATP:cytidine 5-phosphotransferase",
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},
{
"id":"RC04496",
"name":"S-Adenosyl-L-methionine:protein-C-terminal-S-farnesyl-L-cysteine O-methyltransferase",
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"protSfarCmet_c":1.0
},
"lower_bound":-0.0,
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"gene_reaction_rule":"WBGene00017673 or WBGene00019710",
"subsystem":"Terpenoid backbone biosynthesis",
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"kegg.reaction":"R04496",
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},
{
"id":"DGR0004",
"name":"Bacterial fatty acid composition",
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"fa17c9_c":0.311026,
"fa19c11_c":0.065863,
"hdca_c":0.430027,
"ttdca_c":0.056282,
"vacc_c":0.09472
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},
{
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},
{
"id":"DGR0006",
"name":"Bacterial soluble pool composition",
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},
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}
},
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},
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"lower_bound":-1000.0,
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}
},
{
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},
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},
{
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}
},
{
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}
},
{
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}
},
{
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},
{
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},
{
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},
{
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},
{
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"name":"Acyl-CoA:L-carnitine O-acyltransferase II (eicosatetranoyl CoA)",
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}
},
{
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"lower_bound":-0.0,
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}
},
{
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"subsystem":"Carnitine shuttle",
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},
{
"id":"RMC0110",
"name":"Acyl-CoA:L-carnitine O-acyltransferase II (linoleic CoA)",
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},
{
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}
},
{
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},
{
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}
},
{
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},
{
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"retpalm_c":1.0
},
"lower_bound":-1000.0,
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"subsystem":"Retinol metabolism",
"annotation":{
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"kegg.reaction":"R02367",
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}
},
{
"id":"TCE5306",
"name":"3,5-Diiodo-L-tyrosine transport",
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"na1_c":1.0,
"na1_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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}
},
{
"id":"TCE5305",
"name":"3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate transport",
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},
"lower_bound":-1000.0,
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}
},
{
"id":"RC02364",
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},
"lower_bound":-0.0,
"upper_bound":1000.0,
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},
{
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"name":"25-Hydroxycholesterol transport",
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"xol25oh_e":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
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},
{
"id":"TCE5308",
"name":"27-Hydroxycholesterol transport",
"metabolites":{
"xol27oh_c":-1.0,
"xol27oh_e":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
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},
{
"id":"EX01888",
"name":"Aminoacetone exchange",
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
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},
{
"id":"EX01885",
"name":"monoacylglycerol 2  exchange",
"metabolites":{
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
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},
{
"id":"EX05984",
"name":"2-Hydroxybutyrate exchange",
"metabolites":{
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
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},
{
"id":"TCE0474",
"name":"Prostaglandin E2 transport",
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"prostge2_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM0195",
"name":"CDP diacylglycerol  transport",
"metabolites":{
"cdpdag_c":-1.0,
"cdpdag_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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}
},
{
"id":"TCE1310",
"name":"CO2 transport",
"metabolites":{
"co2_c":1.0,
"co2_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE1311",
"name":"Acetate transport",
"metabolites":{
"ac_c":1.0,
"ac_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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}
},
{
"id":"TCE1312",
"name":"H2O transport",
"metabolites":{
"h2o_c":1.0,
"h2o_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RM00833",
"name":"(R)-Methylmalonyl-CoA CoA-carbonylmutase",
"metabolites":{
"mmcoa-R_m":-1.0,
"succoa_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00014202",
"subsystem":"Valine, leucine and isoleucine degradation",
"annotation":{
"ec-code":"5.4.99.2",
"kegg.reaction":"R00833",
"sbo":"SBO:0000176"
}
},
{
"id":"RC02103",
"name":"xanthine:NAD+ oxidoreductase",
"metabolites":{
"h2o_c":-1.0,
"h_c":1.0,
"nad_c":-1.0,
"nadh_c":1.0,
"urate_c":1.0,
"xan_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00010083",
"subsystem":"Purine metabolism",
"annotation":{
"ec-code":"1.17.1.4",
"kegg.reaction":"R02103",
"sbo":"SBO:0000176"
}
},
{
"id":"RC02102",
"name":"2-Deoxyuridine 5-monophosphate phosphohydrolase",
"metabolites":{
"dump_c":-1.0,
"duri_c":1.0,
"h2o_c":-1.0,
"pi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00017775 or WBGene00012423 or WBGene00022201",
"subsystem":"Pyrimidine metabolism",
"annotation":{
"ec-code":"3.1.3.5",
"kegg.reaction":"R02102",
"sbo":"SBO:0000176"
}
},
{
"id":"RC02101",
"name":"5,10-Methylenetetrahydrofolate:dUMP C-methyltransferase",
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"dhf_c":1.0,
"dtmp_c":1.0,
"dump_c":-1.0,
"mlthf_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00022455",
"subsystem":"Pyrimidine metabolism",
"annotation":{
"ec-code":"2.1.1.45",
"kegg.reaction":"R02101",
"sbo":"SBO:0000176"
}
},
{
"id":"RC02100",
"name":"dUTP nucleotidohydrolase",
"metabolites":{
"dump_c":1.0,
"dutp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"ppi_c":1.0
},
"lower_bound":-0.0,
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"gene_reaction_rule":"WBGene00001823 or WBGene00010609",
"subsystem":"Pyrimidine metabolism",
"annotation":{
"ec-code":[
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"3.6.1.23"
],
"kegg.reaction":"R02100",
"sbo":"SBO:0000176"
}
},
{
"id":"RC02107",
"name":"Xanthine:oxygen oxidoreductase",
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"h2o_c":-1.0,
"o2_c":-1.0,
"urate_c":1.0,
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"lower_bound":-0.0,
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"subsystem":"Purine metabolism",
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"kegg.reaction":"R02107",
"sbo":"SBO:0000176"
}
},
{
"id":"RMC0028",
"name":"artificial quinone conversion (q9 to q pool)",
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},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Miscellaneous",
"annotation":{
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}
},
{
"id":"RMC0023",
"name":"Tetrahydrofolyl-[Glu](n):L-glutamate gamma-ligase (ADP-forming) (producing 5thf)",
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"atp_m":-4.0,
"glu-L_m":-4.0,
"h_m":4.0,
"pi_m":4.0,
"thf_m":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00017777",
"subsystem":"Folate biosynthesis",
"annotation":{
"ec-code":"6.3.2.17",
"kegg.reaction":[
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"R00942"
],
"sbo":"SBO:0000176"
}
},
{
"id":"RMC0027",
"name":"artificial quinone conversion (q8 to q pool)",
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"q_m":1.0
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"lower_bound":-0.0,
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"gene_reaction_rule":"",
"subsystem":"Miscellaneous",
"annotation":{
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}
},
{
"id":"RMC0026",
"name":"Hydroxylation of 3-Decaprenyl-4-hydroxybenzoate (NADP)",
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"3nphb_m":-1.0,
"h2o_m":1.0,
"h_m":-1.0,
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"nadph_m":-1.0,
"o2_m":-1.0
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"lower_bound":-0.0,
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"gene_reaction_rule":"",
"subsystem":"Ubiquinone and other terpenoid-quinone biosynthesis",
"annotation":{
"kegg.reaction":"R08770",
"sbo":"SBO:0000176"
}
},
{
"id":"RMC0024",
"name":"Tetrahydrofolyl-[Glu](n):L-glutamate gamma-ligase (ADP-forming) (producing 7thf)",
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"7thf_m":1.0,
"adp_m":2.0,
"atp_m":-2.0,
"glu-L_m":-2.0,
"h_m":2.0,
"pi_m":2.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00017777",
"subsystem":"Folate biosynthesis",
"annotation":{
"ec-code":"6.3.2.17",
"kegg.reaction":[
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],
"sbo":"SBO:0000176"
}
},
{
"id":"RM00239",
"name":"ATP:L-glutamate 5-phosphotransferase",
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"atp_m":-1.0,
"glu-L_m":-1.0,
"glu5p_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00011938",
"subsystem":"Arginine and proline metabolism",
"annotation":{
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"kegg.reaction":"R00239",
"sbo":"SBO:0000176"
}
},
{
"id":"RC05979",
"name":"mannosyl-oligosaccharide glucosidase",
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"g3m8masn_c":-1.0,
"glc-D_c":1.0,
"h2o_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00008775",
"subsystem":"N-Glycan biosynthesis",
"annotation":{
"ec-code":"3.2.1.106",
"kegg.reaction":"R05979",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE0687",
"name":"Nicotinate transport",
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"nac_c":1.0,
"nac_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC05973",
"name":"GDP-mannose:glycolipid 3-alpha-D-mannosyltransferase",
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"gdp_c":1.0,
"gdpmann_c":-1.0,
"h_c":1.0,
"m1mpdol_c":1.0,
"mpdol_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00017282",
"subsystem":"N-Glycan biosynthesis",
"annotation":{
"ec-code":"2.4.1.132",
"kegg.reaction":"R05973",
"sbo":"SBO:0000176"
}
},
{
"id":"RC05972",
"name":"chitobiosyldiphosphodolichol beta-mannosyltransferase",
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"gdp_c":1.0,
"gdpmann_c":-1.0,
"h_c":1.0,
"mpdol_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00020820",
"subsystem":"N-Glycan biosynthesis",
"annotation":{
"ec-code":"2.4.1.142",
"kegg.reaction":"R05972",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE5415",
"name":"1-Methylnicotinamide import",
"metabolites":{
"1mncam_c":1.0,
"1mncam_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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}
},
{
"id":"RC05970",
"name":"UDP-GlcNAc:dolichyl-pyrophosphoryl-GlcNAc GlcNAc transferase",
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"h_c":1.0,
"naglc2p_c":-1.0,
"uacgam_c":-1.0,
"udp_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00019725 or WBGene00011193)",
"subsystem":"N-Glycan biosynthesis",
"annotation":{
"ec-code":"2.4.1.141",
"kegg.reaction":"R05970",
"sbo":"SBO:0000176"
}
},
{
"id":"RC07041",
"name":"Arachidonic acid:oxygen 1-oxidoreductase",
"metabolites":{
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"arachd_c":-1.0,
"h2o_c":1.0,
"h_c":-1.0,
"nadp_c":1.0,
"nadph_c":-1.0,
"o2_c":-1.0
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"lower_bound":-0.0,
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"gene_reaction_rule":"WBGene00008499 or WBGene00009226",
"subsystem":"Arachidonic acid metabolism",
"annotation":{
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"kegg.reaction":"R07041",
"sbo":"SBO:0000176"
}
},
{
"id":"RC05976",
"name":"dolichyl-diphosphooligosaccharide-protein glycotransferase",
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"doldp_c":1.0,
"g3m8masn_c":1.0,
"g3m8mpdol_c":-1.0,
"h_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00020437",
"subsystem":"N-Glycan biosynthesis",
"annotation":{
"ec-code":"2.4.99.18",
"kegg.reaction":"R05976",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE5411",
"name":"Spermine transport",
"metabolites":{
"sprm_c":1.0,
"sprm_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE5410",
"name":"Spermidine transport",
"metabolites":{
"spmd_c":-1.0,
"spmd_e":1.0
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"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC03219",
"name":"Procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating)",
"metabolites":{
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"co2_c":1.0,
"o2_c":-1.0,
"pcollg4hpro_c":1.0,
"pcollgpro_c":-1.0,
"succ_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00015773 or WBGene00077688 or WBGene00001077 or WBGene00004025 or WBGene00004026 or WBGene00012815",
"subsystem":"Collagen biosynthesis",
"annotation":{
"ec-code":"1.14.11.2",
"kegg.reaction":"R03219",
"sbo":"SBO:0000176"
}
},
{
"id":"RC03749",
"name":"(5-L-Glutamyl)-L-alanine 5-glutamyltransferase (cyclizing)",
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"ala-L_c":1.0,
"gluala_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00016629",
"subsystem":"Glutathione metabolism",
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"kegg.reaction":"R03749",
"sbo":"SBO:0000176"
}
},
{
"id":"EX00330",
"name":"Deoxyguanosine exchange",
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
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}
},
{
"id":"RM01655",
"name":"5,10-Methenyltetrahydrofolate 5-hydrolase (decyclizing)",
"metabolites":{
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"h2o_m":-1.0,
"h_m":1.0,
"methf_m":-1.0
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"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00019492 or WBGene00000929",
"subsystem":"One carbon pool by folate",
"annotation":{
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"kegg.reaction":"R01655",
"sbo":"SBO:0000176"
}
},
{
"id":"RC02619",
"name":"3-sulfino-L-alanine:2-oxoglutarate aminotransferase",
"metabolites":{
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"3snpyr_c":1.0,
"akg_c":-1.0,
"glu-L_c":1.0,
"h_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00020146",
"subsystem":"Cysteine and methionine metabolism",
"annotation":{
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"kegg.reaction":"R02619",
"sbo":"SBO:0000176"
}
},
{
"id":"RM02050",
"name":"(R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase",
"metabolites":{
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"3aib-D_m":-1.0,
"ala-L_m":1.0,
"pyr_m":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00020382",
"subsystem":"Pyrimidine metabolism (indirect)",
"annotation":{
"ec-code":"2.6.1.40",
"kegg.reaction":"R02050",
"sbo":"SBO:0000176"
}
},
{
"id":"RM02055",
"name":"Phsophatidyl-L-serine carboxy-lyase",
"metabolites":{
"co2_m":1.0,
"h_m":-1.0,
"pe_m":1.0,
"ps_m":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00015159",
"subsystem":"Glycerophospholipid metabolism",
"annotation":{
"ec-code":"4.1.1.65",
"kegg.reaction":"R02055",
"sbo":"SBO:0000176"
}
},
{
"id":"RC03361",
"name":"ATP:1-Phosphatidyl-1D-myo-inositol 4-phosphotransferase",
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"atp_c":-1.0,
"h_c":1.0,
"pail4p_c":1.0,
"pail_c":-1.0
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00008346 or WBGene00022501) or (WBGene00013557 or WBGene00018076)",
"subsystem":"Inositol phosphate metabolism",
"annotation":{
"ec-code":"2.7.1.67",
"kegg.reaction":"R03361",
"sbo":"SBO:0000176"
}
},
{
"id":"RC03362",
"name":"ATP:1-phosphatidyl-1D-myo-inositol 3-phosphotransferase",
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"atp_c":-1.0,
"h_c":1.0,
"pail3p_c":1.0,
"pail_c":-1.0
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00006932",
"subsystem":"Inositol phosphate metabolism",
"annotation":{
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"kegg.reaction":"R03362",
"sbo":"SBO:0000176"
}
},
{
"id":"RC03363",
"name":"1-Phosphatidyl-1D-myo-inositol 3-phosphate 3-phosphohydrolase",
"metabolites":{
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"pail3p_c":-1.0,
"pail_c":1.0,
"pi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00003476",
"subsystem":"Inositol phosphate metabolism",
"annotation":{
"ec-code":"3.1.3.64",
"kegg.reaction":"R03363",
"sbo":"SBO:0000176"
}
},
{
"id":"RC04404",
"name":"Phosphatidyl-myo-inositol-4,5-bisphosphate 4-phosphohydrolase",
"metabolites":{
"h2o_c":-1.0,
"pail45p_c":-1.0,
"pail4p_c":1.0,
"pi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00012016 or WBGene00007620 or WBGene00006763",
"subsystem":"Inositol phosphate metabolism",
"annotation":{
"ec-code":"3.1.3.36",
"kegg.reaction":"R04404",
"sbo":"SBO:0000176"
}
},
{
"id":"RC05802",
"name":"ATP:1-phosphatidyl-1D-myo-inositol-3-phosphate 5-phosphotransferase",
"metabolites":{
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"atp_c":-1.0,
"h_c":1.0,
"pail35p_c":1.0,
"pail3p_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00004089",
"subsystem":"Inositol phosphate metabolism",
"annotation":{
"ec-code":"2.7.1.150",
"kegg.reaction":"R05802",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE0352",
"name":"arachidonic acid transport",
"metabolites":{
"arachd_c":1.0,
"arachd_e":-1.0
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"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC00328",
"name":"GDP phosphohydrolase",
"metabolites":{
"gdp_c":-1.0,
"gmp_c":1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00044355 or WBGene00017244) or WBGene00003254 or WBGene00010697",
"subsystem":"Purine metabolism",
"annotation":{
"ec-code":"3.6.1.6",
"kegg.reaction":"R00328",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00987",
"name":"L-Kynurenine hydrolase",
"metabolites":{
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"ala-L_c":1.0,
"anth_c":1.0,
"h2o_c":-1.0,
"h_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00015802",
"subsystem":"Tryptophan metabolism",
"annotation":{
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"kegg.reaction":"R00987",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00988",
"name":"N-Formylanthranilate amidohydrolase",
"metabolites":{
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"for_c":1.0,
"h2o_c":-1.0,
"h_c":1.0,
"nformanth_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00017051",
"subsystem":"Tryptophan metabolism",
"annotation":{
"ec-code":"3.5.1.9",
"kegg.reaction":"R00988",
"sbo":"SBO:0000176"
}
},
{
"id":"RC04620",
"name":"2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl) dihydropteridine triphosphate phosphohydrolase (alkaline optimum)",
"metabolites":{
"ahdt_c":-1.0,
"dhnpt_c":1.0,
"h2o_c":-3.0,
"h_c":2.0,
"pi_c":3.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00013646",
"subsystem":"Folate biosynthesis",
"annotation":{
"ec-code":"3.1.3.1",
"kegg.reaction":"R04620",
"sbo":"SBO:0000176"
}
},
{
"id":"RC08183",
"name":"Archidonyl-CoA thioesterase",
"metabolites":{
"arachd_c":1.0,
"arachdcoa_c":-1.0,
"coa_c":1.0,
"h2o_c":-1.0,
"h_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00019404 or (WBGene00020989 or WBGene00020258) or WBGene00007857 or (WBGene00015887  or WBGene00015889  or WBGene00016511  or WBGene00017781)",
"subsystem":"Biosynthesis of unsaturated fatty acids",
"annotation":{
"ec-code":"3.1.2.2",
"kegg.reaction":"R08183",
"sbo":"SBO:0000176"
}
},
{
"id":"RC03181",
"name":"4-Maleylacetoacetate cis-trans-isomerase",
"metabolites":{
"4fumacac_c":1.0,
"4mlacac_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00021817 or WBGene00001790 or WBGene00001791",
"subsystem":"Tyrosine metabolism",
"annotation":{
"ec-code":"5.2.1.2",
"kegg.reaction":"R03181",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00188",
"name":"Adenosine 3,5-bisphosphate 3-phosphohydrolase",
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"h2o_c":-1.0,
"pap_c":-1.0,
"pi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00044063 or WBGene00012390",
"subsystem":"Miscellaneous",
"annotation":{
"ec-code":"3.1.3.7",
"kegg.reaction":"R00188",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01123",
"name":"Isopentenyl-diphosphate delta3-delta2-isomerase",
"metabolites":{
"dmpp_c":1.0,
"ipdp_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00019460",
"subsystem":"Terpenoid backbone biosynthesis",
"annotation":{
"ec-code":"5.3.3.2",
"kegg.reaction":"R01123",
"sbo":"SBO:0000176"
}
},
{
"id":"RM02301",
"name":"5-Formyltetrahydrofolate cyclo-ligase (ADP-forming)",
"metabolites":{
"5fthf_m":-1.0,
"adp_m":1.0,
"atp_m":-1.0,
"methf_m":1.0,
"pi_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00013708",
"subsystem":"One carbon pool by folate",
"annotation":{
"ec-code":"6.3.3.2",
"kegg.reaction":"R02301",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01127",
"name":"IMP 1,2-hydrolase (decyclizing)",
"metabolites":{
"fprica_c":1.0,
"h2o_c":-1.0,
"imp_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00016957",
"subsystem":"Purine metabolism",
"annotation":{
"ec-code":[
"2.1.2.3",
"3.5.4.10"
],
"kegg.reaction":"R01127",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00181",
"name":"AMP aminohydrolase",
"metabolites":{
"amp_c":-1.0,
"h2o_c":-1.0,
"h_c":-1.0,
"imp_c":1.0,
"nh4_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00016415",
"subsystem":"Purine metabolism",
"annotation":{
"ec-code":"3.5.4.6",
"kegg.reaction":"R00181",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00183",
"name":"Adenosine 5-monophosphate phosphohydrolase",
"metabolites":{
"adn_c":1.0,
"amp_c":-1.0,
"h2o_c":-1.0,
"pi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00017775 or WBGene00012423 or WBGene00022201",
"subsystem":"Purine metabolism",
"annotation":{
"ec-code":"3.1.3.5",
"kegg.reaction":"R00183",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00185",
"name":"ATP:adenosine 5-phosphotransferase",
"metabolites":{
"adn_c":-1.0,
"adp_c":1.0,
"amp_c":1.0,
"atp_c":-1.0,
"h_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00011128",
"subsystem":"Purine metabolism",
"annotation":{
"ec-code":"2.7.1.20",
"kegg.reaction":"R00185",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE5346",
"name":"L-2-Aminoadipate transport",
"metabolites":{
"L2aadp_c":1.0,
"L2aadp_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC00431",
"name":"GTP:oxaloacetate carboxy-lyase (adding GTP, phosphoenolpyruvate-forming)",
"metabolites":{
"co2_c":1.0,
"gdp_c":1.0,
"gtp_c":-1.0,
"oaa_c":-1.0,
"pep_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00021043 or WBGene00011232 or WBGene00019151",
"subsystem":"Glycolysis / Gluconeogenesis",
"annotation":{
"ec-code":"4.1.1.32",
"kegg.reaction":"R00431",
"sbo":"SBO:0000176"
}
},
{
"id":"EX15519",
"name":"25-Hydroxycholesterol exchange",
"metabolites":{
"xol25oh_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RC00434",
"name":"GTP diphosphate-lyase (cyclizing, 3',5'-cyclic-GMP-forming)",
"metabolites":{
"35cgmp_c":1.0,
"gtp_c":-1.0,
"ppi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"((WBGene00001528 or WBGene00001538 or WBGene00001540 or WBGene00001541 or WBGene00001543 or WBGene00001529 or WBGene00001545 or WBGene00001546 or WBGene00001548 or WBGene00001530 or WBGene00001554 or WBGene00001532 or WBGene00001535) or (WBGene00001542 or WBGene00020131) or (WBGene00001551 or WBGene00001553 or WBGene00001555 or WBGene00001556 or WBGene00001557)) or (WBGene00000068 or WBGene00000071) or WBGene00000069 or (WBGene00000907 or WBGene00001544 or WBGene00001547 or WBGene00001549 or WBGene00007314 or WBGene00001552 or WBGene00001531 or WBGene00001536)",
"subsystem":"Purine metabolism",
"annotation":{
"ec-code":[
"4.6.1.1",
"4.6.1.2"
],
"kegg.reaction":"R00434",
"sbo":"SBO:0000176"
}
},
{
"id":"RM03650",
"name":"L-Cysteine:tRNA(Cys) ligase (AMP-forming)",
"metabolites":{
"amp_m":1.0,
"atp_m":-1.0,
"cys-L_m":-1.0,
"cystrna_m":1.0,
"ppi_m":1.0,
"trnacys_m":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000800",
"subsystem":"Aminoacyl-tRNA biosynthesis",
"annotation":{
"ec-code":"6.1.1.16",
"kegg.reaction":"R03650",
"sbo":"SBO:0000176"
}
},
{
"id":"RM03651",
"name":"L-Glutamate:tRNA(Gln) ligase",
"metabolites":{
"amp_m":1.0,
"atp_m":-1.0,
"glu-L_m":-1.0,
"glutrna_gln_m":1.0,
"ppi_m":1.0,
"trnagln_m":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Aminoacyl-tRNA biosynthesis",
"annotation":{
"ec-code":"6.1.1.24",
"kegg.reaction":"R03651",
"sbo":"SBO:0000176"
}
},
{
"id":"RM03656",
"name":"L-Isoleucine:tRNA(Ile) ligase (AMP-forming)",
"metabolites":{
"amp_m":1.0,
"atp_m":-1.0,
"ile-L_m":-1.0,
"iletrna_m":1.0,
"ppi_m":1.0,
"trnaile_m":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00002153",
"subsystem":"Aminoacyl-tRNA biosynthesis",
"annotation":{
"ec-code":"6.1.1.5",
"kegg.reaction":"R03656",
"sbo":"SBO:0000176"
}
},
{
"id":"RM03657",
"name":"L-Leucine:tRNA(Leu) ligase (AMP-forming)",
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"atp_m":-1.0,
"leu-L_m":-1.0,
"leutrna_m":1.0,
"ppi_m":1.0,
"trnaleu_m":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00003074",
"subsystem":"Aminoacyl-tRNA biosynthesis",
"annotation":{
"ec-code":"6.1.1.4",
"kegg.reaction":"R03657",
"sbo":"SBO:0000176"
}
},
{
"id":"RM03654",
"name":"glycine:tRNA(Gly) ligase (AMP-forming)",
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"gly_m":-1.0,
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"lower_bound":-0.0,
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"subsystem":"Aminoacyl-tRNA biosynthesis",
"annotation":{
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"kegg.reaction":"R03654",
"sbo":"SBO:0000176"
}
},
{
"id":"RM03655",
"name":"L-Histidine:tRNA(His) ligase (AMP-forming)",
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"atp_m":-1.0,
"his-L_m":-1.0,
"histrna_m":1.0,
"ppi_m":1.0,
"trnahis_m":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00002001",
"subsystem":"Aminoacyl-tRNA biosynthesis",
"annotation":{
"ec-code":"6.1.1.21",
"kegg.reaction":"R03655",
"sbo":"SBO:0000176"
}
},
{
"id":"RM03658",
"name":"L-Lysine:tRNALys ligase (AMP-forming)",
"metabolites":{
"amp_m":1.0,
"atp_m":-1.0,
"lys-L_m":-1.0,
"lystrna_m":1.0,
"ppi_m":1.0,
"trnalys_m":-1.0
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"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00002238",
"subsystem":"Aminoacyl-tRNA biosynthesis",
"annotation":{
"ec-code":"6.1.1.6",
"kegg.reaction":"R03658",
"sbo":"SBO:0000176"
}
},
{
"id":"RM03659",
"name":"L-Methionine:tRNAMet ligase (AMP-forming)",
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"atp_m":-1.0,
"met-L_m":-1.0,
"mettrna_m":1.0,
"ppi_m":1.0,
"trnamet_m":-1.0
},
"lower_bound":-0.0,
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"gene_reaction_rule":"WBGene00013678",
"subsystem":"Aminoacyl-tRNA biosynthesis",
"annotation":{
"ec-code":"6.1.1.10",
"kegg.reaction":"R03659",
"sbo":"SBO:0000176"
}
},
{
"id":"SNK1002",
"name":"Peptide histidine sink",
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},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Protein modification",
"annotation":{
"sbo":"SBO:0000632"
}
},
{
"id":"SNK1003",
"name":"Peptide diphtine sink",
"metabolites":{
"pdipht_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Protein modification",
"annotation":{
"sbo":"SBO:0000632"
}
},
{
"id":"DMN0018",
"name":"thiamine pyrophosphate demand (mitochondrial)",
"metabolites":{
"thmpp_m":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Thiamine metabolism",
"annotation":{
"sbo":"SBO:0000628"
}
},
{
"id":"DMN0015",
"name":"melanin demand",
"metabolites":{
"eumelanin_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Melanin biosynthesis",
"annotation":{
"sbo":"SBO:0000628"
}
},
{
"id":"DMN0017",
"name":"thiamine pyrophosphate demand (cytosolic)",
"metabolites":{
"thmpp_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Thiamine metabolism",
"annotation":{
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}
},
{
"id":"RC01878",
"name":"Cytidine aminohydrolase",
"metabolites":{
"cytd_c":-1.0,
"h2o_c":-1.0,
"h_c":-1.0,
"nh4_c":1.0,
"uri_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000391 or WBGene00000392",
"subsystem":"Pyrimidine metabolism",
"annotation":{
"ec-code":"3.5.4.5",
"kegg.reaction":"R01878",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01876",
"name":"Uridine:phosphate alpha-D-ribosyltransferase",
"metabolites":{
"pi_c":-1.0,
"r1p_c":1.0,
"ura_c":1.0,
"uri_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00022817",
"subsystem":"Pyrimidine metabolism",
"annotation":{
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"kegg.reaction":"R01876",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01870",
"name":"Orotidine-5-phosphate:diphosphate phospho-alpha-D-ribosyl-transferase",
"metabolites":{
"orot5p_c":-1.0,
"orot_c":1.0,
"ppi_c":-1.0,
"prpp_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00020036 or WBGene00011559",
"subsystem":"Pyrimidine metabolism",
"annotation":{
"ec-code":"2.4.2.10",
"kegg.reaction":"R01870",
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0018",
"name":"melanine biosynthesis (merged)",
"metabolites":{
"34dhphe_c":1.0,
"co2_c":1.0,
"dopaqn_c":-2.0,
"h2o_c":1.0,
"ind56qn_c":1.0,
"o2_c":-0.5
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00015332 or WBGene00010661 or WBGene00009001 or WBGene00016419 or WBGene00021553 or WBGene00022231",
"subsystem":"Tyrosine metabolism",
"annotation":{
"ec-code":"1.14.18.1",
"kegg.reaction":[
"R02962",
"R03672",
"R03674",
"R04884"
],
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0019",
"name":"Acetyl-CoA:carbon-dioxide ligase (ADP-forming); biotin-carboxyl-carrier-protein:carbon-dioxide ligase (ADP-forming)",
"metabolites":{
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"atp_c":-1.0,
"h_c":1.0,
"hco3_c":-1.0,
"malcoa_c":1.0,
"pi_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00012131 or WBGene00004076",
"subsystem":"Fatty acid biosynthesis",
"annotation":{
"ec-code":[
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"6.3.4.14"
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"kegg.reaction":[
"R04386",
"R04385"
],
"sbo":"SBO:0000176"
}
},
{
"id":"RC00507",
"name":"3'-phosphoadenylyl-sulfate sulfohydrolase",
"metabolites":{
"h2o_c":-1.0,
"h_c":2.0,
"pap_c":1.0,
"paps_c":-1.0,
"so4_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00007753 or WBGene00007755",
"subsystem":"Purine metabolism",
"annotation":{
"ec-code":"3.6.1.9",
"kegg.reaction":"R00507",
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0010",
"name":"5-(methylthio)-2,3-dioxopentyl-phosphate phosphohydrolase (isomerizing); 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one:oxygen oxidoreductase (formate-forming)",
"metabolites":{
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"dkmpp_c":-1.0,
"for_c":1.0,
"h2o_c":-1.0,
"h_c":2.0,
"o2_c":-1.0,
"pi_c":1.0
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00010286 and (WBGene00009636 or WBGene00020149)",
"subsystem":"Cysteine and methionine metabolism",
"annotation":{
"ec-code":[
"3.1.3.77",
"1.13.11.54"
],
"kegg.reaction":[
"R07395",
"R07364"
],
"sbo":"SBO:0000176"
}
},
{
"id":"RC01055",
"name":"uracil hydro-lyase",
"metabolites":{
"h2o_c":1.0,
"psd5p_c":1.0,
"r5p_c":-1.0,
"ura_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00020765",
"subsystem":"Pyrimidine metabolism",
"annotation":{
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"kegg.reaction":"R01055",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01056",
"name":"D-ribose-5-phosphate aldose-ketose-isomerase",
"metabolites":{
"r5p_c":-1.0,
"ru5p-D_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00015101",
"subsystem":"Pentose phosphate pathway",
"annotation":{
"ec-code":"5.3.1.6",
"kegg.reaction":"R01056",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01057",
"name":"D-Ribose 1,5-phosphomutase",
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"r5p_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00019890 or WBGene00012803",
"subsystem":"Pentose phosphate pathway",
"annotation":{
"ec-code":[
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"5.4.2.7"
],
"kegg.reaction":"R01057",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00509",
"name":"ATP:adenylylsulfate 3-phosphotransferase",
"metabolites":{
"adp_c":1.0,
"aps_c":-1.0,
"atp_c":-1.0,
"h_c":1.0,
"paps_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00004091",
"subsystem":"Purine metabolism",
"annotation":{
"ec-code":"2.7.1.25",
"kegg.reaction":"R00509",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00508",
"name":"3-Phospho-5-adenylyl sulfate 3-phosphohydrolase",
"metabolites":{
"aps_c":1.0,
"h2o_c":-1.0,
"paps_c":-1.0,
"pi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00044063 or WBGene00012390",
"subsystem":"Sulfur metabolism",
"annotation":{
"ec-code":"3.1.3.7",
"kegg.reaction":"R00508",
"sbo":"SBO:0000176"
}
},
{
"id":"RC05578",
"name":"L-glutamate:tRNA(Glu) ligase (AMP-forming)",
"metabolites":{
"amp_c":1.0,
"atp_c":-1.0,
"glu-L_c":-1.0,
"glutrna_c":1.0,
"ppi_c":1.0,
"trnaglu_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00001337",
"subsystem":"Aminoacyl-tRNA biosynthesis",
"annotation":{
"ec-code":"6.1.1.17",
"kegg.reaction":"R05578",
"sbo":"SBO:0000176"
}
},
{
"id":"TCM1291",
"name":"L-Proline transport",
"metabolites":{
"pro-L_c":-1.0,
"pro-L_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM1290",
"name":"\"5,6,7,8-Tetrahydrofolate\" transport",
"metabolites":{
"thf_c":-1.0,
"thf_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM1292",
"name":"Phosphate transport",
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"upper_bound":1000.0,
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}
},
{
"id":"RC01903",
"name":"L-arabinitol 4-dehydrogenase",
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"xylu-L_c":1.0
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"lower_bound":-1000.0,
"upper_bound":1000.0,
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}
},
{
"id":"RC01904",
"name":"Xylitol:NADP+ 4-oxidoreductase (L-xylulose-forming)",
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"nadph_c":-1.0,
"xylt_c":1.0,
"xylu-L_c":-1.0
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"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000984",
"subsystem":"Pentose and glucuronate interconversions",
"annotation":{
"ec-code":"1.1.1.10",
"kegg.reaction":"R01904",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01905",
"name":"dehydro-L-gulonate decarboxylase",
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"3dhguln_c":-1.0,
"co2_c":1.0,
"h_c":-1.0,
"xylu-L_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Pentose and glucuronate interconversions",
"annotation":{
"ec-code":"4.1.1.34",
"kegg.reaction":"R01905",
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}
},
{
"id":"RC01909",
"name":"ATP:pyridoxine 5-phosphotransferase",
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"adp_c":1.0,
"atp_c":-1.0,
"h_c":1.0,
"pdx5p_c":1.0,
"pydxn_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00019008",
"subsystem":"Vitamin B6 metabolism",
"annotation":{
"ec-code":"2.7.1.35",
"kegg.reaction":"R01909",
"sbo":"SBO:0000176"
}
},
{
"id":"EXC0181",
"name":"Ascaroside 18 exchange",
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"ascr18_e":-1.0
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RC01274",
"name":"Palmitoyl-CoA hydrolase",
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"coa_c":1.0,
"h2o_c":-1.0,
"h_c":1.0,
"hdca_c":1.0,
"pmtcoa_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00004092",
"subsystem":"Fatty acid elongation",
"annotation":{
"ec-code":"3.1.2.22",
"kegg.reaction":"R01274",
"sbo":"SBO:0000176"
}
},
{
"id":"EXC0141",
"name":"3-mercaptolactate-cysteine disulfide exchange",
"metabolites":{
"mercplaccys_e":-1.0
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EXC0142",
"name":"phospholipid component of E. coli diet exchange",
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RC00619",
"name":"ATP:thiamine diphosphotransferase",
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"atp_c":-1.0,
"h_c":1.0,
"thm_c":-1.0,
"thmpp_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00014027",
"subsystem":"Thiamine metabolism",
"annotation":{
"ec-code":"2.7.6.2",
"kegg.reaction":"R00619",
"sbo":"SBO:0000176"
}
},
{
"id":"RM00238",
"name":"Acetyl-CoA:acetyl-CoA C-acetyltransferase",
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"aacoa_m":1.0,
"accoa_m":-2.0,
"coa_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00020166 or WBGene00002183",
"subsystem":"Fatty acid metabolism",
"annotation":{
"ec-code":"2.3.1.9",
"kegg.reaction":"R00238",
"sbo":"SBO:0000176"
}
},
{
"id":"RM04203",
"name":"(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA:NAD+ oxidoreductase",
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"3hmbcoa_m":-1.0,
"h_m":1.0,
"nad_m":-1.0,
"nadh_m":1.0
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"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000181 or (WBGene00007129 or WBGene00010035 or WBGene00001157 or WBGene00001158 or WBGene00019978)",
"subsystem":"Valine, leucine and isoleucine degradation",
"annotation":{
"ec-code":[
"1.1.1.178",
"1.1.1.35"
],
"kegg.reaction":"R04203",
"sbo":"SBO:0000176"
}
},
{
"id":"RM04204",
"name":"(2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA hydro-liase",
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"3hmbcoa_m":1.0,
"h2o_m":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00001155 or WBGene00001156) or (WBGene00020347 or WBGene00001150) or WBGene00001152",
"subsystem":"Valine, leucine and isoleucine degradation",
"annotation":{
"ec-code":"4.2.1.17",
"kegg.reaction":"R04204",
"sbo":"SBO:0000176"
}
},
{
"id":"SNK0069",
"name":"Phosphoglycolic acid sink",
"metabolites":{
"2pglyc_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Glyoxylate and dicarboxylate metabolism",
"annotation":{
"sbo":"SBO:0000632"
}
},
{
"id":"RCC0109",
"name":"Acyl-CoA:L-carnitine O-acyltransferase I (Octadecenoyl-CoA )",
"metabolites":{
"coa_c":1.0,
"crn_c":-1.0,
"odecoa_c":-1.0,
"odecrn_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00012907 or WBGene00021703 or WBGene00019644 or WBGene00008629 or WBGene00020911",
"subsystem":"Carnitine shuttle",
"annotation":{
"ec-code":"2.3.1.21",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01470",
"name":"sn-Glycero-3-phosphoethanolamine glycerophosphohydrolase",
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"etha_c":1.0,
"g3pe_c":-1.0,
"glyc3p_c":1.0,
"h2o_c":-1.0,
"h_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00020446 or WBGene00011929 or WBGene00022532",
"subsystem":"Glycerophospholipid metabolism",
"annotation":{
"ec-code":"3.1.4.46",
"kegg.reaction":"R01470",
"sbo":"SBO:0000176"
}
},
{
"id":"RM00355",
"name":"L-Aspartate:2-oxoglutarate aminotransferase",
"metabolites":{
"akg_m":-1.0,
"asp-L_m":-1.0,
"glu-L_m":1.0,
"oaa_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00016652 or WBGene00015778",
"subsystem":"Alanine, aspartate and glutamate metabolism",
"annotation":{
"ec-code":"2.6.1.1",
"kegg.reaction":"R00355",
"sbo":"SBO:0000176"
}
},
{
"id":"RM00351",
"name":"acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)",
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"accoa_m":-1.0,
"cit_m":1.0,
"coa_m":1.0,
"h2o_m":-1.0,
"h_m":1.0,
"oaa_m":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000833",
"subsystem":"Citrate cycle (TCA cycle)",
"annotation":{
"ec-code":"2.3.3.1",
"kegg.reaction":"R00351",
"sbo":"SBO:0000176"
}
},
{
"id":"EX01419",
"name":"Cys-Gly exchange",
"metabolites":{
"cgly_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX02470",
"name":"Xanthurenic acid exchange",
"metabolites":{
"xanate_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"TCE5343",
"name":"Phenylpyruvate transport",
"metabolites":{
"phpyr_c":1.0,
"phpyr_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM0168",
"name":"Deoxyguanosine transport",
"metabolites":{
"dgsn_c":-1.0,
"dgsn_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM0169",
"name":"Fe2+ transport",
"metabolites":{
"fe2_c":-1.0,
"fe2_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"EX00385",
"name":"Xanthine exchange",
"metabolites":{
"xan_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00387",
"name":"Guanosine exchange",
"metabolites":{
"gsn_e":-1.0
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00438",
"name":"N-Carbamoyl-L-aspartate exchange",
"metabolites":{
"cbasp_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"TCM0160",
"name":"dTDP and dTTP transport",
"metabolites":{
"dtdp_c":1.0,
"dtdp_m":-1.0,
"dttp_c":-1.0,
"dttp_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM0161",
"name":"ADP and dCDP transport",
"metabolites":{
"adp_c":1.0,
"adp_m":-1.0,
"dcdp_c":-1.0,
"dcdp_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM0162",
"name":"Thiocyanate transport",
"metabolites":{
"tcynt_c":1.0,
"tcynt_m":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM0163",
"name":"dTDP and dCDP transport",
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"dcdp_c":1.0,
"dcdp_m":-1.0,
"dtdp_c":-1.0,
"dtdp_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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}
},
{
"id":"TCM0165",
"name":"ADP and dCTP transport",
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"adp_m":-1.0,
"dctp_c":-1.0,
"dctp_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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}
},
{
"id":"TCM0167",
"name":"dTTP and dADP transport",
"metabolites":{
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"dadp_m":-1.0,
"dttp_c":-1.0,
"dttp_m":1.0
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"BIO0012",
"name":"Fatty acid composition (TAG)",
"metabolites":{
"Rtotal3coa_c":-1.0,
"Rtotal4coa_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Biomass assembly",
"annotation":{
"sbo":"SBO:0000176"
}
},
{
"id":"BIO0013",
"name":"Fatty acid composition (TAG)",
"metabolites":{
"Rtotal3coa_c":-1.0,
"Rtotal5coa_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Biomass assembly",
"annotation":{
"sbo":"SBO:0000176"
}
},
{
"id":"BIO0010",
"name":"Drain of Biomass",
"metabolites":{
"Biomass_c":-1.0,
"adp_c":16.0,
"atp_c":-16.0,
"h2o_c":-16.0,
"h_c":16.0,
"pi_c":16.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"objective_coefficient":1.0,
"subsystem":"Biomass assembly",
"annotation":{
"sbo":"SBO:0000629"
}
},
{
"id":"BIO0011",
"name":"Fatty acid composition (phospholipids)",
"metabolites":{
"Rtotal2coa_c":1.0,
"Rtotalcoa_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Biomass assembly",
"annotation":{
"sbo":"SBO:0000176"
}
},
{
"id":"BIO0014",
"name":"Fatty acid composition (Ether-lipid acyl)",
"metabolites":{
"Rtotal6coa_c":1.0,
"Rtotalcoa_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Biomass assembly",
"annotation":{
"sbo":"SBO:0000176"
}
},
{
"id":"BIO0015",
"name":"Assembly of minor components of biomass",
"metabolites":{
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"apoISclustprot_m":1.0,
"apocytc_m":1.0,
"apohemeprotein_c":1.0,
"biomass_minor_c":1.0,
"focytC_m":-1.0,
"hemeprotein_c":-1.0,
"pepd_c":-4.0,
"protCys_c":6.0,
"protSfarC_c":-1.0,
"protSfarCmet_c":-1.0,
"protSfar_c":-1.0,
"protSgerC_c":-1.0,
"protSgerCmet_c":-1.0,
"protSger_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
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"annotation":{
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}
},
{
"id":"EX17339",
"name":"\"7alpha,12alpha-Dihydroxycholest-4-en-3-one\" exchange",
"metabolites":{
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
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}
},
{
"id":"EX01013",
"name":"3-Hydroxypropanoate exchange",
"metabolites":{
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
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}
},
{
"id":"EX17337",
"name":"7alpha-Hydroxy-3-oxo-4-cholestenoate exchange",
"metabolites":{
"7a3o4chlstnt_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
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}
},
{
"id":"EX00354",
"name":"\"D-Fructose 1,6-bisphosphate\" exchange",
"metabolites":{
"fdp_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00655",
"name":"Xanthosine 5'-phosphate exchange",
"metabolites":{
"xmp_e":-1.0
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00166",
"name":"Phenylpyruvate exchange",
"metabolites":{
"phpyr_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
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}
},
{
"id":"RC02778",
"name":"Trehalose-6-phosphate phosphohydrolase",
"metabolites":{
"h2o_c":-1.0,
"pi_c":1.0,
"tre6p_c":-1.0,
"tre_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00001649",
"subsystem":"Starch and sucrose metabolism",
"annotation":{
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"kegg.reaction":"R02778",
"sbo":"SBO:0000176"
}
},
{
"id":"EX00439",
"name":"N-Formimidoyl-L-glutamate exchange",
"metabolites":{
"forglu_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"TCE5080",
"name":"N-acetylglucosamine uptake",
"metabolites":{
"acgam_c":-1.0,
"acgam_e":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"EX00437",
"name":"N2-Acetyl-L-ornithine exchange",
"metabolites":{
"acorn_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RM02918",
"name":"L-Tyrosine:tRNA(Tyr) ligase (AMP-forming)",
"metabolites":{
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"atp_m":-1.0,
"ppi_m":1.0,
"trnatyr_m":-1.0,
"tyr-L_m":-1.0,
"tyrtrna_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00006968",
"subsystem":"Aminoacyl-tRNA biosynthesis",
"annotation":{
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"kegg.reaction":"R02918",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE5083",
"name":"xanthurenate transport",
"metabolites":{
"xanate_c":-1.0,
"xanate_e":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RMC0108",
"name":"Acyl-CoA:L-carnitine O-acyltransferase II (vaccenyl CoA)",
"metabolites":{
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"crn_m":1.0,
"vacccoa_m":1.0,
"vacccrn_m":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00011122",
"subsystem":"Carnitine shuttle",
"annotation":{
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"sbo":"SBO:0000176"
}
},
{
"id":"RMC0109",
"name":"Acyl-CoA:L-carnitine O-acyltransferase II (Octadecenoyl-CoA )",
"metabolites":{
"coa_m":-1.0,
"crn_m":1.0,
"odecoa_m":1.0,
"odecrn_m":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00011122",
"subsystem":"Carnitine shuttle",
"annotation":{
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"sbo":"SBO:0000176"
}
},
{
"id":"TCE5086",
"name":"cholesterol uptake",
"metabolites":{
"chsterol_c":1.0,
"chsterol_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00006477",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"EX00388",
"name":"Histamine exchange",
"metabolites":{
"hista_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RMC0104",
"name":"Beta oxidation of fa15p0iso (mitochondrial)",
"metabolites":{
"accoa_m":3.0,
"coa_m":-3.0,
"fa15p0isocoa_m":-1.0,
"fa9p0isocoa_m":1.0,
"fad_m":-3.0,
"fadh2_m":3.0,
"h2o_m":-3.0,
"h_m":3.0,
"nad_m":-3.0,
"nadh_m":3.0
},
"lower_bound":-0.0,
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"gene_reaction_rule":"(WBGene00020812 or WBGene00019406 or WBGene00020366 or WBGene00017125) and ((WBGene00001155 or WBGene00001156) or (WBGene00020347 or WBGene00001150) or WBGene00001152) and ((WBGene00020347 or WBGene00001150) or (WBGene00007129 or WBGene00010035 or WBGene00001157 or WBGene00001158 or WBGene00019978)) and (WBGene00015125 or WBGene00009952)",
"subsystem":"Mitochondrial fatty acid beta oxidation",
"annotation":{
"ec-code":[
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"4.2.1.17",
"1.1.1.211",
"1.1.1.35",
"2.3.1.16"
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"kegg.reaction":[
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"R02685",
"R01778",
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"sbo":"SBO:0000176"
}
},
{
"id":"RMC0105",
"name":"Beta oxidation of fa9p0iso",
"metabolites":{
"accoa_m":2.0,
"coa_m":-2.0,
"fa9p0isocoa_m":-1.0,
"fad_m":-2.0,
"fadh2_m":2.0,
"h2o_m":-2.0,
"h_m":2.0,
"ivcoa_m":1.0,
"nad_m":-2.0,
"nadh_m":2.0
},
"lower_bound":-0.0,
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"gene_reaction_rule":"(WBGene00020812 or WBGene00019406 or WBGene00020366) and ((WBGene00001155 or WBGene00001156) or (WBGene00020347 or WBGene00001150) or WBGene00001152) and ((WBGene00020347 or WBGene00001150) or (WBGene00007129 or WBGene00010035 or WBGene00001157 or WBGene00001158 or WBGene00019978)) and (WBGene00015125 or WBGene00009952)",
"subsystem":"Mitochondrial fatty acid beta oxidation",
"annotation":{
"ec-code":[
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"4.2.1.17",
"1.1.1.211",
"1.1.1.35",
"2.3.1.16"
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"R02685",
"R01778",
"R00391"
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"sbo":"SBO:0000176"
}
},
{
"id":"RMC0106",
"name":"Beta oxidation of fa19c11 (mitochondrial)",
"metabolites":{
"accoa_m":1.0,
"coa_m":-1.0,
"fa17c9coa_m":1.0,
"fa19c11coa_m":-1.0,
"fad_m":-1.0,
"fadh2_m":1.0,
"h2o_m":-1.0,
"h_m":1.0,
"nad_m":-1.0,
"nadh_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00020812 or WBGene00019406 or WBGene00020366 or WBGene00017125) and ((WBGene00001155 or WBGene00001156) or (WBGene00020347 or WBGene00001150) or WBGene00001152) and ((WBGene00020347 or WBGene00001150) or (WBGene00007129 or WBGene00010035 or WBGene00001157 or WBGene00001158 or WBGene00019978)) and (WBGene00015125 or WBGene00009952)",
"subsystem":"Mitochondrial fatty acid beta oxidation",
"annotation":{
"ec-code":[
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"4.2.1.17",
"1.1.1.211",
"1.1.1.35",
"2.3.1.16"
],
"kegg.reaction":[
"R00392",
"R02685",
"R01778",
"R00391"
],
"sbo":"SBO:0000176"
}
},
{
"id":"RMC0107",
"name":"Beta oxidation of fa17c9 (mitochondrial)",
"metabolites":{
"accoa_m":3.0,
"coa_m":-3.0,
"fa11c3coa_m":1.0,
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"fadh2_m":3.0,
"h2o_m":-3.0,
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"nad_m":-3.0,
"nadh_m":3.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00020812 or WBGene00019406 or WBGene00020366 or WBGene00017125) and ((WBGene00001155 or WBGene00001156) or (WBGene00020347 or WBGene00001150) or WBGene00001152) and ((WBGene00020347 or WBGene00001150) or (WBGene00007129 or WBGene00010035 or WBGene00001157 or WBGene00001158 or WBGene00019978)) and (WBGene00015125 or WBGene00009952)",
"subsystem":"Mitochondrial fatty acid beta oxidation",
"annotation":{
"ec-code":[
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"4.2.1.17",
"1.1.1.211",
"1.1.1.35",
"2.3.1.16"
],
"kegg.reaction":[
"R00392",
"R02685",
"R01778",
"R00391"
],
"sbo":"SBO:0000176"
}
},
{
"id":"RMC0100",
"name":"Beta oxidation of intermediary fatty acid fa8p1n3",
"metabolites":{
"accoa_m":2.0,
"btcoa_m":1.0,
"coa_m":-2.0,
"fa8p1n3coa_m":-1.0,
"fad_m":-1.0,
"fadh2_m":1.0,
"h2o_m":-2.0,
"h_m":2.0,
"nad_m":-2.0,
"nadh_m":2.0
},
"lower_bound":-0.0,
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"gene_reaction_rule":"(WBGene00020812 or WBGene00019406 or WBGene00020366) and (WBGene00001153 or WBGene00007130) and ((WBGene00001155 or WBGene00001156) or (WBGene00020347 or WBGene00001150) or WBGene00001152) and ((WBGene00020347 or WBGene00001150) or (WBGene00007129 or WBGene00010035 or WBGene00001157 or WBGene00001158 or WBGene00019978)) and (WBGene00015125 or WBGene00009952)",
"subsystem":"Mitochondrial fatty acid beta oxidation",
"annotation":{
"ec-code":[
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"5.3.3.8",
"4.2.1.17",
"1.1.1.211",
"1.1.1.35",
"2.3.1.16"
],
"kegg.reaction":[
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"R02685",
"R01778",
"R00391"
],
"sbo":"SBO:0000176"
}
},
{
"id":"RMC0103",
"name":"Beta oxidation of fa17p0iso (mitochondrial)",
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"coa_m":-1.0,
"fa15p0isocoa_m":1.0,
"fa17p0isocoa_m":-1.0,
"fad_m":-1.0,
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"h2o_m":-1.0,
"h_m":1.0,
"nad_m":-1.0,
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"lower_bound":-0.0,
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"subsystem":"Mitochondrial fatty acid beta oxidation",
"annotation":{
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"4.2.1.17",
"1.1.1.211",
"1.1.1.35",
"2.3.1.16"
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"sbo":"SBO:0000176"
}
},
{
"id":"TCE5310",
"name":"7alpha-Hydroxycholest-4-en-3-one transport",
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"na1_e":1.0,
"xol7aone_c":-1.0,
"xol7aone_e":1.0
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"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE5311",
"name":"S-Adenosyl-L-homocysteine transport",
"metabolites":{
"ahcys_c":1.0,
"ahcys_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE5312",
"name":"Orotidine 5'-phosphate transport",
"metabolites":{
"orot5p_c":1.0,
"orot5p_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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}
},
{
"id":"TCE5313",
"name":"Xanthosine 5'-phosphate transport",
"metabolites":{
"xmp_c":1.0,
"xmp_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE5314",
"name":"S-Adenosylmethioninamine transport",
"metabolites":{
"ametam_c":-1.0,
"ametam_e":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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}
},
{
"id":"TCE5315",
"name":"IMP transport",
"metabolites":{
"imp_c":1.0,
"imp_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE5316",
"name":"5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide transport",
"metabolites":{
"aicar_c":1.0,
"aicar_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE5317",
"name":"D-Fructose 1,6-bisphosphate transport",
"metabolites":{
"fdp_c":-1.0,
"fdp_e":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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}
},
{
"id":"TCE5318",
"name":"Nicotinate D-ribonucleotide transport",
"metabolites":{
"nicrnt_c":1.0,
"nicrnt_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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}
},
{
"id":"TCE5319",
"name":"dCMP transport",
"metabolites":{
"dcmp_c":1.0,
"dcmp_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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}
},
{
"id":"RC02976",
"name":"sphinganine kinase",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"h_c":1.0,
"sph1p_ce_c":1.0,
"sphgn_ce_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00007918",
"subsystem":"Sphingolipid metabolism",
"annotation":{
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"kegg.reaction":"R02976",
"sbo":"SBO:0000176"
}
},
{
"id":"RC02110",
"name":"1,4-alpha-D-Glucan:1,4-alpha-D-glucan 6-alpha-D-(1,4-alpha-D-glucano)-transferase",
"metabolites":{
"glycogen_c":1.0,
"nbglycogen_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00011409",
"subsystem":"Starch and sucrose metabolism",
"annotation":{
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"kegg.reaction":"R02110",
"sbo":"SBO:0000176"
}
},
{
"id":"RC02978",
"name":"3-dehydrosphinganine reductase",
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"h_c":-1.0,
"nadp_c":1.0,
"nadph_c":-1.0,
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},
"lower_bound":-0.0,
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"gene_reaction_rule":"",
"subsystem":"Sphingolipid metabolism",
"annotation":{
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"kegg.reaction":"R02978",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE5504",
"name":"L-sulfolactate transport (cytosol to extracellular)",
"metabolites":{
"sl-L_c":-1.0,
"sl-L_e":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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}
},
{
"id":"EX01879",
"name":"5-Oxoproline exchange",
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
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}
},
{
"id":"EX05828",
"name":"3-Methylimidazoleacetic acid exchange",
"metabolites":{
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
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},
{
"id":"DMN0033",
"name":"oxidation of quinone",
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"qh2_c":-1.0
},
"lower_bound":0.0,
"upper_bound":0.0,
"gene_reaction_rule":"",
"subsystem":"Miscellaneous",
"annotation":{
"sbo":"SBO:0000628"
}
},
{
"id":"EX00095",
"name":"D-Fructose exchange",
"metabolites":{
"fru_e":-1.0
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
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}
},
{
"id":"EX05356",
"name":"\"5-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoate\" exchange",
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
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}
},
{
"id":"RC05969",
"name":"UDP-N-acetyl-D-glucosamine:dolichyl-phosphate N-acetyl-D-glucosamine phosphotransferase",
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"naglc2p_c":1.0,
"uacgam_c":-1.0,
"ump_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00013362",
"subsystem":"N-Glycan biosynthesis",
"annotation":{
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"kegg.reaction":"R05969",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE5408",
"name":"Putrescine transport",
"metabolites":{
"ptrc_c":1.0,
"ptrc_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE5409",
"name":"Riboflavin active secretion",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0,
"ribflv_c":-1.0,
"ribflv_e":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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}
},
{
"id":"RM01248",
"name":"L-Proline:NAD+ 5-oxidoreductase",
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"h_m":-2.0,
"nad_m":1.0,
"nadh_m":-1.0,
"pro-L_m":1.0
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00010924 or WBGene00018904",
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"kegg.reaction":"R01248",
"sbo":"SBO:0000176"
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},
{
"id":"TCE5404",
"name":"S-Adenosyl-L-methionine transport",
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"amet_e":1.0
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"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
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}
},
{
"id":"TCE5405",
"name":"Nicotinic acid (niacin) transport",
"metabolites":{
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"nac_c":1.0,
"nac_e":-1.0
},
"lower_bound":-1000.0,
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"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC07050",
"name":"aryl hydrocarbon hydroxylase",
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"eet_c":1.0,
"h2o_c":1.0,
"h_c":-1.0,
"nadp_c":1.0,
"nadph_c":-1.0,
"o2_c":-1.0
},
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"gene_reaction_rule":"WBGene00015399 or WBGene00015400 or WBGene00016786 or WBGene00019473",
"subsystem":"Arachidonic acid metabolism",
"annotation":{
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"kegg.reaction":"R07050",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE5407",
"name":"Phosphatidylserine active export",
"metabolites":{
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"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0,
"ps_c":-1.0,
"ps_e":1.0
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"lower_bound":-0.0,
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"subsystem":"Transport",
"annotation":{
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}
},
{
"id":"TCE5400",
"name":"Sphingomyelin secretion",
"metabolites":{
"sphmyln_ce_c":-1.0,
"sphmyln_ce_e":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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}
},
{
"id":"RC02577",
"name":"Propane-1,2-diol:NAD+ 1-oxidoreductase",
"metabolites":{
"12ppd-R_c":-1.0,
"h_c":1.0,
"lald-D_c":1.0,
"nadp_c":-1.0,
"nadph_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00012722",
"subsystem":"Glycerolipid metabolism",
"annotation":{
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"kegg.reaction":"R02577",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE5402",
"name":"Oxidized glutathione active transport",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"gthox_c":-1.0,
"gthox_e":1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":-0.0,
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"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE5403",
"name":"Protoheme active transport",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pheme_c":-1.0,
"pheme_e":1.0,
"pi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RM01465",
"name":"L-Threonine:NAD+ oxidoreductase",
"metabolites":{
"2aobut_m":1.0,
"h_m":1.0,
"nad_m":-1.0,
"nadh_m":1.0,
"thr-L_m":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00017262",
"subsystem":"Glycine, serine and threonine metabolism",
"annotation":{
"ec-code":"1.1.1.103",
"kegg.reaction":"R01465",
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0210",
"name":"Octacosanoic acid synthesis ",
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"h_c":-6.0,
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"nadph_c":-4.0
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"lower_bound":-0.0,
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"1.1.1.330",
"4.2.1.134",
"1.3.1.93"
],
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}
},
{
"id":"RCC0211",
"name":"very long chain ascaroside (w-ascr-C27)  synthesis",
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"akg_c":-1.0,
"amp_c":1.0,
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"succ_c":1.0
},
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}
},
{
"id":"TCE0342",
"name":"Bicarbonate and Chloride transport",
"metabolites":{
"cl_c":1.0,
"cl_e":-1.0,
"hco3_c":-2.0,
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},
"lower_bound":-0.0,
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}
},
{
"id":"RC03421",
"name":"N4-(beta-N-Acetyl-D-glucosaminyl)-L-asparagine amidohydrolase",
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"asp-L_c":1.0,
"h2o_c":-1.0,
"h_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00019867",
"subsystem":"Protein modification by hydroxylation",
"annotation":{
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"kegg.reaction":"R03421",
"sbo":"SBO:0000176"
}
},
{
"id":"RC03646",
"name":"L-Arginine:tRNA(Arg) ligase (AMP-forming)",
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"arg-L_c":-1.0,
"argtrna_c":1.0,
"atp_c":-1.0,
"ppi_c":1.0,
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},
"lower_bound":-0.0,
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"gene_reaction_rule":"WBGene00004679",
"subsystem":"Aminoacyl-tRNA biosynthesis",
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"kegg.reaction":"R03646",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00332",
"name":"ATP:GMP phosphotransferase",
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"atp_c":-1.0,
"gdp_c":1.0,
"gmp_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00020190",
"subsystem":"Purine metabolism",
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"kegg.reaction":"R00332",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00330",
"name":"ATP:GDP phosphotransferase",
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"atp_c":-1.0,
"gdp_c":-1.0,
"gtp_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00019899 or WBGene00021692 or WBGene00009119",
"subsystem":"Purine metabolism",
"annotation":{
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"kegg.reaction":"R00330",
"sbo":"SBO:0000176"
}
},
{
"id":"RM00751",
"name":"L-threonine acetaldehyde-lyase (glycine-forming)",
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"gly_m":1.0,
"thr-L_m":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00011291",
"subsystem":"Glycine, serine and threonine metabolism",
"annotation":{
"ec-code":"4.1.2.5",
"kegg.reaction":"R00751",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00335",
"name":"GTP phosphohydrolase",
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"gtp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":-0.0,
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"gene_reaction_rule":"WBGene00001093 or WBGene00001130",
"subsystem":"Purine metabolism",
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"kegg.reaction":"R00335",
"sbo":"SBO:0000176"
}
},
{
"id":"RC04184",
"name":"Trihexosylceramide N-acetylhexosaminohydrolase",
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"gbside_ce_c":1.0,
"h2o_c":1.0,
"thcrm_ce_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00020509 or WBGene00015767 or WBGene00012663 or WBGene00021766 or WBGene00013497",
"subsystem":"Miscellaneous",
"annotation":{
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"kegg.reaction":"R04184",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01857",
"name":"ATP:dGDP phosphotransferase",
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"atp_c":-1.0,
"dgdp_c":-1.0,
"dgtp_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00019899 or WBGene00021692 or WBGene00009119",
"subsystem":"Purine metabolism",
"annotation":{
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"kegg.reaction":"R01857",
"sbo":"SBO:0000176"
}
},
{
"id":"RC04183",
"name":"alpha-N-Acetyl-D-galactosaminide N-acetylgalactosaminohydrolase",
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"forssman_ce_c":1.0,
"gbside_ce_c":-1.0,
"h2o_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00011095",
"subsystem":"Miscellaneous",
"annotation":{
"ec-code":"3.2.1.49",
"kegg.reaction":"R04183",
"sbo":"SBO:0000176"
}
},
{
"id":"RC08198",
"name":"alphaKG reductase",
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"akg_c":1.0,
"h_c":1.0,
"nad_c":-1.0,
"nadh_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00007836",
"subsystem":"Butanoate metabolism (indirect)",
"annotation":{
"ec-code":"1.1.1.95",
"kegg.reaction":"R08198",
"sbo":"SBO:0000176"
}
},
{
"id":"RC08193",
"name":"N-Acetyl-D-glucosamine 1-phosphate 1,6-phosphomutase",
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"acgam6p_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00009006",
"subsystem":"Amino sugar and nucleotide sugar metabolism",
"annotation":{
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"kegg.reaction":"R08193",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00426",
"name":"GTP diphosphohydrolase (diphosphate-forming)",
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"gtp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"ppi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00001823",
"subsystem":"Purine metabolism",
"annotation":{
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"kegg.reaction":"R00426",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00424",
"name":"GTP cyclohydrolase I",
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"for_c":1.0,
"gtp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000298",
"subsystem":"Folate biosynthesis",
"annotation":{
"ec-code":"3.5.4.16",
"kegg.reaction":[
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"R04639",
"R05046",
"R05048"
],
"sbo":"SBO:0000176"
}
},
{
"id":"RM01939",
"name":"L-2-aminoadipate:2-oxoglutarate aminotransferase",
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"L2aadp_m":-1.0,
"akg_m":-1.0,
"glu-L_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Lysine degradation",
"annotation":{
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"kegg.reaction":"R01939",
"sbo":"SBO:0000176"
}
},
{
"id":"RM02313",
"name":"N6-(L-1,3-Dicarboxypropyl)-L-lysine:NAD+ oxidoreductase",
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"glu-L_m":1.0,
"h2o_m":-1.0,
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"nad_m":-1.0,
"nadh_m":1.0,
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"lower_bound":-1000.0,
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"gene_reaction_rule":"WBGene00019819",
"subsystem":"Lysine degradation",
"annotation":{
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"kegg.reaction":"R02313",
"sbo":"SBO:0000176"
}
},
{
"id":"RM01931",
"name":"thiosulfate:cyanide sulfurtranserase",
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"h_m":1.0,
"so3_m":1.0,
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"lower_bound":-1000.0,
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"gene_reaction_rule":"WBGene00008409 or WBGene00010380 or WBGene00010383 or WBGene00017387 or WBGene00022006 or WBGene00022007 or WBGene00011307",
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"kegg.reaction":"R01931",
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}
},
{
"id":"RM03225",
"name":"(S)-3-Hydroxybutanoate:2-oxoglutarate oxidoreductase",
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"lower_bound":-1000.0,
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"subsystem":"Butanoate metabolism (indirect)",
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}
},
{
"id":"EX00266",
"name":"Glycolaldehyde exchange",
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"gcald_e":-1.0
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
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}
},
{
"id":"RC04293",
"name":"Quinolinate synthase (eukaryotic)",
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"h2o_c":1.0,
"h_c":1.0,
"quln_c":1.0
},
"lower_bound":-0.0,
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"gene_reaction_rule":"",
"subsystem":"Tryptophan metabolism",
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},
{
"id":"DMN0008",
"name":"fe3 storage",
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"lower_bound":-0.0,
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"gene_reaction_rule":"",
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"annotation":{
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}
},
{
"id":"RCC0174",
"name":"Tropocollagen formation",
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"tropcollgtyr_c":0.00186
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"lower_bound":-0.0,
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"subsystem":"Collagen biosynthesis",
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},
{
"id":"DMN0002",
"name":"vitamin B12 demand (adocbl form)",
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"lower_bound":-0.0,
"upper_bound":1000.0,
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"subsystem":"Vitamin B12 metabolism",
"annotation":{
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}
},
{
"id":"EX00262",
"name":"Hypoxanthine exchange",
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"gene_reaction_rule":"",
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},
{
"id":"DMN0001",
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"lower_bound":-0.0,
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"gene_reaction_rule":"",
"subsystem":"Vitamin B6 metabolism",
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},
{
"id":"DMN0006",
"name":"heme A demand",
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"gene_reaction_rule":"",
"subsystem":"Iron metabolism",
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},
{
"id":"DMN0007",
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},
{
"id":"DMN0005",
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"gene_reaction_rule":"",
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"annotation":{
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}
},
{
"id":"RCC0021",
"name":"S-Adenosyl-L-methionine:methylethanolamine-phosphate N-methyltransferase",
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"amet_c":-2.0,
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"lower_bound":-0.0,
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"gene_reaction_rule":"WBGene00018811",
"subsystem":"Glycerophospholipid metabolism",
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}
},
{
"id":"RCC0020",
"name":"fatty acid synthetase (palmitate, n-C16:0)",
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},
"lower_bound":-0.0,
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"gene_reaction_rule":"WBGene00009342",
"subsystem":"Fatty acid biosynthesis",
"annotation":{
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"kegg.reaction":"R05188",
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0022",
"name":"Propionyladenylate:CoA propionyltransferase; ATP:propanoate adenylyltransferase",
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"atp_c":-1.0,
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"lower_bound":-0.0,
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"subsystem":"Propanoate metabolism",
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"kegg.reaction":[
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}
},
{
"id":"RC01802",
"name":"CDP-diacylglycerol:myo-inositol 3-phosphatidyltransferase",
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"h_c":1.0,
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"pail_c":1.0
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"lower_bound":-1000.0,
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"gene_reaction_rule":"WBGene00012897",
"subsystem":"Inositol phosphate metabolism",
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"kegg.reaction":"R01802",
"sbo":"SBO:0000176"
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},
{
"id":"RC01801",
"name":"CDP-diacylglycerol:sn-glycerol-3-phosphate 3-phosphatidyltransferase",
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"h_c":1.0,
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"lower_bound":-1000.0,
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"subsystem":"Glycerophospholipid metabolism",
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"kegg.reaction":"R01801",
"sbo":"SBO:0000176"
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},
{
"id":"RCC0029",
"name":"dehydrodolichol diphosphate phosphatase",
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"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"N-Glycan biosynthesis",
"annotation":{
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}
},
{
"id":"RC00512",
"name":"ATP:CMP phosphotransferase",
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"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00007812 or WBGene00009575",
"subsystem":"Pyrimidine metabolism",
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"kegg.reaction":"R00512",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00513",
"name":"ATP:cytidine 5-phosphotransferase",
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"cytd_c":-1.0,
"h_c":1.0
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00007089 or WBGene00008948",
"subsystem":"Pyrimidine metabolism",
"annotation":{
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"kegg.reaction":"R00513",
"sbo":"SBO:0000176"
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},
{
"id":"TCM1284",
"name":"L-Glutamate transport",
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"glu-L_m":1.0
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"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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},
{
"id":"RC00511",
"name":"Cytidine-5-monophosphate phosphohydrolase",
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"h2o_c":-1.0,
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"gene_reaction_rule":"WBGene00017775 or WBGene00012423 or WBGene00022201",
"subsystem":"Pyrimidine metabolism",
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"kegg.reaction":"R00511",
"sbo":"SBO:0000176"
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},
{
"id":"TCM1282",
"name":"Phosphate and L-Malate transport",
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"pi_m":-1.0
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"lower_bound":-1000.0,
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"gene_reaction_rule":"",
"subsystem":"Transport",
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},
{
"id":"TCM1283",
"name":"L-Carnitine transport",
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"crn_m":-1.0
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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},
{
"id":"TCM1280",
"name":"Pyruvate transport",
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"pyr_m":1.0
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"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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},
{
"id":"TCM1281",
"name":"\"7,8-Dihydrofolate\" transport",
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"dhf_m":1.0
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"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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}
},
{
"id":"RC01061",
"name":"D-glyceraldehyde-3-phosphate:NAD+ oxidoreductase (phosphorylating)",
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"g3p_c":-1.0,
"h_c":1.0,
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"subsystem":"Glycolysis / Gluconeogenesis",
"annotation":{
"ec-code":"1.2.1.12",
"kegg.reaction":"R01061",
"sbo":"SBO:0000176"
}
},
{
"id":"TCM5048",
"name":"Carnitine-acylcarnitine translocase (occrn)",
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"occrn_c":-1.0,
"occrn_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000996 or WBGene00008320",
"subsystem":"Carnitine shuttle",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"EX18125",
"name":"1-Acyl-sn-glycero-3-phosphoserine exchange",
"metabolites":{
"acg3ps_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"TCM1288",
"name":"Glycerol 3-phosphate transport",
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"glyc3p_c":-1.0,
"glyc3p_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC01066",
"name":"2-deoxy-D-ribose-5-phosphate acetaldehyde-lyase (D-glyceraldehyde-3-phosphate-forming)",
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"2dr5p_c":-1.0,
"acald_c":1.0,
"g3p_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00017283",
"subsystem":"Pentose phosphate pathway",
"annotation":{
"ec-code":"4.1.2.4",
"kegg.reaction":"R01066",
"sbo":"SBO:0000176"
}
},
{
"id":"EX00546",
"name":"Methylglyoxal exchange",
"metabolites":{
"mthgxl_e":-1.0
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00156",
"name":"4-Hydroxybenzoate exchange",
"metabolites":{
"4hbz_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RC00192",
"name":"S-Adenosyl-L-homocysteine hydrolase",
"metabolites":{
"adn_c":1.0,
"ahcys_c":-1.0,
"h2o_c":-1.0,
"hcys-L_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00019322",
"subsystem":"Cysteine and methionine metabolism",
"annotation":{
"ec-code":"3.3.1.1",
"kegg.reaction":"R00192",
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0179",
"name":"artificial transformation of peptide to peptidyl-asparagine",
"metabolites":{
"asn-L_c":-1.0,
"h2o_c":1.0,
"pepX_c":-1.0,
"pepasn_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Protein modification by hydroxylation",
"annotation":{
"sbo":"SBO:0000176"
}
},
{
"id":"RC00190",
"name":"AMP:diphosphate phospho-D-ribosyltransferase",
"metabolites":{
"ade_c":-1.0,
"amp_c":1.0,
"ppi_c":1.0,
"prpp_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00020557 or WBGene00013690",
"subsystem":"Purine metabolism",
"annotation":{
"ec-code":[
"2.4.2.7",
"2.4.2.8"
],
"kegg.reaction":"R00190",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00191",
"name":"adenosine 3,5-phosphate 5-nucleotidohydrolase",
"metabolites":{
"amp_c":1.0,
"camp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00020114 or WBGene00022389",
"subsystem":"Purine metabolism",
"annotation":{
"ec-code":"3.1.4.17",
"kegg.reaction":"R00191",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00199",
"name":"ATP:pyruvate,water phosphotransferase",
"metabolites":{
"amp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":2.0,
"pep_c":1.0,
"pi_c":1.0,
"pyr_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00011893",
"subsystem":"Pyruvate metabolism",
"annotation":{
"ec-code":"2.7.9.2",
"kegg.reaction":"R00199",
"sbo":"SBO:0000176"
}
},
{
"id":"TCM0084",
"name":"pentaglutamyl folate (THF) transport",
"metabolites":{
"5thf_c":1.0,
"5thf_m":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"DGR0028",
"name":"Bacterial glycogen degradation",
"metabolites":{
"dxtrn1_c":0.5,
"g1p_c":0.5,
"glycogen_BAC_c":-1.0,
"pi_c":-0.5
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00020696",
"subsystem":"Bacterial digestion",
"annotation":{
"ec-code":"2.4.1.1",
"kegg.reaction":"R01821",
"sbo":"SBO:0000176"
}
},
{
"id":"DGR0029",
"name":"Dephosphorylation of thiamine pyrophosphate",
"metabolites":{
"h2o_e":-2.0,
"h_e":1.0,
"pi_e":2.0,
"thm_e":1.0,
"thmpp_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Bacterial digestion",
"annotation":{
"sbo":"SBO:0000176"
}
},
{
"id":"RC06262",
"name":"dolichyl-P-Glc:Man9GlcNAc2-PP-dolichol alpha-1,3-glucosyltransferase",
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"dolglcp_c":-1.0,
"dolp_c":1.0,
"g1m8mpdol_c":1.0,
"h_c":1.0,
"m8mpdol_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00007435",
"subsystem":"N-Glycan biosynthesis",
"annotation":{
"ec-code":"2.4.1.267",
"kegg.reaction":"R06262",
"sbo":"SBO:0000176"
}
},
{
"id":"RC06263",
"name":"dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichol alpha-1,3-glucosyltransferase",
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"dolglcp_c":-1.0,
"dolp_c":1.0,
"g1m8mpdol_c":-1.0,
"g2m8mpdol_c":1.0,
"h_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00007464",
"subsystem":"N-Glycan biosynthesis",
"annotation":{
"ec-code":"2.4.1.265",
"kegg.reaction":"R06263",
"sbo":"SBO:0000176"
}
},
{
"id":"RC06260",
"name":"dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (7man to 8man)",
"metabolites":{
"dolmanp_c":-1.0,
"dolp_c":1.0,
"h_c":1.0,
"m6mpdol_c":-1.0,
"m7mpdol_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00022629",
"subsystem":"N-Glycan biosynthesis",
"annotation":{
"ec-code":"2.4.1.260",
"kegg.reaction":"R06260",
"sbo":"SBO:0000176"
}
},
{
"id":"RC06261",
"name":"dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (8man to 9man)",
"metabolites":{
"dolmanp_c":-1.0,
"dolp_c":1.0,
"h_c":1.0,
"m7mpdol_c":-1.0,
"m8mpdol_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00007556",
"subsystem":"N-Glycan biosynthesis",
"annotation":{
"ec-code":"2.4.1.261",
"kegg.reaction":"R06261",
"sbo":"SBO:0000176"
}
},
{
"id":"DGR0022",
"name":"Bacterial cardiolipin uptake",
"metabolites":{
"clpn_BAC_c":1.0,
"clpn_BAC_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Bacterial digestion",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"DGR0023",
"name":"Bacterial cardiolipin degradation (major components)",
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"clpn_BAC_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pa_BAC_c":1.0,
"pg_BAC_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Bacterial digestion",
"annotation":{
"sbo":"SBO:0000176"
}
},
{
"id":"RC06264",
"name":"dolichyl-P-Glc:Glc2Man9GlcNAc2-PP-dolichol alpha-1,2-glucosyltransferase",
"metabolites":{
"dolglcp_c":-1.0,
"dolp_c":1.0,
"g2m8mpdol_c":-1.0,
"g3m8mpdol_c":1.0,
"h_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00007043",
"subsystem":"N-Glycan biosynthesis",
"annotation":{
"ec-code":"2.4.1.256",
"kegg.reaction":"R06264",
"sbo":"SBO:0000176"
}
},
{
"id":"DGR0021",
"name":"Bacterial phosphatidylglycerol degradation",
"metabolites":{
"Rtotal_BAC_c":2.0,
"glyc3p_c":1.0,
"glyc_c":1.0,
"h2o_c":-3.0,
"h_c":3.0,
"pg_BAC_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00019747 or WBGene00009801 or WBGene00012319 or WBGene00017026 or WBGene00019229 or WBGene00022233 or WBGene00011423 or WBGene00007419 or WBGene00044468",
"subsystem":"Bacterial digestion",
"annotation":{
"ec-code":"3.1.1.4",
"sbo":"SBO:0000176"
}
},
{
"id":"EXC0174",
"name":"Ascaroside 7 exchange",
"metabolites":{
"ascr7_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RC00602",
"name":"methanol:hydrogen-peroxide oxidoreductase",
"metabolites":{
"fald_c":1.0,
"h2o2_c":-1.0,
"h2o_c":2.0,
"meoh_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00000830 or WBGene00000831 or WBGene00013220) or (WBGene00021401)",
"subsystem":"Methane metabolism",
"annotation":{
"ec-code":[
"1.11.1.6",
"1.11.1.7"
],
"kegg.reaction":"R00602",
"sbo":"SBO:0000176"
}
},
{
"id":"SNK0070",
"name":"acetylhistone sink",
"metabolites":{
"Naclys_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Histone modification",
"annotation":{
"sbo":"SBO:0000632"
}
},
{
"id":"SNK0071",
"name":"non-methylated histone sink",
"metabolites":{
"Nlys_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Histone modification",
"annotation":{
"sbo":"SBO:0000632"
}
},
{
"id":"SNK0074",
"name":"beta-fructose 2,6-bisphosphate sink",
"metabolites":{
"f26bp_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Glycolysis / Gluconeogenesis (indirect)",
"annotation":{
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}
},
{
"id":"EXC0050",
"name":"Bacterial uptake",
"metabolites":{
"BAC_e":-1.0
},
"lower_bound":-0.1,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Bacterial digestion",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RC04996",
"name":"3-Methylimidazole acetaldehyde:NAD+ oxidoreductase",
"metabolites":{
"3mlda_c":1.0,
"3mldz_c":-1.0,
"h2o_c":-1.0,
"h_c":2.0,
"nad_c":-1.0,
"nadh_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000111",
"subsystem":"Histidine metabolism",
"annotation":{
"ec-code":"1.2.1.5",
"kegg.reaction":"R04996",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01481",
"name":"gulonate dehydrogenase, endoplasmic reticulum",
"metabolites":{
"glcur_c":-1.0,
"guln_c":1.0,
"h_c":-1.0,
"nadp_c":1.0,
"nadph_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Pentose and glucuronate interconversions",
"annotation":{
"ec-code":"1.1.1.19",
"kegg.reaction":"R01481",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01641",
"name":"Sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glycolaldehyde transferase",
"metabolites":{
"g3p_c":-1.0,
"r5p_c":1.0,
"s7p_c":-1.0,
"xu5p-D_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00008506",
"subsystem":"Pentose phosphate pathway",
"annotation":{
"ec-code":"2.2.1.1",
"kegg.reaction":"R01641",
"sbo":"SBO:0000176"
}
},
{
"id":"TCM0154",
"name":"dUDP and dUTP transport",
"metabolites":{
"dudp_c":1.0,
"dudp_m":-1.0,
"dutp_c":-1.0,
"dutp_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM0156",
"name":"dTDP and dUDP transport",
"metabolites":{
"dtdp_c":1.0,
"dtdp_m":-1.0,
"dudp_c":-1.0,
"dudp_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM0151",
"name":"Cholesterol transport",
"metabolites":{
"chsterol_c":-1.0,
"chsterol_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM0150",
"name":"dUTP and dCDP transport",
"metabolites":{
"dcdp_c":1.0,
"dcdp_m":-1.0,
"dutp_c":-1.0,
"dutp_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM0153",
"name":"dTTP and dCDP transport",
"metabolites":{
"dcdp_c":1.0,
"dcdp_m":-1.0,
"dttp_c":-1.0,
"dttp_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RM07411",
"name":"protoheme farnesyltransferase",
"metabolites":{
"frdp_c":-1.0,
"h2o_m":-1.0,
"hemeo_m":1.0,
"pheme_m":-1.0,
"ppi_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00012895",
"subsystem":"Iron metabolism",
"annotation":{
"ec-code":"2.5.1.-",
"kegg.reaction":"R07411",
"sbo":"SBO:0000176"
}
},
{
"id":"RM07412",
"name":"heme A synthase",
"metabolites":{
"h2o_m":1.0,
"hemea_m":1.0,
"hemeo_m":-1.0,
"o2_m":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00011526",
"subsystem":"Iron metabolism",
"annotation":{
"kegg.reaction":"R07412",
"sbo":"SBO:0000176"
}
},
{
"id":"EX00429",
"name":"\"5,6-dihydrouracil\" exchange",
"metabolites":{
"56dura_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00398",
"name":"Tryptamine exchange",
"metabolites":{
"trypta_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00427",
"name":"Prostaglandin H2 exchange",
"metabolites":{
"prostgh2_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00422",
"name":"triacylglycerol exchange",
"metabolites":{
"tag_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RC00966",
"name":"UMP:diphosphate phospho-alpha-D-ribosyltransferase",
"metabolites":{
"ppi_c":1.0,
"prpp_c":-1.0,
"ump_c":1.0,
"ura_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00008131",
"subsystem":"Pyrimidine metabolism",
"annotation":{
"ec-code":"2.4.2.9",
"kegg.reaction":"R00966",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE5082",
"name":"Trehalose transport",
"metabolites":{
"tre_c":-1.0,
"tre_e":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"EX05697",
"name":"Selenate exchange",
"metabolites":{
"sel_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"TCE5084",
"name":"folate transport",
"metabolites":{
"fol_c":-1.0,
"fol_e":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00007388",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"EX00642",
"name":"4-Hydroxyphenylacetate exchange",
"metabolites":{
"4hphac_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00643",
"name":"5-Hydroxy-L-tryptophan exchange",
"metabolites":{
"5htrp_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"TCE5085",
"name":"glucose transport",
"metabolites":{
"glc-D_c":-1.0,
"glc-D_e":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00019207",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC02749",
"name":"2-deoxy-D-ribose 1-phosphate 1,5-phosphomutase",
"metabolites":{
"2dr1p_c":-1.0,
"2dr5p_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00012803",
"subsystem":"Pentose phosphate pathway",
"annotation":{
"ec-code":"5.4.2.7",
"kegg.reaction":"R02749",
"sbo":"SBO:0000176"
}
},
{
"id":"RC02748",
"name":"Deoxyinosine:orthophosphate ribosyltransferase",
"metabolites":{
"2dr1p_c":1.0,
"din_c":-1.0,
"hxan_c":1.0,
"pi_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00019298",
"subsystem":"Purine metabolism",
"annotation":{
"ec-code":"2.4.2.1",
"kegg.reaction":"R02748",
"sbo":"SBO:0000176"
}
},
{
"id":"RC02740",
"name":"alpha-D-Glucose 6-phosphate ketol-isomerase (producing beta-D-Fructose 6-phosphate)",
"metabolites":{
"f6p_c":1.0,
"g6p-A_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00013597",
"subsystem":"Glycolysis / Gluconeogenesis",
"annotation":{
"ec-code":"5.3.1.9",
"kegg.reaction":"R02740",
"sbo":"SBO:0000176"
}
},
{
"id":"RC02743",
"name":"(5-L-Glutamyl)-L-cysteine 5-glutamyltransferase (cyclizing)",
"metabolites":{
"5oxpro_c":1.0,
"cys-L_c":1.0,
"glucys_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00016629",
"subsystem":"Glutathione metabolism",
"annotation":{
"ec-code":"2.3.2.4",
"kegg.reaction":"R02743",
"sbo":"SBO:0000176"
}
},
{
"id":"RC02297",
"name":"Xanthosine:orthophosphate ribosyltransferase",
"metabolites":{
"pi_c":-1.0,
"r1p_c":1.0,
"xan_c":1.0,
"xtsn_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00019298",
"subsystem":"Purine metabolism",
"annotation":{
"ec-code":"2.4.2.1",
"kegg.reaction":"R02297",
"sbo":"SBO:0000176"
}
},
{
"id":"EX06232",
"name":"Molybdate exchange",
"metabolites":{
"mobd_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RC02295",
"name":"Nicotinate D-ribonucleoside:orthophosphate ribosyltransferase",
"metabolites":{
"h_c":-1.0,
"nac_c":-1.0,
"nicrns_c":1.0,
"pi_c":1.0,
"r1p_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00019298",
"subsystem":"Nicotinate and nicotinamide metabolism",
"annotation":{
"ec-code":"2.4.2.1",
"kegg.reaction":"R02295",
"sbo":"SBO:0000176"
}
},
{
"id":"RC02746",
"name":"1-Acyl-sn-glycero-3-phosphocholine acylhydrolase",
"metabolites":{
"Rtotal_c":1.0,
"g3pc_c":1.0,
"h2o_c":-1.0,
"h_c":1.0,
"lpchol_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00022718 or WBGene00007756 or WBGene00010872 or WBGene00010564",
"subsystem":"Glycerophospholipid metabolism",
"annotation":{
"ec-code":"3.1.1.5",
"kegg.reaction":[
"R02746",
"R02747"
],
"sbo":"SBO:0000176"
}
},
{
"id":"TCM5095",
"name":"Aspartate-glutamate mitochondrial shuttle",
"metabolites":{
"asp-L_c":1.0,
"asp-L_m":-1.0,
"glu-L_c":-1.0,
"glu-L_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RMC0133",
"name":"branched-chain 2-oxo acid dehydrogenase",
"metabolites":{
"2obut_m":-1.0,
"co2_m":1.0,
"coa_m":-1.0,
"nad_m":-1.0,
"nadh_m":1.0,
"ppcoa_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"((WBGene00012713 or WBGene00012799) and WBGene00006518) and WBGene00010794 and WBGene00014054",
"subsystem":"Propanoate metabolism",
"annotation":{
"ec-code":[
"1.2.4.4",
"1.8.1.4",
"2.3.1.168"
],
"sbo":"SBO:0000176"
}
},
{
"id":"RMC0132",
"name":"iron-sulfur cluster biosynthesis",
"metabolites":{
"ISclustprot_m":1.0,
"adp_m":1.0,
"ala-L_m":2.0,
"apoISclustprot_m":-1.0,
"atp_m":-1.0,
"cys-L_m":-2.0,
"fe3_m":-2.0,
"h2o_m":-1.0,
"h_m":1.0,
"pi_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00015021 and WBGene00012885 and (WBGene00001486 or WBGene00012666) and WBGene00001033 and WBGene00002010",
"subsystem":"Iron-sulfur cluster biosynthesis",
"annotation":{
"ec-code":"2.8.1.7",
"kegg.reaction":"R07460",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE0591",
"name":"Dehydroascorbate transport",
"metabolites":{
"dhdascb_c":1.0,
"dhdascb_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"EX00239",
"name":"dCMP exchange",
"metabolites":{
"dcmp_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"TCE5329",
"name":"Isocitrate transport",
"metabolites":{
"icit_c":1.0,
"icit_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE5328",
"name":"N6,N6,N6-Trimethyl-L-lysine transport",
"metabolites":{
"tmlys_c":-1.0,
"tmlys_e":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE0758",
"name":"L-Phenylalanine transport",
"metabolites":{
"phe-L_c":1.0,
"phe-L_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE5325",
"name":"6,7-Dihydrobiopterin transport",
"metabolites":{
"dhbpt_c":-1.0,
"dhbpt_e":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE5324",
"name":"Tetrahydrobiopterin transport",
"metabolites":{
"thbpt_c":-1.0,
"thbpt_e":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE5327",
"name":"Dodecanoate (n-C12:0) transport",
"metabolites":{
"ddca_c":-1.0,
"ddca_e":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE5326",
"name":"L-Kynurenine transport",
"metabolites":{
"Lkynr_c":1.0,
"Lkynr_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE5321",
"name":"Retinal transport",
"metabolites":{
"retinal_c":-1.0,
"retinal_e":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE5320",
"name":"5-Methylthioadenosine transport",
"metabolites":{
"5mta_c":1.0,
"5mta_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE5323",
"name":"Pyridoxal 5'-phosphate transport",
"metabolites":{
"pydx5p_c":1.0,
"pydx5p_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE5322",
"name":"sn-Glycero-3-phosphocholine transport",
"metabolites":{
"g3pc_c":1.0,
"g3pc_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RM10151",
"name":"Thiosulfate oxidation (cytochrome c reducing)",
"metabolites":{
"ficytC_m":-8.0,
"focytC_m":8.0,
"h2o_m":-5.0,
"h_m":10.0,
"so4_m":2.0,
"tsul_m":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00017121 or WBGene00013854",
"subsystem":"Sulfur metabolism",
"annotation":{
"kegg.reaction":"R10151",
"sbo":"SBO:0000176"
}
},
{
"id":"EX00238",
"name":"potassium exchange",
"metabolites":{
"k_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RC02902",
"name":"UDP-glucuronate-retinol glucuronyltransferase",
"metabolites":{
"retn_c":-1.0,
"retnglc_c":1.0,
"udp_c":1.0,
"udpglcur_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00015371 or WBGene00016959 or WBGene00017334 or WBGene00018789 or WBGene00019235 or WBGene00019379 or WBGene00007072 or WBGene00020594 or WBGene00020593 or WBGene00020592 or WBGene00019232 or WBGene00019233 or WBGene00008097 or WBGene00013901 or WBGene00007422 or WBGene00013900 or WBGene00019515 or WBGene00007073 or WBGene00019516 or WBGene00007885 or WBGene00007455 or WBGene00007650 or WBGene00016762 or WBGene00015692 or WBGene00015695 or WBGene00015694 or WBGene00021709 or WBGene00013903 or WBGene00011340 or WBGene00021464 or WBGene00018543 or WBGene00007946 or WBGene00009255 or WBGene00044286 or WBGene00017315 or WBGene00017332 or WBGene00017333 or WBGene00017329 or WBGene00013905 or WBGene00017331 or WBGene00017336 or WBGene00017959 or WBGene00008485 or WBGene00008486 or WBGene00021372 or WBGene00015141 or WBGene00011006 or WBGene00015965 or WBGene00007070 or WBGene00013906 or WBGene00011564 or WBGene00015369 or WBGene00018931 or WBGene00020182 or WBGene00012013 or WBGene00011452 or WBGene00011453 or WBGene00009450 or WBGene00011238 or WBGene00013904 or WBGene00007402 or WBGene00018206 or WBGene00010904 or WBGene00015449 or WBGene00015577 or WBGene00008583 or WBGene00015739 or WBGene00019234 or WBGene00020587",
"subsystem":"Retinol metabolism",
"annotation":{
"ec-code":"2.4.1.17",
"kegg.reaction":"R02902",
"sbo":"SBO:0000176"
}
},
{
"id":"RC02908",
"name":"5-Hydroxytryptamine:oxygen oxidoreductase (deaminating) (flavin-containing)",
"metabolites":{
"5hoxindact_c":1.0,
"h2o2_c":1.0,
"h2o_c":-1.0,
"nh4_c":1.0,
"o2_c":-1.0,
"srtn_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000138",
"subsystem":"Tryptophan metabolism",
"annotation":{
"ec-code":"1.4.3.4",
"kegg.reaction":"R02908",
"sbo":"SBO:0000176"
}
},
{
"id":"RMC0005",
"name":"ATP phosphohydrolase",
"metabolites":{
"adp_m":-1.0,
"atp_m":1.0,
"h2o_m":1.0,
"h_c":-3.0,
"h_m":2.0,
"pi_m":-1.0
},
"lower_bound":0.0,
"upper_bound":0.0,
"gene_reaction_rule":"(WBGene00010419 or WBGene00012040) and WBGene00000229 and WBGene00022089 and WBGene00019061 and (WBGene00017982 or WBGene00019880 or WBGene00022582) and WBGene00000230 and WBGene00010960 and (WBGene00000207 or WBGene00000206) and WBGene00022336 and WBGene00007385 and WBGene00011015 and WBGene00011273 and (WBGene00000210 or WBGene00000209)",
"subsystem":"Oxidative phosphorylation",
"annotation":{
"ec-code":"3.6.3.14",
"kegg.reaction":"R00086",
"sbo":"SBO:0000176"
}
},
{
"id":"RMC0004",
"name":"ATP phosphohydrolase",
"metabolites":{
"adp_m":-1.0,
"atp_m":1.0,
"h2o_m":1.0,
"h_c":-4.0,
"h_m":3.0,
"pi_m":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00010419 or WBGene00012040) and WBGene00000229 and WBGene00022089 and WBGene00019061 and (WBGene00017982 or WBGene00019880 or WBGene00022582) and WBGene00000230 and WBGene00010960 and (WBGene00000207 or WBGene00000206) and WBGene00022336 and WBGene00007385 and WBGene00011015 and WBGene00011273 and (WBGene00000210 or WBGene00000209)",
"subsystem":"Oxidative phosphorylation",
"annotation":{
"ec-code":"3.6.3.14",
"kegg.reaction":"R00086",
"sbo":"SBO:0000176"
}
},
{
"id":"RMC0007",
"name":"NADH:ubiquinone oxidoreductase",
"metabolites":{
"h_c":-1.0,
"nad_m":1.0,
"nadh_m":-1.0,
"q_m":-1.0,
"qh2_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00010959 and WBGene00010961 and WBGene00010966 and WBGene00010963 and WBGene00010967 and WBGene00010957 and WBGene00010958) and (WBGene00009992 and (WBGene00001520 or WBGene00006463) and WBGene00020417 and WBGene00003831 and WBGene00021562 and WBGene00012376 and WBGene00020636 and WBGene00003061 and WBGene00021839 and WBGene00009051) and (WBGene00009294 and WBGene00013406 and WBGene00007880 and WBGene00013308 and WBGene00009740 and WBGene00021849 and WBGene00021800 and WBGene00019401 and (WBGene00018151 or WBGene00013237) and WBGene00016393) and (WBGene00009712 and WBGene00007684 and WBGene00012166 and WBGene00016118 and WBGene00014086 and WBGene00008414 and WBGene00013094 and WBGene00015810 and WBGene00010326 and WBGene00022169 and WBGene00018361)",
"subsystem":"Oxidative phosphorylation",
"annotation":{
"ec-code":[
"1.6.5.3",
"1.6.99.3"
],
"kegg.reaction":"R02163",
"sbo":"SBO:0000176"
}
},
{
"id":"RMC0006",
"name":"NADH:ubiquinone oxidoreductase",
"metabolites":{
"h_c":4.0,
"h_m":-5.0,
"nad_m":1.0,
"nadh_m":-1.0,
"q_m":-1.0,
"qh2_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00010959 and WBGene00010961 and WBGene00010966 and WBGene00010963 and WBGene00010967 and WBGene00010957 and WBGene00010958) and (WBGene00009992 and (WBGene00001520 or WBGene00006463) and WBGene00020417 and WBGene00003831 and WBGene00021562 and WBGene00012376 and WBGene00020636 and WBGene00003061 and WBGene00021839 and WBGene00009051) and (WBGene00009294 and WBGene00013406 and WBGene00007880 and WBGene00013308 and WBGene00009740 and WBGene00021849 and WBGene00021800 and WBGene00019401 and (WBGene00018151 or WBGene00013237) and WBGene00016393) and (WBGene00009712 and WBGene00007684 and WBGene00012166 and WBGene00016118 and WBGene00014086 and WBGene00008414 and WBGene00013094 and WBGene00015810 and WBGene00010326 and WBGene00022169 and WBGene00018361)",
"subsystem":"Oxidative phosphorylation",
"annotation":{
"ec-code":[
"1.6.5.3",
"1.6.99.3"
],
"kegg.reaction":"R02163",
"sbo":"SBO:0000176"
}
},
{
"id":"RMC0001",
"name":"isocitrate hydro-lyase (cis-aconitate-forming)",
"metabolites":{
"cit_m":-1.0,
"icit_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000041",
"subsystem":"Citrate cycle (TCA cycle)",
"annotation":{
"ec-code":"4.2.1.3",
"kegg.reaction":[
"R01325",
"R01900"
],
"sbo":"SBO:0000176"
}
},
{
"id":"RMC0003",
"name":"2-oxoglutarate dehydrogenase",
"metabolites":{
"akg_m":-1.0,
"co2_m":1.0,
"coa_m":-1.0,
"nad_m":-1.0,
"nadh_m":1.0,
"succoa_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00020679 and WBGene00014098) and WBGene00020950 and WBGene00010794",
"subsystem":"Citrate cycle (TCA cycle)",
"annotation":{
"ec-code":[
"1.2.4.2",
"2.3.1.61",
"1.8.1.4"
],
"kegg.reaction":[
"R00621",
"R03316",
"R02570",
"R07618"
],
"sbo":"SBO:0000176"
}
},
{
"id":"RMC0009",
"name":"3-sulfinopyruvate hydrolase",
"metabolites":{
"3snpyr_m":-1.0,
"h2o_m":-1.0,
"h_m":1.0,
"pyr_m":1.0,
"so3_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Cysteine and methionine metabolism",
"annotation":{
"sbo":"SBO:0000176"
}
},
{
"id":"RMC0008",
"name":"NADH:ubiquinone oxidoreductase",
"metabolites":{
"h_m":-1.0,
"nad_m":1.0,
"nadh_m":-1.0,
"q_m":-1.0,
"qh2_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00010959 and WBGene00010961 and WBGene00010966 and WBGene00010963 and WBGene00010967 and WBGene00010957 and WBGene00010958) and (WBGene00009992 and (WBGene00001520 or WBGene00006463) and WBGene00020417 and WBGene00003831 and WBGene00021562 and WBGene00012376 and WBGene00020636 and WBGene00003061 and WBGene00021839 and WBGene00009051) and (WBGene00009294 and WBGene00013406 and WBGene00007880 and WBGene00013308 and WBGene00009740 and WBGene00021849 and WBGene00021800 and WBGene00019401 and (WBGene00018151 or WBGene00013237) and WBGene00016393) and (WBGene00009712 and WBGene00007684 and WBGene00012166 and WBGene00016118 and WBGene00014086 and WBGene00008414 and WBGene00013094 and WBGene00015810 and WBGene00010326 and WBGene00022169 and WBGene00018361)",
"subsystem":"Oxidative phosphorylation",
"annotation":{
"ec-code":[
"1.6.5.3",
"1.6.99.3"
],
"kegg.reaction":"R02163",
"sbo":"SBO:0000176"
}
},
{
"id":"RM01492",
"name":"ATP:cob(I)alamin Co-beta-adenosyltransferase",
"metabolites":{
"adocbl_m":1.0,
"atp_m":-1.0,
"cbl1_m":-1.0,
"h_m":-1.0,
"pppi_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00016144  or WBGene00013577",
"subsystem":"Vitamin B12 metabolism",
"annotation":{
"ec-code":"2.5.1.17",
"kegg.reaction":"R01492",
"sbo":"SBO:0000176"
}
},
{
"id":"RM01251",
"name":"L-Proline:NADP+ 5-oxidoreductase",
"metabolites":{
"1pyr5c_m":-1.0,
"h_m":-2.0,
"nadp_m":1.0,
"nadph_m":-1.0,
"pro-L_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00010924 or WBGene00018904",
"subsystem":"Arginine and proline metabolism",
"annotation":{
"ec-code":"1.5.1.2",
"kegg.reaction":"R01251",
"sbo":"SBO:0000176"
}
},
{
"id":"RM01253",
"name":"L-proline:(acceptor) oxidoreductase",
"metabolites":{
"1pyr5c_m":1.0,
"fad_m":-1.0,
"fadh2_m":1.0,
"h_m":1.0,
"pro-L_m":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00007197",
"subsystem":"Arginine and proline metabolism",
"annotation":{
"ec-code":"1.5.-.-",
"kegg.reaction":"R10507",
"sbo":"SBO:0000176"
}
},
{
"id":"EX02642",
"name":"N-Carbamoyl-beta-alanine exchange",
"metabolites":{
"cala_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RC03720",
"name":"Choloyl-CoA:taurine N-choloyltransferase",
"metabolites":{
"cholcoa_c":-1.0,
"coa_c":1.0,
"taur_c":-1.0,
"tchola_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00007857 or WBGene00020989 or WBGene00020258 or WBGene00019404",
"subsystem":"Primary bile acid biosynthesis",
"annotation":{
"ec-code":"2.3.1.65",
"kegg.reaction":"R03720",
"sbo":"SBO:0000176"
}
},
{
"id":"EX01179",
"name":"3-(4-Hydroxyphenyl)pyruvate exchange",
"metabolites":{
"34hpp_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00197",
"name":"3-Phospho-D-glycerate exchange",
"metabolites":{
"3pg_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"TCE0374",
"name":"Retinol transport",
"metabolites":{
"retinol_c":1.0,
"retinol_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE0376",
"name":"linoleic acid (all cis C18:2) n-6 transport",
"metabolites":{
"lnlc_c":1.0,
"lnlc_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE0370",
"name":"3-mercaptolactate-cysteine disulfide transport",
"metabolites":{
"mercplaccys_c":-1.0,
"mercplaccys_e":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE1202",
"name":"Formate transport",
"metabolites":{
"for_c":1.0,
"for_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE0379",
"name":"Hydrogen peroxide transport",
"metabolites":{
"h2o2_c":1.0,
"h2o2_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE5505",
"name":"proton transport",
"metabolites":{
"h_c":-1.0,
"h_e":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC02124",
"name":"retinol:NAD+ oxidoreductase",
"metabolites":{
"h_c":1.0,
"nad_c":-1.0,
"nadh_c":1.0,
"retinal_c":1.0,
"retinol_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00019240 or (WBGene00017060 or WBGene00010790 or WBGene00010791)) or (WBGene00000982 or WBGene00000967)",
"subsystem":"Retinol metabolism",
"annotation":{
"ec-code":[
"1.1.1.1",
"1.1.1.105"
],
"kegg.reaction":"R02124",
"sbo":"SBO:0000176"
}
},
{
"id":"RC03348",
"name":"Nicotinate-nucleotide:pyrophosphate phosphoribosyltransferase (carboxylating)",
"metabolites":{
"co2_c":1.0,
"h_c":-2.0,
"nicrnt_c":1.0,
"ppi_c":1.0,
"prpp_c":-1.0,
"quln_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00011559",
"subsystem":"Nicotinate and nicotinamide metabolism",
"annotation":{
"ec-code":"2.4.2.19",
"kegg.reaction":"R03348",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE0574",
"name":"1-Methylnicotinamide transport",
"metabolites":{
"1mncam_c":-1.0,
"1mncam_e":1.0,
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE5501",
"name":"chloride uptake with hydroxide exchange",
"metabolites":{
"cl_c":2.0,
"cl_e":-2.0,
"oh1_c":-1.0,
"oh1_e":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RM02678",
"name":"Indole-3-acetaldehyde:NAD+ oxidoreductase",
"metabolites":{
"h2o_m":-1.0,
"h_m":2.0,
"id3acald_m":-1.0,
"ind3ac_m":1.0,
"nad_m":-1.0,
"nadh_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00000107 or WBGene00000108 or WBGene00000110) or WBGene00000115",
"subsystem":"Tryptophan metabolism",
"annotation":{
"ec-code":"1.2.1.3",
"kegg.reaction":"R02678",
"sbo":"SBO:0000176"
}
},
{
"id":"RC03435",
"name":"1-Phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase",
"metabolites":{
"dag_pl_c":1.0,
"h2o_c":-1.0,
"h_c":1.0,
"mi145p_c":1.0,
"pail45p_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00004036 or WBGene00004037 or WBGene00004038 or WBGene00004039 or WBGene00001177",
"subsystem":"Inositol phosphate metabolism",
"annotation":{
"ec-code":"3.1.4.11",
"kegg.reaction":"R03435",
"sbo":"SBO:0000176"
}
},
{
"id":"RC04420",
"name":"5-methylthioribose-1-phosphate isomerase",
"metabolites":{
"5mdr1p_c":-1.0,
"5mdru1p_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00007236",
"subsystem":"Cysteine and methionine metabolism",
"annotation":{
"ec-code":"5.3.1.23",
"kegg.reaction":"R04420",
"sbo":"SBO:0000176"
}
},
{
"id":"RC03430",
"name":"D-myo-Inositol 1,3,4,5-tetrakisphosphate 5-phosphohydrolase",
"metabolites":{
"h2o_c":-1.0,
"mi1345p_c":-1.0,
"mi134p_c":1.0,
"pi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00015278 or WBGene00002146",
"subsystem":"Inositol phosphate metabolism",
"annotation":{
"ec-code":"3.1.3.56",
"kegg.reaction":"R03430",
"sbo":"SBO:0000176"
}
},
{
"id":"RC03433",
"name":"ATP:1D-myo-inositol-1,4,5-trisphosphate 3-phosphotransferase",
"metabolites":{
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"atp_c":-1.0,
"h_c":1.0,
"mi1345p_c":1.0,
"mi145p_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00002979",
"subsystem":"Inositol phosphate metabolism",
"annotation":{
"ec-code":"2.7.1.127",
"kegg.reaction":"R03433",
"sbo":"SBO:0000176"
}
},
{
"id":"RC03654",
"name":"glycine:tRNA(Gly) ligase (AMP-forming)",
"metabolites":{
"amp_c":1.0,
"atp_c":-1.0,
"gly_c":-1.0,
"glytrna_c":1.0,
"ppi_c":1.0,
"trnagly_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00001744",
"subsystem":"Aminoacyl-tRNA biosynthesis",
"annotation":{
"ec-code":"6.1.1.14",
"kegg.reaction":"R03654",
"sbo":"SBO:0000176"
}
},
{
"id":"RC03655",
"name":"L-Histidine:tRNA(His) ligase (AMP-forming)",
"metabolites":{
"amp_c":1.0,
"atp_c":-1.0,
"his-L_c":-1.0,
"histrna_c":1.0,
"ppi_c":1.0,
"trnahis_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00002001",
"subsystem":"Aminoacyl-tRNA biosynthesis",
"annotation":{
"ec-code":"6.1.1.21",
"kegg.reaction":"R03655",
"sbo":"SBO:0000176"
}
},
{
"id":"RC03656",
"name":"L-Isoleucine:tRNA(Ile) ligase (AMP-forming)",
"metabolites":{
"amp_c":1.0,
"atp_c":-1.0,
"ile-L_c":-1.0,
"iletrna_c":1.0,
"ppi_c":1.0,
"trnaile_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00002152",
"subsystem":"Aminoacyl-tRNA biosynthesis",
"annotation":{
"ec-code":"6.1.1.5",
"kegg.reaction":"R03656",
"sbo":"SBO:0000176"
}
},
{
"id":"RC03657",
"name":"L-Leucine:tRNA(Leu) ligase (AMP-forming)",
"metabolites":{
"amp_c":1.0,
"atp_c":-1.0,
"leu-L_c":-1.0,
"leutrna_c":1.0,
"ppi_c":1.0,
"trnaleu_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00003073",
"subsystem":"Aminoacyl-tRNA biosynthesis",
"annotation":{
"ec-code":"6.1.1.4",
"kegg.reaction":"R03657",
"sbo":"SBO:0000176"
}
},
{
"id":"RC03650",
"name":"L-Cysteine:tRNA(Cys) ligase (AMP-forming)",
"metabolites":{
"amp_c":1.0,
"atp_c":-1.0,
"cys-L_c":-1.0,
"cystrna_c":1.0,
"ppi_c":1.0,
"trnacys_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000800",
"subsystem":"Aminoacyl-tRNA biosynthesis",
"annotation":{
"ec-code":"6.1.1.16",
"kegg.reaction":"R03650",
"sbo":"SBO:0000176"
}
},
{
"id":"RC03652",
"name":"L-Glutamine:tRNA(Gln) ligase (AMP-forming)",
"metabolites":{
"amp_c":1.0,
"atp_c":-1.0,
"gln-L_c":-1.0,
"glntrna_c":1.0,
"ppi_c":1.0,
"trnagln_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00001336",
"subsystem":"Aminoacyl-tRNA biosynthesis",
"annotation":{
"ec-code":"6.1.1.18",
"kegg.reaction":"R03652",
"sbo":"SBO:0000176"
}
},
{
"id":"TCM5058",
"name":"2-Oxobutanoate transport (mitochondria/cytosol)",
"metabolites":{
"2obut_c":1.0,
"2obut_m":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM5057",
"name":"Carnitine-acylcarnitine translocase (vacccrn)",
"metabolites":{
"vacccrn_c":-1.0,
"vacccrn_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000996 or WBGene00008320",
"subsystem":"Carnitine shuttle",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RCC0230",
"name":"ascr-coa (ascr3) hydrolysis",
"metabolites":{
"ascr3_c":1.0,
"ascr3coa_c":-1.0,
"coa_c":1.0,
"h2o_c":-1.0,
"h_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Ascaroside biosynthesis",
"annotation":{
"sbo":"SBO:0000176"
}
},
{
"id":"TCM5055",
"name":"Carnitine-acylcarnitine translocase (stcrn)",
"metabolites":{
"stcrn_c":-1.0,
"stcrn_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000996 or WBGene00008320",
"subsystem":"Carnitine shuttle",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM5054",
"name":"Carnitine-acylcarnitine translocase (odecrn)",
"metabolites":{
"odecrn_c":-1.0,
"odecrn_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000996 or WBGene00008320",
"subsystem":"Carnitine shuttle",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC03658",
"name":"L-Lysine:tRNALys ligase (AMP-forming)",
"metabolites":{
"amp_c":1.0,
"atp_c":-1.0,
"lys-L_c":-1.0,
"lystrna_c":1.0,
"ppi_c":1.0,
"trnalys_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00002238",
"subsystem":"Aminoacyl-tRNA biosynthesis",
"annotation":{
"ec-code":"6.1.1.6",
"kegg.reaction":"R03658",
"sbo":"SBO:0000176"
}
},
{
"id":"RC03659",
"name":"L-Methionine:tRNAMet ligase (AMP-forming)",
"metabolites":{
"amp_c":1.0,
"atp_c":-1.0,
"met-L_c":-1.0,
"mettrna_c":1.0,
"ppi_c":1.0,
"trnamet_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00003415 or WBGene00013678",
"subsystem":"Aminoacyl-tRNA biosynthesis",
"annotation":{
"ec-code":"6.1.1.10",
"kegg.reaction":"R03659",
"sbo":"SBO:0000176"
}
},
{
"id":"TCM5051",
"name":"Carnitine-acylcarnitine translocase (eicostetcrn)",
"metabolites":{
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"eicostetcrn_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000996 or WBGene00008320",
"subsystem":"Carnitine shuttle",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RCC0231",
"name":"ascr-coa (ascr1) hydrolysis",
"metabolites":{
"ascr1_c":1.0,
"ascr1coa_c":-1.0,
"coa_c":1.0,
"h2o_c":-1.0,
"h_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Ascaroside biosynthesis",
"annotation":{
"sbo":"SBO:0000176"
}
},
{
"id":"DMN0057",
"name":"Protein N6,N6,N6-trimethyl-L-lysine demand",
"metabolites":{
"Ntmelys_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Histone modification",
"annotation":{
"sbo":"SBO:0000628"
}
},
{
"id":"EX02737",
"name":"Phosphatidylserine exchange",
"metabolites":{
"ps_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RM00709",
"name":"Isocitrate:NAD+ oxidoreductase (decarboxylating)",
"metabolites":{
"akg_m":1.0,
"co2_m":1.0,
"icit_m":-1.0,
"nad_m":-1.0,
"nadh_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00009664 and WBGene00007993 and (WBGene00009440 or WBGene00016266)",
"subsystem":"Citrate cycle (TCA cycle)",
"annotation":{
"ec-code":"1.1.1.41",
"kegg.reaction":"R00709",
"sbo":"SBO:0000176"
}
},
{
"id":"TCM0214",
"name":"dATP and ADP transport",
"metabolites":{
"adp_c":1.0,
"adp_m":-1.0,
"datp_c":-1.0,
"datp_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"EX05122",
"name":"taurocholic acid exchange",
"metabolites":{
"tchola_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RC04513",
"name":"phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase",
"metabolites":{
"h2o_c":-1.0,
"pail345p_c":-1.0,
"pail45p_c":1.0,
"pi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000913",
"subsystem":"Inositol phosphate metabolism",
"annotation":{
"ec-code":"3.1.3.67",
"kegg.reaction":"R04513",
"sbo":"SBO:0000176"
}
},
{
"id":"EX00469",
"name":"Ethanol exchange",
"metabolites":{
"etoh_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RM05373",
"name":"methylmalonyl-CoA carboxy-lyase",
"metabolites":{
"co2_m":1.0,
"h_m":-1.0,
"mmcoa-S_m":-1.0,
"ppcoa_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00009439",
"subsystem":"Propanoate metabolism",
"annotation":{
"ec-code":"4.1.1.9",
"kegg.reaction":"R05373",
"sbo":"SBO:0000176"
}
},
{
"id":"RC08723",
"name":"3beta-hydroxy-Delta5-C27-steroid oxidoreductase",
"metabolites":{
"h_c":1.0,
"nad_c":-1.0,
"nadh_c":1.0,
"xol25one_c":1.0,
"xoltri25_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00012394 or WBGene00022498 or WBGene00022616",
"subsystem":"Primary bile acid biosynthesis",
"annotation":{
"ec-code":"1.1.1.181",
"kegg.reaction":"R08723",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00851",
"name":"acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase (acting on Rtotal group)",
"metabolites":{
"Rtotalcoa_c":-1.0,
"alpa_pl_c":1.0,
"coa_c":1.0,
"glyc3p_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00017261 or (WBGene00018657 or WBGene00011106)",
"subsystem":"Glycerolipid metabolism",
"annotation":{
"ec-code":"2.3.1.15",
"kegg.reaction":"R00851",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01108",
"name":"glutathione dehydrogenase (ascorbate)",
"metabolites":{
"ascb-L_c":1.0,
"dhdascb_c":-1.0,
"gthox_c":1.0,
"gthrd_c":-2.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Glutathione metabolism",
"annotation":{
"ec-code":"1.8.5.1",
"kegg.reaction":"R01108",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01103",
"name":"Raffinose galactohydrolase",
"metabolites":{
"gal_c":1.0,
"h2o_c":-1.0,
"raffin_c":-1.0,
"sucr_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00011095",
"subsystem":"Galactose metabolism",
"annotation":{
"ec-code":"3.2.1.22",
"kegg.reaction":"R01103",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01100",
"name":"Lactose galactohydrolase",
"metabolites":{
"gal_c":1.0,
"glc-D_c":1.0,
"h2o_c":-1.0,
"lcts_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00011832",
"subsystem":"Galactose metabolism",
"annotation":{
"ec-code":"3.2.1.23",
"kegg.reaction":"R01100",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01101",
"name":"melibiose galactohydrolase",
"metabolites":{
"gal_c":1.0,
"glc-D_c":1.0,
"h2o_c":-1.0,
"melib_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00011095",
"subsystem":"Galactose metabolism",
"annotation":{
"ec-code":"3.2.1.22",
"kegg.reaction":"R01101",
"sbo":"SBO:0000176"
}
},
{
"id":"EX05127",
"name":"N-Methylhistamine exchange",
"metabolites":{
"mhista_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RC00291",
"name":"UDP-glucose 4-epimerase",
"metabolites":{
"udpg_c":-1.0,
"udpgal_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00008132",
"subsystem":"Galactose metabolism",
"annotation":{
"ec-code":"5.1.3.2",
"kegg.reaction":"R00291",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00293",
"name":"UDP-glucose 4,6-hydro-lyase (UDP-4-dehydro-6-deoxy-D-glucose-forming)",
"metabolites":{
"h2o_c":1.0,
"udp4k6dg_c":1.0,
"udpg_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00015298",
"subsystem":"Amino sugar and nucleotide sugar metabolism",
"annotation":{
"ec-code":"4.2.1.76",
"kegg.reaction":"R00293",
"sbo":"SBO:0000176"
}
},
{
"id":"RC04779",
"name":"ATP:D-fructose-6-phosphate 1-phosphotransferase",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"f6p_c":-1.0,
"fdp_c":1.0,
"h_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00008230 or WBGene00022199",
"subsystem":"Glycolysis / Gluconeogenesis",
"annotation":{
"ec-code":"2.7.1.11",
"kegg.reaction":"R04779",
"sbo":"SBO:0000176"
}
},
{
"id":"RC02055",
"name":"Phsophatidyl-L-serine carboxy-lyase",
"metabolites":{
"co2_c":1.0,
"h_c":-1.0,
"pe_c":1.0,
"ps_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00015159",
"subsystem":"Glycerophospholipid metabolism",
"annotation":{
"ec-code":"4.1.1.65",
"kegg.reaction":"R02055",
"sbo":"SBO:0000176"
}
},
{
"id":"TCM0196",
"name":"Choline transport",
"metabolites":{
"chol_c":-1.0,
"chol_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC04770",
"name":"Selenomethionine methanethiol-lyase (deaminating)",
"metabolites":{
"2obut_c":1.0,
"h2o_c":-1.0,
"h_c":1.0,
"metsel_c":1.0,
"nh4_c":1.0,
"selmeth_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00007533 or WBGene00009048 or WBGene00022856",
"subsystem":"Selenocompound metabolism",
"annotation":{
"ec-code":"4.4.1.1",
"kegg.reaction":"R04770",
"sbo":"SBO:0000176"
}
},
{
"id":"RC04286",
"name":"2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl) dihydropteridine triphosphate lyase",
"metabolites":{
"6pthp_c":1.0,
"ahdt_c":-1.0,
"pppi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00015010",
"subsystem":"Folate biosynthesis",
"annotation":{
"ec-code":"4.2.3.12",
"kegg.reaction":"R04286",
"sbo":"SBO:0000176"
}
},
{
"id":"TCM1071",
"name":"Mixed transport",
"metabolites":{
"fad_m":1.0,
"fadh2_m":-1.0,
"fum_c":-1.0,
"succ_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"EX00299",
"name":"Uridine exchange",
"metabolites":{
"uri_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RC02059",
"name":"N-Acetyl-D-glucosamine-6-phosphate amidohydrolase",
"metabolites":{
"ac_c":1.0,
"acgam6p_c":-1.0,
"gam6p_c":1.0,
"h2o_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00010308",
"subsystem":"Amino sugar and nucleotide sugar metabolism",
"annotation":{
"ec-code":"3.5.1.25",
"kegg.reaction":"R02059",
"sbo":"SBO:0000176"
}
},
{
"id":"TCM1073",
"name":"2-Oxoadipate transport",
"metabolites":{
"2oxoadp_c":1.0,
"2oxoadp_m":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RCC0250",
"name":"V-ATPase",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_pumped_c":1.0,
"pi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00013025 and (WBGene00006921 or WBGene00004959) and WBGene00006920 and WBGene00010130 and WBGene00006917 and WBGene00006918 and WBGene00006919 and (WBGene00018698 or WBGene00020507) and (WBGene00006916 or WBGene00006914 or WBGene00006915 or WBGene00006768) and (WBGene00006911 or WBGene00006910 or WBGene00006913 or WBGene00006912) and WBGene00009882 and WBGene00021952",
"subsystem":"Miscellaneous",
"annotation":{
"ec-code":"3.6.3.14",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00366",
"name":"glycine:oxygen oxidoreductase (deaminating)",
"metabolites":{
"glx_c":1.0,
"gly_c":-1.0,
"h2o2_c":1.0,
"h2o_c":-1.0,
"nh4_c":1.0,
"o2_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00022076",
"subsystem":"Glycine, serine and threonine metabolism",
"annotation":{
"ec-code":"1.4.3.3",
"kegg.reaction":"R00366",
"sbo":"SBO:0000176"
}
},
{
"id":"RM02529",
"name":"aminoacetone:oxygen oxidoreductase(deaminating)",
"metabolites":{
"aact_m":-1.0,
"h2o2_m":1.0,
"h2o_m":-1.0,
"mthgxl_m":1.0,
"nh4_m":1.0,
"o2_m":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000138",
"subsystem":"Glycine, serine and threonine metabolism",
"annotation":{
"ec-code":"1.4.3.4",
"kegg.reaction":"R02529",
"sbo":"SBO:0000176"
}
},
{
"id":"EX15520",
"name":"\"7-alpha,25-Dihydroxycholesterol\" exchange",
"metabolites":{
"xoltri25_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RCC0032",
"name":"geranylgeranyltransferase",
"metabolites":{
"ppi_c":1.0,
"protCys_c":-1.0,
"protSger_c":1.0,
"ttc-ggdp_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00013002 or (WBGene00019778 and WBGene00015099)",
"subsystem":"Terpenoid backbone biosynthesis",
"annotation":{
"ec-code":[
"2.5.1.59",
"2.5.1.60"
],
"sbo":"SBO:0000176"
}
},
{
"id":"RC01819",
"name":"D-mannose-6-phosphate aldose-ketose-isomerase",
"metabolites":{
"f6p_c":1.0,
"man6p_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00015464 or WBGene00014013",
"subsystem":"Fructose and mannose metabolism",
"annotation":{
"ec-code":"5.3.1.8",
"kegg.reaction":"R01819",
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0030",
"name":"dehydrodolichol phosphate phosphatase",
"metabolites":{
"dedol_c":1.0,
"dedolp_c":-1.0,
"h2o_c":-1.0,
"pi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"N-Glycan biosynthesis",
"annotation":{
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0031",
"name":"Polyprenol reductase",
"metabolites":{
"dedol_c":-1.0,
"dolichol_c":1.0,
"h_c":-1.0,
"nadp_c":1.0,
"nadph_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00007102",
"subsystem":"N-Glycan biosynthesis",
"annotation":{
"sbo":"SBO:0000176"
}
},
{
"id":"RC01072",
"name":"5-phosphoribosylamine:diphosphate phospho-alpha-D-ribosyltransferase (glutamate-amidating)",
"metabolites":{
"gln-L_c":-1.0,
"glu-L_c":1.0,
"h2o_c":-1.0,
"ppi_c":1.0,
"pram_c":1.0,
"prpp_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00011407",
"subsystem":"Purine metabolism",
"annotation":{
"ec-code":"2.4.2.14",
"kegg.reaction":"R01072",
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0037",
"name":"GDP-mannose:glycolipid 1,2-alpha-D-mannosyltransferase; GDP-mannose:glycolipid 1,2-alpha-D-mannosyltransferase",
"metabolites":{
"gdp_c":2.0,
"gdpmann_c":-2.0,
"h_c":2.0,
"m2mpdol_c":-1.0,
"m4mpdol_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00015162",
"subsystem":"N-Glycan biosynthesis",
"annotation":{
"ec-code":"2.4.1.131",
"kegg.reaction":[
"R06127",
"R06128"
],
"sbo":"SBO:0000176"
}
},
{
"id":"RC01070",
"name":"beta-D-fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase (glycerone-phosphate-forming)",
"metabolites":{
"dhap_c":1.0,
"fdp_c":-1.0,
"g3p_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00017166 or WBGene00011474",
"subsystem":"Glycolysis / Gluconeogenesis",
"annotation":{
"ec-code":"4.1.2.13",
"kegg.reaction":"R01070",
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0038",
"name":"mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase (acting on nm4masn)",
"metabolites":{
"h2o_c":-1.0,
"man_c":1.0,
"nm3masn_c":1.0,
"nm4masn_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00010284",
"subsystem":"N-Glycan biosynthesis",
"annotation":{
"ec-code":"3.2.1.114",
"kegg.reaction":"R05984",
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0039",
"name":"mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase (acting on nm3masn)",
"metabolites":{
"h2o_c":-1.0,
"man_c":1.0,
"nm2masn_c":1.0,
"nm3masn_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00010284",
"subsystem":"N-Glycan biosynthesis",
"annotation":{
"ec-code":"3.2.1.114",
"kegg.reaction":"R05984",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01814",
"name":"L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating) (Dihydrobiopterin forming)",
"metabolites":{
"5htrp_c":1.0,
"dhbpt_c":1.0,
"h2o_c":1.0,
"o2_c":-1.0,
"thbpt_c":-1.0,
"trp-L_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00006600",
"subsystem":"Tryptophan metabolism",
"annotation":{
"ec-code":"1.14.16.4",
"kegg.reaction":"R01814",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01815",
"name":"L-Tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating) (Dihydrobiopterin forming)",
"metabolites":{
"34dhphe_c":1.0,
"dhbpt_c":1.0,
"h2o_c":1.0,
"o2_c":-1.0,
"thbpt_c":-1.0,
"tyr-L_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000296",
"subsystem":"Tyrosine metabolism",
"annotation":{
"ec-code":"1.14.16.2",
"kegg.reaction":"R01815",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01816",
"name":"anthranilate 3-monooxygenase",
"metabolites":{
"3hanthrn_c":1.0,
"anth_c":-1.0,
"dhbpt_c":1.0,
"h2o_c":1.0,
"h_c":-1.0,
"o2_c":-1.0,
"thbpt_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Tryptophan metabolism",
"annotation":{
"ec-code":"1.14.16.3",
"kegg.reaction":"R01816",
"sbo":"SBO:0000176"
}
},
{
"id":"RC05556",
"name":"(2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate cistransferase (adding 10-55 isopentenyl units)",
"metabolites":{
"dedoldp_c":1.0,
"frdp_c":-1.0,
"ipdp_c":-19.0,
"ppi_c":19.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00044025",
"subsystem":"Terpenoid backbone biosynthesis",
"annotation":{
"ec-code":"2.5.1.87",
"kegg.reaction":"R05556",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00078",
"name":"Fe(II):oxygen oxidoreductase",
"metabolites":{
"fe2_c":-4.0,
"fe3_c":4.0,
"h2o_c":2.0,
"h_c":-4.0,
"o2_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00001500 or WBGene00001501",
"subsystem":"Porphyrin and chlorophyll metabolism",
"annotation":{
"ec-code":"1.16.3.1",
"kegg.reaction":"R00078",
"sbo":"SBO:0000176"
}
},
{
"id":"RM00781",
"name":"sulfur dioxygenase",
"metabolites":{
"h2o_m":-1.0,
"h_m":2.0,
"o2_m":-1.0,
"s_m":-1.0,
"so3_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00007886",
"subsystem":"Sulfur metabolism",
"annotation":{
"ec-code":"1.13.11.18",
"kegg.reaction":"R00781",
"sbo":"SBO:0000176"
}
},
{
"id":"EX00232",
"name":"Succinic semialdehyde exchange",
"metabolites":{
"sucsal_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"DMN0100",
"name":"vATPase-pumped proton demand",
"metabolites":{
"h_pumped_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Miscellaneous",
"annotation":{
"sbo":"SBO:0000628"
}
},
{
"id":"RC01252",
"name":"L-Proline,2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating)",
"metabolites":{
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"akg_c":-1.0,
"co2_c":1.0,
"o2_c":-1.0,
"pro-L_c":-1.0,
"succ_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00015773 or WBGene00077688 or WBGene00001077 or WBGene00004025 or WBGene00004026 or WBGene00012815",
"subsystem":"Arginine and proline metabolism",
"annotation":{
"ec-code":"1.14.11.2",
"kegg.reaction":"R01252",
"sbo":"SBO:0000176"
}
},
{
"id":"RM08781",
"name":"methyltransferase COQ3",
"metabolites":{
"2npmhobq_m":-1.0,
"ahcys_m":1.0,
"amet_m":-1.0,
"h_m":1.0,
"q9_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000763",
"subsystem":"Ubiquinone and other terpenoid-quinone biosynthesis",
"annotation":{
"ec-code":"2.1.1.114",
"kegg.reaction":"R08781",
"sbo":"SBO:0000176"
}
},
{
"id":"EX00099",
"name":"beta-Alanine exchange",
"metabolites":{
"ala-B_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RM04224",
"name":"(S)-3-Hydroxyisobutyryl-CoA hydro-lyase",
"metabolites":{
"2mp2coa_m":-1.0,
"3hibutcoa_m":1.0,
"h2o_m":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00001155 or WBGene00001156) or (WBGene00020347 or WBGene00001150) or WBGene00001152",
"subsystem":"Valine, leucine and isoleucine degradation",
"annotation":{
"ec-code":"4.2.1.17",
"kegg.reaction":"R04224",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE7572",
"name":"5-Hydroxyindoleacetate transport",
"metabolites":{
"5hoxindoa_c":-1.0,
"5hoxindoa_e":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"EX00094",
"name":"Sulfite exchange",
"metabolites":{
"so3_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00097",
"name":"L-Cysteine exchange",
"metabolites":{
"cys-L_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00093",
"name":"Glycerol 3-phosphate exchange",
"metabolites":{
"glyc3p_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"TCE1184",
"name":"L-Lysine transport",
"metabolites":{
"lys-L_c":1.0,
"lys-L_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RM00258",
"name":"L-Alanine:2-oxoglutarate aminotransferase",
"metabolites":{
"akg_m":-1.0,
"ala-L_m":-1.0,
"glu-L_m":1.0,
"pyr_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00016333",
"subsystem":"Alanine, aspartate and glutamate metabolism",
"annotation":{
"ec-code":"2.6.1.2",
"kegg.reaction":"R00258",
"sbo":"SBO:0000176"
}
},
{
"id":"EX00708",
"name":"Iodide exchange",
"metabolites":{
"i_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00259",
"name":"L-Arabinose exchange",
"metabolites":{
"arab-L_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00257",
"name":"gluconate uptake",
"metabolites":{
"glcn_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00704",
"name":"Superoxide anion exchange",
"metabolites":{
"o2s_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00255",
"name":"riboflavin exchange",
"metabolites":{
"ribflv_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RC00670",
"name":"L-ornithine carboxy-lyase (putrescine-forming)",
"metabolites":{
"co2_c":1.0,
"h_c":-1.0,
"orn_c":-1.0,
"ptrc_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00018764 or WBGene00003844",
"subsystem":"Arginine and proline metabolism",
"annotation":{
"ec-code":"4.1.1.17",
"kegg.reaction":"R00670",
"sbo":"SBO:0000176"
}
},
{
"id":"EXC0162",
"name":"Ascaroside 10 exchange",
"metabolites":{
"ascr10_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EXC0163",
"name":"Ascaroside 1 exchange",
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"ascr1_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EXC0160",
"name":"Ascaroside 3 exchange",
"metabolites":{
"ascr3_e":-1.0
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00250",
"name":"pyridoxal exchange/defecation",
"metabolites":{
"pydx_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"SNK0045",
"name":"ITP sink",
"metabolites":{
"itp_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Purine metabolism",
"annotation":{
"sbo":"SBO:0000632"
}
},
{
"id":"EX00378",
"name":"thiamine exchange",
"metabolites":{
"thm_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RM08657",
"name":"sn-glycerol 3-phosphate:quinone oxidoreductase",
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"dhap_c":1.0,
"glyc3p_c":-1.0,
"q_m":-1.0,
"qh2_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00012031 or WBGene00013049",
"subsystem":"Glycerophospholipid metabolism",
"annotation":{
"ec-code":"1.1.5.3",
"kegg.reaction":"R08657",
"sbo":"SBO:0000176"
}
},
{
"id":"TCM2002",
"name":"Phosphatidylserine transport",
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"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0,
"ps_c":-1.0,
"ps_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC01498",
"name":"D-Glucosyl-N-acylsphingosine glucohydrolase",
"metabolites":{
"crm_ce_c":1.0,
"glc-D_c":1.0,
"gluside_ce_c":-1.0,
"h2o_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00019965 or WBGene00013670) or (WBGene00016335 or WBGene00016340 or WBGene00008706 or WBGene00021160)",
"subsystem":"Sphingolipid metabolism",
"annotation":{
"ec-code":"3.2.1.45",
"kegg.reaction":"R01498",
"sbo":"SBO:0000176"
}
},
{
"id":"RM00335",
"name":"GTP phosphohydrolase",
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"gdp_m":1.0,
"gtp_m":-1.0,
"h2o_m":-1.0,
"h_m":1.0,
"pi_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00001093 or WBGene00001134",
"subsystem":"Purine metabolism",
"annotation":{
"ec-code":"3.6.5.5",
"kegg.reaction":"R00335",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01494",
"name":"N-Acylsphingosine amidohydrolase",
"metabolites":{
"Rtotal_c":1.0,
"crm_ce_c":-1.0,
"h2o_c":-1.0,
"sphings_ce_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00020947 or (WBGene00009192 or WBGene00010769)",
"subsystem":"Sphingolipid metabolism",
"annotation":{
"ec-code":"3.5.1.23",
"kegg.reaction":"R01494",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01495",
"name":"ATP:ceramide 1-phosphotransferase",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"crm_ce_c":-1.0,
"crmp_ce_c":1.0,
"h_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00020398",
"subsystem":"Sphingolipid metabolism",
"annotation":{
"ec-code":"2.7.1.138",
"kegg.reaction":"R01495",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01496",
"name":"Acyl-CoA:sphingosine N-acyltransferase",
"metabolites":{
"Rtotalcoa_c":-1.0,
"coa_c":1.0,
"crm_ce_c":1.0,
"h_c":1.0,
"sphings_ce_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00002043 or WBGene00002044 or WBGene00006505",
"subsystem":"Sphingolipid metabolism",
"annotation":{
"ec-code":"2.3.1.24",
"kegg.reaction":"R01496",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01497",
"name":"UDP-glucose:N-acylsphingosine D-glucosyltransferase",
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"crm_ce_c":-1.0,
"gluside_ce_c":1.0,
"h_c":1.0,
"udp_c":1.0,
"udpg_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00011517 or WBGene00017625 or WBGene00019127",
"subsystem":"Sphingolipid metabolism",
"annotation":{
"ec-code":"2.4.1.80",
"kegg.reaction":"R01497",
"sbo":"SBO:0000176"
}
},
{
"id":"TCM2004",
"name":"Phosphatidylethanolamine transport",
"metabolites":{
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"pe_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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}
},
{
"id":"TCM0143",
"name":"dGTP and ATP transport",
"metabolites":{
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"atp_m":-1.0,
"dgtp_c":-1.0,
"dgtp_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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}
},
{
"id":"TCM0140",
"name":"dGDP and ATP transport",
"metabolites":{
"atp_c":1.0,
"atp_m":-1.0,
"dgdp_c":-1.0,
"dgdp_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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}
},
{
"id":"TCM0141",
"name":"L-Glutamine transport",
"metabolites":{
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"gln-L_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC00703",
"name":"(S)-Lactate:NAD+ oxidoreductase",
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"lac-L_c":-1.0,
"nad_c":-1.0,
"nadh_c":1.0,
"pyr_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00002262",
"subsystem":"Glycolysis / Gluconeogenesis",
"annotation":{
"ec-code":"1.1.1.27",
"kegg.reaction":"R00703",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01658",
"name":"Dimethylallyl-diphosphate:isopentenyl-diphosphate dimethylallyltranstransferase",
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"grdp_c":1.0,
"ipdp_c":-1.0,
"ppi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00011058",
"subsystem":"Terpenoid backbone biosynthesis",
"annotation":{
"ec-code":"2.5.1.1",
"kegg.reaction":"R01658",
"sbo":"SBO:0000176"
}
},
{
"id":"TCM0145",
"name":"Glycine transport",
"metabolites":{
"gly_c":-1.0,
"gly_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM0148",
"name":"dTDP and ATP transport",
"metabolites":{
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"atp_m":-1.0,
"dtdp_c":-1.0,
"dtdp_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC01655",
"name":"5,10-Methenyltetrahydrofolate 5-hydrolase (decyclizing)",
"metabolites":{
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"h2o_c":-1.0,
"h_c":1.0,
"methf_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00019492 or WBGene00000929",
"subsystem":"One carbon pool by folate",
"annotation":{
"ec-code":"3.5.4.9",
"kegg.reaction":"R01655",
"sbo":"SBO:0000176"
}
},
{
"id":"EX00379",
"name":"Xylitol exchange",
"metabolites":{
"xylt_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX05332",
"name":"Phenethylamine exchange",
"metabolites":{
"peamn_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX05335",
"name":"Selenomethionine exchange",
"metabolites":{
"selmeth_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"TCE0518",
"name":"Thymine transport",
"metabolites":{
"thym_c":1.0,
"thym_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"EX00671",
"name":"(S)-3-Methyl-2-oxopentanoate exchange",
"metabolites":{
"3mop_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00670",
"name":"sn-Glycero-3-phosphocholine exchange",
"metabolites":{
"g3pc_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RM05577",
"name":"L-Aspartate:tRNA(Asp) ligase (AMP-forming)",
"metabolites":{
"amp_m":1.0,
"asp-L_m":-1.0,
"asptrna_m":1.0,
"atp_m":-1.0,
"ppi_m":1.0,
"trnaasp_m":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00001095",
"subsystem":"Aminoacyl-tRNA biosynthesis",
"annotation":{
"ec-code":"6.1.1.12",
"kegg.reaction":"R05577",
"sbo":"SBO:0000176"
}
},
{
"id":"RM05578",
"name":"L-glutamate:tRNA(Glu) ligase (AMP-forming)",
"metabolites":{
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"atp_m":-1.0,
"glu-L_m":-1.0,
"glutrna_m":1.0,
"ppi_m":1.0,
"trnaglu_m":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00001338",
"subsystem":"Aminoacyl-tRNA biosynthesis",
"annotation":{
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"kegg.reaction":"R05578",
"sbo":"SBO:0000176"
}
},
{
"id":"EX00077",
"name":"Ornithine exchange",
"metabolites":{
"orn_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00075",
"name":"UTP exchange",
"metabolites":{
"utp_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00074",
"name":"Phosphoenolpyruvate exchange",
"metabolites":{
"pep_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00073",
"name":"L-Methionine exchange",
"metabolites":{
"met-L_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00072",
"name":"L-Ascorbate exchange",
"metabolites":{
"ascb-L_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00079",
"name":"L-Phenylalanine exchange",
"metabolites":{
"phe-L_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00078",
"name":"L-Tryptophan exchange",
"metabolites":{
"trp-L_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RC02288",
"name":"imidazolonepropionase",
"metabolites":{
"4izp_c":-1.0,
"forglu_c":1.0,
"h2o_c":-1.0,
"h_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00020436",
"subsystem":"Histidine metabolism",
"annotation":{
"ec-code":"3.5.2.7",
"kegg.reaction":"R02288",
"sbo":"SBO:0000176"
}
},
{
"id":"RMC0122",
"name":"Acyl-CoA:L-carnitine O-acyltransferase II (Fatty acyl [C17:iso] CoA)",
"metabolites":{
"coa_m":-1.0,
"crn_m":1.0,
"fa17p0isocoa_m":1.0,
"fa17p0isocrn_m":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00011122",
"subsystem":"Carnitine shuttle",
"annotation":{
"ec-code":"2.3.1.21",
"sbo":"SBO:0000176"
}
},
{
"id":"RMC0123",
"name":"Acyl-CoA:L-carnitine O-acyltransferase II (Fatty acyl [C9:iso] CoA)",
"metabolites":{
"coa_m":-1.0,
"crn_m":1.0,
"fa9p0isocoa_m":1.0,
"fa9p0isocrn_m":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00011122",
"subsystem":"Carnitine shuttle",
"annotation":{
"ec-code":"2.3.1.21",
"sbo":"SBO:0000176"
}
},
{
"id":"RMC0120",
"name":"Acyl-CoA:L-carnitine O-acyltransferase II (cis-11,12-methyleneoctadecanoyl-CoA)",
"metabolites":{
"coa_m":-1.0,
"crn_m":1.0,
"fa19c11coa_m":1.0,
"fa19c11crn_m":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00011122",
"subsystem":"Carnitine shuttle",
"annotation":{
"ec-code":"2.3.1.21",
"sbo":"SBO:0000176"
}
},
{
"id":"RMC0121",
"name":"Acyl-CoA:L-carnitine O-acyltransferase II (Fatty acyl [C15:iso] CoA)",
"metabolites":{
"coa_m":-1.0,
"crn_m":1.0,
"fa15p0isocoa_m":1.0,
"fa15p0isocrn_m":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00011122",
"subsystem":"Carnitine shuttle",
"annotation":{
"ec-code":"2.3.1.21",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE1298",
"name":"D-Xylose transport",
"metabolites":{
"xyl-D_c":1.0,
"xyl-D_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE0699",
"name":"Phosphatidylserine (bacteria) transport",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0,
"ps_BAC_c":1.0,
"ps_BAC_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC02286",
"name":"formimidoylglutamate deiminase",
"metabolites":{
"Nforglu_c":1.0,
"forglu_c":-1.0,
"h2o_c":-1.0,
"h_c":-3.0,
"nh4_c":1.0
},
"lower_bound":-0.0,
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},
{
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"name":"dGDP and dADP transport",
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},
{
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},
{
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},
{
"id":"TCE5338",
"name":"L-Cysteate transport",
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},
{
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"name":"Dihydroxyacetone phosphate transport",
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},
{
"id":"TCE5332",
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},
{
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},
{
"id":"TCE5330",
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},
{
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},
{
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},
{
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},
{
"id":"TCE5334",
"name":"3-(4-Hydroxyphenyl)pyruvate transport",
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},
{
"id":"TCE5335",
"name":"N-Carbamoyl-L-aspartate transport",
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},
{
"id":"TCE1185",
"name":"Xanthine transport",
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},
{
"id":"RC04940",
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"selnt_c":1.0
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"lower_bound":-1000.0,
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},
{
"id":"TCE1186",
"name":"Fumarate transport",
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},
{
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"name":"Phosphate transport",
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},
{
"id":"EX01613",
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},
{
"id":"TCE1189",
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"gene_reaction_rule":"",
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},
{
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},
{
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},
{
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{
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{
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{
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{
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{
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{
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},
{
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},
{
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{
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{
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},
{
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},
{
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},
{
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{
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{
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{
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},
{
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},
{
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},
{
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},
{
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},
{
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},
{
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},
{
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},
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}
},
{
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}
},
{
"id":"TCM5510",
"name":"2-oxoadipate shuttle (cytosol/mitochondria)",
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},
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},
{
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}
},
{
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"subsystem":"Ether lipid metabolism",
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"ec-code":"1.1.1.101",
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}
},
{
"id":"RC03393",
"name":"inositol-1,4-bisphosphate 1-phosphatase",
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"lower_bound":-0.0,
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"subsystem":"Inositol phosphate metabolism",
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}
},
{
"id":"RC03394",
"name":"D-myo-Inositol-1,4,5-trisphosphate 5-phosphohydrolase",
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"mi145p_c":-1.0,
"mi14p_c":1.0,
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"lower_bound":-0.0,
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"gene_reaction_rule":"WBGene00015278 or WBGene00002146",
"subsystem":"Inositol phosphate metabolism",
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"ec-code":"3.1.3.56",
"kegg.reaction":"R03394",
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}
},
{
"id":"RC04162",
"name":"1-Alkyl-2-acyl-sn-glycero-3-phosphate phosphohydrolase",
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"akac2gp_c":-1.0,
"h2o_c":-1.0,
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"lower_bound":-0.0,
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"subsystem":"Ether lipid metabolism",
"annotation":{
"ec-code":"3.1.3.4",
"kegg.reaction":"R04162",
"sbo":"SBO:0000176"
}
},
{
"id":"RM03425",
"name":"glycine:lipoylprotein oxidoreductase (decarboxylating and acceptor-aminomethylating)",
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"co2_m":1.0,
"gly_m":-1.0,
"h_m":-1.0,
"lpro_m":-1.0
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"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00020022 and (WBGene00008354 or WBGene00009918)",
"subsystem":"Glycine, serine and threonine metabolism",
"annotation":{
"ec-code":"1.4.4.2",
"kegg.reaction":"R03425",
"sbo":"SBO:0000176"
}
},
{
"id":"RC04560",
"name":"10-Formyltetrahydrofolate:5-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase",
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"aicar_c":-1.0,
"fprica_c":1.0,
"thf_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00016957",
"subsystem":"Purine metabolism",
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"ec-code":"2.1.2.3",
"kegg.reaction":"R04560",
"sbo":"SBO:0000176"
}
},
{
"id":"EX03722",
"name":"Quinolinate exchange",
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"quln_e":-1.0
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
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"sbo":"SBO:0000627"
}
},
{
"id":"RC03245",
"name":"ATP:(R)-5-phosphomevalonate phosphotransferase",
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"5pmev_c":-1.0,
"adp_c":1.0,
"atp_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
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"subsystem":"Terpenoid backbone biosynthesis",
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"kegg.reaction":"R03245",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00847",
"name":"ATP:glycerol 3-phosphotransferase",
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"glyc_c":-1.0,
"h_c":1.0
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00020007",
"subsystem":"Glycerolipid metabolism",
"annotation":{
"ec-code":"2.7.1.30",
"kegg.reaction":"R00847",
"sbo":"SBO:0000176"
}
},
{
"id":"RC03719",
"name":"3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA:propanoyl-CoA C-acyltransferase",
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"cholcoaone_c":-1.0,
"coa_c":-1.0,
"ppcoa_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00013284 or WBGene00003773)",
"subsystem":"Primary bile acid biosynthesis",
"annotation":{
"ec-code":"2.3.1.176",
"kegg.reaction":"R03719",
"sbo":"SBO:0000176"
}
},
{
"id":"RC03718",
"name":"Choloyl-CoA:glycine N-choloyltransferase",
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"coa_c":1.0,
"gchola_c":1.0,
"gly_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00007857 or WBGene00020989 or WBGene00020258 or WBGene00019404",
"subsystem":"Primary bile acid biosynthesis",
"annotation":{
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"kegg.reaction":"R03718",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00842",
"name":"sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase",
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"glyc3p_c":1.0,
"h_c":-1.0,
"nad_c":1.0,
"nadh_c":-1.0
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"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00009824",
"subsystem":"Glycerophospholipid metabolism",
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"kegg.reaction":"R00842",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00286",
"name":"UDP-glucose:NAD+ 6-oxidoreductase",
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"h_c":3.0,
"nad_c":-2.0,
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"udpglcur_c":1.0
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00005022",
"subsystem":"Pentose and glucuronate interconversions",
"annotation":{
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"kegg.reaction":"R00286",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00287",
"name":"UDP-glucose glucophosphohydrolase",
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"h2o_c":-1.0,
"h_c":2.0,
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"ump_c":1.0
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"lower_bound":-0.0,
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"gene_reaction_rule":"WBGene00007753 or WBGene00007755",
"subsystem":"Pyrimidine metabolism",
"annotation":{
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"kegg.reaction":"R00287",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00289",
"name":"UTP:alpha-D-glucose-1-phosphate uridylyltransferase",
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"h_c":-1.0,
"ppi_c":1.0,
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"utp_c":-1.0
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"subsystem":"Pentose and glucuronate interconversions",
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"kegg.reaction":"R00289",
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}
},
{
"id":"RM07136",
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"h_m":1.0,
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"nadh_m":1.0,
"sl-L_m":-1.0
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"subsystem":"Cysteine and methionine metabolism",
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"kegg.reaction":"R07136",
"sbo":"SBO:0000176"
}
},
{
"id":"RC09394",
"name":"cyclic pyranopterin phosphate synthase",
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"gtp_c":-1.0,
"ppi_c":1.0
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00009885 or WBGene00009908",
"subsystem":"Folate biosynthesis",
"annotation":{
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"kegg.reaction":"R09394",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE0710",
"name":"\"3,4-Dihydroxy-L-phenylalanine\" transport",
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"34dhphe_e":-1.0
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"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
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}
},
{
"id":"RM02530",
"name":"glyoxalase-1",
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"mthgxl_m":-1.0
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"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00006448",
"subsystem":"Pyruvate metabolism",
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}
},
{
"id":"RM03336",
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"gene_reaction_rule":"",
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"kegg.reaction":"R03336",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01001",
"name":"L-cystathionine cysteine-lyase (deaminating, 2-oxobutanoate-forming)",
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"lower_bound":-0.0,
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"gene_reaction_rule":"WBGene00007533 or WBGene00009048 or WBGene00022856",
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"sbo":"SBO:0000176"
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},
{
"id":"RC01000",
"name":"2-Hydroxybutyrate:NAD+ oxidoreductase",
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"h_c":1.0,
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"subsystem":"Propanoate metabolism",
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"kegg.reaction":"R01000",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01005",
"name":"UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase",
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"dolp_c":-1.0,
"udp_c":1.0,
"udpg_c":-1.0
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00019276",
"subsystem":"N-Glycan biosynthesis",
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"kegg.reaction":"R01005",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01009",
"name":"GDPmannose:dolichyl-phosphate O-beta-D-mannosyltransferase",
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"dolp_c":-1.0,
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"gdpmann_c":-1.0
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"lower_bound":-1000.0,
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"gene_reaction_rule":"WBGene00022044 or WBGene00009219",
"subsystem":"N-Glycan biosynthesis",
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"sbo":"SBO:0000176"
}
},
{
"id":"RM01868",
"name":"(S)-dihydroorotate:quinone oxidoreductase",
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"q_m":-1.0,
"qh2_m":1.0
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00020932",
"subsystem":"Pyrimidine metabolism",
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"sbo":"SBO:0000176"
}
},
{
"id":"RC03866",
"name":"leukotriene B4 p450",
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"o2_c":-1.0
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"lower_bound":-0.0,
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"gene_reaction_rule":"WBGene00007140 or WBGene00016147 or WBGene00021167",
"subsystem":"Arachidonic acid metabolism",
"annotation":{
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"kegg.reaction":"R03866",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE5100",
"name":"Ceramide 1-phosphate transport",
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"crmp_ce_e":1.0
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"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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}
},
{
"id":"TCE5102",
"name":"Sphinganine 1-phosphate transport",
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"sph1p_ce_e":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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}
},
{
"id":"RM03758",
"name":"L-2-Amino-3-oxobutanoic acid decarboxylation",
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"co2_m":1.0,
"h_m":-1.0
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Glycine, serine and threonine metabolism",
"annotation":{
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"sbo":"SBO:0000176"
}
},
{
"id":"RC10633",
"name":"NAD-dependent histone deacetylase",
"metabolites":{
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"Nlys_c":1.0,
"ac_adprib_c":1.0,
"h2o_c":-1.0,
"nad_c":-1.0,
"ncam_c":1.0
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"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00004800 or WBGene00004801 or WBGene00004802 or WBGene00004803",
"subsystem":"Nicotinate and nicotinamide metabolism",
"annotation":{
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"kegg.reaction":"R10633",
"sbo":"SBO:0000176"
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},
{
"id":"TCE5109",
"name":"Globoside transport",
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"gbside_ce_e":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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}
},
{
"id":"EX00089",
"name":"Sucrose exchange",
"metabolites":{
"sucr_e":-1.0
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
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}
},
{
"id":"EX00082",
"name":"L-Tyrosine exchange",
"metabolites":{
"tyr-L_e":-1.0
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
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}
},
{
"id":"EX00080",
"name":"H+ exchange",
"metabolites":{
"h_e":-1.0
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"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
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},
{
"id":"EX00081",
"name":"ITP exchange",
"metabolites":{
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
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}
},
{
"id":"RCC0167",
"name":"Lauroyl-CoA oxidase",
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"ddcacoa_c":-1.0,
"h2o2_c":1.0,
"o2_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00008167 or WBGene00008564 or WBGene00008565 or WBGene00008566 or WBGene00008567 or WBGene00019060 or WBGene00010336",
"subsystem":"Peroxisomal fatty acid beta oxidation",
"annotation":{
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"kegg.reaction":"R00388",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01711",
"name":"Pyridoxine:oxygen oxidoreductase (deaminating)",
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"o2_c":-1.0,
"pydx_c":1.0,
"pydxn_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00018996",
"subsystem":"Vitamin B6 metabolism",
"annotation":{
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"kegg.reaction":"R01711",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01710",
"name":"Pyridoxamine:oxygen oxidoreductase (deaminating)",
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"h2o_c":-1.0,
"nh4_c":1.0,
"o2_c":-1.0,
"pydam_c":-1.0,
"pydx_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00018996",
"subsystem":"Vitamin B6 metabolism",
"annotation":{
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"kegg.reaction":"R01710",
"sbo":"SBO:0000176"
}
},
{
"id":"RM00248",
"name":"L-Glutamate:NADP+ oxidoreductase (deaminating)",
"metabolites":{
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"glu-L_m":-1.0,
"h2o_m":-1.0,
"h_m":1.0,
"nadp_m":-1.0,
"nadph_m":1.0,
"nh4_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00014095",
"subsystem":"Alanine, aspartate and glutamate metabolism",
"annotation":{
"ec-code":[
"1.4.1.3",
"1.4.1.13"
],
"kegg.reaction":"R00248",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00669",
"name":"N2-Acetyl-L-ornithine amidohydrolase",
"metabolites":{
"ac_c":1.0,
"acorn_c":-1.0,
"h2o_c":-1.0,
"orn_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00015509 or WBGene00007507 or WBGene00007508 or WBGene00007509) or WBGene00016657",
"subsystem":"Arginine and proline metabolism",
"annotation":{
"ec-code":[
"3.5.1.14",
"3.5.1.16"
],
"kegg.reaction":"R00669",
"sbo":"SBO:0000176"
}
},
{
"id":"EX00366",
"name":"Urate exchange",
"metabolites":{
"urate_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00719",
"name":"Glycine betaine exchange",
"metabolites":{
"glyb_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"DMN0065",
"name":"20-Hydroxyeicosatetraenoic acid demand",
"metabolites":{
"20HETE_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Arachidonic acid metabolism",
"annotation":{
"sbo":"SBO:0000628"
}
},
{
"id":"EX00249",
"name":"Hexadecanoate (n-C16:0) exchange",
"metabolites":{
"hdca_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EXC0053",
"name":"DNA component of bacterial diet exchange",
"metabolites":{
"dna_BAC_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00245",
"name":"Taurine exchange",
"metabolites":{
"taur_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RC00662",
"name":"Uridine triphosphate pyrophosphohydrolase",
"metabolites":{
"h2o_c":-1.0,
"h_c":1.0,
"ppi_c":1.0,
"ump_c":1.0,
"utp_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00001823",
"subsystem":"Pyrimidine metabolism",
"annotation":{
"ec-code":"3.6.1.19",
"kegg.reaction":"R00662",
"sbo":"SBO:0000176"
}
},
{
"id":"RM00243",
"name":"L-glutamate:NAD+ oxidoreductase (deaminating)",
"metabolites":{
"akg_m":1.0,
"glu-L_m":-1.0,
"h2o_m":-1.0,
"h_m":1.0,
"nad_m":-1.0,
"nadh_m":1.0,
"nh4_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00014095",
"subsystem":"Alanine, aspartate and glutamate metabolism",
"annotation":{
"ec-code":"1.4.1.3",
"kegg.reaction":"R00243",
"sbo":"SBO:0000176"
}
},
{
"id":"RM00245",
"name":"L-Glutamate 5-semialdehyde:NAD+ oxidoreductase",
"metabolites":{
"glu-L_m":1.0,
"glu5sa_m":-1.0,
"h2o_m":-1.0,
"h_m":2.0,
"nad_m":-1.0,
"nadh_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000112",
"subsystem":"Arginine and proline metabolism",
"annotation":{
"ec-code":"1.2.1.88",
"kegg.reaction":"R00245",
"sbo":"SBO:0000176"
}
},
{
"id":"EX00242",
"name":"Guanine exchange",
"metabolites":{
"gua_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00243",
"name":"Lactose exchange",
"metabolites":{
"lcts_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RC01393",
"name":"hydroxypyruvate decarboxylase",
"metabolites":{
"co2_c":1.0,
"gcald_c":1.0,
"h_c":-1.0,
"hpyr_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Glyoxylate and dicarboxylate metabolism",
"annotation":{
"ec-code":"4.1.1.40",
"kegg.reaction":"R01393",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01827",
"name":"sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase",
"metabolites":{
"e4p_c":1.0,
"f6p_c":1.0,
"g3p_c":-1.0,
"s7p_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00021286",
"subsystem":"Pentose phosphate pathway",
"annotation":{
"ec-code":"2.2.1.2",
"kegg.reaction":"R01827",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01397",
"name":"carbamoyl-phosphate:L-aspartate carbamoyltransferase",
"metabolites":{
"asp-L_c":-1.0,
"cbasp_c":1.0,
"cbp_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00004259",
"subsystem":"Pyrimidine metabolism",
"annotation":{
"ec-code":"2.1.3.2",
"kegg.reaction":"R01397",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE0346",
"name":"Sodium and Selenate transport",
"metabolites":{
"na1_c":3.0,
"na1_e":-3.0,
"sel_c":1.0,
"sel_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"EXC0056",
"name":"KDO(2)-lipid (A) exchange",
"metabolites":{
"lipa_BAC_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"SNK0056",
"name":"Protein N6,N6-dimethyl-L-lysine sink",
"metabolites":{
"Ndmelys_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Histone modification",
"annotation":{
"sbo":"SBO:0000632"
}
},
{
"id":"EXC0057",
"name":"Outer section of lipopolysaccharide (bacteria) exchange",
"metabolites":{
"outerlps_BAC_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00881",
"name":"Deoxycytidine exchange",
"metabolites":{
"dcyt_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX01530",
"name":"octadecanoate (n-C18:0) exchange",
"metabolites":{
"ocdca_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EXC0055",
"name":"Lipopolysaccharide (bacteria) exchange",
"metabolites":{
"lps_BAC_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RC10928",
"name":"phosphatidylinositol 3,5-bisphosphate 3-phosphatase",
"metabolites":{
"h2o_c":-1.0,
"pail35p_c":-1.0,
"pail5p_c":1.0,
"pi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00003475 or WBGene00003476 or WBGene00003478",
"subsystem":"Inositol phosphate metabolism",
"annotation":{
"ec-code":"3.1.3.95",
"kegg.reaction":"R10928",
"sbo":"SBO:0000176"
}
},
{
"id":"EX05100",
"name":"3-Ureidoisobutyrate exchange",
"metabolites":{
"3uib_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00407",
"name":"L-Isoleucine exchange",
"metabolites":{
"ile-L_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RC00710",
"name":"Acetaldehyde:NAD+ oxidoreductase",
"metabolites":{
"ac_c":1.0,
"acald_c":-1.0,
"h2o_c":-1.0,
"h_c":2.0,
"nad_c":-1.0,
"nadh_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00000108 or WBGene00000110) or (WBGene00000117 or WBGene00000118)",
"subsystem":"Glycolysis / Gluconeogenesis",
"annotation":{
"ec-code":"1.2.1.3",
"kegg.reaction":"R00710",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00711",
"name":"Acetaldehyde:NADP+ oxidoreductase",
"metabolites":{
"ac_c":1.0,
"acald_c":-1.0,
"h2o_c":-1.0,
"h_c":2.0,
"nadp_c":-1.0,
"nadph_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000111",
"subsystem":"Glycolysis / Gluconeogenesis",
"annotation":{
"ec-code":"1.2.1.5",
"kegg.reaction":"R00711",
"sbo":"SBO:0000176"
}
},
{
"id":"RC08707",
"name":"N-linked-glycopeptide-(N-acetyl-beta-D-glucosaminyl)-L-asparagine amidohydrolase",
"metabolites":{
"acBgamam_c":1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pepasp_acgamam_c":-1.0,
"pepasp_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00010160",
"subsystem":"Protein modification by hydroxylation",
"annotation":{
"ec-code":"3.5.1.52",
"kegg.reaction":"R08707",
"sbo":"SBO:0000176"
}
},
{
"id":"EX00086",
"name":"Urea exchange",
"metabolites":{
"urea_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RC00996",
"name":"L-threonine ammonia-lyase (2-oxobutanoate-forming)",
"metabolites":{
"2obut_c":1.0,
"nh4_c":1.0,
"thr-L_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00010456 or WBGene00021787",
"subsystem":"Glycine, serine and threonine metabolism",
"annotation":{
"ec-code":"4.3.1.19",
"kegg.reaction":"R00996",
"sbo":"SBO:0000176"
}
},
{
"id":"EX00084",
"name":"Acetaldehyde exchange",
"metabolites":{
"acald_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RE10092",
"name":"carbonate hydro-lyase (carbon-dioxide-forming)",
"metabolites":{
"co2_e":-1.0,
"h2o_e":-1.0,
"h_e":1.0,
"hco3_e":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000283",
"subsystem":"Nitrogen metabolism",
"annotation":{
"ec-code":"4.2.1.1",
"kegg.reaction":"R10092",
"sbo":"SBO:0000176"
}
},
{
"id":"RC03648",
"name":"L-Asparagine:tRNA(Asn) ligase (AMP-forming)",
"metabolites":{
"amp_c":1.0,
"asn-L_c":-1.0,
"asntrna_c":1.0,
"atp_c":-1.0,
"ppi_c":1.0,
"trnaasn_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00003815",
"subsystem":"Aminoacyl-tRNA biosynthesis",
"annotation":{
"ec-code":"6.1.1.22",
"kegg.reaction":"R03648",
"sbo":"SBO:0000176"
}
},
{
"id":"EX00669",
"name":"gamma-L-Glutamyl-L-cysteine exchange",
"metabolites":{
"glucys_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00064",
"name":"L-Glutamine exchange",
"metabolites":{
"gln-L_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00065",
"name":"L-Serine exchange",
"metabolites":{
"ser-L_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00067",
"name":"Formaldehyde exchange",
"metabolites":{
"fald_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00061",
"name":"FMN exchange",
"metabolites":{
"fmn_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00062",
"name":"L-Arginine exchange",
"metabolites":{
"arg-L_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00068",
"name":"Thiamine diphosphate exchange",
"metabolites":{
"thmpp_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX01595",
"name":"linoleic acid (all cis C18:2) n-6 exchange",
"metabolites":{
"lnlc_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RMC0155",
"name":"electron transfer flavoprotein",
"metabolites":{
"etfox_m":-1.0,
"etfrd_m":1.0,
"fad_m":1.0,
"fadh2_m":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Miscellaneous",
"annotation":{
"sbo":"SBO:0000176"
}
},
{
"id":"RMC0154",
"name":"Propionyl-CoA:carnitine O-propionyltransferase II",
"metabolites":{
"coa_m":-1.0,
"crn_m":1.0,
"pcrn_m":-1.0,
"ppcoa_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00011122",
"subsystem":"Propanoate metabolism",
"annotation":{
"ec-code":"2.3.1.7",
"sbo":"SBO:0000176"
}
},
{
"id":"EX00170",
"name":"5-Methylthioadenosine exchange",
"metabolites":{
"5mta_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"TCE0779",
"name":"Adenosine transport",
"metabolites":{
"adn_c":1.0,
"adn_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RM01301",
"name":"4-Hydroxybenzoyl-CoA hydrolase",
"metabolites":{
"4hbz_m":1.0,
"4hbzcoa_m":-1.0,
"coa_m":1.0,
"h2o_m":-1.0,
"h_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Ubiquinone and other terpenoid-quinone biosynthesis",
"annotation":{
"ec-code":"3.1.2.23",
"kegg.reaction":"R01301",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE0777",
"name":"\"7-alpha,27-Dihydroxycholesterol\" transport",
"metabolites":{
"xoltri27_c":-1.0,
"xoltri27_e":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"EX05635",
"name":"5-Hydroxyindoleacetate exchange",
"metabolites":{
"5hoxindoa_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"TCE1197",
"name":"Ornithine transport",
"metabolites":{
"orn_c":1.0,
"orn_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE1194",
"name":"L-Threonine transport",
"metabolites":{
"thr-L_c":1.0,
"thr-L_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC02383",
"name":"Monophenol,L-dopa:oxygen oxidoreductase",
"metabolites":{
"dopa_c":1.0,
"h2o_c":1.0,
"h_c":-1.0,
"nad_c":1.0,
"nadh_c":-1.0,
"o2_c":-1.0,
"tym_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00015332 or WBGene00010661 or WBGene00009001 or WBGene00016419 or WBGene00021553 or WBGene00022231",
"subsystem":"Isoquinoline alkaloid biosynthesis",
"annotation":{
"ec-code":"1.14.18.1",
"kegg.reaction":"R02383",
"sbo":"SBO:0000176"
}
},
{
"id":"RC02382",
"name":"Tyramine:oxygen oxidoreductase (deaminating) (flavin-containing)",
"metabolites":{
"4hoxpacd_c":1.0,
"h2o2_c":1.0,
"h2o_c":-1.0,
"nh4_c":1.0,
"o2_c":-1.0,
"tym_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000138",
"subsystem":"Tyrosine metabolism",
"annotation":{
"ec-code":"1.4.3.4",
"kegg.reaction":"R02382",
"sbo":"SBO:0000176"
}
},
{
"id":"RC02389",
"name":"UDP-glucuronate-bilirubin glucuronyltransferase",
"metabolites":{
"bildglcur_c":1.0,
"bilirub_c":-1.0,
"udp_c":2.0,
"udpglcur_c":-2.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
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"subsystem":"Porphyrin and chlorophyll metabolism",
"annotation":{
"ec-code":"2.4.1.17",
"kegg.reaction":"R02389",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE0482",
"name":"Deoxycytidine transport",
"metabolites":{
"dcyt_c":1.0,
"dcyt_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE0487",
"name":"Thiocyanate transport",
"metabolites":{
"tcynt_c":-1.0,
"tcynt_e":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE0486",
"name":"Sodium and Sulfate transport",
"metabolites":{
"na1_c":2.0,
"na1_e":-2.0,
"so4_c":1.0,
"so4_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE0484",
"name":"Ammonium transport",
"metabolites":{
"nh4_c":-1.0,
"nh4_e":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC01829",
"name":"Sedoheptulose 1,7-bisphosphate D-glyceraldehyde-3-phosphate-lyase",
"metabolites":{
"dhap_c":1.0,
"e4p_c":1.0,
"s17bp_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00017166 or WBGene00011474",
"subsystem":"Pentose phosphate pathway (indirect)",
"annotation":{
"ec-code":"4.1.2.13",
"kegg.reaction":"R01829",
"sbo":"SBO:0000176"
}
},
{
"id":"RM01278",
"name":"hexadecanoyl-CoA:NADP+ trans-2-oxidoreductase",
"metabolites":{
"h_m":-1.0,
"hdd2coa_m":-1.0,
"nadp_m":1.0,
"nadph_m":-1.0,
"pmtcoa_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00012375 or WBGene00012970",
"subsystem":"Fatty acid elongation",
"annotation":{
"ec-code":"1.3.1.38",
"kegg.reaction":"R01278",
"sbo":"SBO:0000176"
}
},
{
"id":"EX01132",
"name":"N-Acetyl-D-galactosamine exchange",
"metabolites":{
"acgal_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX01137",
"name":"S-Adenosylmethioninamine exchange",
"metabolites":{
"ametam_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX03197",
"name":"(S)-3-Hydroxybutanoate exchange",
"metabolites":{
"S3hb_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RM00908",
"name":"beta-alanine:2-oxoglutarate aminotransferase",
"metabolites":{
"akg_m":-1.0,
"ala-B_m":-1.0,
"glu-L_m":1.0,
"msa_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00001794",
"subsystem":"Propanoate metabolism",
"annotation":{
"ec-code":"2.6.1.19",
"kegg.reaction":"R00908",
"sbo":"SBO:0000176"
}
},
{
"id":"RC03416",
"name":"1-Acyl-sn-glycero-3-phosphoethanolamine aldehydohydrolase",
"metabolites":{
"Rtotal_c":1.0,
"acg3pe_c":-1.0,
"g3pe_c":1.0,
"h2o_c":-1.0,
"h_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00022718 or WBGene00007756 or WBGene00010564",
"subsystem":"Glycerophospholipid metabolism",
"annotation":{
"ec-code":"3.1.1.5",
"kegg.reaction":[
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"R03417"
],
"sbo":"SBO:0000176"
}
},
{
"id":"TCE0399",
"name":"Sodium and Cholate transport",
"metabolites":{
"cholate_c":1.0,
"cholate_e":-1.0,
"na1_c":2.0,
"na1_e":-2.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE0392",
"name":"D-Ribose transport",
"metabolites":{
"rib-D_c":1.0,
"rib-D_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE5071",
"name":"L-allo-threonine transport",
"metabolites":{
"athr-L_c":-1.0,
"athr-L_e":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE5070",
"name":"FMN transport into cytoplasm",
"metabolites":{
"fmn_c":1.0,
"fmn_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE5073",
"name":"1-Acyl-sn-glycero-3-phosphoglycerol transport",
"metabolites":{
"lpglyc_c":1.0,
"lpglyc_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE5072",
"name":"Selenomethionine transport",
"metabolites":{
"selmeth_c":1.0,
"selmeth_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE5075",
"name":"2-Hydroxyphenylacetate transport",
"metabolites":{
"2hyoxplac_c":-1.0,
"2hyoxplac_e":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE5074",
"name":"1-Acyl-sn-glycero-3-phosphoserine transport",
"metabolites":{
"acg3ps_c":1.0,
"acg3ps_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE5077",
"name":"2-Phenylacetamide transport",
"metabolites":{
"pad_c":-1.0,
"pad_e":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE5076",
"name":"Phenethylamine transport",
"metabolites":{
"peamn_c":-1.0,
"peamn_e":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE5079",
"name":"Bacterial ubiquinone uptake",
"metabolites":{
"q8_c":-1.0,
"q8_e":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE5078",
"name":"2-Hydroxy-3-phenylpropenoate transport",
"metabolites":{
"enphpyr_c":-1.0,
"enphpyr_e":1.0
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC07396",
"name":"2-keto-4-methylthiobutyrate transamination",
"metabolites":{
"2kmb_c":-1.0,
"akg_c":1.0,
"glu-L_c":-1.0,
"met-L_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00009628",
"subsystem":"Cysteine and methionine metabolism",
"annotation":{
"ec-code":"2.6.1.5",
"kegg.reaction":"R07396",
"sbo":"SBO:0000176"
}
},
{
"id":"RC07392",
"name":"S-Methyl-5-thio-D-ribulose-1-phosphate hydro-lyase",
"metabolites":{
"5mdru1p_c":-1.0,
"dkmpp_c":1.0,
"h2o_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00013870",
"subsystem":"Cysteine and methionine metabolism",
"annotation":{
"ec-code":"4.2.1.109",
"kegg.reaction":"R07392",
"sbo":"SBO:0000176"
}
},
{
"id":"RC08383",
"name":"retinol dehydrogenase (9-cis,NADH)",
"metabolites":{
"h_c":1.0,
"nadp_c":-1.0,
"nadph_c":1.0,
"retinal-cis-9_c":1.0,
"retinol-9-cis_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00010063 or WBGene00000976) or WBGene00007780",
"subsystem":"Retinol metabolism",
"annotation":{
"ec-code":"1.1.-.-",
"kegg.reaction":"R08383",
"sbo":"SBO:0000176"
}
},
{
"id":"RC08381",
"name":"Palmitoyl-CoA:retinol O-acyltransferase (cis)",
"metabolites":{
"coa_c":1.0,
"pmtcoa_c":-1.0,
"retinol-cis-11_c":-1.0,
"retpalm-cis-11_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00010408",
"subsystem":"Retinol metabolism",
"annotation":{
"ec-code":"2.3.1.76",
"kegg.reaction":"R08381",
"sbo":"SBO:0000176"
}
},
{
"id":"RC08388",
"name":"all-trans-retinyl ester acylhydrolase, 11-cis-retinol forming",
"metabolites":{
"h2o_c":-1.0,
"h_c":1.0,
"hdca_c":1.0,
"retinol-cis-11_c":1.0,
"retpalm_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00018755",
"subsystem":"Retinol metabolism",
"annotation":{
"ec-code":"3.1.1.64",
"kegg.reaction":"R08388",
"sbo":"SBO:0000176"
}
},
{
"id":"RC07377",
"name":"phosphatidylserine synthase 1",
"metabolites":{
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"pchol_c":-1.0,
"ps_c":1.0,
"ser-L_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00013920",
"subsystem":"Glycerophospholipid metabolism",
"annotation":{
"ec-code":"2.7.8.-",
"kegg.reaction":"R07377",
"sbo":"SBO:0000176"
}
},
{
"id":"RC07372",
"name":"oxysterol 7alpha-hydroxylase (acting on 27-hydroxycholesterol)",
"metabolites":{
"h2o_c":1.0,
"h_c":-1.0,
"nadp_c":1.0,
"nadph_c":-1.0,
"o2_c":-1.0,
"xol27oh_c":-1.0,
"xoltri27_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Primary bile acid biosynthesis",
"annotation":{
"ec-code":[
"1.14.13.100",
"1.14.13.17"
],
"kegg.reaction":"R07372",
"sbo":"SBO:0000176"
}
},
{
"id":"RM01214",
"name":"L-Valine:2-oxoglutarate aminotransferase",
"metabolites":{
"3mob_m":1.0,
"akg_m":-1.0,
"glu-L_m":1.0,
"val-L_m":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00001149 or WBGene00012855",
"subsystem":"Valine, leucine and isoleucine degradation",
"annotation":{
"ec-code":"2.6.1.42",
"kegg.reaction":"R01214",
"sbo":"SBO:0000176"
}
},
{
"id":"RC04176",
"name":"NAD+:poly(adenosine diphosphate D-ribose)ADP-D-ribosyltransferase (PARP)",
"metabolites":{
"h_c":1.0,
"nad_c":-1.0,
"ncam_c":1.0,
"polyadprib_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00004049 or WBGene00004050 or WBGene00004053",
"subsystem":"Nicotinate and nicotinamide metabolism",
"annotation":{
"ec-code":"2.4.2.30",
"kegg.reaction":"R04176",
"sbo":"SBO:0000176"
}
},
{
"id":"RC04171",
"name":"3-Hydroxy-L-kynurenine:2-oxoglutarate aminotransferase",
"metabolites":{
"42A3HP24DB_c":1.0,
"akg_c":-1.0,
"glu-L_c":1.0,
"hLkynr_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00009232",
"subsystem":"Tryptophan metabolism",
"annotation":{
"ec-code":"2.6.1.7",
"kegg.reaction":"R04171",
"sbo":"SBO:0000176"
}
},
{
"id":"RC07379",
"name":"Plasmenylethanolamine 2-acylhydrolase",
"metabolites":{
"Rtotal6_c":1.0,
"alken2gpe_c":1.0,
"alkenac2gpe_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00019747 or WBGene00009801 or WBGene00012319 or WBGene00017026 or WBGene00019229 or WBGene00022233 or WBGene00011423 or WBGene00007419 or WBGene00044468",
"subsystem":"Ether lipid metabolism",
"annotation":{
"ec-code":"3.1.1.4",
"kegg.reaction":"R07379",
"sbo":"SBO:0000176"
}
},
{
"id":"RC04173",
"name":"3-Phosphoserine:2-oxoglutarate aminotransferase",
"metabolites":{
"3php_c":-1.0,
"akg_c":1.0,
"glu-L_c":-1.0,
"pser-L_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00009177",
"subsystem":"Glycine, serine and threonine metabolism",
"annotation":{
"ec-code":"2.6.1.52",
"kegg.reaction":"R04173",
"sbo":"SBO:0000176"
}
},
{
"id":"RC02541",
"name":"Sphingomyelin cholinephosphohydrolase",
"metabolites":{
"cholp_c":1.0,
"crm_ce_c":1.0,
"h2o_c":-1.0,
"h_c":1.0,
"sphmyln_ce_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00000211 or WBGene00000212 or WBGene00000213) or WBGene00012105 or WBGene00011037",
"subsystem":"Sphingolipid metabolism",
"annotation":{
"ec-code":"3.1.4.12",
"kegg.reaction":"R02541",
"sbo":"SBO:0000176"
}
},
{
"id":"RM02433",
"name":"L-cysteate:2-oxoglutarate aminotransferase",
"metabolites":{
"3spyr_m":1.0,
"Lcyst_m":-1.0,
"akg_m":-1.0,
"glu-L_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00016652 or WBGene00015778",
"subsystem":"Cysteine and methionine metabolism",
"annotation":{
"ec-code":"2.6.1.1",
"kegg.reaction":"R02433",
"sbo":"SBO:0000176"
}
},
{
"id":"RC04571",
"name":"alkyl acyl glycerophosphoethanolamine desaturase",
"metabolites":{
"akac2gpe_c":-1.0,
"alkenac2gpe_c":1.0,
"h2o_c":2.0,
"h_c":-1.0,
"nadp_c":1.0,
"nadph_c":-1.0,
"o2_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Ether lipid metabolism",
"annotation":{
"ec-code":"1.14.99.19",
"kegg.reaction":"R04571",
"sbo":"SBO:0000176"
}
},
{
"id":"EX03758",
"name":"Dopamine exchange",
"metabolites":{
"dopa_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RC00875",
"name":"D-sorbitol dehydrogenase",
"metabolites":{
"fru_c":1.0,
"h_c":1.0,
"nad_c":-1.0,
"nadh_c":1.0,
"sbt-D_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00011003 or WBGene00011004",
"subsystem":"Fructose and mannose metabolism",
"annotation":{
"ec-code":"1.1.1.14",
"kegg.reaction":"R00875",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01547",
"name":"ATP:dAMP phosphotransferase",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"dadp_c":1.0,
"damp_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00008458 or (WBGene00009531 or WBGene00014058 or WBGene00002879)",
"subsystem":"Purine metabolism",
"annotation":{
"ec-code":"2.7.4.3",
"kegg.reaction":"R01547",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00475",
"name":"Glycolate:oxygen 2-oxidoreductase",
"metabolites":{
"glx_c":1.0,
"glyclt_c":-1.0,
"h2o2_c":1.0,
"o2_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00018286",
"subsystem":"Glyoxylate and dicarboxylate metabolism",
"annotation":{
"ec-code":"1.1.3.15",
"kegg.reaction":"R00475",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00471",
"name":"D-4-Hydroxy-2-oxoglutarate glyoxylate-lyase",
"metabolites":{
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"glx_c":1.0,
"pyr_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Arginine and Proline metabolism",
"annotation":{
"ec-code":"4.1.3.16",
"kegg.reaction":"R00471",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE0622",
"name":"Sodium and Sulfate transport",
"metabolites":{
"na1_c":3.0,
"na1_e":-3.0,
"so4_c":1.0,
"so4_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE0825",
"name":"Peptidyl-L-lysine transport",
"metabolites":{
"peplys_c":1.0,
"peplys_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE0621",
"name":"\"5,6,7,8-Tetrahydrofolate\" and hydroxide ion transport",
"metabolites":{
"oh1_c":-1.0,
"oh1_e":1.0,
"thf_c":1.0,
"thf_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC00278",
"name":"Pyridoxine 5-phosphate:oxygen oxidoreductase",
"metabolites":{
"h2o2_c":1.0,
"o2_c":-1.0,
"pdx5p_c":-1.0,
"pydx5p_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00018996",
"subsystem":"Vitamin B6 metabolism",
"annotation":{
"ec-code":"1.4.3.5",
"kegg.reaction":"R00278",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00277",
"name":"Pyridoxamine-5-phosphate:oxygen oxidoreductase (deaminating)",
"metabolites":{
"h2o2_c":1.0,
"h2o_c":-1.0,
"nh4_c":1.0,
"o2_c":-1.0,
"pyam5p_c":-1.0,
"pydx5p_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00018996",
"subsystem":"Vitamin B6 metabolism",
"annotation":{
"ec-code":"1.4.3.5",
"kegg.reaction":"R00277",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00275",
"name":"superoxide:superoxide oxidoreductase",
"metabolites":{
"h2o2_c":1.0,
"h_c":-2.0,
"o2_c":1.0,
"o2s_c":-2.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00004930 or WBGene00004933 or WBGene00007036",
"subsystem":"Reactive oxygen species degradation",
"annotation":{
"ec-code":"1.15.1.1",
"kegg.reaction":"R00275",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00274",
"name":"glutathione:hydrogen-peroxide oxidoreductase",
"metabolites":{
"gthox_c":1.0,
"gthrd_c":-2.0,
"h2o2_c":-1.0,
"h2o_c":2.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00009165 or WBGene00011045 or WBGene00007517 or WBGene00022377 or WBGene00007516 or WBGene00019846 or WBGene00018850",
"subsystem":"Glutathione metabolism",
"annotation":{
"ec-code":"1.11.1.9",
"kegg.reaction":"R00274",
"sbo":"SBO:0000176"
}
},
{
"id":"RE00548",
"name":"riboflavin-5-phosphate phosphohydrolase (acid optimum)",
"metabolites":{
"fmn_e":-1.0,
"h2o_e":-1.0,
"pi_e":1.0,
"ribflv_e":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00022770",
"subsystem":"Riboflavin metabolism",
"annotation":{
"ec-code":"3.1.3.2",
"kegg.reaction":"R00548",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00585",
"name":"L-Serine:pyruvate aminotransferase",
"metabolites":{
"ala-L_c":1.0,
"hpyr_c":1.0,
"pyr_c":-1.0,
"ser-L_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00011767",
"subsystem":"Glycine, serine and threonine metabolism",
"annotation":{
"ec-code":"2.6.1.51",
"kegg.reaction":"R00585",
"sbo":"SBO:0000176"
}
},
{
"id":"RM00197",
"name":"(R)-Lactate:ferricytochrome-c 2-oxidoreductase",
"metabolites":{
"ficytC_m":-2.0,
"focytC_m":2.0,
"h_m":2.0,
"lac-D_m":-1.0,
"pyr_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00009334 and (WBGene00017121 or WBGene00013854)",
"subsystem":"Pyruvate metabolism",
"annotation":{
"ec-code":"1.1.2.4",
"kegg.reaction":"R00197",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01010",
"name":"Glycerone phosphate phosphohydrolase",
"metabolites":{
"dha_c":1.0,
"dhap_c":-1.0,
"h2o_c":-1.0,
"pi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00013646 or ((WBGene00009146 or WBGene00014076 or WBGene00007328 or WBGene00007331) or (WBGene00020471 or WBGene00015161 or WBGene00011262) or WBGene00022379 or WBGene00008531) or (WBGene00206373 or WBGene00008802 or WBGene00008801 or WBGene00022246 or WBGene00004020 or WBGene00016152 or WBGene00004023 or WBGene00018696 or WBGene00011879 or WBGene00022181)",
"subsystem":"Glycerolipid metabolism (indirect)",
"annotation":{
"ec-code":[
"3.1.3.1",
"3.1.3.2"
],
"kegg.reaction":"R01010",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01011",
"name":"ATP:glycerone phosphotransferase",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"dha_c":-1.0,
"dhap_c":1.0,
"h_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00020962",
"subsystem":"Glycerolipid metabolism",
"annotation":{
"ec-code":"2.7.1.29",
"kegg.reaction":"R01011",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01013",
"name":"Acyl-CoA:glycerone-phosphate O-acyltransferase",
"metabolites":{
"Rtotalcoa_c":-1.0,
"adhap_c":1.0,
"coa_c":1.0,
"dhap_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00012911",
"subsystem":"Glycerophospholipid metabolism",
"annotation":{
"ec-code":"2.3.1.42",
"kegg.reaction":"R01013",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01015",
"name":"D-glyceraldehyde-3-phosphate aldose-ketose-isomerase",
"metabolites":{
"dhap_c":1.0,
"g3p_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00006601",
"subsystem":"Glycolysis / Gluconeogenesis",
"annotation":{
"ec-code":"5.3.1.1",
"kegg.reaction":"R01015",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01016",
"name":"methylglyoxal synthase",
"metabolites":{
"dhap_c":-1.0,
"mthgxl_c":1.0,
"pi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Pyruvate metabolism",
"annotation":{
"ec-code":"4.2.3.3",
"kegg.reaction":"R01016",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01018",
"name":"Dolichol kinase",
"metabolites":{
"cdp_c":1.0,
"ctp_c":-1.0,
"dolichol_c":-1.0,
"dolp_c":1.0,
"h_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00044233",
"subsystem":"N-Glycan biosynthesis",
"annotation":{
"ec-code":"2.7.1.108",
"kegg.reaction":"R01018",
"sbo":"SBO:0000176"
}
},
{
"id":"RM03102",
"name":"L-2-Aminoadipate-6-semialdehyde:NAD+ 6-oxidoreductase",
"metabolites":{
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"L2aadp_m":1.0,
"h2o_m":-1.0,
"h_m":2.0,
"nad_m":-1.0,
"nadh_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000115",
"subsystem":"Lysine degradation",
"annotation":{
"ec-code":"1.2.1.31",
"kegg.reaction":"R03102",
"sbo":"SBO:0000176"
}
},
{
"id":"RM03103",
"name":"L-2-Aminoadipate-6-semialdehyde:NADP+ 6-oxidoreductase",
"metabolites":{
"L2aadp6sa_m":-1.0,
"L2aadp_m":1.0,
"h2o_m":-1.0,
"h_m":2.0,
"nadp_m":-1.0,
"nadph_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000115",
"subsystem":"Lysine degradation",
"annotation":{
"ec-code":"1.2.1.31",
"kegg.reaction":"R03103",
"sbo":"SBO:0000176"
}
},
{
"id":"RC09036",
"name":"K13510   lysophosphatidylcholine acyltransferase / lyso-PAF acetyltransferase [EC:2.3.1.23 2.3.1.67]; K13512   lysophospholipid acyltransferase [EC:2.3.1.23 2.3.1.-]; K13513   lysocardiolipin and lysophospholipid acyltransferase [EC:2.3.1.- 2.3.1.51]; K13514   lysophosphatidylglycerol acyltransferase 1 [EC:2.3.1.-]; K13519   lysophospholipid acyltransferase [EC:2.3.1.51 2.3.1.23 2.3.1.-]",
"metabolites":{
"Rtotal2coa_c":-1.0,
"coa_c":1.0,
"lpglyc_c":-1.0,
"pglyc_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00020264 or WBGene00022646 or WBGene00044631 or WBGene00019465 or WBGene00008581",
"subsystem":"Glycerophospholipid metabolism",
"annotation":{
"ec-code":"2.3.1.-",
"kegg.reaction":"R09036",
"sbo":"SBO:0000176"
}
},
{
"id":"RC09035",
"name":"acyl-CoA:1-acyl-sn-glycero-3-phosphoserine O-acyltransferase",
"metabolites":{
"Rtotal2coa_c":-1.0,
"acg3ps_c":-1.0,
"coa_c":1.0,
"ps_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00020115 or WBGene00016934 or WBGene00007446",
"subsystem":"Glycerophospholipid metabolism",
"annotation":{
"ec-code":"2.3.1.-",
"kegg.reaction":"R09035",
"sbo":"SBO:0000176"
}
},
{
"id":"EX00402",
"name":"D-Aspartate exchange",
"metabolites":{
"asp-D_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RC00010",
"name":"alpha,alpha-trehalose glucohydrolase",
"metabolites":{
"glc-D_c":2.0,
"h2o_c":-1.0,
"tre_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00006607 or WBGene00006608 or WBGene00006609 or WBGene00006610 or WBGene00006611",
"subsystem":"Starch and sucrose metabolism",
"annotation":{
"ec-code":"3.2.1.28",
"kegg.reaction":"R00010",
"sbo":"SBO:0000176"
}
},
{
"id":"RC03875",
"name":"S-adenosyl-L-methionine:histone-L-lysine N6-methyltransferase",
"metabolites":{
"Nlys_c":-1.0,
"Nmelys_c":1.0,
"ahcys_c":1.0,
"amet_c":-1.0,
"h_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00011729 or WBGene00003040 or (WBGene00016603 or WBGene00019584) or WBGene00004782 or WBGene00019883 or WBGene00018023 or WBGene00003220 or WBGene00021515 or (WBGene00021474 or WBGene00010067 or WBGene00012302 or WBGene00010120 or WBGene00022512) or WBGene00016313 or WBGene00004781) or (WBGene00019690 or WBGene00020006 or WBGene00021282 or WBGene00008062 or WBGene00022431 or WBGene00008206)",
"subsystem":"Histone modification",
"annotation":{
"ec-code":"2.1.1.43",
"kegg.reaction":"R03875",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00383",
"name":"Acyl-CoA hydrolase",
"metabolites":{
"coa_c":1.0,
"h2o_c":-1.0,
"h_c":1.0,
"ppa_c":1.0,
"ppcoa_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Propanoate metabolism",
"annotation":{
"ec-code":"3.1.2.18",
"kegg.reaction":"R00383",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE0784",
"name":"Cytidine transport",
"metabolites":{
"cytd_c":1.0,
"cytd_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE1302",
"name":"Acetaldehyde transport",
"metabolites":{
"acald_c":1.0,
"acald_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"EX15610",
"name":"27-Hydroxycholesterol exchange",
"metabolites":{
"xol27oh_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RM00275",
"name":"superoxide:superoxide oxidoreductase",
"metabolites":{
"h2o2_m":1.0,
"h_m":-2.0,
"o2_m":1.0,
"o2s_m":-2.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00004930 or WBGene00004931 or WBGene00004932",
"subsystem":"Reactive oxygen species degradation",
"annotation":{
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"kegg.reaction":"R00275",
"sbo":"SBO:0000176"
}
},
{
"id":"EX00315",
"name":"Spermidine exchange",
"metabolites":{
"spmd_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RC00650",
"name":"S-Adenosyl-L-methionine:L-homocysteine S-methyltransferase",
"metabolites":{
"ahcys_c":1.0,
"amet_c":-1.0,
"h_c":1.0,
"hcys-L_c":-1.0,
"met-L_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00020491",
"subsystem":"Cysteine and methionine metabolism",
"annotation":{
"ec-code":"2.1.1.10",
"kegg.reaction":"R00650",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01704",
"name":"long-chain-aldehyde dehydrogenase",
"metabolites":{
"fa17p0iso_c":1.0,
"h2o_c":-1.0,
"h_c":2.0,
"m15hxdcal_c":-1.0,
"nad_c":-1.0,
"nadh_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000110",
"subsystem":"Fatty acid metabolism",
"annotation":{
"ec-code":"1.2.1.48",
"kegg.reaction":"R01704",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00658",
"name":"2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)",
"metabolites":{
"2pg_c":-1.0,
"h2o_c":1.0,
"pep_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00011884",
"subsystem":"Glycolysis / Gluconeogenesis",
"annotation":{
"ec-code":"4.2.1.11",
"kegg.reaction":"R00658",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00497",
"name":"gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"glucys_c":-1.0,
"gly_c":-1.0,
"gthrd_c":1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00010941",
"subsystem":"Glutathione metabolism",
"annotation":{
"ec-code":"6.3.2.3",
"kegg.reaction":"R00497",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00494",
"name":"glutathione gamma-glutamylaminopeptidase",
"metabolites":{
"cgly_c":1.0,
"glu-L_c":1.0,
"gthrd_c":-1.0,
"h2o_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00016906 or WBGene00019204 or WBGene00011393 or WBGene00020590 or WBGene00012416 or WBGene00022397",
"subsystem":"Glutathione metabolism",
"annotation":{
"ec-code":"3.4.19.13",
"kegg.reaction":"R00494",
"sbo":"SBO:0000176"
}
},
{
"id":"RE00160",
"name":"FAD diphosphatase",
"metabolites":{
"amp_e":1.0,
"fad_e":-1.0,
"fmn_e":1.0,
"h2o_e":-1.0,
"h_e":2.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00007753 or WBGene00007755",
"subsystem":"Riboflavin metabolism",
"annotation":{
"ec-code":"3.6.1.9",
"kegg.reaction":"R00160",
"sbo":"SBO:0000176"
}
},
{
"id":"RM00471",
"name":"D-4-Hydroxy-2-oxoglutarate glyoxylate-lyase",
"metabolites":{
"4h2oglt_m":-1.0,
"glx_m":1.0,
"pyr_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Arginine and Proline metabolism",
"annotation":{
"ec-code":"4.1.3.16",
"kegg.reaction":"R00471",
"sbo":"SBO:0000176"
}
},
{
"id":"EX00272",
"name":"Tetrahydrobiopterin exchange",
"metabolites":{
"thbpt_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RM00479",
"name":"isocitrate lyase",
"metabolites":{
"glx_m":1.0,
"icit_m":-1.0,
"succ_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00001564",
"subsystem":"Glyoxylate and dicarboxylate metabolism",
"annotation":{
"ec-code":"4.1.3.1",
"kegg.reaction":"R00479",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01830",
"name":"beta-D-Fructose 6-phosphate:D-glyceraldehyde-3-phosphate glycolaldehyde transferase",
"metabolites":{
"e4p_c":1.0,
"f6p_c":-1.0,
"g3p_c":-1.0,
"xu5p-D_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00008506",
"subsystem":"Pentose phosphate pathway",
"annotation":{
"ec-code":"2.2.1.1",
"kegg.reaction":"R01830",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01384",
"name":"UDP-D-glucuronate carboxy-lyase (UDP-D-xylose-forming)",
"metabolites":{
"co2_c":1.0,
"h_c":-1.0,
"udpglcur_c":-1.0,
"udpxyl_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00005019",
"subsystem":"Starch and sucrose metabolism",
"annotation":{
"ec-code":"4.1.1.35",
"kegg.reaction":"R01384",
"sbo":"SBO:0000176"
}
},
{
"id":"EX00183",
"name":"L-Valine exchange",
"metabolites":{
"val-L_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00181",
"name":"D-Xylose exchange",
"metabolites":{
"xyl-D_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00187",
"name":"Cholesterol exchange",
"metabolites":{
"chsterol_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00186",
"name":"L-Lactate exchange",
"metabolites":{
"lac-L_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00185",
"name":"Cellobiose exchange",
"metabolites":{
"clb_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00189",
"name":"Ethanolamine exchange",
"metabolites":{
"etha_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00188",
"name":"L-Threonine exchange",
"metabolites":{
"thr-L_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00473",
"name":"Retinol exchange",
"metabolites":{
"retinol_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RC00720",
"name":"Inosine 5-triphosphate pyrophosphohydrolase",
"metabolites":{
"h2o_c":-1.0,
"h_c":1.0,
"imp_c":1.0,
"itp_c":-1.0,
"ppi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00001823",
"subsystem":"Purine metabolism",
"annotation":{
"ec-code":"3.6.1.19",
"kegg.reaction":"R00720",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00722",
"name":"ATP:IDP phosphotransferase",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"idp_c":-1.0,
"itp_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00019899 or WBGene00021692 or WBGene00009119",
"subsystem":"Purine metabolism",
"annotation":{
"ec-code":"2.7.4.6",
"kegg.reaction":"R00722",
"sbo":"SBO:0000176"
}
},
{
"id":"EX00475",
"name":"Cytidine exchange",
"metabolites":{
"cytd_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RCC0172",
"name":"Procollagen registration",
"metabolites":{
"pcollg_diS_c":1.0,
"pcollg_mod_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00003962 or WBGene00003963 or WBGene00003964 or WBGene00015168 or WBGene00015752 or WBGene00014807 or WBGene00013030 or WBGene00022836",
"subsystem":"Collagen biosynthesis",
"annotation":{
"ec-code":"5.3.4.1",
"sbo":"SBO:0000176"
}
},
{
"id":"RC06099",
"name":"beta-D-Galactosyl-1,4-beta-D-glucosylceramide galactohydrolase",
"metabolites":{
"gal_c":1.0,
"galgluside_ce_c":-1.0,
"gluside_ce_c":1.0,
"h2o_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00011832 or WBGene00019225",
"subsystem":"Sphingolipid metabolism",
"annotation":{
"ec-code":"3.2.1.23",
"kegg.reaction":"R06099",
"sbo":"SBO:0000176"
}
},
{
"id":"RM00004",
"name":"diphosphate phosphohydrolase",
"metabolites":{
"h2o_m":-1.0,
"h_m":1.0,
"pi_m":2.0,
"ppi_m":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00008149",
"subsystem":"Miscellaneous",
"annotation":{
"ec-code":"3.6.1.1",
"kegg.reaction":"R00004",
"sbo":"SBO:0000176"
}
},
{
"id":"RC02957",
"name":"D-Glucuronolactone:NAD+ oxidoreductase",
"metabolites":{
"glac_c":-1.0,
"glcr_c":1.0,
"h2o_c":-2.0,
"h_c":3.0,
"nad_c":-1.0,
"nadh_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00000108 or WBGene00000110) or (WBGene00000117 or WBGene00000118)",
"subsystem":"Ascorbate and aldarate metabolism",
"annotation":{
"ec-code":"1.2.1.3",
"kegg.reaction":"R02957",
"sbo":"SBO:0000176"
}
},
{
"id":"EX00698",
"name":"Chloride exchange",
"metabolites":{
"cl_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00696",
"name":"Prostaglandin D2 exchange",
"metabolites":{
"prostgd2_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00695",
"name":"Cholate exchange",
"metabolites":{
"cholate_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RC01528",
"name":"6-phospho-D-gluconate:NADP+ 2-oxidoreductase (decarboxylating)",
"metabolites":{
"6pgc_c":-1.0,
"co2_c":1.0,
"nadp_c":-1.0,
"nadph_c":1.0,
"ru5p-D_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00012015",
"subsystem":"Pentose phosphate pathway",
"annotation":{
"ec-code":"1.1.1.44",
"kegg.reaction":"R01528",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01529",
"name":"D-Ribulose-5-phosphate 3-epimerase",
"metabolites":{
"ru5p-D_c":-1.0,
"xu5p-D_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00017272",
"subsystem":"Pentose phosphate pathway",
"annotation":{
"ec-code":"5.1.3.1",
"kegg.reaction":"R01529",
"sbo":"SBO:0000176"
}
},
{
"id":"EX00051",
"name":"Reduced glutathione exchange",
"metabolites":{
"gthrd_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"TCM0059",
"name":"Hydrogen cyanide transport",
"metabolites":{
"cyan_c":-1.0,
"cyan_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"DMN0009",
"name":"gamma-glutamyl-beta-cyanoalanine demand",
"metabolites":{
"gcynala_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Cyanoamino acid metabolism",
"annotation":{
"sbo":"SBO:0000628"
}
},
{
"id":"EX00054",
"name":"\"Adenosine 3',5'-bisphosphate\" exchange",
"metabolites":{
"pap_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00059",
"name":"Sulfate exchange",
"metabolites":{
"so4_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00058",
"name":"Formate exchange",
"metabolites":{
"for_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RC08725",
"name":"7alpha,26-dihydroxy-4-cholesten-3-one,NADPH:oxygen oxidoreductase (26-hydroxylating)",
"metabolites":{
"7a3o4chlstnt_c":1.0,
"h2o_c":3.0,
"h_c":-1.0,
"nadp_c":2.0,
"nadph_c":-2.0,
"o2_c":-2.0,
"xol27one_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000905",
"subsystem":"Primary bile acid biosynthesis",
"annotation":{
"ec-code":"1.14.13.15",
"kegg.reaction":"R08725",
"sbo":"SBO:0000176"
}
},
{
"id":"TCM0208",
"name":"dTDP and dUDP transport",
"metabolites":{
"dtdp_c":-1.0,
"dtdp_m":1.0,
"dudp_c":1.0,
"dudp_m":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE0766",
"name":"Nicotinamide transport",
"metabolites":{
"ncam_c":1.0,
"ncam_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE0437",
"name":"retinoyl glucuronide transport",
"metabolites":{
"retnglc_c":-1.0,
"retnglc_e":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC06364",
"name":"CDPethanolamine:1-alkyl-2-acylglycerol ethanolaminephosphotransferase",
"metabolites":{
"akac2g_c":-1.0,
"akac2gpe_c":1.0,
"cdpea_c":-1.0,
"cmp_c":1.0,
"h_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00009057",
"subsystem":"Ether lipid metabolism",
"annotation":{
"ec-code":"2.7.8.1",
"kegg.reaction":"R06364",
"sbo":"SBO:0000176"
}
},
{
"id":"RM03313",
"name":"L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating)",
"metabolites":{
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"glu5sa_m":1.0,
"h_m":-1.0,
"nadp_m":1.0,
"nadph_m":-1.0,
"pi_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00011938",
"subsystem":"Arginine and proline metabolism",
"annotation":{
"ec-code":"1.2.1.41",
"kegg.reaction":"R03313",
"sbo":"SBO:0000176"
}
},
{
"id":"EX14818",
"name":"Fe2+ exchange",
"metabolites":{
"fe2_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX14819",
"name":"Fe3+ exchange",
"metabolites":{
"fe3_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RC04929",
"name":"ATP:selenate adenylyltransferase",
"metabolites":{
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"atp_c":-1.0,
"h_c":-1.0,
"ppi_c":1.0,
"sel_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00004091",
"subsystem":"Selenocompound metabolism",
"annotation":{
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"kegg.reaction":"R04929",
"sbo":"SBO:0000176"
}
},
{
"id":"RC04928",
"name":"ATP:adenylylsulfate 3'-phosphotransferase",
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"adp_c":1.0,
"adsel_c":-1.0,
"atp_c":-1.0,
"h_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00004091",
"subsystem":"Selenocompound metabolism (indirect)",
"annotation":{
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"kegg.reaction":"R04928",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE1169",
"name":"(R)-Pantothenate transport",
"metabolites":{
"pnto-R_c":1.0,
"pnto-R_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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}
},
{
"id":"TCE1164",
"name":"L-Glutamate transport",
"metabolites":{
"glu-L_c":1.0,
"glu-L_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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}
},
{
"id":"TCE1161",
"name":"L-Malate transport",
"metabolites":{
"mal-L_c":1.0,
"mal-L_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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}
},
{
"id":"RC02396",
"name":"Acetyl-CoA:carnitine O-acetyltransferase I",
"metabolites":{
"accoa_c":-1.0,
"acrn_c":1.0,
"coa_c":1.0,
"crn_c":-1.0
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00007175",
"subsystem":"Carnitine shuttle",
"annotation":{
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"kegg.reaction":"R02396",
"sbo":"SBO:0000176"
}
},
{
"id":"RC02397",
"name":"4-Trimethylammoniobutanoate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)",
"metabolites":{
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"akg_c":-1.0,
"co2_c":1.0,
"crn_c":1.0,
"o2_c":-1.0,
"succ_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00001522",
"subsystem":"Carnitine biosynthesis",
"annotation":{
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"kegg.reaction":"R02397",
"sbo":"SBO:0000176"
}
},
{
"id":"RC07140",
"name":"S-(hydroxymethyl)glutathione:NADP+ oxidoreductase",
"metabolites":{
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"h_c":1.0,
"hmgth_c":-1.0,
"nadp_c":-1.0,
"nadph_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00019240",
"subsystem":"Methane metabolism",
"annotation":{
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"kegg.reaction":"R07140",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE5401",
"name":"Sphingomyelin uptake",
"metabolites":{
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"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0,
"sphmyln_ce_c":1.0,
"sphmyln_ce_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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}
},
{
"id":"RC02731",
"name":"D-Fructose-2,6-bisphosphate 2-phosphohydrolase",
"metabolites":{
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"f6p_c":1.0,
"h2o_c":-1.0,
"pi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00022456 or WBGene00019295",
"subsystem":"Fructose and mannose metabolism",
"annotation":{
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"kegg.reaction":"R02731",
"sbo":"SBO:0000176"
}
},
{
"id":"RC02732",
"name":"ATP:D-fructose-6-phosphate 2-phosphotransferase",
"metabolites":{
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"atp_c":-1.0,
"f26bp_c":1.0,
"f6p_c":-1.0,
"h_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00019295 or WBGene00022456",
"subsystem":"Fructose and mannose metabolism",
"annotation":{
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"kegg.reaction":"R02732",
"sbo":"SBO:0000176"
}
},
{
"id":"RC02736",
"name":"beta-D-Glucose-6-phosphate:NADP+ 1-oxoreductase",
"metabolites":{
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"g6p-B_c":-1.0,
"h_c":1.0,
"nadp_c":-1.0,
"nadph_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00007108",
"subsystem":"Pentose phosphate pathway",
"annotation":{
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"kegg.reaction":"R02736",
"sbo":"SBO:0000176"
}
},
{
"id":"RC02737",
"name":"trehalose 6-phosphate synthase",
"metabolites":{
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"h_c":1.0,
"tre6p_c":1.0,
"udp_c":1.0,
"udpg_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00006602 or WBGene00006603",
"subsystem":"Starch and sucrose metabolism",
"annotation":{
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"kegg.reaction":"R02737",
"sbo":"SBO:0000176"
}
},
{
"id":"RC02739",
"name":"alpha-D-Glucose 6-phosphate ketol-isomerase (producing beta-D-Glucose 6-phosphate)",
"metabolites":{
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"g6p-B_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00013597",
"subsystem":"Glycolysis / Gluconeogenesis",
"annotation":{
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"kegg.reaction":"R02739",
"sbo":"SBO:0000176"
}
},
{
"id":"RC02640",
"name":"L-Gulonate:NAD+ 3-oxidoreductase",
"metabolites":{
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"guln_c":-1.0,
"h_c":1.0,
"nad_c":-1.0,
"nadh_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"((WBGene00022130))",
"subsystem":"Pentose and glucuronate interconversions",
"annotation":{
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"kegg.reaction":"R02640",
"sbo":"SBO:0000176"
}
},
{
"id":"EX02165",
"name":"Leukotriene B4 exchange",
"metabolites":{
"leuktrB4_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"TCE0531",
"name":"L-Leucine transport",
"metabolites":{
"leu-L_c":1.0,
"leu-L_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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}
},
{
"id":"EX00318",
"name":"L-Carnitine exchange",
"metabolites":{
"crn_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"TCM1286",
"name":"4-Aminobutanoate transport",
"metabolites":{
"4abut_c":-1.0,
"4abut_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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}
},
{
"id":"TCE0389",
"name":"myo-Inositol transport",
"metabolites":{
"inost_c":1.0,
"inost_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RM00533",
"name":"Sulfite:oxygen oxidoreductase",
"metabolites":{
"h2o2_m":1.0,
"h2o_c":-1.0,
"o2_m":-1.0,
"so3_c":-1.0,
"so4_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00010397",
"subsystem":"Sulfur metabolism",
"annotation":{
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"kegg.reaction":"R00533",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE0384",
"name":"Cholesterol transport",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"chsterol_c":-1.0,
"chsterol_e":1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC03469",
"name":"ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 5-phosphotransferase",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"h_c":1.0,
"pail45p_c":1.0,
"pail4p_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00004087",
"subsystem":"Inositol phosphate metabolism",
"annotation":{
"ec-code":"2.7.1.68",
"kegg.reaction":"R03469",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE0382",
"name":"L-Isoleucine transport",
"metabolites":{
"ile-L_c":1.0,
"ile-L_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RM04753",
"name":"trans-Dec-2-enoyl-CoA reductase",
"metabolites":{
"dc2coa_m":-1.0,
"dcacoa_m":1.0,
"h_m":-1.0,
"nadp_m":1.0,
"nadph_m":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00012375 or WBGene00012970",
"subsystem":"Fatty acid elongation",
"annotation":{
"ec-code":"1.3.1.38",
"kegg.reaction":"R04753",
"sbo":"SBO:0000176"
}
},
{
"id":"RM04741",
"name":"(S)-3-hydroxydodecanoyl-CoA:NAD+ oxidoreductase",
"metabolites":{
"3hddcoa_m":1.0,
"3oddcoa_m":-1.0,
"h_m":-1.0,
"nad_m":1.0,
"nadh_m":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00007129 or WBGene00010035 or WBGene00001157 or WBGene00001158 or WBGene00019978) or (WBGene00020347 or WBGene00001150)",
"subsystem":"Fatty acid elongation",
"annotation":{
"ec-code":[
"1.1.1.211",
"1.1.1.35"
],
"kegg.reaction":"R04741",
"sbo":"SBO:0000176"
}
},
{
"id":"RM04740",
"name":"(S)-3-Hydroxytetradecanoyl-CoA hydro-lyase",
"metabolites":{
"3htdcoa_m":-1.0,
"h2o_m":1.0,
"td2coa_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00001155 or WBGene00001156) or (WBGene00020347 or WBGene00001150) or WBGene00001152",
"subsystem":"Fatty acid elongation",
"annotation":{
"ec-code":"4.2.1.17",
"kegg.reaction":"R04740",
"sbo":"SBO:0000176"
}
},
{
"id":"RM04743",
"name":"(S)-hydroxydecanoyl-CoA:NAD+ oxidoreductase",
"metabolites":{
"3hdcoa_m":1.0,
"3odcoa_m":-1.0,
"h_m":-1.0,
"nad_m":1.0,
"nadh_m":-1.0
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"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00007129 or WBGene00010035 or WBGene00001157 or WBGene00001158 or WBGene00019978) or (WBGene00020347 or WBGene00001150)",
"subsystem":"Fatty acid elongation",
"annotation":{
"ec-code":[
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"1.1.1.35"
],
"kegg.reaction":"R04743",
"sbo":"SBO:0000176"
}
},
{
"id":"RC07389",
"name":"alkyl acylglycerol phosphocholine transferase",
"metabolites":{
"akac2g_c":-1.0,
"akac2gchol_c":1.0,
"cdpchol_c":-1.0,
"cmp_c":1.0,
"h_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00013024",
"subsystem":"Ether lipid metabolism",
"annotation":{
"ec-code":"2.7.8.2",
"kegg.reaction":"R07389",
"sbo":"SBO:0000176"
}
},
{
"id":"RM04745",
"name":"(S)-hydroxyoctanoyl-CoA:NAD+ oxidoreductase",
"metabolites":{
"3hocoa_m":1.0,
"3oocoa_m":-1.0,
"h_m":-1.0,
"nad_m":1.0,
"nadh_m":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00007129 or WBGene00010035 or WBGene00001157 or WBGene00001158 or WBGene00019978) or (WBGene00020347 or WBGene00001150)",
"subsystem":"Fatty acid elongation",
"annotation":{
"ec-code":[
"1.1.1.211",
"1.1.1.35"
],
"kegg.reaction":"R04745",
"sbo":"SBO:0000176"
}
},
{
"id":"RM04744",
"name":"(S)-Hydroxydecanoyl-CoA hydro-lyase",
"metabolites":{
"3hdcoa_m":-1.0,
"dc2coa_m":1.0,
"h2o_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00001155 or WBGene00001156) or (WBGene00020347 or WBGene00001150) or WBGene00001152",
"subsystem":"Fatty acid elongation",
"annotation":{
"ec-code":"4.2.1.17",
"kegg.reaction":"R04744",
"sbo":"SBO:0000176"
}
},
{
"id":"RM04747",
"name":"Hexanoyl-CoA:acetyl-CoA C-acyltransferase",
"metabolites":{
"3oocoa_m":-1.0,
"accoa_m":1.0,
"coa_m":-1.0,
"hxcoa_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00015125 or WBGene00009952",
"subsystem":"Fatty acid elongation",
"annotation":{
"ec-code":"2.3.1.16",
"kegg.reaction":"R04747",
"sbo":"SBO:0000176"
}
},
{
"id":"RM04746",
"name":"(S)-Hydroxyoctanoyl-CoA hydro-lyase",
"metabolites":{
"3hocoa_m":-1.0,
"h2o_m":1.0,
"oc2coa_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00001155 or WBGene00001156) or (WBGene00020347 or WBGene00001150) or WBGene00001152",
"subsystem":"Fatty acid elongation",
"annotation":{
"ec-code":"4.2.1.17",
"kegg.reaction":"R04746",
"sbo":"SBO:0000176"
}
},
{
"id":"RM04749",
"name":"(S)-Hydroxyhexanoyl-CoA hydro-lyase",
"metabolites":{
"3hhcoa_m":-1.0,
"h2o_m":1.0,
"hx2coa_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00001155 or WBGene00001156) or (WBGene00020347 or WBGene00001150) or WBGene00001152",
"subsystem":"Fatty acid elongation",
"annotation":{
"ec-code":"4.2.1.17",
"kegg.reaction":"R04749",
"sbo":"SBO:0000176"
}
},
{
"id":"RM04748",
"name":"(S)-hydroxyhexanoyl-CoA:NAD+ oxidoreductase",
"metabolites":{
"3hhcoa_m":1.0,
"3ohcoa_m":-1.0,
"h_m":-1.0,
"nad_m":1.0,
"nadh_m":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00007129 or WBGene00010035 or WBGene00001157 or WBGene00001158 or WBGene00019978) or (WBGene00020347 or WBGene00001150)",
"subsystem":"Fatty acid elongation",
"annotation":{
"ec-code":[
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"1.1.1.35"
],
"kegg.reaction":"R04748",
"sbo":"SBO:0000176"
}
},
{
"id":"RC07380",
"name":"Lysoplasmalogen ethanolamine phosphohydrolase",
"metabolites":{
"alken2gpe_c":-1.0,
"alkenglyc_c":1.0,
"ethamp_c":1.0,
"h2o_c":-1.0,
"h_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00020195 or WBGene00007753 or WBGene00007755 or WBGene00008776",
"subsystem":"Ether lipid metabolism",
"annotation":{
"ec-code":"3.1.4.-",
"kegg.reaction":"R07380",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE0542",
"name":"L-Tryptophan transport",
"metabolites":{
"trp-L_c":1.0,
"trp-L_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE5063",
"name":"propanediol transport",
"metabolites":{
"12ppd-R_c":1.0,
"12ppd-R_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC07384",
"name":"O-1-Alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine + CMP <=> 1-Alkenyl-2-acylglycerol + CDP-ethanolamine",
"metabolites":{
"alkenac2g_c":1.0,
"alkenac2gpe_c":-1.0,
"cdpea_c":1.0,
"cmp_c":-1.0,
"h_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00009057 or WBGene00018797",
"subsystem":"Ether lipid metabolism",
"annotation":{
"ec-code":"2.7.8.1",
"kegg.reaction":"R07384",
"sbo":"SBO:0000176"
}
},
{
"id":"RC07385",
"name":"O-1-Alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine phosphatidohydrolase",
"metabolites":{
"alkenac2gp_c":1.0,
"alkenac2gpe_c":-1.0,
"etha_c":1.0,
"h2o_c":-1.0,
"h_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00004040 or (WBGene00017316 or WBGene00020256 or WBGene00013080)",
"subsystem":"Ether lipid metabolism",
"annotation":{
"ec-code":"3.1.4.4",
"kegg.reaction":"R07385",
"sbo":"SBO:0000176"
}
},
{
"id":"RM01736",
"name":"(R)-S-Lactoylglutathione hydrolase",
"metabolites":{
"gthrd_m":1.0,
"h2o_m":-1.0,
"h_m":1.0,
"lac-D_m":1.0,
"lgt-S_m":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00012459",
"subsystem":"Pyruvate metabolism",
"annotation":{
"ec-code":"3.1.2.6",
"kegg.reaction":"R01736",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01184",
"name":"myo-Inositol:oxygen oxidoreductase",
"metabolites":{
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"h2o_c":1.0,
"h_c":1.0,
"inost_c":-1.0,
"o2_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00016920",
"subsystem":"Ascorbate and aldarate metabolism",
"annotation":{
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"kegg.reaction":"R01184",
"sbo":"SBO:0000176"
}
},
{
"id":"EX02763",
"name":"enol-Phenylpyruvate exchange",
"metabolites":{
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},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
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}
},
{
"id":"RC03601",
"name":"O3-Acetyl-L-serine acetate-lyase (adding hydrogen sulfide)",
"metabolites":{
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"acser_c":-1.0,
"selcys_c":1.0,
"seln_c":-1.0
},
"lower_bound":-1000.0,
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"gene_reaction_rule":"WBGene00008490 or WBGene00008732 or WBGene00019094 or WBGene00020797 or WBGene00007653 or WBGene00010759 or WBGene00019962 or WBGene00019096",
"subsystem":"Cysteine and methionine metabolism",
"annotation":{
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"kegg.reaction":"R03601",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01185",
"name":"1D-myo-Inositol 1-phosphate phosphohydrolase",
"metabolites":{
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"inost_c":1.0,
"mi1p-D_c":-1.0,
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},
"lower_bound":-0.0,
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"gene_reaction_rule":"(WBGene00008765 or WBGene00012390)",
"subsystem":"Inositol phosphate metabolism",
"annotation":{
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"kegg.reaction":"R01185",
"sbo":"SBO:0000176"
}
},
{
"id":"RC08505",
"name":"cholesterol 26-hydroxylase",
"metabolites":{
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"h2o_c":1.0,
"h_c":-1.0,
"nadp_c":1.0,
"nadph_c":-1.0,
"o2_c":-1.0,
"xol27oh_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000905",
"subsystem":"Primary bile acid biosynthesis",
"annotation":{
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"kegg.reaction":"R08505",
"sbo":"SBO:0000176"
}
},
{
"id":"RC04144",
"name":"5-Phospho-D-ribosylamine:glycine ligase (ADP-forming)",
"metabolites":{
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"pram_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00018174",
"subsystem":"Purine metabolism",
"annotation":{
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"kegg.reaction":"R04144",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00867",
"name":"ATP:D-fructose 6-phosphotransferase",
"metabolites":{
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"atp_c":-1.0,
"f6p_c":1.0,
"fru_c":-1.0,
"h_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00008780 or WBGene00010416 or WBGene00022306",
"subsystem":"Fructose and mannose metabolism",
"annotation":{
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"kegg.reaction":"R00867",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00160",
"name":"FAD diphosphatase",
"metabolites":{
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"fad_c":-1.0,
"fmn_c":1.0,
"h2o_c":-1.0,
"h_c":2.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00007753 or WBGene00007755",
"subsystem":"Riboflavin metabolism",
"annotation":{
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"kegg.reaction":"R00160",
"sbo":"SBO:0000176"
}
},
{
"id":"EX05422",
"name":"Dehydroascorbate exchange",
"metabolites":{
"dhdascb_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00109",
"name":"2-Oxobutanoate exchange",
"metabolites":{
"2obut_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RC00694",
"name":"L-Phenylalanine:2-oxoglutarate aminotransferase",
"metabolites":{
"akg_c":-1.0,
"glu-L_c":1.0,
"phe-L_c":-1.0,
"phpyr_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00020146 or WBGene00009628",
"subsystem":"Phenylalanine metabolism",
"annotation":{
"ec-code":[
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"2.6.1.5"
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"kegg.reaction":"R00694",
"sbo":"SBO:0000176"
}
},
{
"id":"EX00108",
"name":"Anthranilate exchange",
"metabolites":{
"anth_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RC03269",
"name":"N-[(R)-4-Phosphopantothenoyl]-L-cysteine carboxy-lyase",
"metabolites":{
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"co2_c":1.0,
"h_c":-1.0,
"pan4p_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00009138",
"subsystem":"Pantothenate and CoA biosynthesis",
"annotation":{
"ec-code":"4.1.1.36",
"kegg.reaction":"R03269",
"sbo":"SBO:0000176"
}
},
{
"id":"EX00233",
"name":"4-Methyl-2-oxopentanoate exchange",
"metabolites":{
"4mop_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RC04545",
"name":"ATP:1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 3-phosphotransferase",
"metabolites":{
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"atp_c":-1.0,
"h_c":1.0,
"pail345p_c":1.0,
"pail45p_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000090 and WBGene00000001",
"subsystem":"Inositol phosphate metabolism",
"annotation":{
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"kegg.reaction":"R04545",
"sbo":"SBO:0000176"
}
},
{
"id":"TCM1289",
"name":"Hydroxymethylglutaryl-CoA transport",
"metabolites":{
"hmgcoa_c":-1.0,
"hmgcoa_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RM00489",
"name":"L-aspartate 1-carboxy-lyase (beta-alanine-forming)",
"metabolites":{
"ala-B_m":1.0,
"asp-L_m":-1.0,
"co2_m":1.0,
"h_m":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00006762",
"subsystem":"beta-Alanine metabolism",
"annotation":{
"ec-code":"4.1.1.15",
"kegg.reaction":"R00489",
"sbo":"SBO:0000176"
}
},
{
"id":"RC03970",
"name":"(5-Glutamyl)-peptide:amino-acid 5-glutamyltransferase",
"metabolites":{
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"gcynala_c":1.0,
"glu-L_c":-1.0,
"h2o_c":1.0,
"h_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00016906 or WBGene00019204 or WBGene00011393 or WBGene00020590 or WBGene00012416 or WBGene00022397",
"subsystem":"Cyanoamino acid metabolism",
"annotation":{
"ec-code":"2.3.2.2",
"kegg.reaction":"R03970",
"sbo":"SBO:0000176"
}
},
{
"id":"RC03284",
"name":"3-hydroxy-6-N-trimethyllysine aldolase",
"metabolites":{
"3htmelys_c":-1.0,
"4tmeabut_c":1.0,
"gly_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Carnitine biosynthesis",
"annotation":{
"ec-code":"4.1.2.-",
"kegg.reaction":"R03284",
"sbo":"SBO:0000176"
}
},
{
"id":"RC03283",
"name":"4-Trimethylammoniobutanal:NAD+ 1-oxidoreductase",
"metabolites":{
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"4tmeabutn_c":1.0,
"h2o_c":-1.0,
"h_c":2.0,
"nad_c":-1.0,
"nadh_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00000108 or WBGene00000110) or (WBGene00000117 or WBGene00000118)",
"subsystem":"Carnitine biosynthesis",
"annotation":{
"ec-code":[
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"1.2.1.47"
],
"kegg.reaction":"R03283",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00267",
"name":"Isocitrate:NADP+ oxidoreductase",
"metabolites":{
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"co2_c":1.0,
"icit_c":-1.0,
"nadp_c":-1.0,
"nadph_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00010317",
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"kegg.reaction":"R00267",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00261",
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"co2_c":1.0,
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"h_c":-1.0
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"lower_bound":-0.0,
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"kegg.reaction":"R00261",
"sbo":"SBO:0000176"
}
},
{
"id":"EX00106",
"name":"Uracil exchange",
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"lower_bound":-0.0,
"upper_bound":1000.0,
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"subsystem":"Exchange with the environment",
"annotation":{
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}
},
{
"id":"TCM5067",
"name":"L-sulfolactate transport",
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"sl-L_c":-1.0,
"sl-L_m":1.0
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"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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}
},
{
"id":"TCM5064",
"name":"Trimethyl lysine transport to mitochondria",
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"lower_bound":-1000.0,
"upper_bound":1000.0,
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}
},
{
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"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
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}
},
{
"id":"TCM5062",
"name":"D-3-Amino-isobutanoate transport (cytosol/mitochondria)",
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"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
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}
},
{
"id":"TCM5060",
"name":"methylglyoxal transport",
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"mthgxl_m":1.0
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM5061",
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"fe3_c":-1.0,
"fe3_m":1.0
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"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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}
},
{
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"etfrd_m":1.0
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"lower_bound":-1000.0,
"upper_bound":1000.0,
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}
},
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"h_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000035 or WBGene00000036 or WBGene00000038",
"subsystem":"Glycerophospholipid metabolism",
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}
},
{
"id":"RC01021",
"name":"ATP:choline phosphotransferase",
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"chol_c":-1.0,
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},
{
"id":"RC01023",
"name":"Acetyl-CoA:choline O-acetyltransferase",
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"chol_c":-1.0,
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"lower_bound":-1000.0,
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}
},
{
"id":"RC00009",
"name":"catalase",
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"h2o_c":2.0,
"o2_c":1.0
},
"lower_bound":-0.0,
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"gene_reaction_rule":"WBGene00000830 or WBGene00000831 or WBGene00013220",
"subsystem":"Reactive oxygen species degradation",
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}
},
{
"id":"RC00004",
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"lower_bound":-0.0,
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}
},
{
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}
},
{
"id":"RM03776",
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},
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}
},
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"caphis_c":-1.0,
"h_c":3.0,
"pdipht_c":1.0
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"lower_bound":-1000.0,
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}
},
{
"id":"RC01281",
"name":"Palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating)",
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},
"lower_bound":-0.0,
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}
},
{
"id":"RC01280",
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"sbo":"SBO:0000176"
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},
{
"id":"RCC0177",
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}
},
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"id":"RCC0176",
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"annotation":{
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}
},
{
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},
{
"id":"RC00137",
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},
{
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},
{
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},
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},
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"iletrna_c":-0.027694,
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"lower_bound":-0.0,
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},
{
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},
{
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"kegg.reaction":"R00138",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01737",
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"h_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00017818",
"subsystem":"Pentose phosphate pathway",
"annotation":{
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"kegg.reaction":"R01737",
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0178",
"name":"artificial transformation of peptide to peptidyl-aspartate",
"metabolites":{
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"h2o_c":1.0,
"pepX_c":-1.0,
"pepasp_c":1.0
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"lower_bound":-0.0,
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"subsystem":"Protein modification by hydroxylation",
"annotation":{
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}
},
{
"id":"RC00485",
"name":"L-Asparagine amidohydrolase",
"metabolites":{
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},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00007756",
"subsystem":"Alanine, aspartate and glutamate metabolism",
"annotation":{
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"kegg.reaction":"R00485",
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}
},
{
"id":"RC09752",
"name":"GDP:alpha-D-glucose 1-phosphate guanylyltransferase",
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"gdp_c":1.0,
"gdpg_c":-1.0,
"h_c":1.0,
"pi_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00015678",
"subsystem":"Fructose and mannose metabolism",
"annotation":{
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"kegg.reaction":"R09752",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00489",
"name":"L-aspartate 1-carboxy-lyase (beta-alanine-forming)",
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00006762",
"subsystem":"beta-Alanine metabolism",
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"kegg.reaction":"R00489",
"sbo":"SBO:0000176"
}
},
{
"id":"EX00864",
"name":"pantothenic acid uptake",
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},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
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"annotation":{
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}
},
{
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"name":"Thymidine transport",
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"thymd_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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}
},
{
"id":"RC01357",
"name":"Acetoacetate:CoA ligase (AMP-forming)",
"metabolites":{
"aacoa_c":1.0,
"acac_c":-1.0,
"amp_c":1.0,
"atp_c":-1.0,
"coa_c":-1.0,
"ppi_c":1.0
},
"lower_bound":-0.0,
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"gene_reaction_rule":"WBGene00006351",
"subsystem":"Butanoate metabolism",
"annotation":{
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"kegg.reaction":"R01357",
"sbo":"SBO:0000176"
}
},
{
"id":"EX00191",
"name":"D-Glucuronate exchange",
"metabolites":{
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},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
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}
},
{
"id":"EX00194",
"name":"adenosylcobalamin exchange/defecation",
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
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}
},
{
"id":"RC01600",
"name":"ATP:beta-D-glucose 6-phosphotransferase",
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"glc-D-B_c":-1.0,
"h_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00008780 or WBGene00010416 or WBGene00022306",
"subsystem":"Glycolysis / Gluconeogenesis",
"annotation":{
"ec-code":"2.7.1.1",
"kegg.reaction":"R01600",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01351",
"name":"1-acylglycerol acylhydrolase",
"metabolites":{
"Rtotal4_c":1.0,
"glyc_c":1.0,
"h2o_c":-1.0,
"h_c":1.0,
"mag_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00022393",
"subsystem":"Glycerolipid metabolism",
"annotation":{
"ec-code":"3.1.1.23",
"kegg.reaction":"R01352",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01602",
"name":"D-Glucose 1-epimerase",
"metabolites":{
"glc-D-A_c":-1.0,
"glc-D-B_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00015270 or WBGene00044734",
"subsystem":"Glycolysis / Gluconeogenesis",
"annotation":{
"ec-code":"5.1.3.3",
"kegg.reaction":"R01602",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00955",
"name":"UDP-glucose:alpha-D-galactose-1-phosphate uridylyltransferase",
"metabolites":{
"g1p_c":1.0,
"gal1p_c":-1.0,
"udpg_c":-1.0,
"udpgal_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00014203",
"subsystem":"Galactose metabolism",
"annotation":{
"ec-code":"2.7.7.12",
"kegg.reaction":"R00955",
"sbo":"SBO:0000176"
}
},
{
"id":"TCM0199",
"name":"dUDP and dATP transport",
"metabolites":{
"datp_c":-1.0,
"datp_m":1.0,
"dudp_c":1.0,
"dudp_m":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM0198",
"name":"dADP and dCTP transport",
"metabolites":{
"dadp_c":1.0,
"dadp_m":-1.0,
"dctp_c":-1.0,
"dctp_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC00736",
"name":"L-tyrosine carboxy-lyase (tyramine-forming)",
"metabolites":{
"co2_c":1.0,
"h_c":-1.0,
"tym_c":1.0,
"tyr-L_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00006562",
"subsystem":"Tyrosine metabolism",
"annotation":{
"ec-code":"4.1.1.28",
"kegg.reaction":"R00736",
"sbo":"SBO:0000176"
}
},
{
"id":"TCM0190",
"name":"Acetate transport",
"metabolites":{
"ac_c":-1.0,
"ac_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC00734",
"name":"L-tyrosine:2-oxoglutarate aminotransferase",
"metabolites":{
"34hpp_c":1.0,
"akg_c":-1.0,
"glu-L_c":1.0,
"tyr-L_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00020146 or WBGene00009628",
"subsystem":"Ubiquinone and other terpenoid-quinone biosynthesis",
"annotation":{
"ec-code":[
"2.6.1.1",
"2.6.1.5"
],
"kegg.reaction":"R00734",
"sbo":"SBO:0000176"
}
},
{
"id":"TCM0192",
"name":"beta-Alanine transport",
"metabolites":{
"ala-B_c":-1.0,
"ala-B_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RM06985",
"name":"trans-Hex-2-enoyl-CoA reductase",
"metabolites":{
"h_m":-1.0,
"hx2coa_m":-1.0,
"hxcoa_m":1.0,
"nadp_m":1.0,
"nadph_m":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00012375 or WBGene00012970",
"subsystem":"Fatty acid elongation",
"annotation":{
"ec-code":"1.3.1.38",
"kegg.reaction":"R06985",
"sbo":"SBO:0000176"
}
},
{
"id":"RC08724",
"name":"3beta-hydroxy-Delta5-C27-steroid oxidoreductase",
"metabolites":{
"h_c":1.0,
"nad_c":-1.0,
"nadh_c":1.0,
"xol27one_c":1.0,
"xoltri27_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00012394 or WBGene00022498 or WBGene00022616",
"subsystem":"Primary bile acid biosynthesis",
"annotation":{
"ec-code":"1.1.1.181",
"kegg.reaction":"R08724",
"sbo":"SBO:0000176"
}
},
{
"id":"TCM0197",
"name":"Guanosine transport",
"metabolites":{
"gsn_c":-1.0,
"gsn_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC00731",
"name":"L-Tyrosine:oxygen oxidoreductase",
"metabolites":{
"34dhphe_c":2.0,
"o2_c":-1.0,
"tyr-L_c":-2.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00015332 or WBGene00010661 or WBGene00009001 or WBGene00016419 or WBGene00021553 or WBGene00022231",
"subsystem":"Tyrosine metabolism",
"annotation":{
"ec-code":"1.14.18.1",
"kegg.reaction":"R00731",
"sbo":"SBO:0000176"
}
},
{
"id":"DGR0026",
"name":"Bacterial phosphatidylserine degradation",
"metabolites":{
"Rtotal_BAC_c":2.0,
"glyc_c":1.0,
"h2o_c":-3.0,
"h_c":3.0,
"ps_BAC_c":-1.0,
"pser-L_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00019747 or WBGene00009801 or WBGene00012319 or WBGene00017026 or WBGene00019229 or WBGene00022233 or WBGene00011423 or WBGene00007419 or WBGene00044468",
"subsystem":"Bacterial digestion",
"annotation":{
"ec-code":"3.1.1.4",
"sbo":"SBO:0000176"
}
},
{
"id":"DGR0027",
"name":"Glycogen assimilation",
"metabolites":{
"glycogen_BAC_c":1.0,
"glycogen_BAC_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Bacterial digestion",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"DGR0024",
"name":"Bacterial phosphatidate degradation",
"metabolites":{
"Rtotal_BAC_c":2.0,
"glyc_c":1.0,
"h2o_c":-3.0,
"h_c":2.0,
"pa_BAC_c":-1.0,
"pi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00019747 or WBGene00009801 or WBGene00012319 or WBGene00017026 or WBGene00019229 or WBGene00022233 or WBGene00011423 or WBGene00007419 or WBGene00044468",
"subsystem":"Bacterial digestion",
"annotation":{
"ec-code":"3.1.1.4",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE5122",
"name":"phosphatidylcholine export",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pchol_c":-1.0,
"pchol_e":1.0,
"pi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"DGR0025",
"name":"Bacterial phosphatidylserine uptake",
"metabolites":{
"ps_BAC_c":1.0,
"ps_BAC_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Bacterial digestion",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE0441",
"name":"Deoxyinosine transport",
"metabolites":{
"din_c":1.0,
"din_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE0440",
"name":"Urea transport",
"metabolites":{
"urea_c":1.0,
"urea_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"DGR0020",
"name":"Bacterial phosphatidylglycerol uptake",
"metabolites":{
"pg_BAC_c":1.0,
"pg_BAC_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Bacterial digestion",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM0064",
"name":"Formate transport",
"metabolites":{
"for_c":1.0,
"for_m":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC01513",
"name":"3-Phospho-D-glycerate:NAD+ 2-oxidoreductase",
"metabolites":{
"3pg_c":-1.0,
"3php_c":1.0,
"h_c":1.0,
"nad_c":-1.0,
"nadh_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00007836",
"subsystem":"Glycine, serine and threonine metabolism",
"annotation":{
"ec-code":"1.1.1.95",
"kegg.reaction":"R01513",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01512",
"name":"ATP:3-phospho-D-glycerate 1-phosphotransferase",
"metabolites":{
"13dpg_c":1.0,
"3pg_c":-1.0,
"adp_c":1.0,
"atp_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00020185",
"subsystem":"Glycolysis / Gluconeogenesis",
"annotation":{
"ec-code":"2.7.2.3",
"kegg.reaction":"R01512",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01514",
"name":"ATP:(R)-glycerate 3-phosphotransferase",
"metabolites":{
"3pg_c":1.0,
"adp_c":1.0,
"atp_c":-1.0,
"glyc-R_c":-1.0,
"h_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00015733",
"subsystem":"Glycine, serine and threonine metabolism",
"annotation":{
"ec-code":"2.7.1.31",
"kegg.reaction":"R01514",
"sbo":"SBO:0000176"
}
},
{
"id":"TCM0062",
"name":"Pyridoxal 5'-phosphate transport",
"metabolites":{
"pydx5p_c":-1.0,
"pydx5p_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC01518",
"name":"2-Phospho-D-glycerate 2,3-phosphomutase",
"metabolites":{
"2pg_c":-1.0,
"3pg_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00019001",
"subsystem":"Glycolysis / Gluconeogenesis",
"annotation":{
"ec-code":"5.4.2.12",
"kegg.reaction":"R01518",
"sbo":"SBO:0000176"
}
},
{
"id":"RC04807",
"name":"5beta-Cholestane-3alpha,7alpha,12alpha-triol,NADPH:oxygen oxidoreductase (26-hydroxylating)",
"metabolites":{
"h2o_c":1.0,
"h_c":-1.0,
"nadp_c":1.0,
"nadph_c":-1.0,
"o2_c":-1.0,
"xoltetrol_c":1.0,
"xoltriol_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000905",
"subsystem":"Primary bile acid biosynthesis",
"annotation":{
"ec-code":"1.14.13.15",
"kegg.reaction":"R04807",
"sbo":"SBO:0000176"
}
},
{
"id":"TCM0069",
"name":"10-Formyltetrahydrofolate transport",
"metabolites":{
"10fthf_c":-1.0,
"10fthf_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"EX00048",
"name":"Glyoxylate exchange",
"metabolites":{
"glx_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00049",
"name":"L-Aspartate exchange",
"metabolites":{
"asp-L_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00047",
"name":"L-Lysine exchange",
"metabolites":{
"lys-L_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00042",
"name":"Succinate exchange",
"metabolites":{
"succ_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00041",
"name":"L-Alanine exchange",
"metabolites":{
"ala-L_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"TCE0772",
"name":"Guanosine transport",
"metabolites":{
"gsn_c":1.0,
"gsn_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"EX05270",
"name":"Hexanoyl-CoA (n-C6:0CoA) exchange",
"metabolites":{
"hxcoa_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"TCE0713",
"name":"Pyridoxamine transport",
"metabolites":{
"pydam_c":1.0,
"pydam_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE0712",
"name":"4-Hydroxyphenylacetate transport",
"metabolites":{
"4hphac_c":-1.0,
"4hphac_e":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC06171",
"name":"L-Allothreonine acetaldehyde-lyase",
"metabolites":{
"acald_c":1.0,
"athr-L_c":-1.0,
"gly_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00011291",
"subsystem":"Glycine, serine and threonine metabolism",
"annotation":{
"ec-code":"4.1.2.5",
"kegg.reaction":"R06171",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE0716",
"name":"D-Lactate transport",
"metabolites":{
"lac-D_c":1.0,
"lac-D_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RM04170",
"name":"(S)-3-Hydroxydodecanoyl-CoA hydro-lyase",
"metabolites":{
"3hddcoa_m":-1.0,
"dd2coa_m":1.0,
"h2o_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00001155 or WBGene00001156) or (WBGene00020347 or WBGene00001150) or WBGene00001152",
"subsystem":"Fatty acid elongation",
"annotation":{
"ec-code":"4.2.1.17",
"kegg.reaction":"R04170",
"sbo":"SBO:0000176"
}
},
{
"id":"EX05787",
"name":"Bilirubin beta-diglucuronide exchange",
"metabolites":{
"bildglcur_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"TCE0719",
"name":"4-Aminobutanoate transport",
"metabolites":{
"4abut_c":1.0,
"4abut_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE0718",
"name":"L-Methionine transport",
"metabolites":{
"met-L_c":1.0,
"met-L_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"EX02918",
"name":"1-Methylnicotinamide exchange",
"metabolites":{
"1mncam_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RM02161",
"name":"Ubiquinol:ferricytochrome-c oxidoreductase",
"metabolites":{
"ficytC_m":-2.0,
"focytC_m":2.0,
"h_c":4.0,
"h_m":-2.0,
"q_m":1.0,
"qh2_m":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00002162 and WBGene00000829 and WBGene00000869 and (WBGene00020757 or WBGene00012158 or WBGene00011679) and WBGene00012094 and WBGene00020181 and (WBGene00009739 or WBGene00019937) and WBGene00019007 and (WBGene00017121 or WBGene00013854)",
"subsystem":"Oxidative phosphorylation",
"annotation":{
"ec-code":"1.10.2.2",
"kegg.reaction":"R02161",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE1179",
"name":"L-Arabinitol transport",
"metabolites":{
"abt_c":1.0,
"abt_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"EX01330",
"name":"Sodium exchange",
"metabolites":{
"na1_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"TCE5389",
"name":"Prostaglandin H2 transport",
"metabolites":{
"prostgh2_c":1.0,
"prostgh2_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE5388",
"name":"1-Alkyl-2-lyso-sn-glycero-3-phosphocholine uptake",
"metabolites":{
"ak2lgchol_c":1.0,
"ak2lgchol_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"EX01801",
"name":"Deoxyribose exchange",
"metabolites":{
"drib_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"TCE5383",
"name":"glucocerebroside  transport",
"metabolites":{
"gluside_ce_c":-1.0,
"gluside_ce_e":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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}
},
{
"id":"TCE5382",
"name":"phosphatidylglycerol  transport",
"metabolites":{
"pglyc_c":1.0,
"pglyc_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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}
},
{
"id":"TCE5381",
"name":"triacylglycerol transport",
"metabolites":{
"tag_c":1.0,
"tag_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC07172",
"name":"NADPH:oxygen oxidoreductase",
"metabolites":{
"h2o2_c":1.0,
"h_c":-1.0,
"nadp_c":1.0,
"nadph_c":-1.0,
"o2_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000253 or WBGene00018771",
"subsystem":"Miscellaneous",
"annotation":{
"ec-code":"1.6.3.1",
"kegg.reaction":"R07172",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE5387",
"name":"1-Alkyl-2-lyso-sn-glycero-3-phosphocholine secretion",
"metabolites":{
"adp_c":1.0,
"ak2lgchol_c":-1.0,
"ak2lgchol_e":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE5386",
"name":"Lysophosphatidylcholine transport",
"metabolites":{
"lpchol_c":1.0,
"lpchol_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE5385",
"name":"Platelet-activating factor uptake",
"metabolites":{
"paf_c":1.0,
"paf_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE5384",
"name":"Platelet-activating factor secretion",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"paf_c":-1.0,
"paf_e":1.0,
"pi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC02099",
"name":"ATP:deoxyuridine 5-phosphotransferase",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"dump_c":1.0,
"duri_c":-1.0,
"h_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00006568",
"subsystem":"Pyrimidine metabolism",
"annotation":{
"ec-code":"2.7.1.21",
"kegg.reaction":"R02099",
"sbo":"SBO:0000176"
}
},
{
"id":"RC02098",
"name":"ATP:dUMP phosphotransferase",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"dudp_c":1.0,
"dump_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00011272",
"subsystem":"Pyrimidine metabolism",
"annotation":{
"ec-code":"2.7.4.9",
"kegg.reaction":"R02098",
"sbo":"SBO:0000176"
}
},
{
"id":"EXC0063",
"name":"Cardiolipin (bacteria) exchange",
"metabolites":{
"clpn_BAC_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"TCE0627",
"name":"Superoxide anion transport",
"metabolites":{
"o2s_c":-1.0,
"o2s_e":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC02094",
"name":"ATP:dTMP phosphotransferase",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"dtdp_c":1.0,
"dtmp_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00011272",
"subsystem":"Pyrimidine metabolism",
"annotation":{
"ec-code":"2.7.4.9",
"kegg.reaction":"R02094",
"sbo":"SBO:0000176"
}
},
{
"id":"RC02090",
"name":"ATP:dGMP phosphotransferase",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"dgdp_c":1.0,
"dgmp_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00020190",
"subsystem":"Purine metabolism",
"annotation":{
"ec-code":"2.7.4.8",
"kegg.reaction":"R02090",
"sbo":"SBO:0000176"
}
},
{
"id":"RC02093",
"name":"ATP:dTDP phosphotransferase",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"dtdp_c":-1.0,
"dttp_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00019899 or WBGene00021692 or WBGene00009119",
"subsystem":"Pyrimidine metabolism",
"annotation":{
"ec-code":"2.7.4.6",
"kegg.reaction":"R02093",
"sbo":"SBO:0000176"
}
},
{
"id":"RC02701",
"name":"5-Hydroxy-L-tryptophan decarboxy-lyase",
"metabolites":{
"5htrp_c":-1.0,
"co2_c":1.0,
"h_c":-1.0,
"srtn_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000239",
"subsystem":"Tryptophan metabolism",
"annotation":{
"ec-code":"4.1.1.28",
"kegg.reaction":"R02701",
"sbo":"SBO:0000176"
}
},
{
"id":"RC02251",
"name":"acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase",
"metabolites":{
"Rtotal3coa_c":-1.0,
"coa_c":1.0,
"dag_tag_c":-1.0,
"tag_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00010408",
"subsystem":"Glycerolipid metabolism",
"annotation":{
"ec-code":"2.3.1.20",
"kegg.reaction":"R02251",
"sbo":"SBO:0000176"
}
},
{
"id":"RC02250",
"name":"Triacylglycerol acylhydrolase",
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"dag_tag_c":1.0,
"h2o_c":-1.0,
"h_c":1.0,
"tag_c":-1.0
},
"lower_bound":-0.0,
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"gene_reaction_rule":"WBGene00015484 or WBGene00016704",
"subsystem":"Glycerolipid metabolism",
"annotation":{
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"3.1.1.79"
],
"kegg.reaction":[
"R02250",
"R01369"
],
"sbo":"SBO:0000176"
}
},
{
"id":"RM00927",
"name":"acetyl-CoA:propanoyl-CoA 2-C-acetyltransferase",
"metabolites":{
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"accoa_m":1.0,
"coa_m":-1.0,
"ppcoa_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00015125 or WBGene00009952",
"subsystem":"Valine, leucine and isoleucine degradation",
"annotation":{
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"kegg.reaction":"R00927",
"sbo":"SBO:0000176"
}
},
{
"id":"RC02078",
"name":"L-Tyrosine,L-dopa:oxygen oxidoreductase",
"metabolites":{
"34dhphe_c":-2.0,
"dopaqn_c":2.0,
"h2o_c":2.0,
"o2_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00015332 or WBGene00010661 or WBGene00009001 or WBGene00016419 or WBGene00021553 or WBGene00022231",
"subsystem":"Tyrosine metabolism",
"annotation":{
"ec-code":"1.14.18.1",
"kegg.reaction":"R02078",
"sbo":"SBO:0000176"
}
},
{
"id":"RC05861",
"name":"D-alanine:oxygen oxidoreductase (deaminating)",
"metabolites":{
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"h2o2_c":1.0,
"h2o_c":-1.0,
"nh4_c":1.0,
"o2_c":-1.0,
"pyr_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00022076",
"subsystem":"Miscellaneous",
"annotation":{
"ec-code":"1.4.3.3",
"kegg.reaction":"R05861",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE5019",
"name":"Na+/K+ exchanging ATPase",
"metabolites":{
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"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"k_c":2.0,
"k_e":-2.0,
"na1_c":-3.0,
"na1_e":3.0,
"pi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00001137 or WBGene00007248 or WBGene00015660 or WBGene00015338 or WBGene00013672) and (WBGene00007646 or WBGene00008074 or WBGene00010117)",
"subsystem":"Transport",
"annotation":{
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"sbo":"SBO:0000185"
}
},
{
"id":"TCE0533",
"name":"5-Methyltetrahydrofolate transport",
"metabolites":{
"5mthf_c":1.0,
"5mthf_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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}
},
{
"id":"RM04754",
"name":"Decanoyl-CoA:(acceptor) 2,3-oxidoreductase",
"metabolites":{
"dc2coa_m":1.0,
"dcacoa_m":-1.0,
"etfox_m":-1.0,
"etfrd_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00020812 or WBGene00019406 or WBGene00020366)",
"subsystem":"Fatty acid metabolism",
"annotation":{
"ec-code":"1.3.8.7",
"kegg.reaction":"R04754",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE5017",
"name":"thiamine uptake",
"metabolites":{
"thm_c":1.0,
"thm_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE5016",
"name":"gluconate transport",
"metabolites":{
"glcn_c":1.0,
"glcn_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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}
},
{
"id":"RM04751",
"name":"Hexanoyl-CoA:(acceptor) 2,3-oxidoreductase",
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"etfrd_m":1.0,
"hx2coa_m":1.0,
"hxcoa_m":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00020812 or WBGene00019406 or WBGene00020366) or (WBGene00016943 or WBGene00015894)",
"subsystem":"Fatty acid metabolism",
"annotation":{
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"1.3.8.1"
],
"kegg.reaction":"R04751",
"sbo":"SBO:0000176"
}
},
{
"id":"RC03618",
"name":"Trihexosylceramide galactohydrolase",
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"galgluside_ce_c":1.0,
"h2o_c":-1.0,
"thcrm_ce_c":-1.0
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"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00011095",
"subsystem":"Miscellaneous",
"annotation":{
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"kegg.reaction":"R03618",
"sbo":"SBO:0000176"
}
},
{
"id":"EX18126",
"name":"1-Acyl-sn-glycero-3-phosphoglycerol exchange",
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
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}
},
{
"id":"RC03617",
"name":"D-galactosyl-N-acylsphingosine galactohydrolase",
"metabolites":{
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"gal_c":1.0,
"galside_ce_c":-1.0,
"h2o_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00016207",
"subsystem":"Sphingolipid metabolism",
"annotation":{
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"kegg.reaction":"R03617",
"sbo":"SBO:0000176"
}
},
{
"id":"RM03905",
"name":"Glu-tRNA(Gln):L-glutamine amido-ligase",
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"atp_m":-1.0,
"gln-L_m":-1.0,
"glntrna_m":1.0,
"glu-L_m":1.0,
"glutrna_gln_m":-1.0,
"h2o_m":-1.0,
"h_m":1.0,
"pi_m":1.0
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"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00016524 and WBGene00013433 and WBGene00021508",
"subsystem":"Aminoacyl-tRNA biosynthesis",
"annotation":{
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"kegg.reaction":"R03905",
"sbo":"SBO:0000176"
}
},
{
"id":"RC04480",
"name":"Acyl-CoA:1-acyl-sn-glycero-3-phosphoethanolamine O-acyltransferase",
"metabolites":{
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"acg3pe_c":-1.0,
"coa_c":1.0,
"pe_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00020115 or (WBGene00016934 or WBGene00007446)",
"subsystem":"Glycerophospholipid metabolism",
"annotation":{
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"kegg.reaction":"R04480",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE0447",
"name":"Androsterone transport",
"metabolites":{
"andrstrn_c":1.0,
"andrstrn_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC04559",
"name":"1-(5-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole AMP-lyase",
"metabolites":{
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"aicar_c":1.0,
"fum_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00011064",
"subsystem":"Purine metabolism",
"annotation":{
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"kegg.reaction":"R04559",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE5123",
"name":"phosphatidylcholine import",
"metabolites":{
"pchol_c":1.0,
"pchol_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC02670",
"name":"Hydroxyanthranilate oxidation",
"metabolites":{
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"cinnavalininate_c":1.0,
"h2o2_c":2.0,
"h_c":4.0,
"o2_c":-4.0,
"o2s_c":2.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000830 or WBGene00000831 or WBGene00013220",
"subsystem":"Tryptophan metabolism",
"annotation":{
"ec-code":"1.11.1.6",
"kegg.reaction":"R02670",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE5121",
"name":"ascr2 transport",
"metabolites":{
"ascr2_c":-1.0,
"ascr2_e":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Ascaroside biosynthesis",
"annotation":{
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}
},
{
"id":"TCE5120",
"name":"ascr7 transport",
"metabolites":{
"ascr7_c":-1.0,
"ascr7_e":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Ascaroside biosynthesis",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC02678",
"name":"Indole-3-acetaldehyde:NAD+ oxidoreductase",
"metabolites":{
"h2o_c":-1.0,
"h_c":2.0,
"id3acald_c":-1.0,
"ind3ac_c":1.0,
"nad_c":-1.0,
"nadh_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00000108 or WBGene00000110) or (WBGene00000117 or WBGene00000118)",
"subsystem":"Tryptophan metabolism",
"annotation":{
"ec-code":"1.2.1.3",
"kegg.reaction":"R02678",
"sbo":"SBO:0000176"
}
},
{
"id":"RC03104",
"name":"3-Mercaptolactate:NAD+ oxidoreductase",
"metabolites":{
"h_c":1.0,
"mercplac_c":-1.0,
"mercppyr_c":1.0,
"nad_c":-1.0,
"nadh_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00002262",
"subsystem":"Cysteine and methionine metabolism",
"annotation":{
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"kegg.reaction":"R03104",
"sbo":"SBO:0000176"
}
},
{
"id":"RC03105",
"name":"3-Mercaptopyruvate:cyanide sulfurtransferase",
"metabolites":{
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"pyr_c":1.0,
"so3_c":-1.0,
"tsul_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00008409 or WBGene00010380 or WBGene00010383 or WBGene00017387 or WBGene00022006 or WBGene00022007 or WBGene00011307",
"subsystem":"Cysteine and methionine metabolism",
"annotation":{
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"kegg.reaction":"R03105",
"sbo":"SBO:0000176"
}
},
{
"id":"RC03106",
"name":"3-mercaptopyruvate:cyanide sulfurtransferase",
"metabolites":{
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"h_c":1.0,
"mercppyr_c":-1.0,
"pyr_c":1.0,
"tcynt_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00008409 or WBGene00010380 or WBGene00010383 or WBGene00017387 or WBGene00022006 or WBGene00022007 or WBGene00011307",
"subsystem":"Miscellaneous",
"annotation":{
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"kegg.reaction":"R03106",
"sbo":"SBO:0000176"
}
},
{
"id":"RM02164",
"name":"Succinate:ubiquinone oxidoreductase",
"metabolites":{
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"q_m":-1.0,
"qh2_m":1.0,
"succ_m":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"((WBGene00015391 or WBGene00016392) and WBGene00006433) and WBGene00003225 and WBGene00009353",
"subsystem":"Citrate cycle (TCA cycle)",
"annotation":{
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"kegg.reaction":"R02164",
"sbo":"SBO:0000176"
}
},
{
"id":"RC04734",
"name":"4a-hydroxytetrahydrobiopterin hydro-lyase",
"metabolites":{
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"h2o_c":1.0,
"thbpt4acam_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00020397",
"subsystem":"Phenylalanine metabolism",
"annotation":{
"ec-code":"4.2.1.96",
"kegg.reaction":"R04734",
"sbo":"SBO:0000176"
}
},
{
"id":"EX03793",
"name":"N6,N6,N6-Trimethyl-L-lysine exchange",
"metabolites":{
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},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
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}
},
{
"id":"RC00251",
"name":"5-oxo-L-proline amidohydrolase (ATP-hydrolysing)",
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"adp_c":1.0,
"atp_c":-1.0,
"glu-L_c":1.0,
"h2o_c":-2.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00021430",
"subsystem":"Glutathione metabolism",
"annotation":{
"ec-code":"3.5.2.9",
"kegg.reaction":"R00251",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00253",
"name":"L-Glutamate:ammonia ligase (ADP-forming)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"gln-L_c":1.0,
"glu-L_c":-1.0,
"h_c":1.0,
"nh4_c":-1.0,
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},
"lower_bound":-0.0,
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"gene_reaction_rule":"WBGene00001602 or WBGene00001603 or WBGene00001604 or WBGene00001606 or WBGene00001607",
"subsystem":"Alanine, aspartate and glutamate metabolism",
"annotation":{
"ec-code":"6.3.1.2",
"kegg.reaction":"R00253",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00257",
"name":"Deamido-NAD+:L-glutamine amido-ligase (AMP-forming)",
"metabolites":{
"amp_c":1.0,
"atp_c":-1.0,
"dnad_c":-1.0,
"gln-L_c":-1.0,
"glu-L_c":1.0,
"h2o_c":-1.0,
"h_c":1.0,
"nad_c":1.0,
"ppi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00007698",
"subsystem":"Nicotinate and nicotinamide metabolism",
"annotation":{
"ec-code":"6.3.5.1",
"kegg.reaction":"R00257",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00256",
"name":"L-Glutamine amidohydrolase",
"metabolites":{
"gln-L_c":-1.0,
"glu-L_c":1.0,
"h2o_c":-1.0,
"nh4_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00007480 or WBGene00008435 or WBGene00009271",
"subsystem":"Alanine, aspartate and glutamate metabolism",
"annotation":{
"ec-code":"3.5.1.2",
"kegg.reaction":"R00256",
"sbo":"SBO:0000176"
}
},
{
"id":"TCM5013",
"name":"Carnitine-acylcarnitine translocase (translocating fa15p0isocrn)",
"metabolites":{
"fa15p0isocrn_c":-1.0,
"fa15p0isocrn_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000996 or WBGene00008320",
"subsystem":"Carnitine shuttle",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM5012",
"name":"Carnitine-acylcarnitine translocase (translocating fa19c11crn)",
"metabolites":{
"fa19c11crn_c":-1.0,
"fa19c11crn_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000996 or WBGene00008320",
"subsystem":"Carnitine shuttle",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM5011",
"name":"Carnitine-acylcarnitine translocase (translocating fa17c9crn)",
"metabolites":{
"fa17c9crn_c":-1.0,
"fa17c9crn_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000996 or WBGene00008320",
"subsystem":"Carnitine shuttle",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM5010",
"name":"Carnitine-acylcarnitine translocase (translocating fa11c3crn)",
"metabolites":{
"fa11c3crn_c":-1.0,
"fa11c3crn_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000996 or WBGene00008320",
"subsystem":"Carnitine shuttle",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM5015",
"name":"Carnitine-acylcarnitine translocase (translocating fa9p0isocrn)",
"metabolites":{
"fa9p0isocrn_c":-1.0,
"fa9p0isocrn_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000996 or WBGene00008320",
"subsystem":"Carnitine shuttle",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM5014",
"name":"Carnitine-acylcarnitine translocase (translocating fa17p0isocrn)",
"metabolites":{
"fa17p0isocrn_c":-1.0,
"fa17p0isocrn_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000996 or WBGene00008320",
"subsystem":"Carnitine shuttle",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE0576",
"name":"Vaccenic acid transport",
"metabolites":{
"vacc_c":1.0,
"vacc_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM5018",
"name":"thiamine transport to mitochondria",
"metabolites":{
"thmpp_c":-1.0,
"thmpp_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RM02566",
"name":"p-Cumic alcohol:NADP+ oxidoreductase",
"metabolites":{
"betald_m":-1.0,
"glyb_m":1.0,
"h2o_m":-1.0,
"h_m":2.0,
"nadp_m":-1.0,
"nadph_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000115",
"subsystem":"Glycine, serine and threonine metabolism",
"annotation":{
"ec-code":"1.2.1.8",
"kegg.reaction":"R02566",
"sbo":"SBO:0000176"
}
},
{
"id":"RM02565",
"name":"p-Cumic alcohol:NADP+ oxidoreductase",
"metabolites":{
"betald_m":-1.0,
"glyb_m":1.0,
"h2o_m":-1.0,
"h_m":2.0,
"nad_m":-1.0,
"nadh_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000115",
"subsystem":"Glycine, serine and threonine metabolism",
"annotation":{
"ec-code":"1.2.1.8",
"kegg.reaction":"R02565",
"sbo":"SBO:0000176"
}
},
{
"id":"RM01859",
"name":"Propanoyl-CoA:carbon-dioxide ligase (ADP-forming)",
"metabolites":{
"adp_m":1.0,
"atp_m":-1.0,
"h_m":1.0,
"hco3_m":-1.0,
"mmcoa-S_m":1.0,
"pi_m":1.0,
"ppcoa_m":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00017864 and WBGene00018701",
"subsystem":"Valine, leucine and isoleucine degradation",
"annotation":{
"ec-code":"6.4.1.3",
"kegg.reaction":"R01859",
"sbo":"SBO:0000176"
}
},
{
"id":"RM00585",
"name":"L-Serine:pyruvate aminotransferase",
"metabolites":{
"ala-L_m":1.0,
"hpyr_m":1.0,
"pyr_m":-1.0,
"ser-L_m":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00011767",
"subsystem":"Glycine, serine and threonine metabolism",
"annotation":{
"ec-code":"2.6.1.51",
"kegg.reaction":"R00585",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00032",
"name":"beta-carotene 15,15'-monooxygenase",
"metabolites":{
"caro_c":-1.0,
"o2_c":-1.0,
"retinal_c":2.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00012914",
"subsystem":"Retinol metabolism",
"annotation":{
"ec-code":"1.14.99.36",
"kegg.reaction":"R00032",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01030",
"name":"sn-Glycero-3-phosphocholine glycerophosphohydrolase",
"metabolites":{
"chol_c":1.0,
"g3pc_c":-1.0,
"glyc3p_c":1.0,
"h2o_c":-1.0,
"h_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00020446 or WBGene00011929 or WBGene00022532",
"subsystem":"Glycerophospholipid metabolism",
"annotation":{
"ec-code":"3.1.4.46",
"kegg.reaction":"R01030",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01036",
"name":"Glycerol:NAD+ oxidoreductase",
"metabolites":{
"glyald_c":-1.0,
"glyc_c":1.0,
"h_c":-1.0,
"nad_c":1.0,
"nadh_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00012722",
"subsystem":"Glycerolipid metabolism",
"annotation":{
"ec-code":"1.1.1.21",
"kegg.reaction":"R01036",
"sbo":"SBO:0000176"
}
},
{
"id":"RC04025",
"name":"N-Acetylputrescine:oxygen oxidoreductase (deaminating) (flavin-containing)",
"metabolites":{
"aprut_c":-1.0,
"h2o2_c":1.0,
"h2o_c":-1.0,
"n4abutn_c":1.0,
"nh4_c":1.0,
"o2_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000138",
"subsystem":"Arginine and proline metabolism",
"annotation":{
"ec-code":"1.4.3.4",
"kegg.reaction":"R04025",
"sbo":"SBO:0000176"
}
},
{
"id":"TCM1039",
"name":"Pantetheine 4'-phosphate transport",
"metabolites":{
"pan4p_c":-1.0,
"pan4p_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC03858",
"name":"Lauroyl-CoA:acetyl-CoA C-acyltransferase",
"metabolites":{
"3otdcoa_c":-1.0,
"accoa_c":1.0,
"coa_c":-1.0,
"ddcacoa_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00013284",
"subsystem":"Peroxisomal fatty acid beta oxidation",
"annotation":{
"ec-code":"2.3.1.16",
"kegg.reaction":"R03858",
"sbo":"SBO:0000176"
}
},
{
"id":"TCM1031",
"name":"Ammonium transport",
"metabolites":{
"nh4_c":-1.0,
"nh4_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM1033",
"name":"4-Hydroxybenzoate transport",
"metabolites":{
"4hbz_c":-1.0,
"4hbz_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM1035",
"name":"5-Methyltetrahydrofolate transport",
"metabolites":{
"5mthf_c":-1.0,
"5mthf_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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}
},
{
"id":"TCM1034",
"name":"3-Methyl-2-oxobutanoate transport",
"metabolites":{
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"3mob_m":1.0
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"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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}
},
{
"id":"TCM1037",
"name":"3-(4-Hydroxyphenyl)pyruvate transport",
"metabolites":{
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"34hpp_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RCC0180",
"name":"Peptide-L-aspartate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)",
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"akg_c":-1.0,
"co2_c":1.0,
"o2_c":-1.0,
"pepasn3oh_c":1.0,
"pepasn_c":-1.0,
"succ_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00010703",
"subsystem":"Protein modification by hydroxylation",
"annotation":{
"ec-code":"1.14.11.16",
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0181",
"name":"Selenocysteine:tRNASec ligase (AMP-forming)",
"metabolites":{
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"atp_c":-1.0,
"ppi_c":1.0,
"sectrna_c":1.0,
"selcys_c":-1.0,
"trnasec_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00005663",
"subsystem":"Aminoacyl-tRNA biosynthesis",
"annotation":{
"ec-code":"6.1.1.11",
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0185",
"name":"(2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase (adding 7 isopentenyl units)",
"metabolites":{
"frdp_c":-1.0,
"ipdp_c":-6.0,
"nonadp_c":1.0,
"ppi_c":6.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000761",
"subsystem":"Terpenoid backbone biosynthesis",
"annotation":{
"ec-code":"2.5.1.91",
"kegg.reaction":"R09249",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01724",
"name":"Nicotinate D-ribonucleotide:diphosphate phosphoribosyltransferase",
"metabolites":{
"h_c":-1.0,
"nac_c":-1.0,
"nicrnt_c":1.0,
"ppi_c":1.0,
"prpp_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00021882",
"subsystem":"Nicotinate and nicotinamide metabolism",
"annotation":{
"ec-code":"6.3.4.21",
"kegg.reaction":"R01724",
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0165",
"name":"Palmitoyl-CoA oxidase",
"metabolites":{
"h2o2_c":1.0,
"hdd2coa_c":1.0,
"o2_c":-1.0,
"pmtcoa_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00008167 or WBGene00008564 or WBGene00008565 or WBGene00008566 or WBGene00008567 or WBGene00019060 or WBGene00010336",
"subsystem":"Peroxisomal fatty acid beta oxidation",
"annotation":{
"ec-code":"1.3.3.6",
"kegg.reaction":"R00388",
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0166",
"name":"Tetradecanoyl-CoA oxidase",
"metabolites":{
"h2o2_c":1.0,
"o2_c":-1.0,
"td2coa_c":1.0,
"tdcoa_c":-1.0
},
"lower_bound":-0.0,
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"gene_reaction_rule":"WBGene00008167 or WBGene00008564 or WBGene00008565 or WBGene00008566 or WBGene00008567 or WBGene00019060 or WBGene00010336",
"subsystem":"Peroxisomal fatty acid beta oxidation",
"annotation":{
"ec-code":"1.3.3.6",
"kegg.reaction":"R00388",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00102",
"name":"NAD nucleosidase",
"metabolites":{
"adprib_c":1.0,
"h2o_c":-1.0,
"h_c":1.0,
"nad_c":-1.0,
"ncam_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00004800 or WBGene00004801 or WBGene00004802 or WBGene00004803",
"subsystem":"Nicotinate and nicotinamide metabolism",
"annotation":{
"ec-code":"3.5.1.-",
"kegg.reaction":"R00102",
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0162",
"name":"3-mercaptolactate:cysteine reductase",
"metabolites":{
"cys-L_c":-1.0,
"h_c":1.0,
"mercplac_c":-1.0,
"mercplaccys_c":1.0,
"nad_c":-1.0,
"nadh_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Cysteine and methionine metabolism",
"annotation":{
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0163",
"name":"O-acetyl-ADP-ribose deacetylase",
"metabolites":{
"ac_adprib_c":-1.0,
"ac_c":1.0,
"adprib_c":1.0,
"h2o_c":-1.0,
"h_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Protein modification",
"annotation":{
"sbo":"SBO:0000176"
}
},
{
"id":"EX00219",
"name":"arachidonic acid exchange",
"metabolites":{
"arachd_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RCC0168",
"name":"Decanoyl-CoA oxidase",
"metabolites":{
"dc2coa_c":1.0,
"dcacoa_c":-1.0,
"h2o2_c":1.0,
"o2_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00008167 or WBGene00008564 or WBGene00008565 or WBGene00008566 or WBGene00008567 or WBGene00019060 or WBGene00010336",
"subsystem":"Peroxisomal fatty acid beta oxidation",
"annotation":{
"ec-code":"1.3.3.6",
"kegg.reaction":"R00388",
"sbo":"SBO:0000176"
}
},
{
"id":"TCM1104",
"name":"Dihydroneopterin transport",
"metabolites":{
"dhnpt_c":-1.0,
"dhnpt_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM1101",
"name":"CMP transport",
"metabolites":{
"cmp_c":-1.0,
"cmp_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM1102",
"name":"D-Erythrose 4-phosphate transport",
"metabolites":{
"e4p_c":-1.0,
"e4p_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC01483",
"name":"uronolactonase",
"metabolites":{
"glac_c":1.0,
"glcur_c":-1.0,
"h2o_c":1.0,
"h_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Ascorbate and aldarate metabolism",
"annotation":{
"ec-code":"3.1.1.19",
"kegg.reaction":"R01483",
"sbo":"SBO:0000176"
}
},
{
"id":"TCM1109",
"name":"4-Hydroxy-2-oxoglutarate transport",
"metabolites":{
"4h2oglt_c":-1.0,
"4h2oglt_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC10065",
"name":"ATP:1D-myo-inositol-1,4,5-trisphosphate 3,6-phosphotransferase",
"metabolites":{
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"atp_c":-2.0,
"h_c":2.0,
"mi13456p_c":1.0,
"mi145p_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00014081",
"subsystem":"Inositol phosphate metabolism",
"annotation":{
"ec-code":"2.7.1.151",
"kegg.reaction":"R10065",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE5359",
"name":"4-Methyl-2-oxopentanoate transport",
"metabolites":{
"4mop_c":1.0,
"4mop_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"EX00014",
"name":"Ammonium exchange",
"metabolites":{
"nh4_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00853",
"name":"cobalamin exchange/defecation",
"metabolites":{
"cbl1_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"TCM0187",
"name":"dUDP and ATP transport",
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"atp_c":1.0,
"atp_m":-1.0,
"dudp_c":-1.0,
"dudp_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC08734",
"name":"alpha-methylacyl-CoA racemase",
"metabolites":{
"cholcoar_c":-1.0,
"cholcoas_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00016034 or WBGene00014128",
"subsystem":"Primary bile acid biosynthesis",
"annotation":{
"ec-code":"5.1.99.4",
"kegg.reaction":"R08734",
"sbo":"SBO:0000176"
}
},
{
"id":"RC08735",
"name":"Branched-chain acyl-CoA oxidase",
"metabolites":{
"cholcoads_c":1.0,
"cholcoas_c":-1.0,
"h2o2_c":1.0,
"o2_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00008564 or WBGene00008565 or WBGene00008566  or WBGene00008567  or WBGene00010336  or WBGene00008167",
"subsystem":"Primary bile acid biosynthesis",
"annotation":{
"ec-code":"1.17.99.3",
"kegg.reaction":"R08735",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01616",
"name":"4-Coumarate:CoA ligase (AMP-forming)",
"metabolites":{
"4cmcoa_c":1.0,
"T4hcinnm_c":-1.0,
"amp_c":1.0,
"atp_c":-1.0,
"coa_c":-1.0,
"ppi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00022849 or WBGene00008669",
"subsystem":"Ubiquinone and other terpenoid-quinone biosynthesis",
"annotation":{
"ec-code":"6.2.1.12",
"kegg.reaction":"R01616",
"sbo":"SBO:0000176"
}
},
{
"id":"RC08733",
"name":"bile acid CoA ligase",
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"amp_c":1.0,
"atp_c":-1.0,
"cholcoar_c":1.0,
"coa_c":-1.0,
"ppi_c":1.0,
"thcholstoic_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00009218 or WBGene00017012",
"subsystem":"Primary bile acid biosynthesis",
"annotation":{
"ec-code":"6.2.1.7",
"kegg.reaction":"R08733",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE5355",
"name":"Urocanate transport",
"metabolites":{
"urcan_c":-1.0,
"urcan_e":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"EX00011",
"name":"CO2 exchange",
"metabolites":{
"co2_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"TCM0188",
"name":"dGDP and dCTP transport",
"metabolites":{
"dctp_c":-1.0,
"dctp_m":1.0,
"dgdp_c":1.0,
"dgdp_m":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM0189",
"name":"Uridine transport",
"metabolites":{
"uri_c":-1.0,
"uri_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC00748",
"name":"ethanolamine-phosphate phosphate-lyase (deaminating) (acetaldehyde-forming)",
"metabolites":{
"acald_c":1.0,
"ethamp_c":-1.0,
"h2o_c":-1.0,
"nh4_c":1.0,
"pi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00020139",
"subsystem":"Glycerophospholipid metabolism",
"annotation":{
"ec-code":"4.2.3.2",
"kegg.reaction":"R00748",
"sbo":"SBO:0000176"
}
},
{
"id":"EX00459",
"name":"dTTP exchange",
"metabolites":{
"dttp_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00329",
"name":"D-Glucosamine exchange",
"metabolites":{
"gam_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00328",
"name":"L-Kynurenine exchange",
"metabolites":{
"Lkynr_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00455",
"name":"NMN exchange",
"metabolites":{
"nmn_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00544",
"name":"Homogentisate exchange",
"metabolites":{
"hgentis_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00322",
"name":"2-Oxoadipate exchange",
"metabolites":{
"2oxoadp_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"TCE5351",
"name":"3-Ureidoisobutyrate transport",
"metabolites":{
"3uib_c":-1.0,
"3uib_e":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM0094",
"name":"L-Arginine transport",
"metabolites":{
"arg-L_c":-1.0,
"arg-L_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC01290",
"name":"L-serine hydro-lyase (adding homocysteine",
"metabolites":{
"cyst-L_c":1.0,
"h2o_c":1.0,
"hcys-L_c":-1.0,
"ser-L_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00013866 or WBGene00018783",
"subsystem":"Glycine, serine and threonine metabolism",
"annotation":{
"ec-code":"4.2.1.22",
"kegg.reaction":"R01290",
"sbo":"SBO:0000176"
}
},
{
"id":"TCM0095",
"name":"Hydrogen peroxide transport",
"metabolites":{
"h2o2_c":-1.0,
"h2o2_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM0097",
"name":"dUTP and dADP transport",
"metabolites":{
"dadp_c":1.0,
"dadp_m":-1.0,
"dutp_c":-1.0,
"dutp_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"EX00019",
"name":"S-Adenosyl-L-methionine exchange",
"metabolites":{
"amet_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"TCM0158",
"name":"Superoxide anion transport",
"metabolites":{
"o2s_c":-1.0,
"o2s_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC06983",
"name":"S-(hydroxymethyl)glutathione dehydrogenase",
"metabolites":{
"Sfglutth_c":1.0,
"h_c":1.0,
"hmgth_c":-1.0,
"nad_c":-1.0,
"nadh_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00019240",
"subsystem":"Methane metabolism",
"annotation":{
"ec-code":"1.1.1.284",
"kegg.reaction":"R06983",
"sbo":"SBO:0000176"
}
},
{
"id":"RC06982",
"name":"formaldehyde glutathione ligase (spontaneous)",
"metabolites":{
"fald_c":-1.0,
"gthrd_c":-1.0,
"hmgth_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Methane metabolism",
"annotation":{
"kegg.reaction":"R06982",
"sbo":"SBO:0000176"
}
},
{
"id":"TCM0093",
"name":"L-Lactate transport",
"metabolites":{
"lac-L_c":-1.0,
"lac-L_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"EX00018",
"name":"Pyridoxal 5'-phosphate exchange",
"metabolites":{
"pydx5p_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"TCM0072",
"name":"Acetoacetate transport",
"metabolites":{
"acac_c":-1.0,
"acac_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM0073",
"name":"Acetaldehyde transport",
"metabolites":{
"acald_c":1.0,
"acald_m":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM0070",
"name":"dTDP and dGTP transport",
"metabolites":{
"dgtp_c":-1.0,
"dgtp_m":1.0,
"dtdp_c":1.0,
"dtdp_m":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM0076",
"name":"dUDP and dGDP transport",
"metabolites":{
"dgdp_c":1.0,
"dgdp_m":-1.0,
"dudp_c":-1.0,
"dudp_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM0077",
"name":"Coenzyme A transport",
"metabolites":{
"coa_c":-1.0,
"coa_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM0075",
"name":"L-Aspartate and 3-Sulfino-L-alanine transport",
"metabolites":{
"3sala_c":1.0,
"3sala_m":-1.0,
"asp-L_c":-1.0,
"asp-L_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC09511",
"name":"protein-N6-methyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase",
"metabolites":{
"Nlys_c":1.0,
"Nmelys_c":-1.0,
"akg_c":-1.0,
"co2_c":1.0,
"fald_c":1.0,
"o2_c":-1.0,
"succ_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00020821",
"subsystem":"Histone modification",
"annotation":{
"ec-code":"1.14.11.27",
"kegg.reaction":"R09511",
"sbo":"SBO:0000176"
}
},
{
"id":"RC09510",
"name":"protein-N6,N6-dimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase",
"metabolites":{
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"Nmelys_c":1.0,
"akg_c":-1.0,
"co2_c":1.0,
"fald_c":1.0,
"o2_c":-1.0,
"succ_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00020821",
"subsystem":"Histone modification",
"annotation":{
"ec-code":"1.14.11.27",
"kegg.reaction":"R09510",
"sbo":"SBO:0000176"
}
},
{
"id":"TCM0078",
"name":"Phosphatidylethanolamine (bacteria) transport",
"metabolites":{
"pe_BAC_c":-1.0,
"pe_BAC_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM0079",
"name":"dADP and ATP transport",
"metabolites":{
"atp_c":1.0,
"atp_m":-1.0,
"dadp_c":-1.0,
"dadp_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC01500",
"name":"UDP-alpha-D-galactose:N-acylsphingosine D-galactosyltransferase",
"metabolites":{
"crm_ce_c":-1.0,
"galside_ce_c":1.0,
"h_c":1.0,
"udp_c":1.0,
"udpgal_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Sphingolipid metabolism",
"annotation":{
"ec-code":"2.7.1.47",
"kegg.reaction":"R01500",
"sbo":"SBO:0000176"
}
},
{
"id":"EX00506",
"name":"L-Cysteate exchange",
"metabolites":{
"Lcyst_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00033",
"name":"Acetate exchange",
"metabolites":{
"ac_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00032",
"name":"Protoheme exchange",
"metabolites":{
"pheme_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00031",
"name":"D-Glucose exchange",
"metabolites":{
"glc-D_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00037",
"name":"Glycine exchange",
"metabolites":{
"gly_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00526",
"name":"Deoxyuridine exchange",
"metabolites":{
"duri_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"TCE0706",
"name":"Acetoacetate transport",
"metabolites":{
"acac_c":1.0,
"acac_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE0707",
"name":"Cholate transport",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"cholate_c":-1.0,
"cholate_e":1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE0709",
"name":"5-Formyltetrahydrofolate and hydroxide ion transport",
"metabolites":{
"5fthf_c":1.0,
"5fthf_e":-1.0,
"oh1_c":-1.0,
"oh1_e":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC04903",
"name":"5-Hydroxyindoleacetaldehyde:NAD+ oxidoreductase",
"metabolites":{
"5hoxindact_c":-1.0,
"5hoxindoa_c":1.0,
"h2o_c":-1.0,
"h_c":2.0,
"nad_c":-1.0,
"nadh_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00000108 or WBGene00000110) or (WBGene00000117 or WBGene00000118)",
"subsystem":"Tryptophan metabolism",
"annotation":{
"ec-code":"1.2.1.3",
"kegg.reaction":"R04903",
"sbo":"SBO:0000176"
}
},
{
"id":"RM00115",
"name":"glutathione:NADP+ oxidoreductase",
"metabolites":{
"gthox_m":-1.0,
"gthrd_m":2.0,
"h_m":-1.0,
"nadp_m":1.0,
"nadph_m":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00014028",
"subsystem":"Glutathione metabolism",
"annotation":{
"ec-code":"1.8.1.7",
"kegg.reaction":"R00115",
"sbo":"SBO:0000176"
}
},
{
"id":"RM00112",
"name":"NADPH:NAD+ oxidoreductase",
"metabolites":{
"nad_m":1.0,
"nadh_m":-1.0,
"nadp_m":-1.0,
"nadph_m":1.0
},
"lower_bound":0.0,
"upper_bound":0.0,
"gene_reaction_rule":"WBGene00003778",
"subsystem":"Nicotinate and nicotinamide metabolism",
"annotation":{
"ec-code":"1.6.1.2",
"kegg.reaction":"R00112",
"sbo":"SBO:0000176"
}
},
{
"id":"EX00147",
"name":"Adenine exchange",
"metabolites":{
"ade_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"TCE1148",
"name":"Oxidized glutathione transport",
"metabolites":{
"gthox_c":1.0,
"gthox_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"EX01328",
"name":"hydroxide ion exchange",
"metabolites":{
"oh1_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00141",
"name":"3-Methyl-2-oxobutanoate exchange",
"metabolites":{
"3mob_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00140",
"name":"N-acetylglucosamine uptake",
"metabolites":{
"acgam_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"TCE1143",
"name":"potassium transport",
"metabolites":{
"k_c":1.0,
"k_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"EX00149",
"name":"L-Malate exchange",
"metabolites":{
"mal-L_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00148",
"name":"L-Proline exchange",
"metabolites":{
"pro-L_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"TCE5398",
"name":"Sphinganine transport",
"metabolites":{
"sphgn_ce_c":1.0,
"sphgn_ce_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE5399",
"name":"Sphingosine transport",
"metabolites":{
"sphings_ce_c":-1.0,
"sphings_ce_e":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"EX05512",
"name":"Deoxyinosine exchange",
"metabolites":{
"din_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"TCE5390",
"name":"w-hydroxyl leukotriene B4 secretion",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"leuktrB4woh_c":-1.0,
"leuktrB4woh_e":1.0,
"pi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE5391",
"name":"monoacylglycerol 2  transport",
"metabolites":{
"mag_c":1.0,
"mag_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE5392",
"name":"Leukotriene B4 transport",
"metabolites":{
"leuktrB4_c":1.0,
"leuktrB4_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE5393",
"name":"5-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoate transport",
"metabolites":{
"5HPET_c":-1.0,
"5HPET_e":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE5394",
"name":"Leukotriene A4 transport",
"metabolites":{
"leuktrA4_c":1.0,
"leuktrA4_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE5395",
"name":"R total 2 position transport",
"metabolites":{
"Rtotal2_c":1.0,
"Rtotal2_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE5396",
"name":"R total transport",
"metabolites":{
"Rtotal_c":1.0,
"Rtotal_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE5397",
"name":"gamma-L-Glutamyl-L-cysteine secretion",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"glucys_c":-1.0,
"glucys_e":1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC05985",
"name":"alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase",
"metabolites":{
"h_c":1.0,
"n2m2masn_c":1.0,
"nm2masn_c":-1.0,
"uacgam_c":-1.0,
"udp_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00001645",
"subsystem":"N-Glycan biosynthesis",
"annotation":{
"ec-code":"2.4.1.143",
"kegg.reaction":"R05985",
"sbo":"SBO:0000176"
}
},
{
"id":"RC05982",
"name":"mannosyl-oligosaccharide 1,2-alpha-mannosidase",
"metabolites":{
"h2o_c":-4.0,
"m4masn_c":1.0,
"m8masn_c":-1.0,
"man_c":4.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00008411 or WBGene00008258 or WBGene00020197 or WBGene00013881",
"subsystem":"N-Glycan biosynthesis",
"annotation":{
"ec-code":"3.2.1.113",
"kegg.reaction":"R05982",
"sbo":"SBO:0000176"
}
},
{
"id":"RC05983",
"name":"alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase",
"metabolites":{
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"m4masn_c":-1.0,
"nm4masn_c":1.0,
"uacgam_c":-1.0,
"udp_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00001637 or WBGene00001638 or WBGene00001639",
"subsystem":"N-Glycan biosynthesis",
"annotation":{
"ec-code":"2.4.1.101",
"kegg.reaction":"R05983",
"sbo":"SBO:0000176"
}
},
{
"id":"RC05980",
"name":"glucan 1,3-alpha-glucosidase (acting on g2m8masn)",
"metabolites":{
"g1m8masn_c":1.0,
"g2m8masn_c":-1.0,
"glc-D_c":1.0,
"h2o_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00009583 or WBGene00018682",
"subsystem":"N-Glycan biosynthesis",
"annotation":{
"ec-code":"3.2.1.84",
"kegg.reaction":"R05980",
"sbo":"SBO:0000176"
}
},
{
"id":"RC05981",
"name":"glucan 1,3-alpha-glucosidase (acting on g1m8masn)",
"metabolites":{
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"glc-D_c":1.0,
"h2o_c":-1.0,
"m8masn_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00009583 or WBGene00018682",
"subsystem":"N-Glycan biosynthesis",
"annotation":{
"ec-code":"3.2.1.84",
"kegg.reaction":"R05981",
"sbo":"SBO:0000176"
}
},
{
"id":"RC05988",
"name":"glycoprotein 6-alpha-L-fucosyltransferase (acting on n2m2masn)",
"metabolites":{
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"gdp_c":1.0,
"gdpfuc_c":-1.0,
"h_c":1.0,
"n2m2masn_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00001508",
"subsystem":"N-Glycan biosynthesis",
"annotation":{
"ec-code":"2.4.1.68",
"kegg.reaction":"R05988",
"sbo":"SBO:0000176"
}
},
{
"id":"RC05989",
"name":"UDP-galactose:N-acetyl-beta-D-glucosaminylglycopeptide beta-1,4-galactosyltransferase",
"metabolites":{
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"h_c":2.0,
"l2fn2m2masn_c":1.0,
"udp_c":2.0,
"udpgal_c":-2.0
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000269",
"subsystem":"N-Glycan biosynthesis",
"annotation":{
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"kegg.reaction":"R05989",
"sbo":"SBO:0000176"
}
},
{
"id":"RC02088",
"name":"2-Deoxyadenosine 5-monophosphate phosphohydrolase",
"metabolites":{
"dad-2_c":1.0,
"damp_c":-1.0,
"h2o_c":-1.0,
"pi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00017775 or WBGene00012423 or WBGene00022201",
"subsystem":"Purine metabolism",
"annotation":{
"ec-code":"3.1.3.5",
"kegg.reaction":"R02088",
"sbo":"SBO:0000176"
}
},
{
"id":"RC02082",
"name":"(R)-Mevalonate:NADP+ oxidoreductase (CoA acylating)",
"metabolites":{
"coa_c":1.0,
"h_c":-2.0,
"hmgcoa_c":-1.0,
"mev-R_c":1.0,
"nadp_c":2.0,
"nadph_c":-2.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00017268",
"subsystem":"Terpenoid backbone biosynthesis",
"annotation":{
"ec-code":"1.1.1.34",
"kegg.reaction":"R02082",
"sbo":"SBO:0000176"
}
},
{
"id":"RC02080",
"name":"3,4-Dihydroxy-L-phenylalanine carboxy-lyase",
"metabolites":{
"34dhphe_c":-1.0,
"co2_c":1.0,
"dopa_c":1.0,
"h_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000239",
"subsystem":"Tyrosine metabolism",
"annotation":{
"ec-code":"4.1.1.28",
"kegg.reaction":"R02080",
"sbo":"SBO:0000176"
}
},
{
"id":"RM01220",
"name":"5,10-methylenetetrahydrofolate:NADP+ oxidoreductase",
"metabolites":{
"methf_m":1.0,
"mlthf_m":-1.0,
"nadp_m":-1.0,
"nadph_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00019492",
"subsystem":"One carbon pool by folate",
"annotation":{
"ec-code":"1.5.1.5",
"kegg.reaction":"R01220",
"sbo":"SBO:0000176"
}
},
{
"id":"RC02719",
"name":"Xanthosine 5-phosphate phosphohydrolase",
"metabolites":{
"h2o_c":-1.0,
"pi_c":1.0,
"xmp_c":-1.0,
"xtsn_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00017775 or WBGene00012423 or WBGene00022201",
"subsystem":"Purine metabolism",
"annotation":{
"ec-code":"3.1.3.5",
"kegg.reaction":"R02719",
"sbo":"SBO:0000176"
}
},
{
"id":"EX01921",
"name":"glycocholate exchange",
"metabolites":{
"gchola_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RC02245",
"name":"ATP:(R)-mevalonate 5-phosphotransferase",
"metabolites":{
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"adp_c":1.0,
"atp_c":-1.0,
"h_c":1.0,
"mev-R_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00021534",
"subsystem":"Terpenoid backbone biosynthesis",
"annotation":{
"ec-code":"2.7.1.36",
"kegg.reaction":"R02245",
"sbo":"SBO:0000176"
}
},
{
"id":"RC02240",
"name":"ATP:1,2-diacylglycerol 3-phosphotransferase (acting on phospholipid components)",
"metabolites":{
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"atp_c":-1.0,
"dag_pl_c":-1.0,
"h_c":1.0,
"pa_pl_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000958 or WBGene00000959 or WBGene00000960 or WBGene00006483 or WBGene00019428",
"subsystem":"Glycerolipid metabolism",
"annotation":{
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"kegg.reaction":"R02240",
"sbo":"SBO:0000176"
}
},
{
"id":"RC02241",
"name":"acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase (Rtotal2 group)",
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"alpa_pl_c":-1.0,
"coa_c":1.0,
"pa_pl_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"((WBGene00020264 or WBGene00022646 or WBGene00044631) or (WBGene00010339 or WBGene00011543) or (WBGene00016934 or WBGene00007446)) or WBGene00017888",
"subsystem":"Glycerolipid metabolism",
"annotation":{
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"kegg.reaction":"R02241",
"sbo":"SBO:0000176"
}
},
{
"id":"RC07760",
"name":"3-hydroxyacyl-CoA dehydratase 2",
"metabolites":{
"3hodcoa_c":-1.0,
"h2o_c":1.0,
"od2coa_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00020517",
"subsystem":"Fatty acid elongation",
"annotation":{
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"kegg.reaction":"R07760",
"sbo":"SBO:0000176"
}
},
{
"id":"RC07761",
"name":" very-long-chain enoyl-CoA reductase",
"metabolites":{
"h_c":-1.0,
"nadp_c":1.0,
"nadph_c":-1.0,
"od2coa_c":-1.0,
"stcoa_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000198",
"subsystem":"Fatty acid elongation",
"annotation":{
"ec-code":"1.3.1.93",
"kegg.reaction":"R07761",
"sbo":"SBO:0000176"
}
},
{
"id":"RC03599",
"name":"L-selenocysteine selenide-lyase (L-alanine-forming)",
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"h_c":1.0,
"pdx5p_c":-1.0,
"pydx5p_c":1.0,
"selcys_c":-1.0,
"seln_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00017442",
"subsystem":"Selenocompound metabolism",
"annotation":{
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"kegg.reaction":"R03599",
"sbo":"SBO:0000176"
}
},
{
"id":"RC02061",
"name":"geranylgeranyl diphosphate synthase",
"metabolites":{
"frdp_c":-1.0,
"ipdp_c":-1.0,
"ppi_c":1.0,
"ttc-ggdp_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000761 or WBGene00011058",
"subsystem":"Terpenoid backbone biosynthesis",
"annotation":{
"ec-code":"2.5.1.29",
"kegg.reaction":"R02061",
"sbo":"SBO:0000176"
}
},
{
"id":"RM00935",
"name":"(S)-Methylmalonate semialdehyde:NAD+ oxidoreductase (CoA-propanoylating)",
"metabolites":{
"2mop_m":-1.0,
"co2_m":1.0,
"coa_m":-1.0,
"nad_m":-1.0,
"nadh_m":1.0,
"ppcoa_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000114",
"subsystem":"Valine, leucine and isoleucine degradation",
"annotation":{
"ec-code":"1.2.1.27",
"kegg.reaction":"R00935",
"sbo":"SBO:0000176"
}
},
{
"id":"RC03596",
"name":"Hydrogen selenide:NADP+ oxidoreductase",
"metabolites":{
"h2o_c":-3.0,
"h_c":4.0,
"nadp_c":-3.0,
"nadph_c":3.0,
"seln_c":-1.0,
"selnt_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00015553",
"subsystem":"Selenocompound metabolism",
"annotation":{
"ec-code":"1.8.1.9",
"kegg.reaction":"R03596",
"sbo":"SBO:0000176"
}
},
{
"id":"RC03595",
"name":"ATP:selenide, water phosphotransferase",
"metabolites":{
"amp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"pi_c":1.0,
"seln_c":-1.0,
"selnp_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00012867",
"subsystem":"Selenocompound metabolism",
"annotation":{
"ec-code":"2.7.9.3",
"kegg.reaction":"R03595",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE5380",
"name":"Hexanoyl-CoA (n-C6:0CoA) transport",
"metabolites":{
"hxcoa_c":-1.0,
"hxcoa_e":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RMC0184",
"name":"NADH:rhodoquinone oxidoreductase",
"metabolites":{
"h_c":4.0,
"h_m":-5.0,
"nad_m":1.0,
"nadh_m":-1.0,
"rq9_m":-1.0,
"rq9h2_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00010959 and WBGene00010961 and WBGene00010966 and WBGene00010963 and WBGene00010967 and WBGene00010957 and WBGene00010958) and (WBGene00009992 and (WBGene00001520 or WBGene00006463) and WBGene00020417 and WBGene00003831 and WBGene00021562 and WBGene00012376 and WBGene00020636 and WBGene00003061 and WBGene00021839 and WBGene00009051) and (WBGene00009294 and WBGene00013406 and WBGene00007880 and WBGene00013308 and WBGene00009740 and WBGene00021849 and WBGene00021800 and WBGene00019401 and (WBGene00018151 or WBGene00013237) and WBGene00016393) and (WBGene00009712 and WBGene00007684 and WBGene00012166 and WBGene00016118 and WBGene00014086 and WBGene00008414 and WBGene00013094 and WBGene00015810 and WBGene00010326 and WBGene00022169 and WBGene00018361)",
"subsystem":"Oxidative phosphorylation",
"annotation":{
"ec-code":[
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"1.6.99.3"
],
"kegg.reaction":"R00281",
"sbo":"SBO:0000176"
}
},
{
"id":"RMC0187",
"name":"Uncoupling ATP synthesis from electron transport",
"metabolites":{
"h_c":-1.0,
"h_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00006729",
"subsystem":"Oxidative phosphorylation",
"annotation":{
"sbo":"SBO:0000176"
}
},
{
"id":"RMC0182",
"name":"rhodoquinone-9 biosynthesis",
"metabolites":{
"co2_m":1.0,
"h2o_m":-1.0,
"h_m":4.0,
"nad_m":-3.0,
"nadh_m":3.0,
"nh4_m":-1.0,
"q9_m":-1.0,
"rq9_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Ubiquinone and other terpenoid-quinone biosynthesis",
"annotation":{
"sbo":"SBO:0000176"
}
},
{
"id":"RMC0183",
"name":"fumarate reductase",
"metabolites":{
"fum_m":-1.0,
"rq9_m":1.0,
"rq9h2_m":-1.0,
"succ_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00018610",
"subsystem":"Citrate cycle (TCA cycle)",
"annotation":{
"ec-code":"1.3.5.4",
"kegg.reaction":"R02164",
"sbo":"SBO:0000176"
}
},
{
"id":"RC03445",
"name":"4-(2-Aminophenyl)-2,4-dioxobutanoate dehydratase",
"metabolites":{
"4aphdob_c":-1.0,
"h2o_c":1.0,
"kynate_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Tryptophan metabolism",
"annotation":{
"kegg.reaction":"R03445",
"sbo":"SBO:0000176"
}
},
{
"id":"RM01082",
"name":"(S)-malate hydro-lyase (fumarate-forming)",
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"h2o_m":1.0,
"mal-L_m":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00001503",
"subsystem":"Citrate cycle (TCA cycle)",
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"ec-code":"4.2.1.2",
"kegg.reaction":"R01082",
"sbo":"SBO:0000176"
}
},
{
"id":"RM00842",
"name":"sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase",
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"h_m":-1.0,
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"nadh_m":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00010778",
"subsystem":"Glycerophospholipid metabolism",
"annotation":{
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"kegg.reaction":"R00842",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE0521",
"name":"L-Tyrosine transport",
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"tyr-L_c":1.0,
"tyr-L_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE5004",
"name":"cobalamin transport into cytosol",
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"adp_c":1.0,
"atp_c":-1.0,
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"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Vitamin B12 metabolism",
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"sbo":"SBO:0000185"
}
},
{
"id":"TCE5005",
"name":"adenosylcobalamin transport into cytosol",
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"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Vitamin B12 metabolism",
"annotation":{
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}
},
{
"id":"TCE5006",
"name":"heme transport into intestine",
"metabolites":{
"pheme_c":1.0,
"pheme_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00019830 or WBGene00009493",
"subsystem":"Iron metabolism",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE5007",
"name":"beta cyanoalanine transport to and from cytosol",
"metabolites":{
"cyanala_c":1.0,
"cyanala_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Cyanoamino acid metabolism",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC00801",
"name":"sucrose glucohydrolase",
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"fru_c":1.0,
"glc-D_c":1.0,
"h2o_c":-1.0,
"sucr_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00017071 or WBGene00019895",
"subsystem":"Galactose metabolism",
"annotation":{
"ec-code":"3.2.1.20",
"kegg.reaction":"R00801",
"sbo":"SBO:0000176"
}
},
{
"id":"RM02199",
"name":"L-Isoleucine:2-oxoglutarate aminotransferase",
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"3mop_m":1.0,
"akg_m":-1.0,
"glu-L_m":1.0,
"ile-L_m":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00001149 or WBGene00012855",
"subsystem":"Valine, leucine and isoleucine degradation",
"annotation":{
"ec-code":"2.6.1.42",
"kegg.reaction":"R02199",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE0457",
"name":"Bicarbonate and Chloride transport",
"metabolites":{
"cl_c":2.0,
"cl_e":-2.0,
"hco3_c":-1.0,
"hco3_e":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RM04433",
"name":"Electron-transferring-flavoprotein:ubiquinone oxidoreductase",
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"etfox_m":1.0,
"etfrd_m":-1.0,
"q_m":-1.0,
"qh2_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00002855 and (WBGene00009187 and WBGene00017734)",
"subsystem":"Miscellaneous",
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"kegg.reaction":"R04433",
"sbo":"SBO:0000176"
}
},
{
"id":"RM04432",
"name":"Propanoyl-CoA:(acceptor) 2,3-oxidoreductase",
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"etfox_m":-1.0,
"etfrd_m":1.0,
"ppcoa_m":-1.0,
"prpncoa_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00016943",
"subsystem":"Propanoate metabolism",
"annotation":{
"ec-code":"1.3.8.1",
"kegg.reaction":"R04432",
"sbo":"SBO:0000176"
}
},
{
"id":"RC07296",
"name":"choloyl-CoA hydrolase",
"metabolites":{
"cholate_c":1.0,
"cholcoa_c":-1.0,
"coa_c":1.0,
"h2o_c":-1.0,
"h_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00017781",
"subsystem":"Primary bile acid biosynthesis",
"annotation":{
"ec-code":"3.1.2.27",
"kegg.reaction":"R07296",
"sbo":"SBO:0000176"
}
},
{
"id":"RC02665",
"name":"3-Hydroxyanthranilate:oxygen 3,4-oxidoreductase (decyclizing)",
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"3hanthrn_c":-1.0,
"cmusa_c":1.0,
"h_c":1.0,
"o2_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00010595",
"subsystem":"Tryptophan metabolism",
"annotation":{
"ec-code":"1.13.11.6",
"kegg.reaction":"R02665",
"sbo":"SBO:0000176"
}
},
{
"id":"RC07299",
"name":"1-phosphatidyl-1D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase",
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"h2o_c":-1.0,
"pail34p_c":-1.0,
"pail3p_c":1.0,
"pi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00010975",
"subsystem":"Inositol phosphate metabolism",
"annotation":{
"ec-code":"3.1.3.66",
"kegg.reaction":"R07299",
"sbo":"SBO:0000176"
}
},
{
"id":"RC02668",
"name":"3-Hydroxy-L-kynurenine hydrolase",
"metabolites":{
"3hanthrn_c":1.0,
"ala-L_c":1.0,
"h2o_c":-1.0,
"hLkynr_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00015802",
"subsystem":"Tryptophan metabolism",
"annotation":{
"ec-code":"3.7.1.3",
"kegg.reaction":"R02668",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01687",
"name":"(5-L-glutamyl)-peptide:taurine 5-glutamyltransferase",
"metabolites":{
"cgly_c":1.0,
"glutaur_c":1.0,
"gthrd_c":-1.0,
"taur_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00016906 or WBGene00019204 or WBGene00011393 or WBGene00020590 or WBGene00012416 or WBGene00022397",
"subsystem":"Taurine and hypotaurine metabolism",
"annotation":{
"ec-code":"2.3.2.2",
"kegg.reaction":"R01687",
"sbo":"SBO:0000176"
}
},
{
"id":"RM00667",
"name":"L-Ornithine:2-oxo-acid aminotransferase",
"metabolites":{
"akg_m":-1.0,
"glu-L_m":1.0,
"glu5sa_m":1.0,
"orn_m":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00015814",
"subsystem":"Arginine and proline metabolism",
"annotation":{
"ec-code":"2.6.1.13",
"kegg.reaction":"R00667",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE1122",
"name":"L-Glutamine transport",
"metabolites":{
"gln-L_c":1.0,
"gln-L_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"EX04230",
"name":"Lysophosphatidylcholine exchange",
"metabolites":{
"lpchol_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"TCE0559",
"name":"glycocholate transport",
"metabolites":{
"gchola_c":1.0,
"gchola_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE0558",
"name":"Cys-Gly transport",
"metabolites":{
"cgly_c":1.0,
"cgly_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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}
},
{
"id":"TCE1127",
"name":"Sulfate transport",
"metabolites":{
"so4_c":1.0,
"so4_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC04231",
"name":"(R)-4-Phosphopantothenate:L-cysteine ligase (CTP-dependent)",
"metabolites":{
"4ppan_c":-1.0,
"4ppcys_c":1.0,
"cmp_c":1.0,
"ctp_c":-1.0,
"cys-L_c":-1.0,
"h_c":1.0,
"ppi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00022171",
"subsystem":"Pantothenate and CoA biosynthesis",
"annotation":{
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"kegg.reaction":"R04231",
"sbo":"SBO:0000176"
}
},
{
"id":"RC04230",
"name":"(R)-4-Phosphopantothenate:L-cysteine ligase (ATP-dependent)",
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"4ppcys_c":1.0,
"amp_c":1.0,
"atp_c":-1.0,
"cys-L_c":-1.0,
"h_c":1.0,
"ppi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00022171",
"subsystem":"Pantothenate and CoA biosynthesis",
"annotation":{
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"kegg.reaction":"R04230",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00100",
"name":"NADH:ferricytochrome-b5 oxidoreductase",
"metabolites":{
"ficytb_c":-2.0,
"focytb_c":2.0,
"h_c":-1.0,
"nad_c":1.0,
"nadh_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00020267 or WBGene00020268)",
"subsystem":"Miscellaneous",
"annotation":{
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"kegg.reaction":"R00100",
"sbo":"SBO:0000176"
}
},
{
"id":"RC08223",
"name":"L-seryl-tRNA(Sec) kinase",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"serptrna_c":1.0,
"sertrna_sec_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00013041",
"subsystem":"Selenocompound metabolism",
"annotation":{
"ec-code":"2.7.1.164",
"kegg.reaction":"R08223",
"sbo":"SBO:0000176"
}
},
{
"id":"RC08224",
"name":"selenophosphate:O-phospho-L-seryl-tRNA(Sec) selenium transferase",
"metabolites":{
"h_c":1.0,
"ppi_c":1.0,
"sectrna_c":1.0,
"selnp_c":-1.0,
"serptrna_c":-1.0
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"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00008379",
"subsystem":"Selenocompound metabolism",
"annotation":{
"ec-code":"2.9.1.2",
"kegg.reaction":"R08224",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00103",
"name":"NAD+ phosphohydrolase",
"metabolites":{
"amp_c":1.0,
"h2o_c":-1.0,
"h_c":2.0,
"nad_c":-1.0,
"nmn_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00007753 or WBGene00007755",
"subsystem":"Nicotinate and nicotinamide metabolism",
"annotation":{
"ec-code":"3.6.1.9",
"kegg.reaction":"R00103",
"sbo":"SBO:0000176"
}
},
{
"id":"TCM5001",
"name":"Carnitine-acylcarnitine translocase (translocating pmtcrn)",
"metabolites":{
"pmtcrn_c":-1.0,
"pmtcrn_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000996 or WBGene00008320",
"subsystem":"Carnitine shuttle",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM5002",
"name":"Carnitine-acylcarnitine translocase (translocating ttdcrn)",
"metabolites":{
"ttdcrn_c":-1.0,
"ttdcrn_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000996 or WBGene00008320",
"subsystem":"Carnitine shuttle",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM5003",
"name":"Carnitine-acylcarnitine translocase (translocating ddcrn)",
"metabolites":{
"ddcrn_c":-1.0,
"ddcrn_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000996 or WBGene00008320",
"subsystem":"Carnitine shuttle",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM5004",
"name":"Isovaleryl-CoA transport",
"metabolites":{
"ivcoa_c":-1.0,
"ivcoa_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM5005",
"name":"cobalamin transport into mitochondria",
"metabolites":{
"cbl1_c":-1.0,
"cbl1_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Vitamin B12 metabolism",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM5006",
"name":"adenosylcobalamin transport into mitochondria",
"metabolites":{
"adocbl_c":-1.0,
"adocbl_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Vitamin B12 metabolism",
"annotation":{
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}
},
{
"id":"TCM5007",
"name":"beta cyanoalanine transport to and from mitochondrion",
"metabolites":{
"cyanala_c":1.0,
"cyanala_m":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Cyanoamino acid metabolism",
"annotation":{
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}
},
{
"id":"TCM5008",
"name":"sulfide transport to and from mitochondrion",
"metabolites":{
"h2s_c":1.0,
"h2s_m":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Sulfur metabolism",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM5009",
"name":"Carnitine-acylcarnitine translocase (translocating fa16p1n7crn)",
"metabolites":{
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"fa16p1n7crn_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000996 or WBGene00008320",
"subsystem":"Carnitine shuttle",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC00936",
"name":"5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase",
"metabolites":{
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"h_c":-1.0,
"nad_c":1.0,
"nadh_c":-1.0,
"thf_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00007974",
"subsystem":"One carbon pool by folate",
"annotation":{
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"kegg.reaction":"R00936",
"sbo":"SBO:0000176"
}
},
{
"id":"DMN0082",
"name":"rhodoquinone demand",
"metabolites":{
"rq9_m":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Demand reactions",
"annotation":{
"sbo":"SBO:0000628"
}
},
{
"id":"DMN0083",
"name":"l2fn2m2masn demand",
"metabolites":{
"l2fn2m2masn_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"N-Glycan biosynthesis",
"annotation":{
"sbo":"SBO:0000628"
}
},
{
"id":"DMN0080",
"name":"cyclopropane fatty acid demand",
"metabolites":{
"coa_m":1.0,
"fa11c3coa_m":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Miscellaneous",
"annotation":{
"sbo":"SBO:0000628"
}
},
{
"id":"DMN0086",
"name":"vitamin B12 demand (cbl1 form)",
"metabolites":{
"cbl1_m":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Vitamin B12 metabolism",
"annotation":{
"sbo":"SBO:0000628"
}
},
{
"id":"DMN0084",
"name":"UDP-4-dehydro-6-deoxy-D-glucose demand",
"metabolites":{
"udpxyl_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Starch and sucrose metabolism",
"annotation":{
"sbo":"SBO:0000628"
}
},
{
"id":"DMN0085",
"name":"UDP-D-xylose demand",
"metabolites":{
"udp4k6dg_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Amino sugar and nucleotide sugar metabolism",
"annotation":{
"sbo":"SBO:0000628"
}
},
{
"id":"RC00028",
"name":"maltose glucohydrolase",
"metabolites":{
"glc-D-A_c":2.0,
"h2o_c":-1.0,
"malt_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00017071 or WBGene00019895",
"subsystem":"Starch and sucrose metabolism",
"annotation":{
"ec-code":"3.2.1.20",
"kegg.reaction":"R00028",
"sbo":"SBO:0000176"
}
},
{
"id":"EX00214",
"name":"Thymidine exchange",
"metabolites":{
"thymd_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"TCM1027",
"name":"\"3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate\" transport",
"metabolites":{
"thcholstoic_c":1.0,
"thcholstoic_m":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"EX00350",
"name":"Phosphatidylethanolamine exchange",
"metabolites":{
"pe_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RC01998",
"name":"long-chain-alcohol:NAD+ oxidoreductase",
"metabolites":{
"Rtotal7_c":1.0,
"alkylR1oh_c":-1.0,
"h2o_c":-1.0,
"h_c":3.0,
"nad_c":-2.0,
"nadh_c":2.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00022200",
"subsystem":"Fatty acid metabolism",
"annotation":{
"ec-code":"1.1.1.192",
"kegg.reaction":"R01998",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01993",
"name":"(S)-dihydroorotate amidohydrolase",
"metabolites":{
"cbasp_c":1.0,
"dhor-S_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00004259",
"subsystem":"Pyrimidine metabolism",
"annotation":{
"ec-code":"3.5.2.3",
"kegg.reaction":"R01993",
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0005",
"name":"maintenance atp",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":1.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Maintenance",
"annotation":{
"sbo":"SBO:0000176"
}
},
{
"id":"RC00200",
"name":"ATP:pyruvate 2-O-phosphotransferase",
"metabolites":{
"adp_c":-1.0,
"atp_c":1.0,
"h_c":-1.0,
"pep_c":-1.0,
"pyr_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00009126 or WBGene00014001",
"subsystem":"Glycolysis / Gluconeogenesis",
"annotation":{
"ec-code":"2.7.1.40",
"kegg.reaction":"R00200",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01752",
"name":"D-Glyceraldehyde:NAD+ oxidoreductase",
"metabolites":{
"glyald_c":-1.0,
"glyc-R_c":1.0,
"h2o_c":-1.0,
"h_c":2.0,
"nad_c":-1.0,
"nadh_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00000108 or WBGene00000110) or (WBGene00000117 or WBGene00000118)",
"subsystem":"Glycerolipid metabolism",
"annotation":{
"ec-code":"1.2.1.3",
"kegg.reaction":"R01752",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01975",
"name":"(S)-3-Hydroxybutanoyl-CoA:NAD+ oxidoreductase",
"metabolites":{
"3hbcoa_c":1.0,
"aacoa_c":-1.0,
"h_c":-1.0,
"nad_c":1.0,
"nadh_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00010035 or WBGene00001157 or WBGene00001158 or WBGene00019978",
"subsystem":"Fatty acid metabolism",
"annotation":{
"ec-code":"1.1.1.35",
"kegg.reaction":"R01975",
"sbo":"SBO:0000176"
}
},
{
"id":"RM03026",
"name":"(S)-3-Hydroxybutanoyl-CoA hydro-lyase",
"metabolites":{
"3hbcoa_m":-1.0,
"b2coa_m":1.0,
"h2o_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00001155 or WBGene00001156) or (WBGene00020347 or WBGene00001150) or WBGene00001152",
"subsystem":"Fatty acid metabolism",
"annotation":{
"ec-code":"4.2.1.17",
"kegg.reaction":"R03026",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01759",
"name":"L-Arabitol:NADP+ 1-oxidoreductase",
"metabolites":{
"abt_c":1.0,
"arab-L_c":-1.0,
"h_c":-1.0,
"nadp_c":1.0,
"nadph_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00012722",
"subsystem":"Pentose and glucuronate interconversions",
"annotation":{
"ec-code":"1.1.1.21",
"kegg.reaction":"R01759",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01758",
"name":"L-Arabitol:NAD+ 1-oxidoreductase",
"metabolites":{
"abt_c":1.0,
"arab-L_c":-1.0,
"h_c":-1.0,
"nad_c":1.0,
"nadh_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00012722",
"subsystem":"Pentose and glucuronate interconversions",
"annotation":{
"ec-code":"1.1.1.21",
"kegg.reaction":"R01758",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01978",
"name":"acetyl-CoA:acetoacetyl-CoA C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)",
"metabolites":{
"aacoa_c":-1.0,
"accoa_c":-1.0,
"coa_c":1.0,
"h2o_c":-1.0,
"h_c":1.0,
"hmgcoa_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00017769",
"subsystem":"Synthesis and degradation of ketone bodies",
"annotation":{
"ec-code":"2.3.3.10",
"kegg.reaction":"R01978",
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0151",
"name":"fatty-acid--CoA ligase (Rtotal4)",
"metabolites":{
"Rtotal4_c":-1.0,
"Rtotal4coa_c":1.0,
"amp_c":1.0,
"atp_c":-1.0,
"coa_c":-1.0,
"ppi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00009221 or WBGene00020343 or WBGene00018152 or WBGene00013575 or WBGene00022037 or WBGene00019920 or WBGene00016716 or WBGene00011173",
"subsystem":"Fatty acid metabolism",
"annotation":{
"ec-code":"6.2.1.3",
"kegg.reaction":"R00390",
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0150",
"name":"fatty-acid--CoA ligase (Rtotal2)",
"metabolites":{
"Rtotal2_c":-1.0,
"Rtotal2coa_c":1.0,
"amp_c":1.0,
"atp_c":-1.0,
"coa_c":-1.0,
"ppi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00009221 or WBGene00020343 or WBGene00018152 or WBGene00013575 or WBGene00022037 or WBGene00019920 or WBGene00016716 or WBGene00011173",
"subsystem":"Fatty acid metabolism",
"annotation":{
"ec-code":"6.2.1.3",
"kegg.reaction":"R00390",
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0153",
"name":"Propionyl-CoA:carnitine O-propionyltransferase II",
"metabolites":{
"coa_c":1.0,
"crn_c":-1.0,
"pcrn_c":1.0,
"ppcoa_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00007175",
"subsystem":"Propanoate metabolism",
"annotation":{
"ec-code":"2.3.1.7",
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0152",
"name":"fatty-acid--CoA ligase (Rtotal5)",
"metabolites":{
"Rtotal5_c":-1.0,
"Rtotal5coa_c":1.0,
"amp_c":1.0,
"atp_c":-1.0,
"coa_c":-1.0,
"ppi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00009221 or WBGene00020343 or WBGene00018152 or WBGene00013575 or WBGene00022037 or WBGene00019920 or WBGene00016716 or WBGene00011173",
"subsystem":"Fatty acid metabolism",
"annotation":{
"ec-code":"6.2.1.3",
"kegg.reaction":"R00390",
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0157",
"name":"sepiapterin reductase",
"metabolites":{
"6pthp_c":-1.0,
"h_c":-2.0,
"nadp_c":2.0,
"nadph_c":-2.0,
"thbpt_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Folate biosynthesis",
"annotation":{
"ec-code":"1.1.1.153",
"kegg.reaction":[
"R04285",
"R01813"
],
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0156",
"name":"tyramine beta-monooxygenase",
"metabolites":{
"ascb-L_c":-1.0,
"dhdascb_c":1.0,
"h2o_c":1.0,
"o2_c":-1.0,
"octpmn_c":1.0,
"tym_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00006541",
"subsystem":"Miscellaneous",
"annotation":{
"ec-code":"1.14.17.-",
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0159",
"name":"artificial transformation of peptide to peptidyl-lysine",
"metabolites":{
"h2o_c":1.0,
"lys-L_c":-1.0,
"pepX_c":-1.0,
"peplys_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Carnitine biosynthesis",
"annotation":{
"sbo":"SBO:0000176"
}
},
{
"id":"RC00115",
"name":"glutathione:NADP+ oxidoreductase",
"metabolites":{
"gthox_c":-1.0,
"gthrd_c":2.0,
"h_c":-1.0,
"nadp_c":1.0,
"nadph_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00008117",
"subsystem":"Glutathione metabolism",
"annotation":{
"ec-code":"1.8.1.7",
"kegg.reaction":"R00115",
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0083",
"name":"peroxisomal multifunctional enzyme type 2 (acting on hdd2coa)",
"metabolites":{
"3ohdcoa_c":1.0,
"h2o_c":-1.0,
"h_c":1.0,
"hdd2coa_c":-1.0,
"nad_c":-1.0,
"nadh_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000991 or WBGene00017123",
"subsystem":"Peroxisomal fatty acid beta oxidation",
"annotation":{
"ec-code":[
"4.2.1.17",
"1.1.1.211",
"1.1.1.35"
],
"kegg.reaction":[
"R04737",
"R04738"
],
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0082",
"name":"ATP:1,2-diacylglycerol 3-phosphotransferase (acting on neutral lipid components)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"dag_tag_c":-1.0,
"h_c":1.0,
"pa_tag_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000958 or WBGene00000959 or WBGene00000960 or WBGene00006483 or WBGene00019428",
"subsystem":"Glycerolipid metabolism",
"annotation":{
"ec-code":"2.7.1.107",
"kegg.reaction":"R02240",
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0081",
"name":"1,2-diacyl-sn-glycerol 3-phosphate phosphohydrolase (acting on TAG)",
"metabolites":{
"dag_tag_c":1.0,
"h2o_c":-1.0,
"pa_tag_c":-1.0,
"pi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00008749 or WBGene00018756 or WBGene00020895) or WBGene00010425",
"subsystem":"Glycerolipid metabolism",
"annotation":{
"ec-code":"3.1.3.4",
"kegg.reaction":"R02239",
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0080",
"name":"acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase (Rtotal5 group)",
"metabolites":{
"Rtotal5coa_c":-1.0,
"alpa_tag_c":-1.0,
"coa_c":1.0,
"pa_tag_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"((WBGene00020264 or WBGene00022646 or WBGene00044631) or (WBGene00010339 or WBGene00011543) or (WBGene00016934 or WBGene00007446)) or WBGene00017888",
"subsystem":"Glycerolipid metabolism",
"annotation":{
"ec-code":"2.3.1.51",
"kegg.reaction":"R02241",
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0087",
"name":"Octanoyl-CoA:L-carnitine O-octanoyltransferase",
"metabolites":{
"coa_c":1.0,
"crn_c":-1.0,
"occoa_c":-1.0,
"occrn_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00009622 or WBGene00011850",
"subsystem":"Carnitine shuttle",
"annotation":{
"ec-code":"2.3.1.137",
"kegg.reaction":"R03779",
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0086",
"name":"peroxisomal multifunctional enzyme type 2 (acting on dc2coa)",
"metabolites":{
"3odcoa_c":1.0,
"dc2coa_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"nad_c":-1.0,
"nadh_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000991 or WBGene00017123",
"subsystem":"Peroxisomal fatty acid beta oxidation",
"annotation":{
"ec-code":[
"4.2.1.17",
"1.1.1.211",
"1.1.1.35"
],
"kegg.reaction":[
"R04743",
"R04744"
],
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0085",
"name":"peroxisomal multifunctional enzyme type 2 (acting on dd2coa)",
"metabolites":{
"3oddcoa_c":1.0,
"dd2coa_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"nad_c":-1.0,
"nadh_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000991 or WBGene00017123",
"subsystem":"Peroxisomal fatty acid beta oxidation",
"annotation":{
"ec-code":[
"4.2.1.17",
"1.1.1.211",
"1.1.1.35"
],
"kegg.reaction":[
"R04741",
"R04170"
],
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0084",
"name":"peroxisomal multifunctional enzyme type 2 (acting on td2coa)",
"metabolites":{
"3otdcoa_c":1.0,
"h2o_c":-1.0,
"h_c":1.0,
"nad_c":-1.0,
"nadh_c":1.0,
"td2coa_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000991 or WBGene00017123",
"subsystem":"Peroxisomal fatty acid beta oxidation",
"annotation":{
"ec-code":[
"4.2.1.17",
"1.1.1.211",
"1.1.1.35"
],
"kegg.reaction":[
"R04739",
"R04740"
],
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0089",
"name":"Beta oxidation of oleic acid (peroxisomal)",
"metabolites":{
"accoa_c":1.0,
"coa_c":-1.0,
"fa16p1n7coa_c":1.0,
"h2o2_c":1.0,
"h2o_c":-1.0,
"h_c":1.0,
"nad_c":-1.0,
"nadh_c":1.0,
"o2_c":-1.0,
"odecoa_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00008167 or WBGene00008564 or WBGene00008565 or WBGene00008566 or WBGene00008567 or WBGene00019060 or WBGene00010336) and (WBGene00000991 or WBGene00017123) and WBGene00013284",
"subsystem":"Peroxisomal fatty acid beta oxidation",
"annotation":{
"ec-code":[
"1.3.3.6",
"4.2.1.17",
"1.1.1.211",
"1.1.1.35",
"2.3.1.16"
],
"kegg.reaction":[
"R00388",
"R02685",
"R01778",
"R00391"
],
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0088",
"name":"Beta oxidation of palmitoleic acid (peroxisomal)",
"metabolites":{
"accoa_c":4.0,
"coa_c":-4.0,
"fa16p1n7coa_c":-1.0,
"h2o2_c":3.0,
"h2o_c":-4.0,
"h_c":4.0,
"nad_c":-4.0,
"nadh_c":4.0,
"o2_c":-3.0,
"occoa_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00008167 or WBGene00008564 or WBGene00008565 or WBGene00008566 or WBGene00008567 or WBGene00019060 or WBGene00010336) and WBGene00019022 and (WBGene00000991 or WBGene00017123) and WBGene00013284",
"subsystem":"Peroxisomal fatty acid beta oxidation",
"annotation":{
"ec-code":[
"1.3.3.6",
"5.3.3.8",
"4.2.1.17",
"1.1.1.211",
"1.1.1.35",
"2.3.1.16"
],
"kegg.reaction":[
"R00388",
"R01778",
"R00391"
],
"sbo":"SBO:0000176"
}
},
{
"id":"RM03158",
"name":"3-Hydroxypropionyl-CoA hydrolase",
"metabolites":{
"3hpcoa_m":-1.0,
"3hpp_m":1.0,
"coa_m":1.0,
"h2o_m":-1.0,
"h_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00017301",
"subsystem":"Propanoate metabolism",
"annotation":{
"ec-code":"3.1.2.4",
"kegg.reaction":"R03158",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01372",
"name":"Phenylpyruvate:oxygen oxidoreductase (hydroxylating,decarboxylating)",
"metabolites":{
"2hyoxplac_c":1.0,
"co2_c":1.0,
"o2_c":-1.0,
"phpyr_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00016294 or WBGene00001993",
"subsystem":"Phenylalanine metabolism",
"annotation":{
"ec-code":"1.13.11.27",
"kegg.reaction":"R01372",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01375",
"name":"L-Glutamine:phenylpyruvate aminotransferase",
"metabolites":{
"akgm_c":1.0,
"gln-L_c":-1.0,
"phe-L_c":1.0,
"phpyr_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00009232",
"subsystem":"Phenylalanine metabolism (indirect)",
"annotation":{
"ec-code":"2.6.1.64",
"kegg.reaction":"R01375",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01378",
"name":"Phenylpyruvate keto-enol-isomerase",
"metabolites":{
"enphpyr_c":1.0,
"phpyr_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00003234",
"subsystem":"Phenylalanine metabolism",
"annotation":{
"ec-code":"5.3.2.1",
"kegg.reaction":"R01378",
"sbo":"SBO:0000176"
}
},
{
"id":"EX00334",
"name":"4-Aminobutanoate exchange",
"metabolites":{
"4abut_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RC00751",
"name":"L-threonine acetaldehyde-lyase (glycine-forming)",
"metabolites":{
"acald_c":1.0,
"gly_c":1.0,
"thr-L_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00011291",
"subsystem":"Glycine, serine and threonine metabolism",
"annotation":{
"ec-code":"4.1.2.5",
"kegg.reaction":"R00751",
"sbo":"SBO:0000176"
}
},
{
"id":"EX00440",
"name":"5-Methyltetrahydrofolate exchange",
"metabolites":{
"5mthf_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EXC0060",
"name":"Phosphatidylserine (bacteria) exchange",
"metabolites":{
"ps_BAC_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RC00754",
"name":"ethanol:NAD+ oxidoreductase",
"metabolites":{
"acald_c":1.0,
"etoh_c":-1.0,
"h_c":1.0,
"nad_c":-1.0,
"nadh_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00019240 or (WBGene00017060 or WBGene00010790 or WBGene00010791)",
"subsystem":"Glycolysis / Gluconeogenesis",
"annotation":{
"ec-code":"1.1.1.1",
"kegg.reaction":"R00754",
"sbo":"SBO:0000176"
}
},
{
"id":"EXC0065",
"name":"glycogen exchange",
"metabolites":{
"glycogen_BAC_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RC04826",
"name":"7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase",
"metabolites":{
"h2o_c":1.0,
"h_c":-1.0,
"nadp_c":1.0,
"nadph_c":-1.0,
"o2_c":-1.0,
"xol7aone_c":-1.0,
"xoldiolone_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Primary bile acid biosynthesis",
"annotation":{
"ec-code":"1.14.13.95",
"kegg.reaction":"R04826",
"sbo":"SBO:0000176"
}
},
{
"id":"RC04824",
"name":"3alpha-hydroxysteroid dehydrogenase",
"metabolites":{
"h_c":-1.0,
"nad_c":1.0,
"nadh_c":-1.0,
"xoldioloneh_c":-1.0,
"xoltriol_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00012722 or WBGene00020369 or WBGene00015565 or WBGene00013896 or WBGene00012723 or WBGene00009981 or WBGene00009980",
"subsystem":"Primary bile acid biosynthesis",
"annotation":{
"ec-code":"1.1.1.50",
"kegg.reaction":"R04824",
"sbo":"SBO:0000176"
}
},
{
"id":"EXC0001",
"name":"R total 2 position exchange",
"metabolites":{
"Rtotal2_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
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}
},
{
"id":"RC04823",
"name":"3-oxo-Delta4-steroid 5beta-reductase",
"metabolites":{
"h_c":-1.0,
"nadp_c":1.0,
"nadph_c":-1.0,
"xoldiolone_c":-1.0,
"xoldioloneh_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00012722 or WBGene00020369 or WBGene00015565 or WBGene00013896 or WBGene00012723 or WBGene00009981 or WBGene00009980",
"subsystem":"Primary bile acid biosynthesis",
"annotation":{
"ec-code":"1.3.1.3",
"kegg.reaction":"R04823",
"sbo":"SBO:0000176"
}
},
{
"id":"RC02294",
"name":"N-Ribosylnicotinamide:orthophosphate ribosyltransferase",
"metabolites":{
"h_c":1.0,
"ncam_c":1.0,
"pi_c":-1.0,
"r1p_c":1.0,
"rnam_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00019298",
"subsystem":"Nicotinate and nicotinamide metabolism",
"annotation":{
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"kegg.reaction":"R02294",
"sbo":"SBO:0000176"
}
},
{
"id":"EX00534",
"name":"pyridoxamine exchange/defecation",
"metabolites":{
"pydam_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00535",
"name":"Testosterone exchange",
"metabolites":{
"tststerone_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
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}
},
{
"id":"EX00532",
"name":"L-Arabinitol exchange",
"metabolites":{
"abt_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"TCM0089",
"name":"L-Lysine transport",
"metabolites":{
"lys-L_c":-1.0,
"lys-L_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM0088",
"name":"dTDP and ADP transport",
"metabolites":{
"adp_c":1.0,
"adp_m":-1.0,
"dtdp_c":-1.0,
"dtdp_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM0087",
"name":"dUDP and ADP transport",
"metabolites":{
"adp_c":1.0,
"adp_m":-1.0,
"dudp_c":-1.0,
"dudp_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC01570",
"name":"thymidine:phosphate deoxy-alpha-D-ribosyltransferase",
"metabolites":{
"2dr1p_c":1.0,
"pi_c":-1.0,
"thym_c":1.0,
"thymd_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00022817",
"subsystem":"Pyrimidine metabolism",
"annotation":{
"ec-code":"2.4.2.4",
"kegg.reaction":"R01570 ",
"sbo":"SBO:0000176"
}
},
{
"id":"TCM0083",
"name":"dGDP and dCDP transport",
"metabolites":{
"dcdp_c":-1.0,
"dcdp_m":1.0,
"dgdp_c":1.0,
"dgdp_m":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM0082",
"name":"dTDP and dUTP transport",
"metabolites":{
"dtdp_c":1.0,
"dtdp_m":-1.0,
"dutp_c":-1.0,
"dutp_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM0081",
"name":"dTDP and dADP transport",
"metabolites":{
"dadp_c":-1.0,
"dadp_m":1.0,
"dtdp_c":1.0,
"dtdp_m":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM0080",
"name":"dTTP and ATP transport",
"metabolites":{
"atp_c":1.0,
"atp_m":-1.0,
"dttp_c":-1.0,
"dttp_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"EX00020",
"name":"AMP excretion",
"metabolites":{
"amp_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00021",
"name":"S-Adenosyl-L-homocysteine exchange",
"metabolites":{
"ahcys_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00022",
"name":"Pyruvate exchange",
"metabolites":{
"pyr_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00025",
"name":"L-Glutamate exchange",
"metabolites":{
"glu-L_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00026",
"name":"2-Oxoglutarate exchange",
"metabolites":{
"akg_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00027",
"name":"Hydrogen peroxide exchange",
"metabolites":{
"h2o2_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"TCE0739",
"name":"ADPribose transport",
"metabolites":{
"adprib_c":1.0,
"adprib_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC12124",
"name":"phosphatidylinositol 3,5-bisphosphate 5-phosphatase",
"metabolites":{
"h2o_c":-1.0,
"pail35p_c":-1.0,
"pail3p_c":1.0,
"pi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00007912",
"subsystem":"Inositol phosphate metabolism",
"annotation":{
"ec-code":"3.1.3.-",
"kegg.reaction":"R12124",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE0597",
"name":"Methanol transport",
"metabolites":{
"meoh_c":1.0,
"meoh_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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}
},
{
"id":"TCE0732",
"name":"Deoxyadenosine transport",
"metabolites":{
"dad-2_c":1.0,
"dad-2_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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}
},
{
"id":"TCE1156",
"name":"Sucrose transport",
"metabolites":{
"sucr_c":1.0,
"sucr_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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}
},
{
"id":"TCE1157",
"name":"dTTP transport",
"metabolites":{
"dttp_c":1.0,
"dttp_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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}
},
{
"id":"TCE1154",
"name":"Citrate transport",
"metabolites":{
"cit_c":1.0,
"cit_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC01402",
"name":"S-methyl-5-thioadenosine:phosphate S-methyl-5-thio-alpha-D-ribosyl-transferase",
"metabolites":{
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"5mta_c":-1.0,
"ade_c":1.0,
"pi_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00015064",
"subsystem":"Cysteine and methionine metabolism",
"annotation":{
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"kegg.reaction":"R01402",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE1150",
"name":"Peptide transport",
"metabolites":{
"pepd_c":1.0,
"pepd_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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}
},
{
"id":"RM00127",
"name":"ATP:AMP phosphotransferase",
"metabolites":{
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"amp_m":-1.0,
"atp_m":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00014058 or WBGene00002879",
"subsystem":"Purine metabolism",
"annotation":{
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"kegg.reaction":"R00127",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE1159",
"name":"Succinate transport",
"metabolites":{
"succ_c":1.0,
"succ_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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}
},
{
"id":"RC08969",
"name":"ceramide:phosphatidylcholine cholinephosphotransferase",
"metabolites":{
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"dag_pl_c":1.0,
"pchol_c":-1.0,
"sphmyln_ce_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00021075 or WBGene00004892 or WBGene00004893 or WBGene00004894",
"subsystem":"Sphingolipid metabolism",
"annotation":{
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"kegg.reaction":"R08969",
"sbo":"SBO:0000176"
}
},
{
"id":"EX00157",
"name":"Phosphatidylcholine exchange",
"metabolites":{
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},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
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}
},
{
"id":"EX00152",
"name":"L-Asparagine exchange",
"metabolites":{
"asn-L_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
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}
},
{
"id":"EX00153",
"name":"Nicotinamide exchange",
"metabolites":{
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},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
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}
},
{
"id":"EX00158",
"name":"Citrate exchange",
"metabolites":{
"cit_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00159",
"name":"D-Mannose exchange",
"metabolites":{
"man_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
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}
},
{
"id":"TCE0785",
"name":"Bicarbonate and Cholate transport",
"metabolites":{
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"cholate_e":-1.0,
"hco3_c":-1.0,
"hco3_e":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"EX05852",
"name":"2-Hydroxyphenylacetate exchange",
"metabolites":{
"2hyoxplac_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
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}
},
{
"id":"TCE0536",
"name":"Bicarbonate and Bilirubin transport",
"metabolites":{
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"bilirub_e":-1.0,
"hco3_c":-1.0,
"hco3_e":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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}
},
{
"id":"EX01161",
"name":"3-4-Dihydroxyphenylacetate exchange",
"metabolites":{
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},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
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}
},
{
"id":"TCE0600",
"name":"5-Hydroxy-L-tryptophan transport",
"metabolites":{
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"5htrp_e":3.0,
"adp_c":2.0,
"atp_c":-2.0,
"h2o_c":-2.0,
"h_c":2.0,
"pi_c":2.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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}
},
{
"id":"TCE0603",
"name":"\"3',5'-Cyclic GMP\" transport",
"metabolites":{
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"35cgmp_e":1.0,
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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}
},
{
"id":"TCE0602",
"name":"Bicarbonate and Chloride transport",
"metabolites":{
"cl_c":-1.0,
"cl_e":1.0,
"hco3_c":1.0,
"hco3_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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}
},
{
"id":"TCE0605",
"name":"Inosine transport",
"metabolites":{
"ins_c":1.0,
"ins_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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}
},
{
"id":"TCM0184",
"name":"dCDP and dCTP transport",
"metabolites":{
"dcdp_c":1.0,
"dcdp_m":-1.0,
"dctp_c":-1.0,
"dctp_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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}
},
{
"id":"TCE0757",
"name":"Choline transport",
"metabolites":{
"chol_c":1.0,
"chol_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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}
},
{
"id":"TCM0185",
"name":"Adenosine transport",
"metabolites":{
"adn_c":-1.0,
"adn_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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}
},
{
"id":"TCM0183",
"name":"Glyoxylate transport",
"metabolites":{
"glx_c":-1.0,
"glx_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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}
},
{
"id":"RC02051",
"name":"Phosphatidylethanolamine phosphatidohydrolase",
"metabolites":{
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"h2o_c":-1.0,
"h_c":1.0,
"pa_pl_c":1.0,
"pe_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00004040 or (WBGene00017316 or WBGene00020256 or WBGene00013080)",
"subsystem":"Glycerophospholipid metabolism",
"annotation":{
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"kegg.reaction":"R02051",
"sbo":"SBO:0000176"
}
},
{
"id":"RC02053",
"name":"Phosphatidylethanolamine 2-acylhydrolase",
"metabolites":{
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"acg3pe_c":1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pe_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00019747 or WBGene00009801 or WBGene00012319 or WBGene00017026 or WBGene00019229 or WBGene00022233 or WBGene00011423 or WBGene00007419 or WBGene00044468",
"subsystem":"Glycerophospholipid metabolism",
"annotation":{
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"kegg.reaction":"R02053",
"sbo":"SBO:0000176"
}
},
{
"id":"RC07759",
"name":"very-long-chain 3-oxoacyl-CoA reductase",
"metabolites":{
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"3oodcoa_c":-1.0,
"h_c":-1.0,
"nadp_c":1.0,
"nadph_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00002891",
"subsystem":"Fatty acid elongation",
"annotation":{
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"kegg.reaction":"R07759",
"sbo":"SBO:0000176"
}
},
{
"id":"RC07758",
"name":"very-long-chain 3-oxoacyl-CoA synthase",
"metabolites":{
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"co2_c":1.0,
"coa_c":1.0,
"h_c":-1.0,
"malcoa_c":-1.0,
"pmtcoa_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00001239",
"subsystem":"Fatty acid elongation",
"annotation":{
"ec-code":"2.3.1.199",
"kegg.reaction":"R07758",
"sbo":"SBO:0000176"
}
},
{
"id":"RC02057",
"name":"CDPethanolamine:1,2-diacylglycerol ethanolaminephosphotransferase",
"metabolites":{
"cdpea_c":-1.0,
"cmp_c":1.0,
"dag_pl_c":-1.0,
"h_c":1.0,
"pe_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00018797 or WBGene00013024",
"subsystem":"Glycerophospholipid metabolism",
"annotation":{
"ec-code":"2.7.8.1",
"kegg.reaction":"R02057",
"sbo":"SBO:0000176"
}
},
{
"id":"RM00943",
"name":"Formate:tetrahydrofolate ligase (ADP-forming)",
"metabolites":{
"10fthf_m":1.0,
"adp_m":1.0,
"atp_m":-1.0,
"for_m":-1.0,
"pi_m":1.0,
"thf_m":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00019492",
"subsystem":"One carbon pool by folate",
"annotation":{
"ec-code":"6.3.4.3",
"kegg.reaction":"R00943",
"sbo":"SBO:0000176"
}
},
{
"id":"RC02058",
"name":"acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase",
"metabolites":{
"accoa_c":-1.0,
"acgam6p_c":1.0,
"coa_c":1.0,
"gam6p_c":-1.0,
"h_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00001646 or WBGene00001647",
"subsystem":"Amino sugar and nucleotide sugar metabolism",
"annotation":{
"ec-code":"2.3.1.4",
"kegg.reaction":"R02058",
"sbo":"SBO:0000176"
}
},
{
"id":"TCM0181",
"name":"Fumarate and Sulfate transport",
"metabolites":{
"fum_c":-1.0,
"fum_m":1.0,
"so4_c":1.0,
"so4_m":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RM00945",
"name":"5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase",
"metabolites":{
"gly_m":1.0,
"h2o_m":1.0,
"mlthf_m":1.0,
"ser-L_m":-1.0,
"thf_m":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00003214",
"subsystem":"Glycine, serine and threonine metabolism",
"annotation":{
"ec-code":"2.1.2.1",
"kegg.reaction":"R00945",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE0752",
"name":"Glycine betaine and Sodium transport",
"metabolites":{
"glyb_c":1.0,
"glyb_e":-1.0,
"na1_c":2.0,
"na1_e":-2.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RM01090",
"name":"L-Leucine:2-oxoglutarate aminotransferase",
"metabolites":{
"4mop_m":1.0,
"akg_m":-1.0,
"glu-L_m":1.0,
"leu-L_m":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00001149 or WBGene00012855",
"subsystem":"Valine, leucine and isoleucine degradation",
"annotation":{
"ec-code":"2.6.1.42",
"kegg.reaction":"R01090",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE5035",
"name":"propionate transport into and out of cytosol",
"metabolites":{
"ppa_c":1.0,
"ppa_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE0514",
"name":"Uracil transport",
"metabolites":{
"ura_c":1.0,
"ura_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE5036",
"name":"hydroxide transport",
"metabolites":{
"oh1_c":-1.0,
"oh1_e":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE5031",
"name":"transport of N-acetyl ornithine",
"metabolites":{
"acorn_c":1.0,
"acorn_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC02186",
"name":"Dolichyl-diphosphate:polyphosphate phosphotransferase",
"metabolites":{
"doldp_c":-1.0,
"dolp_c":1.0,
"pi_c":-1.0,
"ppi_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"N-Glycan biosynthesis",
"annotation":{
"ec-code":"2.7.4.20",
"kegg.reaction":"R02186",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE0513",
"name":"Phosphatidylethanolamine (bacteria) transport",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pe_BAC_c":1.0,
"pe_BAC_e":-1.0,
"pi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"EX00268",
"name":"\"6,7-Dihydrobiopterin\" exchange",
"metabolites":{
"dhbpt_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"TCE5038",
"name":"cellobiose transport",
"metabolites":{
"clb_c":-1.0,
"clb_e":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC03454",
"name":"1-Alkyl-2-acetyl-sn-glycero-3-phosphate phosphohydrolase",
"metabolites":{
"acakg_c":1.0,
"acakgp_c":-1.0,
"h2o_c":-1.0,
"pi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Ether lipid metabolism",
"annotation":{
"ec-code":"3.1.3.59",
"kegg.reaction":"R03454",
"sbo":"SBO:0000176"
}
},
{
"id":"RC03455",
"name":"Acetyl-CoA:1-alkyl-sn-glycero-3-phosphate 2-O-acetyltransferase",
"metabolites":{
"acakgp_c":1.0,
"accoa_c":-1.0,
"akgp_c":-1.0,
"coa_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Ether lipid metabolism",
"annotation":{
"ec-code":"2.3.1.105",
"kegg.reaction":"R03455",
"sbo":"SBO:0000176"
}
},
{
"id":"RM04738",
"name":"(S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase",
"metabolites":{
"3hhdcoa_m":-1.0,
"h2o_m":1.0,
"hdd2coa_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00001155 or WBGene00001156) or (WBGene00020347 or WBGene00001150) or WBGene00001152",
"subsystem":"Fatty acid elongation",
"annotation":{
"ec-code":"4.2.1.17",
"kegg.reaction":"R04738",
"sbo":"SBO:0000176"
}
},
{
"id":"RM04739",
"name":"(S)-3-Hydroxytetradecanoyl-CoA:NAD+ oxidoreductase",
"metabolites":{
"3htdcoa_m":1.0,
"3otdcoa_m":-1.0,
"h_m":-1.0,
"nad_m":1.0,
"nadh_m":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00007129 or WBGene00010035 or WBGene00001157 or WBGene00001158 or WBGene00019978) or (WBGene00020347 or WBGene00001150)",
"subsystem":"Fatty acid elongation",
"annotation":{
"ec-code":[
"1.1.1.211",
"1.1.1.35"
],
"kegg.reaction":"R04739",
"sbo":"SBO:0000176"
}
},
{
"id":"RC02478",
"name":"UDP-glucuronate-androsterone glucuronyltransferase",
"metabolites":{
"andrstrn_c":-1.0,
"andrstrnglc_c":1.0,
"udp_c":1.0,
"udpglcur_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00015371 or WBGene00016959 or WBGene00017334 or WBGene00018789 or WBGene00019235 or WBGene00019379 or WBGene00007072 or WBGene00020594 or WBGene00020593 or WBGene00020592 or WBGene00019232 or WBGene00019233 or WBGene00008097 or WBGene00013901 or WBGene00007422 or WBGene00013900 or WBGene00019515 or WBGene00007073 or WBGene00019516 or WBGene00007885 or WBGene00007455 or WBGene00007650 or WBGene00016762 or WBGene00015692 or WBGene00015695 or WBGene00015694 or WBGene00021709 or WBGene00013903 or WBGene00011340 or WBGene00021464 or WBGene00018543 or WBGene00007946 or WBGene00009255 or WBGene00044286 or WBGene00017315 or WBGene00017332 or WBGene00017333 or WBGene00017329 or WBGene00013905 or WBGene00017331 or WBGene00017336 or WBGene00017959 or WBGene00008485 or WBGene00008486 or WBGene00021372 or WBGene00015141 or WBGene00011006 or WBGene00015965 or WBGene00007070 or WBGene00013906 or WBGene00011564 or WBGene00015369 or WBGene00018931 or WBGene00020182 or WBGene00012013 or WBGene00011452 or WBGene00011453 or WBGene00009450 or WBGene00011238 or WBGene00013904 or WBGene00007402 or WBGene00018206 or WBGene00010904 or WBGene00015449 or WBGene00015577 or WBGene00008583 or WBGene00015739 or WBGene00019234 or WBGene00020587",
"subsystem":"Steroid hormone biosynthesis",
"annotation":{
"ec-code":"2.4.1.17",
"kegg.reaction":"R02478",
"sbo":"SBO:0000176"
}
},
{
"id":"RM04737",
"name":"(S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase",
"metabolites":{
"3hhdcoa_m":1.0,
"3ohdcoa_m":-1.0,
"h_m":-1.0,
"nad_m":1.0,
"nadh_m":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00007129 or WBGene00010035 or WBGene00001157) or (WBGene00020347 or WBGene00001150)",
"subsystem":"Fatty acid elongation",
"annotation":{
"ec-code":[
"1.1.1.35",
"1.1.1.211"
],
"kegg.reaction":"R04737",
"sbo":"SBO:0000176"
}
},
{
"id":"RM07273",
"name":"nonaprenyl-4-hydroxybenzoate transferase",
"metabolites":{
"3nphb_m":1.0,
"4hbz_m":-1.0,
"nonadp_m":-1.0,
"ppi_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000762",
"subsystem":"Ubiquinone and other terpenoid-quinone biosynthesis",
"annotation":{
"ec-code":"2.5.1.39",
"kegg.reaction":"R07273",
"sbo":"SBO:0000176"
}
},
{
"id":"RC05623",
"name":"trimethylamine monooxygenase",
"metabolites":{
"h2o_c":1.0,
"nadp_c":1.0,
"nadph_c":-1.0,
"o2_c":-1.0,
"tma_c":-1.0,
"tmao_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00001476 or WBGene00001477 or WBGene00001478 or WBGene00001479 or WBGene00001480",
"subsystem":"Methane metabolism",
"annotation":{
"ec-code":"1.14.13.8",
"kegg.reaction":"R05623",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE5101",
"name":"sphingosylphosphorylcholine transport",
"metabolites":{
"spc_ce_c":-1.0,
"spc_ce_e":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC03057",
"name":"(7E,9E,11Z,14Z)-(5S,6S)-5,6-Epoxyicosa-7,9,11,14-tetraenoate hydrolase",
"metabolites":{
"h2o_c":-1.0,
"leuktrA4_c":-1.0,
"leuktrB4_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00016589 or WBGene00022610",
"subsystem":"Arachidonic acid metabolism",
"annotation":{
"ec-code":"3.3.2.6",
"kegg.reaction":"R03057",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE5103",
"name":"Sphingosine 1-phosphate transport",
"metabolites":{
"sphs1p_ce_c":-1.0,
"sphs1p_ce_e":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC03055",
"name":"5,6-Dihydrothymine amidohydrolase",
"metabolites":{
"3uib_c":1.0,
"56dthm_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000963 or WBGene00000964",
"subsystem":"Pyrimidine metabolism",
"annotation":{
"ec-code":"3.5.2.2",
"kegg.reaction":"R03055",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE5105",
"name":"Secretion of cobalamin",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"cbl1_c":-1.0,
"cbl1_e":1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00003411",
"subsystem":"Vitamin B12 metabolism",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE5104",
"name":"FAD diffusion",
"metabolites":{
"fad_c":-1.0,
"fad_e":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE5107",
"name":"Uptake of acetylcholine",
"metabolites":{
"ach_c":1.0,
"ach_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE5106",
"name":"Secretion of acetylcholine",
"metabolites":{
"ach_c":-3.0,
"ach_e":3.0,
"adp_c":2.0,
"atp_c":-2.0,
"h2o_c":-2.0,
"h_c":2.0,
"pi_c":2.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00006756",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC02697",
"name":"4-Hydroxyphenylacetaldehyde:NADP+ oxidoreductase",
"metabolites":{
"4hoxpacd_c":-1.0,
"4hphac_c":1.0,
"h2o_c":-1.0,
"h_c":2.0,
"nadp_c":-1.0,
"nadph_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000111",
"subsystem":"Tyrosine metabolism",
"annotation":{
"ec-code":"1.2.1.5",
"kegg.reaction":"R02697",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE5108",
"name":"3-4-Dihydroxyphenylacetate transport",
"metabolites":{
"34dhpha_c":-1.0,
"34dhpha_e":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC02695",
"name":"4-Hydroxyphenylacetaldehyde:NAD+ oxidoreductase",
"metabolites":{
"4hoxpacd_c":-1.0,
"4hphac_c":1.0,
"h2o_c":-1.0,
"h_c":2.0,
"nad_c":-1.0,
"nadh_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000111",
"subsystem":"Tyrosine metabolism",
"annotation":{
"ec-code":"1.2.1.5",
"kegg.reaction":"R02695",
"sbo":"SBO:0000176"
}
},
{
"id":"RM02765",
"name":"Methylmalonyl-CoA epimerase",
"metabolites":{
"mmcoa-R_m":-1.0,
"mmcoa-S_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00008415",
"subsystem":"Valine, leucine and isoleucine degradation",
"annotation":{
"ec-code":"5.1.99.1",
"kegg.reaction":"R02765",
"sbo":"SBO:0000176"
}
},
{
"id":"RC03058",
"name":"Arachidonate 5-lipoxygenase",
"metabolites":{
"5HPET_c":-1.0,
"h2o_c":1.0,
"leuktrA4_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Arachidonic acid metabolism",
"annotation":{
"ec-code":"1.13.11.34",
"kegg.reaction":"R03058",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00233",
"name":"malonyl-CoA carboxy-lyase (acetyl-CoA-forming)",
"metabolites":{
"accoa_c":1.0,
"co2_c":1.0,
"h_c":-1.0,
"malcoa_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00009439",
"subsystem":"Propanoate metabolism",
"annotation":{
"ec-code":"4.1.1.9",
"kegg.reaction":"R00233",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00235",
"name":"Acetate:CoA ligase (AMP-forming)",
"metabolites":{
"ac_c":-1.0,
"accoa_c":1.0,
"amp_c":1.0,
"atp_c":-1.0,
"coa_c":-1.0,
"ppi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00007969",
"subsystem":"Glycolysis / Gluconeogenesis",
"annotation":{
"ec-code":"6.2.1.1",
"kegg.reaction":"R00235",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00238",
"name":"Acetyl-CoA:acetyl-CoA C-acetyltransferase",
"metabolites":{
"aacoa_c":1.0,
"accoa_c":-2.0,
"coa_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00020166",
"subsystem":"Fatty acid metabolism",
"annotation":{
"ec-code":"2.3.1.9",
"kegg.reaction":"R00238",
"sbo":"SBO:0000176"
}
},
{
"id":"EXC0013",
"name":"Ubiquinone-8 exchange",
"metabolites":{
"q8_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RC07933",
"name":"DELTA6-fatty-acid desaturase",
"metabolites":{
"ficytb_c":2.0,
"focytb_c":-2.0,
"h2o_c":2.0,
"lnlncacoa_c":-1.0,
"o2_c":-1.0,
"strdnccoa_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00001395",
"subsystem":"Biosynthesis of unsaturated fatty acids",
"annotation":{
"ec-code":"1.14.19.3",
"kegg.reaction":"R07933",
"sbo":"SBO:0000176"
}
},
{
"id":"EX00320",
"name":"Thiosulfate exchange",
"metabolites":{
"tsul_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RC08218",
"name":"L-serine:tRNASec ligase (AMP-forming)",
"metabolites":{
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"atp_c":-1.0,
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},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00005663",
"subsystem":"Aminoacyl-tRNA biosynthesis",
"annotation":{
"ec-code":"6.1.1.11",
"kegg.reaction":"R08218",
"sbo":"SBO:0000176"
}
},
{
"id":"RC04591",
"name":"1-(5-Phosphoribosyl)-5-amino-4-carboxyimidazole:L-aspartate ligase (ADP-forming)",
"metabolites":{
"25aics_c":1.0,
"5aizc_c":-1.0,
"adp_c":1.0,
"asp-L_c":-1.0,
"atp_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00015116",
"subsystem":"Purine metabolism",
"annotation":{
"ec-code":"6.3.2.6",
"kegg.reaction":"R04591",
"sbo":"SBO:0000176"
}
},
{
"id":"EX00288",
"name":"Bicarbonate exchange",
"metabolites":{
"hco3_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RM03815",
"name":"dihydrolipoylprotein:NAD+ oxidoreductase",
"metabolites":{
"dhlpro_m":-1.0,
"h_m":1.0,
"lpro_m":1.0,
"nad_m":-1.0,
"nadh_m":1.0
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"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00010794 and (WBGene00008354 or WBGene00009918)",
"subsystem":"Glycine, serine and threonine metabolism",
"annotation":{
"ec-code":"1.8.1.4",
"kegg.reaction":"R03815",
"sbo":"SBO:0000176"
}
},
{
"id":"RM05066",
"name":"3-Hydroxy-2-methylpropanoate:NAD+ oxidoreductase",
"metabolites":{
"2mop_m":1.0,
"3hmp_m":-1.0,
"h_m":1.0,
"nad_m":-1.0,
"nadh_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00007122 or (WBGene00007129 or WBGene00010035 or WBGene00001157 or WBGene00001158 or WBGene00019978)",
"subsystem":"Valine, leucine and isoleucine degradation",
"annotation":{
"ec-code":[
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"1.1.1.35"
],
"kegg.reaction":"R05066",
"sbo":"SBO:0000176"
}
},
{
"id":"RM05064",
"name":"(S)-3-Hydroxyisobutyryl-CoA hydrolase",
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"3hmp_m":1.0,
"coa_m":1.0,
"h2o_m":-1.0,
"h_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00017301",
"subsystem":"Valine, leucine and isoleucine degradation",
"annotation":{
"ec-code":"3.1.2.4",
"kegg.reaction":"R05064",
"sbo":"SBO:0000176"
}
},
{
"id":"RC03634",
"name":"Stachyose galactohydrolase",
"metabolites":{
"gal_c":1.0,
"h2o_c":-1.0,
"raffin_c":1.0,
"stachyose_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00011095",
"subsystem":"Galactose metabolism",
"annotation":{
"ec-code":"3.2.1.22",
"kegg.reaction":"R03634",
"sbo":"SBO:0000176"
}
},
{
"id":"TCM5034",
"name":"propionate transfer between mitochondria and cytosol",
"metabolites":{
"ppa_c":-1.0,
"ppa_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM5037",
"name":"Bacterial ubiquinone transport (cytosol/mitochondria)",
"metabolites":{
"q8_c":-1.0,
"q8_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC00905",
"name":"N-Carbamoyl-beta-alanine amidohydrolase",
"metabolites":{
"ala-B_c":1.0,
"cala_c":-1.0,
"co2_c":1.0,
"h2o_c":-1.0,
"h_c":-2.0,
"nh4_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00017440",
"subsystem":"Pyrimidine metabolism",
"annotation":{
"ec-code":"3.5.1.6",
"kegg.reaction":"R00905",
"sbo":"SBO:0000176"
}
},
{
"id":"TCM5030",
"name":"alanine transport into mitochondria",
"metabolites":{
"ala-L_c":-1.0,
"ala-L_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM5032",
"name":"all-trans-Nonaprenyl diphosphate transport into mitochondria",
"metabolites":{
"nonadp_c":-1.0,
"nonadp_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"EX04317",
"name":"1-Alkyl-2-lyso-sn-glycero-3-phosphocholine exchange",
"metabolites":{
"ak2lgchol_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"DMN0078",
"name":"7alpha,25-Dihydroxy-4-cholesten-3-one demand",
"metabolites":{
"xol25one_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Primary bile acid biosynthesis",
"annotation":{
"sbo":"SBO:0000628"
}
},
{
"id":"DMN0077",
"name":"Dihydroneopterin demand",
"metabolites":{
"dhnpt_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Folate biosynthesis",
"annotation":{
"sbo":"SBO:0000628"
}
},
{
"id":"DMN0075",
"name":"Dolichyl phosphate demand",
"metabolites":{
"dolp_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"N-Glycan biosynthesis",
"annotation":{
"sbo":"SBO:0000628"
}
},
{
"id":"DMN0073",
"name":"Selenoprotein synthesis (single aminoacid)",
"metabolites":{
"adp_c":0.324,
"atp_c":-0.324,
"gdp_c":2.0,
"gtp_c":-2.0,
"h2o_c":-2.324,
"h_c":3.324,
"pi_c":2.324,
"sectrna_c":-1.0,
"trnasec_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00015553",
"subsystem":"Selenocompound metabolism",
"annotation":{
"sbo":"SBO:0000628"
}
},
{
"id":"DMN0072",
"name":"3-hydroxy-L-arginine demand",
"metabolites":{
"asn-L_c":1.0,
"h2o_c":-1.0,
"pepX_c":1.0,
"pepasn3oh_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Protein modification by hydroxylation",
"annotation":{
"sbo":"SBO:0000628"
}
},
{
"id":"RC00582",
"name":"O-phospho-L-serine phosphohydrolase",
"metabolites":{
"h2o_c":-1.0,
"pi_c":1.0,
"pser-L_c":-1.0,
"ser-L_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00013379",
"subsystem":"Glycine, serine and threonine metabolism",
"annotation":{
"ec-code":"3.1.3.3",
"kegg.reaction":"R00582",
"sbo":"SBO:0000176"
}
},
{
"id":"TCM1053",
"name":"Adenine transport",
"metabolites":{
"ade_c":-1.0,
"ade_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM1051",
"name":"L-Tryptophan transport",
"metabolites":{
"trp-L_c":-1.0,
"trp-L_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM1055",
"name":"L-erythro-4-Hydroxyglutamate transport",
"metabolites":{
"e4hglu_c":-1.0,
"e4hglu_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM1054",
"name":"L-Histidine transport",
"metabolites":{
"his-L_c":1.0,
"his-L_m":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM1059",
"name":"5-Phospho-alpha-D-ribose 1-diphosphate transport",
"metabolites":{
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"prpp_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM1058",
"name":"L-Methionine transport",
"metabolites":{
"met-L_c":1.0,
"met-L_m":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC00342",
"name":"(S)-malate:NAD+ oxidoreductase",
"metabolites":{
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"mal-L_c":-1.0,
"nad_c":-1.0,
"nadh_c":1.0,
"oaa_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00018491",
"subsystem":"Citrate cycle (TCA cycle)",
"annotation":{
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"kegg.reaction":"R00342",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01987",
"name":"4-acetamidobutanoate amidohydrolase",
"metabolites":{
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"4abut_c":1.0,
"ac_c":1.0,
"h2o_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Arginine and proline metabolism",
"annotation":{
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"kegg.reaction":"R01987",
"sbo":"SBO:0000176"
}
},
{
"id":"EX04227",
"name":"Octopamine exchange",
"metabolites":{
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
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}
},
{
"id":"RC01960",
"name":"L-Kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating)",
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"h2o_c":1.0,
"hLkynr_c":1.0,
"h_c":-1.0,
"nadp_c":1.0,
"nadph_c":-1.0,
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"lower_bound":-0.0,
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"gene_reaction_rule":"WBGene00011088 or WBGene00011089",
"subsystem":"Tryptophan metabolism",
"annotation":{
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"kegg.reaction":"R01960",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01961",
"name":"ATP:D-glucosamine 6-phosphotransferase",
"metabolites":{
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"atp_c":-1.0,
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"gam_c":-1.0,
"h_c":1.0
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"lower_bound":-0.0,
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"gene_reaction_rule":"WBGene00008780 or WBGene00010416 or WBGene00022306",
"subsystem":"Amino sugar and nucleotide sugar metabolism",
"annotation":{
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"kegg.reaction":"R01961",
"sbo":"SBO:0000176"
}
},
{
"id":"RM03038",
"name":"L-Alanine:tRNA(Ala) ligase (AMP-forming)",
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"alatrna_m":1.0,
"amp_m":1.0,
"atp_m":-1.0,
"ppi_m":1.0,
"trnaala_m":-1.0
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"lower_bound":-0.0,
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"gene_reaction_rule":"WBGene00000196",
"subsystem":"Aminoacyl-tRNA biosynthesis",
"annotation":{
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"kegg.reaction":"R03038",
"sbo":"SBO:0000176"
}
},
{
"id":"RM03035",
"name":"ATP:pantetheine-4-phosphate adenylyltransferase",
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"dpcoa_m":1.0,
"h_m":-1.0,
"pan4p_m":-1.0,
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"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00022031",
"subsystem":"Pantothenate and CoA biosynthesis",
"annotation":{
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"kegg.reaction":"R03035",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01968",
"name":"2-Deoxyguanosine 5-monophosphate phosphohydrolase",
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"dgsn_c":1.0,
"h2o_c":-1.0,
"pi_c":1.0
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"lower_bound":-0.0,
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"gene_reaction_rule":"WBGene00017775 or WBGene00012423 or WBGene00022201",
"subsystem":"Purine metabolism",
"annotation":{
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"kegg.reaction":"R01968",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01969",
"name":"Deoxyguanosine:orthophosphate ribosyltransferase",
"metabolites":{
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"dgsn_c":-1.0,
"gua_c":1.0,
"pi_c":-1.0
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"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00019298",
"subsystem":"Purine metabolism",
"annotation":{
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"kegg.reaction":"R01969",
"sbo":"SBO:0000176"
}
},
{
"id":"EX11061",
"name":"retinoyl glucuronide exchange",
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},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RC00699",
"name":"L-phenylalanine carboxy-lyase (phenylethylamine-forming)",
"metabolites":{
"co2_c":1.0,
"h_c":-1.0,
"peamn_c":1.0,
"phe-L_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000239 or WBGene00001839 or WBGene00006562",
"subsystem":"Phenylalanine metabolism",
"annotation":{
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"kegg.reaction":"R00699",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00698",
"name":"L-phenylalanine:oxygen oxidoreductase (decarboxylating)",
"metabolites":{
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"h2o_c":1.0,
"o2_c":-1.0,
"pad_c":1.0,
"phe-L_c":-1.0
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"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00021401",
"subsystem":"Phenylalanine metabolism",
"annotation":{
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"kegg.reaction":"R00698",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01186",
"name":"1D-myo-Inositol 4-phosphate phosphohydrolase",
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"inost_c":1.0,
"mi4p-D_c":-1.0,
"pi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00008765 or WBGene00012390)",
"subsystem":"Inositol phosphate metabolism",
"annotation":{
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"kegg.reaction":"R01186",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01187",
"name":"1D-myo-Inositol 3-phosphate phosphohydrolase",
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"inost_c":1.0,
"mi3p-D_c":-1.0,
"pi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00008765 or WBGene00012390)",
"subsystem":"Inositol phosphate metabolism",
"annotation":{
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"kegg.reaction":"R01187",
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0148",
"name":"fatty-acid--CoA ligase (fa17c9)",
"metabolites":{
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"atp_c":-1.0,
"coa_c":-1.0,
"fa17c9_c":-1.0,
"fa17c9coa_c":1.0,
"ppi_c":1.0
},
"lower_bound":-0.0,
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"gene_reaction_rule":"WBGene00009221 or WBGene00020343 or WBGene00018152 or WBGene00013575 or WBGene00022037 or WBGene00019920 or WBGene00016716 or WBGene00011173",
"subsystem":"Fatty acid metabolism",
"annotation":{
"ec-code":"6.2.1.3",
"kegg.reaction":"R00390",
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0149",
"name":"fatty-acid--CoA ligase (fa19c11)",
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"coa_c":-1.0,
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"fa19c11coa_c":1.0,
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"lower_bound":-0.0,
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"gene_reaction_rule":"WBGene00009221 or WBGene00020343 or WBGene00018152 or WBGene00013575 or WBGene00022037 or WBGene00019920 or WBGene00016716 or WBGene00011173",
"subsystem":"Fatty acid metabolism",
"annotation":{
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"kegg.reaction":"R00390",
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0147",
"name":"fatty-acid--CoA ligase (fa16p1n7)",
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"atp_c":-1.0,
"coa_c":-1.0,
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"fa16p1n7coa_c":1.0,
"ppi_c":1.0
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"lower_bound":-0.0,
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"gene_reaction_rule":"WBGene00009221 or WBGene00020343 or WBGene00018152 or WBGene00013575 or WBGene00022037 or WBGene00019920 or WBGene00016716 or WBGene00011173",
"subsystem":"Fatty acid metabolism",
"annotation":{
"ec-code":"6.2.1.3",
"kegg.reaction":"R00390",
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0144",
"name":"retinol isomerase (9-cis)",
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"retinol_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Retinol metabolism",
"annotation":{
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}
},
{
"id":"RCC0145",
"name":"fatty acid synthetase (n-C14:0)",
"metabolites":{
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"co2_c":6.0,
"coa_c":7.0,
"h2o_c":5.0,
"h_c":-17.0,
"malcoa_c":-6.0,
"nadp_c":12.0,
"nadph_c":-12.0,
"ttdca_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00009342",
"subsystem":"Fatty acid biosynthesis",
"annotation":{
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"kegg.reaction":"R05188",
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0142",
"name":"molybdopterin synthesis-merged",
"metabolites":{
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"amp_c":2.0,
"atp_c":-2.0,
"cpmp_c":-1.0,
"cys-L_c":-2.0,
"h2o_c":-1.0,
"h_c":4.0,
"molybd_c":1.0,
"ppi_c":2.0,
"trdox_c":2.0,
"trdrd_c":-2.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00015021 and WBGene00018357 and (WBGene00020842 and WBGene00019633)",
"subsystem":"Molybdenum cofactor biosynthesis",
"annotation":{
"ec-code":[
"2.8.1.7",
"2.7.7.80",
"2.8.1.11",
"2.8.1.12"
],
"kegg.reaction":[
"R07460",
"R09395"
],
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0143",
"name":"molybdopterin adenylyl transferase; molybdopterin molybdotransferase",
"metabolites":{
"amp_c":1.0,
"atp_c":-1.0,
"h2o_c":1.0,
"h_c":-2.0,
"mobd_c":-1.0,
"moco_c":1.0,
"molybd_c":-1.0,
"ppi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00003031 or WBGene00003384 or WBGene00003385",
"subsystem":"Molybdenum cofactor biosynthesis",
"annotation":{
"ec-code":[
"2.7.7.75",
"2.10.1.1"
],
"kegg.reaction":[
"R09726",
"R09735"
],
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0140",
"name":"glyceryl-ether monoxygenase",
"metabolites":{
"ak2lgchol_c":-1.0,
"dhbpt_c":1.0,
"h2o_c":1.0,
"hak2lgchol_c":1.0,
"o2_c":-1.0,
"thbpt_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00007210",
"subsystem":"Degradation of alkylacylglycerolipids",
"annotation":{
"ec-code":"1.14.16.5",
"kegg.reaction":"R04044",
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0141",
"name":"Hydroxyalkyl-sn-glycerol decomposition",
"metabolites":{
"fattyald_c":1.0,
"g3pc_c":1.0,
"hak2lgchol_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Degradation of alkylacylglycerolipids",
"annotation":{
"sbo":"SBO:0000176"
}
},
{
"id":"RM00432",
"name":"Succinate:CoA ligase (GDP-forming)",
"metabolites":{
"coa_m":-1.0,
"gdp_m":1.0,
"gtp_m":-1.0,
"pi_m":1.0,
"succ_m":-1.0,
"succoa_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00007350 or WBGene00017759) and WBGene00016844",
"subsystem":"Citrate cycle (TCA cycle)",
"annotation":{
"ec-code":"6.2.1.4",
"kegg.reaction":"R00432",
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0090",
"name":"Beta oxidation of vaccenic acid (peroxisomal)",
"metabolites":{
"accoa_c":5.0,
"coa_c":-5.0,
"h2o2_c":4.0,
"h2o_c":-5.0,
"h_c":5.0,
"nad_c":-5.0,
"nadh_c":5.0,
"o2_c":-4.0,
"occoa_c":1.0,
"vacccoa_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00008167 or WBGene00008564 or WBGene00008565 or WBGene00008566 or WBGene00008567 or WBGene00019060 or WBGene00010336) and WBGene00019022 and (WBGene00000991 or WBGene00017123) and WBGene00013284",
"subsystem":"Peroxisomal fatty acid beta oxidation",
"annotation":{
"ec-code":[
"1.3.3.6",
"5.3.3.8",
"4.2.1.17",
"1.1.1.211",
"1.1.1.35",
"2.3.1.16"
],
"kegg.reaction":[
"R00388",
"R01778",
"R00391"
],
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0091",
"name":"Beta oxidation of linoleic acid (peroxisomal)",
"metabolites":{
"accoa_c":2.0,
"coa_c":-2.0,
"fa14p2n6coa_c":1.0,
"h2o2_c":2.0,
"h2o_c":-2.0,
"h_c":2.0,
"lnlccoa_c":-1.0,
"nad_c":-2.0,
"nadh_c":2.0,
"o2_c":-2.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00008167 or WBGene00008564 or WBGene00008565 or WBGene00008566 or WBGene00008567 or WBGene00019060 or WBGene00010336) and (WBGene00000991 or WBGene00017123) and WBGene00013284",
"subsystem":"Peroxisomal fatty acid beta oxidation",
"annotation":{
"ec-code":[
"1.3.3.6",
"4.2.1.17",
"1.1.1.211",
"1.1.1.35",
"2.3.1.16"
],
"kegg.reaction":[
"R00388",
"R02685",
"R01778",
"R00391"
],
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0092",
"name":"Beta oxidation of intermediary fatty acid C14:2 (peroxisomal)",
"metabolites":{
"accoa_c":3.0,
"coa_c":-3.0,
"fa14p2n6coa_c":-1.0,
"h2o2_c":2.0,
"h2o_c":-3.0,
"h_c":2.0,
"nad_c":-3.0,
"nadh_c":3.0,
"nadp_c":1.0,
"nadph_c":-1.0,
"o2_c":-2.0,
"occoa_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00008167 or WBGene00008564 or WBGene00008565 or WBGene00008566 or WBGene00008567 or WBGene00019060 or WBGene00010336) and WBGene00019022 and WBGene00009973 and (WBGene00000991 or WBGene00017123) and WBGene00013284",
"subsystem":"Peroxisomal fatty acid beta oxidation",
"annotation":{
"ec-code":[
"1.3.3.6",
"5.3.3.8",
"1.3.1.34",
"4.2.1.17",
"1.1.1.211",
"1.1.1.35",
"2.3.1.16"
],
"kegg.reaction":[
"R00388",
"R04319",
"R03224",
"R02685",
"R01778",
"R00391"
],
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0093",
"name":"Beta oxidation of eicosatrieonic acid (peroxisomal)",
"metabolites":{
"accoa_c":2.0,
"coa_c":-2.0,
"dlnlcgcoa_c":-1.0,
"fa16p3n6coa_c":1.0,
"h2o2_c":2.0,
"h2o_c":-2.0,
"h_c":2.0,
"nad_c":-2.0,
"nadh_c":2.0,
"o2_c":-2.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00008167 or WBGene00008564 or WBGene00008565 or WBGene00008566 or WBGene00008567 or WBGene00019060 or WBGene00010336) and (WBGene00000991 or WBGene00017123) and WBGene00013284",
"subsystem":"Peroxisomal fatty acid beta oxidation",
"annotation":{
"ec-code":[
"1.3.3.6",
"4.2.1.17",
"1.1.1.211",
"1.1.1.35",
"2.3.1.16"
],
"kegg.reaction":[
"R00388",
"R03224",
"R02685",
"R01778",
"R00391"
],
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0094",
"name":"Beta oxidation of intermediary fatty acid C16:3 (peroxisomal)",
"metabolites":{
"accoa_c":1.0,
"coa_c":-1.0,
"fa14p2n6coa_c":1.0,
"fa16p3n6coa_c":-1.0,
"h2o2_c":1.0,
"h2o_c":-1.0,
"nad_c":-1.0,
"nadh_c":1.0,
"nadp_c":1.0,
"nadph_c":-1.0,
"o2_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00008167 or WBGene00008564 or WBGene00008565 or WBGene00008566 or WBGene00008567 or WBGene00019060 or WBGene00010336) and WBGene00019022 and WBGene00009973 and (WBGene00000991 or WBGene00017123) and WBGene00013284",
"subsystem":"Peroxisomal fatty acid beta oxidation",
"annotation":{
"ec-code":[
"1.3.3.6",
"5.3.3.8",
"1.3.1.34",
"4.2.1.17",
"1.1.1.211",
"1.1.1.35",
"2.3.1.16"
],
"kegg.reaction":[
"R00388",
"R04319",
"R03224",
"R02685",
"R01778",
"R00391"
],
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0095",
"name":"Beta oxidation of arachidonic acid (peroxisomal)",
"metabolites":{
"accoa_c":2.0,
"arachdcoa_c":-1.0,
"coa_c":-2.0,
"fa16p3n6coa_c":1.0,
"h2o2_c":1.0,
"h2o_c":-2.0,
"h_c":2.0,
"nad_c":-2.0,
"nadh_c":2.0,
"o2_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00008167 or WBGene00008564 or WBGene00008565 or WBGene00008566 or WBGene00008567 or WBGene00019060 or WBGene00010336) and WBGene00019022 and (WBGene00000991 or WBGene00017123) and WBGene00013284",
"subsystem":"Peroxisomal fatty acid beta oxidation",
"annotation":{
"ec-code":[
"1.3.3.6",
"5.3.3.8",
"4.2.1.17",
"1.1.1.211",
"1.1.1.35",
"2.3.1.16"
],
"kegg.reaction":[
"R00388",
"R03224",
"R02685",
"R01778",
"R00391"
],
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0096",
"name":"Beta oxidation of eicosatetraeonic acid (peroxisomal)",
"metabolites":{
"accoa_c":2.0,
"coa_c":-2.0,
"eicostetcoa_c":-1.0,
"fa16p4n3coa_c":1.0,
"h2o2_c":2.0,
"h2o_c":-2.0,
"h_c":2.0,
"nad_c":-2.0,
"nadh_c":2.0,
"o2_c":-2.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00008167 or WBGene00008564 or WBGene00008565 or WBGene00008566 or WBGene00008567 or WBGene00019060 or WBGene00010336) and (WBGene00000991 or WBGene00017123) and WBGene00013284",
"subsystem":"Peroxisomal fatty acid beta oxidation",
"annotation":{
"ec-code":[
"1.3.3.6",
"4.2.1.17",
"1.1.1.211",
"1.1.1.35",
"2.3.1.16"
],
"kegg.reaction":[
"R00388",
"R03224",
"R02685",
"R01778",
"R00391"
],
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0097",
"name":"Beta oxidation of intermediary fatty acid C16:4 (peroxisomal)",
"metabolites":{
"accoa_c":4.0,
"coa_c":-4.0,
"fa16p4n3coa_c":-1.0,
"fa8p1n3coa_c":1.0,
"h2o2_c":3.0,
"h2o_c":-4.0,
"h_c":2.0,
"nad_c":-4.0,
"nadh_c":4.0,
"nadp_c":2.0,
"nadph_c":-2.0,
"o2_c":-3.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00008167 or WBGene00008564 or WBGene00008565 or WBGene00008566 or WBGene00008567 or WBGene00019060 or WBGene00010336) and WBGene00019022 and WBGene00009973 and (WBGene00000991 or WBGene00017123) and WBGene00013284",
"subsystem":"Peroxisomal fatty acid beta oxidation",
"annotation":{
"ec-code":[
"1.3.3.6",
"5.3.3.8",
"1.3.1.34",
"4.2.1.17",
"1.1.1.211",
"1.1.1.35",
"2.3.1.16"
],
"kegg.reaction":[
"R00388",
"R04319",
"R03224",
"R02685",
"R01778",
"R00391"
],
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0098",
"name":"Beta oxidation of eicosapentanoic acid (peroxisomal)",
"metabolites":{
"accoa_c":2.0,
"coa_c":-2.0,
"fa16p4n3coa_c":1.0,
"h2o2_c":1.0,
"h2o_c":-2.0,
"h_c":2.0,
"nad_c":-2.0,
"nadh_c":2.0,
"o2_c":-1.0,
"tmndnccoa_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00008167 or WBGene00008564 or WBGene00008565 or WBGene00008566 or WBGene00008567 or WBGene00019060 or WBGene00010336) and WBGene00019022 and (WBGene00000991 or WBGene00017123) and WBGene00013284",
"subsystem":"Peroxisomal fatty acid beta oxidation",
"annotation":{
"ec-code":[
"1.3.3.6",
"5.3.3.8",
"4.2.1.17",
"1.1.1.211",
"1.1.1.35",
"2.3.1.16"
],
"kegg.reaction":[
"R00388",
"R03224",
"R02685",
"R01778",
"R00391"
],
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0099",
"name":"Acyl-CoA:L-carnitine O-acyltransferase I (intermediary fatty acyl [C8:1]-CoA)",
"metabolites":{
"coa_c":1.0,
"crn_c":-1.0,
"fa8p1n3coa_c":-1.0,
"fa8p1n3crn_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00009622 or WBGene00011850",
"subsystem":"Carnitine shuttle",
"annotation":{
"ec-code":"2.3.1.137",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00765",
"name":"D-glucosamine-6-phosphate aminohydrolase (ketol isomerizing)",
"metabolites":{
"f6p_c":1.0,
"gam6p_c":-1.0,
"h2o_c":-1.0,
"nh4_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00011399",
"subsystem":"Amino sugar and nucleotide sugar metabolism",
"annotation":{
"ec-code":"3.5.99.6",
"kegg.reaction":"R00765",
"sbo":"SBO:0000176"
}
},
{
"id":"RC08759",
"name":" cholestanetriol 26-monooxygenase",
"metabolites":{
"h_c":1.0,
"nadp_c":-1.0,
"nadph_c":1.0,
"thcholst_c":1.0,
"xoltetrol_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000905",
"subsystem":"Primary bile acid biosynthesis",
"annotation":{
"ec-code":"1.14.13.15",
"kegg.reaction":"R08759",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01364",
"name":"4-fumarylacetoacetate fumarylhydrolase",
"metabolites":{
"4fumacac_c":-1.0,
"acac_c":1.0,
"fum_c":1.0,
"h2o_c":-1.0,
"h_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00019620",
"subsystem":"Tyrosine metabolism",
"annotation":{
"ec-code":"3.7.1.2",
"kegg.reaction":"R01364",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00768",
"name":"L-glutamine:D-fructose-6-phosphate isomerase (deaminating)",
"metabolites":{
"f6p_c":-1.0,
"gam6p_c":1.0,
"gln-L_c":-1.0,
"glu-L_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00008546 or WBGene00009035",
"subsystem":"Alanine, aspartate and glutamate metabolism",
"annotation":{
"ec-code":"2.6.1.16",
"kegg.reaction":"R00768",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE0504",
"name":"Fe2+ transport",
"metabolites":{
"fe2_c":1.0,
"fe2_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"EX00301",
"name":"ADPribose exchange",
"metabolites":{
"adprib_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EXC0072",
"name":"Soluble pool in bacterial diet exchange",
"metabolites":{
"soluble_BAC_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RM00549",
"name":"riboflavin kinase",
"metabolites":{
"adp_m":1.0,
"atp_m":-1.0,
"fmn_m":1.0,
"h_m":1.0,
"ribflv_m":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00011224",
"subsystem":"Riboflavin metabolism",
"annotation":{
"ec-code":"2.7.1.26",
"kegg.reaction":"R00549",
"sbo":"SBO:0000176"
}
},
{
"id":"TCM1279",
"name":"D-Lactate transport",
"metabolites":{
"lac-D_c":-1.0,
"lac-D_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM1278",
"name":"O-Acetylcarnitine transport",
"metabolites":{
"acrn_c":-1.0,
"acrn_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM1277",
"name":"Phosphoenolpyruvate and Citrate transport",
"metabolites":{
"cit_c":-1.0,
"cit_m":1.0,
"pep_c":1.0,
"pep_m":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00010780 or WBGene00021345",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM1276",
"name":"H2O transport",
"metabolites":{
"h2o_c":-1.0,
"h2o_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM1275",
"name":"O2 transport",
"metabolites":{
"o2_c":-1.0,
"o2_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM1274",
"name":"Ornithine transport",
"metabolites":{
"orn_c":1.0,
"orn_m":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"EX00942",
"name":"\"3',5'-Cyclic GMP\" exchange",
"metabolites":{
"35cgmp_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00940",
"name":"alpha-Ketoglutaramate exchange",
"metabolites":{
"akgm_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RCC0116",
"name":"Acyl-CoA:L-carnitine O-acyltransferase I (Stearoyl-CoA )",
"metabolites":{
"coa_c":1.0,
"crn_c":-1.0,
"stcoa_c":-1.0,
"stcrn_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00012907 or WBGene00021703 or WBGene00019644 or WBGene00008629 or WBGene00020911",
"subsystem":"Carnitine shuttle",
"annotation":{
"ec-code":"2.3.1.21",
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0111",
"name":"Acyl-CoA:L-carnitine O-acyltransferase I (dihomo-gamma-linolenyl CoA)",
"metabolites":{
"coa_c":1.0,
"crn_c":-1.0,
"dlnlcgcoa_c":-1.0,
"dlnlcgcrn_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00012907 or WBGene00021703 or WBGene00019644 or WBGene00008629 or WBGene00020911",
"subsystem":"Carnitine shuttle",
"annotation":{
"ec-code":"2.3.1.21",
"sbo":"SBO:0000176"
}
},
{
"id":"RM01875",
"name":"Thiosulfate:thiol sulfurtransferase",
"metabolites":{
"gthox_m":-1.0,
"gthrd_m":2.0,
"h2s_m":-1.0,
"so3_m":-1.0,
"tsul_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Sulfur metabolism",
"annotation":{
"ec-code":"2.8.1.3",
"kegg.reaction":"R01875",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01569",
"name":"Thymidylate 5-phosphohydrolase",
"metabolites":{
"dtmp_c":-1.0,
"h2o_c":-1.0,
"pi_c":1.0,
"thymd_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00017775 or WBGene00012423 or WBGene00022201",
"subsystem":"Pyrimidine metabolism",
"annotation":{
"ec-code":"3.1.3.5",
"kegg.reaction":"R01569",
"sbo":"SBO:0000176"
}
},
{
"id":"EX00016",
"name":"Flavin adenine dinucleotide oxidized exchange",
"metabolites":{
"fad_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
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}
},
{
"id":"TCM0098",
"name":"dGDP and dGTP transport",
"metabolites":{
"dgdp_c":1.0,
"dgdp_m":-1.0,
"dgtp_c":-1.0,
"dgtp_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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}
},
{
"id":"TCM0099",
"name":"dGDP and dCDP transport",
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"dcdp_c":1.0,
"dcdp_m":-1.0,
"dgdp_c":-1.0,
"dgdp_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"EX00012",
"name":"Peptide exchange",
"metabolites":{
"pepd_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
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}
},
{
"id":"RC01560",
"name":"adenosine deaminase",
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"adn_c":-1.0,
"h2o_c":-1.0,
"h_c":-1.0,
"ins_c":1.0,
"nh4_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00015551 or WBGene00016632",
"subsystem":"Purine metabolism",
"annotation":{
"ec-code":"3.5.4.4",
"kegg.reaction":"R01560",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01561",
"name":"Adenosine:phosphate alpha-D-ribosyltransferase",
"metabolites":{
"ade_c":1.0,
"adn_c":-1.0,
"pi_c":-1.0,
"r1p_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00019298",
"subsystem":"Purine metabolism",
"annotation":{
"ec-code":"2.4.2.1",
"kegg.reaction":"R01561",
"sbo":"SBO:0000176"
}
},
{
"id":"TCM0096",
"name":"dGTP and ADP transport",
"metabolites":{
"adp_c":1.0,
"adp_m":-1.0,
"dgtp_c":-1.0,
"dgtp_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RCC0112",
"name":"Acyl-CoA:L-carnitine O-acyltransferase I (timnodonyl CoA)",
"metabolites":{
"coa_c":1.0,
"crn_c":-1.0,
"tmndnccoa_c":-1.0,
"tmndnccrn_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00012907 or WBGene00021703 or WBGene00019644 or WBGene00008629 or WBGene00020911",
"subsystem":"Carnitine shuttle",
"annotation":{
"ec-code":"2.3.1.21",
"sbo":"SBO:0000176"
}
},
{
"id":"TCM0090",
"name":"Pyridoxamine 5'-phosphate transport",
"metabolites":{
"pyam5p_c":-1.0,
"pyam5p_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM0091",
"name":"ATP and dCDP transport",
"metabolites":{
"atp_c":1.0,
"atp_m":-1.0,
"dcdp_c":-1.0,
"dcdp_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM0092",
"name":"dTTP and ADP transport",
"metabolites":{
"adp_c":1.0,
"adp_m":-1.0,
"dttp_c":-1.0,
"dttp_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC01567",
"name":"ATP:thymidine 5-phosphotransferase",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"dtmp_c":1.0,
"h_c":1.0,
"thymd_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00006568",
"subsystem":"Pyrimidine metabolism",
"annotation":{
"ec-code":"2.7.1.21",
"kegg.reaction":"R01567",
"sbo":"SBO:0000176"
}
},
{
"id":"EX00785",
"name":"Urocanate exchange",
"metabolites":{
"urcan_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00780",
"name":"Serotonin exchange",
"metabolites":{
"srtn_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RC01931",
"name":"thiosulfate:cyanide sulfurtranserase",
"metabolites":{
"cyan_c":-1.0,
"h_c":1.0,
"so3_c":1.0,
"tcynt_c":1.0,
"tsul_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00008409 or WBGene00010380 or WBGene00010383 or WBGene00017387 or WBGene00022006 or WBGene00022007 or WBGene00011307",
"subsystem":"Miscellaneous",
"annotation":{
"ec-code":"2.8.1.1",
"kegg.reaction":"R01931",
"sbo":"SBO:0000176"
}
},
{
"id":"RC02466",
"name":"3-Sulfino-L-alanine carboxy-lyase",
"metabolites":{
"3sala_c":-1.0,
"co2_c":1.0,
"h_c":-1.0,
"hyptaur_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00006762",
"subsystem":"Taurine and hypotaurine metabolism",
"annotation":{
"ec-code":"4.1.1.15",
"kegg.reaction":"R02466",
"sbo":"SBO:0000176"
}
},
{
"id":"EX00130",
"name":"IMP exchange",
"metabolites":{
"imp_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"TCE0729",
"name":"Bicarbonate and Prostaglandin D2 transport",
"metabolites":{
"hco3_c":-1.0,
"hco3_e":1.0,
"prostgd2_c":1.0,
"prostgd2_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RM00130",
"name":"ATP:dephospho-CoA 3-phosphotransferase",
"metabolites":{
"adp_m":1.0,
"atp_m":-1.0,
"coa_m":1.0,
"dpcoa_m":-1.0,
"h_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00011500 or WBGene00022031",
"subsystem":"Pantothenate and CoA biosynthesis",
"annotation":{
"ec-code":"2.7.1.24",
"kegg.reaction":"R00130",
"sbo":"SBO:0000176"
}
},
{
"id":"RM04125",
"name":"S-aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming)",
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"dhlpro_m":1.0,
"mlthf_m":1.0,
"nh4_m":1.0,
"thf_m":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00017765 and (WBGene00008354 or WBGene00009918)",
"subsystem":"Glycine, serine and threonine metabolism",
"annotation":{
"ec-code":"2.1.2.10",
"kegg.reaction":"R04125",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE0723",
"name":"Retinoate transport",
"metabolites":{
"retn_c":-1.0,
"retn_e":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"EX02946",
"name":"4-Acetamidobutanoate exchange",
"metabolites":{
"4aabutn_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"TCE0726",
"name":"Urate transport",
"metabolites":{
"urate_c":-1.0,
"urate_e":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RM00138",
"name":"inorganic triphosphatase (mitochondrial)",
"metabolites":{
"h2o_m":-1.0,
"h_m":1.0,
"pi_m":1.0,
"ppi_m":1.0,
"pppi_m":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Miscellaneous",
"annotation":{
"ec-code":"3.6.1.25",
"kegg.reaction":"R00138",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01415",
"name":"5,6-Dihydrothymine:NADP+ oxidoreductase",
"metabolites":{
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"h_c":1.0,
"nadp_c":-1.0,
"nadph_c":1.0,
"thym_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00016103",
"subsystem":"Pyrimidine metabolism",
"annotation":{
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"kegg.reaction":"R01415",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE1121",
"name":"2-Oxoglutarate transport",
"metabolites":{
"akg_c":1.0,
"akg_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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}
},
{
"id":"RC01410",
"name":"cyanide conversion to alpha-Aminopropiononitrile",
"metabolites":{
"acald_c":-1.0,
"aprop_c":1.0,
"cyan_c":-1.0,
"h2o_c":1.0,
"nh4_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Cyanoamino acid metabolism",
"annotation":{
"kegg.reaction":"R01410",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE1124",
"name":"D-Sorbitol transport",
"metabolites":{
"sbt-D_c":1.0,
"sbt-D_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"EX00160",
"name":"Glycolate exchange",
"metabolites":{
"glyclt_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00163",
"name":"Propionate (n-C3:0) exchange",
"metabolites":{
"ppa_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
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}
},
{
"id":"EX00162",
"name":"R total exchange",
"metabolites":{
"Rtotal_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00164",
"name":"Acetoacetate exchange",
"metabolites":{
"acac_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00167",
"name":"UDP-D-glucuronate exchange",
"metabolites":{
"udpglcur_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RM02619",
"name":"3-sulfino-L-alanine:2-oxoglutarate aminotransferase",
"metabolites":{
"3sala_m":-1.0,
"3snpyr_m":1.0,
"akg_m":-1.0,
"glu-L_m":1.0,
"h_m":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00016652 or WBGene00015778",
"subsystem":"Cysteine and methionine metabolism",
"annotation":{
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"kegg.reaction":"R02619",
"sbo":"SBO:0000176"
}
},
{
"id":"TCM1072",
"name":"NMN transport",
"metabolites":{
"nmn_c":-1.0,
"nmn_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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}
},
{
"id":"TCE0797",
"name":"D-Alanine transport",
"metabolites":{
"ala-D_c":1.0,
"ala-D_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE0615",
"name":"\"7-alpha,25-Dihydroxycholesterol\" transport",
"metabolites":{
"xoltri25_c":-1.0,
"xoltri25_e":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE0612",
"name":"5alpha-Dihydrotestosterone transport",
"metabolites":{
"5adtststerone_c":1.0,
"5adtststerone_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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}
},
{
"id":"TCE0611",
"name":"Sulfate and Chloride transport",
"metabolites":{
"cl_c":-1.0,
"cl_e":1.0,
"so4_c":2.0,
"so4_e":-2.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE0618",
"name":"D-3-Amino-isobutanoate transport",
"metabolites":{
"3aib-D_c":-1.0,
"3aib-D_e":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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}
},
{
"id":"TCE0619",
"name":"Guanine transport",
"metabolites":{
"gua_c":1.0,
"gua_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC02266",
"name":"Prostaglandin-H2 D-isomerase (Precursor)",
"metabolites":{
"prostgd2_c":1.0,
"prostgh2_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00001759",
"subsystem":"Arachidonic acid metabolism",
"annotation":{
"ec-code":"5.3.99.2",
"kegg.reaction":"R02266",
"sbo":"SBO:0000176"
}
},
{
"id":"RC02265",
"name":"(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13- dienoate E-isomerase",
"metabolites":{
"prostge2_c":1.0,
"prostgh2_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00011239 or WBGene00022599",
"subsystem":"Arachidonic acid metabolism",
"annotation":{
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"kegg.reaction":"R02265",
"sbo":"SBO:0000176"
}
},
{
"id":"RC02269",
"name":"5,6-Dihydrouracil amidohydrolase",
"metabolites":{
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"cala_c":1.0,
"h2o_c":-1.0,
"h_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000963 or WBGene00000964",
"subsystem":"Pyrimidine metabolism",
"annotation":{
"ec-code":"3.5.2.2",
"kegg.reaction":"R02269",
"sbo":"SBO:0000176"
}
},
{
"id":"EX01762",
"name":"Xanthosine exchange",
"metabolites":{
"xtsn_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
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}
},
{
"id":"RM10092",
"name":"carbonate hydro-lyase (carbon-dioxide-forming)",
"metabolites":{
"co2_m":-1.0,
"h2o_m":-1.0,
"h_m":1.0,
"hco3_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000245 or WBGene00000282",
"subsystem":"Nitrogen metabolism",
"annotation":{
"ec-code":"4.2.1.1",
"kegg.reaction":"R10092",
"sbo":"SBO:0000176"
}
},
{
"id":"RC02519",
"name":"Homogentisate:oxygen 1,2-oxidoreductase (decyclizing)",
"metabolites":{
"4mlacac_c":1.0,
"h_c":1.0,
"hgentis_c":-1.0,
"o2_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00001843",
"subsystem":"Tyrosine metabolism",
"annotation":{
"ec-code":"1.13.11.5",
"kegg.reaction":"R02519",
"sbo":"SBO:0000176"
}
},
{
"id":"RC07034",
"name":"Glutathione: 5-HPETE oxidoreductase",
"metabolites":{
"5HETE_c":1.0,
"5HPET_c":-1.0,
"gthox_c":1.0,
"gthrd_c":-2.0,
"h2o_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00009165 or WBGene00011045 or WBGene00007517 or WBGene00022377 or WBGene00007516 or WBGene00019846 or WBGene00018850",
"subsystem":"Arachidonic acid metabolism",
"annotation":{
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"kegg.reaction":"R07034",
"sbo":"SBO:0000176"
}
},
{
"id":"EX02415",
"name":"Histone-L-Lysine exchange",
"metabolites":{
"Nlys_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RC04452",
"name":"Platelet-activating factor acetylhydrolase",
"metabolites":{
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"ak2lgchol_c":1.0,
"h2o_c":-1.0,
"h_c":1.0,
"paf_c":-1.0
},
"lower_bound":-0.0,
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"kegg.reaction":"R04452",
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}
},
{
"id":"RC02869",
"name":"S-adenosylmethioninamine:spermidine 3-aminopropyltransferase",
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"h_c":1.0,
"spmd_c":-1.0,
"sprm_c":1.0
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"subsystem":"Cysteine and methionine metabolism",
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"kegg.reaction":"R02869",
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}
},
{
"id":"EX00523",
"name":"Androsterone exchange",
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"andrstrn_e":-1.0
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
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}
},
{
"id":"EX11499",
"name":"L-sulfolactate exchange",
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"lower_bound":-0.0,
"upper_bound":1000.0,
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},
{
"id":"TCE5022",
"name":"sedoheptulose transport",
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"lower_bound":-1000.0,
"upper_bound":1000.0,
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}
},
{
"id":"TCE5023",
"name":"molybdate transport",
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"h2o_c":-1.0,
"h_c":1.0,
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}
},
{
"id":"TCE5020",
"name":"riboflavin transport in via proton symport",
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"ribflv_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
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},
{
"id":"TCE5021",
"name":"2-hydroxyglutarate transport",
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"2hglut_e":1.0
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"lower_bound":-1000.0,
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}
},
{
"id":"TCE0507",
"name":"Hydrogen cyanide transport",
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"cyan_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
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}
},
{
"id":"TCE5024",
"name":"beta carotene transport",
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"lower_bound":-1000.0,
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"gene_reaction_rule":"",
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}
},
{
"id":"EX02094",
"name":"beta-Carotene exchange",
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"caro_e":-1.0
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
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}
},
{
"id":"TCE0508",
"name":"L-Valine transport",
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"val-L_e":-1.0
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"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
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}
},
{
"id":"RC02464",
"name":"Sphinganine-1-phosphate pamlmitaldehyde-lyase",
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"m15hxdcal_c":1.0,
"sph1p_ce_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00004981 or WBGene00006418",
"subsystem":"Sphingolipid metabolism",
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"kegg.reaction":"R02464",
"sbo":"SBO:0000176"
}
},
{
"id":"RM01393",
"name":"hydroxypyruvate decarboxylase",
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"gcald_m":1.0,
"h_m":-1.0,
"hpyr_m":-1.0
},
"lower_bound":-0.0,
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"subsystem":"Glyoxylate and dicarboxylate metabolism",
"annotation":{
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"kegg.reaction":"R01393",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE0464",
"name":"Histamine transport",
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},
{
"id":"RC07109",
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"h2o_c":-1.0
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}
},
{
"id":"RC03482",
"name":"N-Acetyl-D-glucosaminylphosphatidylinositol acetyhydrolase",
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"lower_bound":-1000.0,
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"subsystem":"Glycosylphosphatidylinositol(GPI)-anchor biosynthesis",
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},
{
"id":"RC03336",
"name":"4-hydroxyphenyllactate:NAD+ oxidoreductase",
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"subsystem":"Ubiquinone and other terpenoid-quinone biosynthesis",
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},
{
"id":"RC03332",
"name":"phosphatidylinositol phospholipase C",
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},
{
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{
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},
{
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},
{
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},
{
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},
{
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},
{
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},
{
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},
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},
{
"id":"RC00220",
"name":"L-serine ammonia-lyase",
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"lower_bound":-0.0,
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},
{
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"name":"3-hydroxypropionate dehydrogenase",
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},
{
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"name":"2-hydroxyglutarate exchange",
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},
{
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"h_c":1.0,
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},
{
"id":"RC03936",
"name":"Formylkynurenine hydrolase",
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"lower_bound":-0.0,
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},
{
"id":"TCM5029",
"name":"Carnitine-acylcarnitine translocase",
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"lower_bound":-0.0,
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},
{
"id":"RM03665",
"name":"L-Valine:tRNAVal ligase (AMP-forming)",
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},
{
"id":"TCM5027",
"name":"cysteine transport to mitochondria",
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},
{
"id":"DMN0068",
"name":"11,12-DHET demand",
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},
{
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},
{
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},
{
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},
{
"id":"RCC0227",
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},
{
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},
{
"id":"DMN0066",
"name":"Prostaglandin E2 demand",
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"gene_reaction_rule":"",
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},
{
"id":"DMN0067",
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},
{
"id":"DMN0060",
"name":"2-Acyl-1-(1-alkenyl)-sn-glycero-3-phosphate demand",
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"subsystem":"Ether lipid metabolism",
"annotation":{
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},
{
"id":"DMN0061",
"name":"1-Alkenyl-2-acylglycerol demand",
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"annotation":{
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},
{
"id":"DMN0062",
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Ether lipid metabolism",
"annotation":{
"sbo":"SBO:0000628"
}
},
{
"id":"DMN0063",
"name":"w-hydroxyl leukotriene B4 demand",
"metabolites":{
"leuktrB4woh_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Arachidonic acid metabolism",
"annotation":{
"sbo":"SBO:0000628"
}
},
{
"id":"TCM1042",
"name":"Quinolinate transport",
"metabolites":{
"quln_c":-1.0,
"quln_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC04674",
"name":"N-Methylhistamine:oxygen oxidoreductase (deaminating) (copper-containing)",
"metabolites":{
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"h2o2_c":1.0,
"h2o_c":-1.0,
"mhista_c":-1.0,
"nh4_c":1.0,
"o2_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000138",
"subsystem":"Histidine metabolism",
"annotation":{
"ec-code":"1.4.3.4",
"kegg.reaction":"R04674",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE7666",
"name":"Methylhistamine transport",
"metabolites":{
"mhista_c":-1.0,
"mhista_e":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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}
},
{
"id":"RC00359",
"name":"D-Aspartate:oxygen oxidoreductase (deaminating)",
"metabolites":{
"asp-D_c":-1.0,
"h2o2_c":1.0,
"h2o_c":-1.0,
"nh4_c":1.0,
"o2_c":-1.0,
"oaa_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00008127 or WBGene00017565 or WBGene00017648)",
"subsystem":"Alanine, aspartate and glutamate metabolism",
"annotation":{
"ec-code":"1.4.3.1",
"kegg.reaction":"R00359",
"sbo":"SBO:0000176"
}
},
{
"id":"TCM1047",
"name":"Isocitrate and Citrate transport",
"metabolites":{
"cit_c":-1.0,
"cit_m":1.0,
"icit_c":1.0,
"icit_m":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RM00734",
"name":"L-tyrosine:2-oxoglutarate aminotransferase",
"metabolites":{
"34hpp_m":1.0,
"akg_m":-1.0,
"glu-L_m":1.0,
"tyr-L_m":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00016652 or WBGene00015778",
"subsystem":"Ubiquinone and other terpenoid-quinone biosynthesis",
"annotation":{
"ec-code":[
"2.6.1.1",
"2.6.1.5"
],
"kegg.reaction":"R00734",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00355",
"name":"L-Aspartate:2-oxoglutarate aminotransferase",
"metabolites":{
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"asp-L_c":-1.0,
"glu-L_c":1.0,
"oaa_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00020146",
"subsystem":"Alanine, aspartate and glutamate metabolism",
"annotation":{
"ec-code":"2.6.1.1",
"kegg.reaction":"R00355",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00352",
"name":"acetyl-CoA:oxaloacetate C-acetyltransferase [(pro-S)-carboxymethyl-forming, ADP-phosphorylating]",
"metabolites":{
"accoa_c":1.0,
"adp_c":1.0,
"atp_c":-1.0,
"cit_c":-1.0,
"coa_c":-1.0,
"oaa_c":1.0,
"pi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00007150 or WBGene00016995",
"subsystem":"Citrate cycle (TCA cycle)",
"annotation":{
"ec-code":"2.3.3.8",
"kegg.reaction":"R00352",
"sbo":"SBO:0000176"
}
},
{
"id":"RC08379",
"name":"retinol: NADP+ oxidoreductase",
"metabolites":{
"h_c":1.0,
"nadp_c":-1.0,
"nadph_c":1.0,
"retinal_c":1.0,
"retinol_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00010063 or WBGene00000976) or WBGene00007780",
"subsystem":"Retinol metabolism",
"annotation":{
"ec-code":"1.1.-.-",
"kegg.reaction":"R08379",
"sbo":"SBO:0000176"
}
},
{
"id":"EX00256",
"name":"D-Lactate exchange",
"metabolites":{
"lac-D_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX01060",
"name":"\"3,5-Diiodo-L-tyrosine\" exchange",
"metabolites":{
"35diotyr_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"TCM5111",
"name":"Phosphatidylserine export from mitochondria",
"metabolites":{
"ps_c":1.0,
"ps_m":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE0573",
"name":"Deoxyuridine transport",
"metabolites":{
"duri_c":1.0,
"duri_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RM02396",
"name":"Acetyl-CoA:carnitine O-acetyltransferase II",
"metabolites":{
"accoa_m":1.0,
"acrn_m":-1.0,
"coa_m":-1.0,
"crn_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00011122",
"subsystem":"Carnitine shuttle",
"annotation":{
"ec-code":"2.3.1.7",
"kegg.reaction":"R02396",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01951",
"name":"fucose-1-phosphate guanylyltransferase",
"metabolites":{
"fuc1p-L_c":-1.0,
"gdpfuc_c":1.0,
"gtp_c":-1.0,
"h_c":-1.0,
"ppi_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00044903",
"subsystem":"Fructose and mannose metabolism",
"annotation":{
"ec-code":"2.7.7.30",
"kegg.reaction":"R01951",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE0694",
"name":"L-Ascorbate transport",
"metabolites":{
"ascb-L_c":1.0,
"ascb-L_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC00685",
"name":"L-Tryptophan decarboxy-lyase",
"metabolites":{
"co2_c":1.0,
"h_c":-1.0,
"trp-L_c":-1.0,
"trypta_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000239 or WBGene00001839 or WBGene00006562",
"subsystem":"Tryptophan metabolism",
"annotation":{
"ec-code":"4.1.1.28",
"kegg.reaction":"R00685",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE5118",
"name":"ascr3 transport",
"metabolites":{
"ascr3_c":-1.0,
"ascr3_e":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Ascaroside biosynthesis",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC01956",
"name":"L-Kynurenine:2-oxoglutarate aminotransferase",
"metabolites":{
"4aphdob_c":1.0,
"Lkynr_c":-1.0,
"akg_c":-1.0,
"glu-L_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00009232",
"subsystem":"Tryptophan metabolism",
"annotation":{
"ec-code":"2.6.1.7",
"kegg.reaction":"R01956",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01959",
"name":"N-Formyl-L-kynurenine amidohydrolase",
"metabolites":{
"Lfmkynr_c":-1.0,
"Lkynr_c":1.0,
"for_c":1.0,
"h2o_c":-1.0,
"h_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00017051",
"subsystem":"Tryptophan metabolism",
"annotation":{
"ec-code":"3.5.1.9",
"kegg.reaction":"R01959",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE5502",
"name":"iodide transport",
"metabolites":{
"i_c":1.0,
"i_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RM03045",
"name":"3-Hydroxypropionyl-CoA hydro-lyase",
"metabolites":{
"3hpcoa_m":1.0,
"h2o_m":-1.0,
"prpncoa_m":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00001155",
"subsystem":"Propanoate metabolism",
"annotation":{
"ec-code":"4.2.1.17",
"kegg.reaction":"R03045",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00178",
"name":"S-adenosyl-L-methionine carboxy-lyase [(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium-forming]",
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"amet_c":-1.0,
"ametam_c":1.0,
"co2_c":1.0,
"h_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00004875",
"subsystem":"Cysteine and methionine metabolism",
"annotation":{
"ec-code":"4.1.1.50",
"kegg.reaction":"R00178",
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0139",
"name":"GTP:alpha-D-glucose-1-phosphate guanylyltransferase",
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"gdpg_c":1.0,
"gtp_c":-1.0,
"h_c":-1.0,
"ppi_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00016583 or WBGene00021628",
"subsystem":"Fructose and mannose metabolism",
"annotation":{
"ec-code":"2.7.7.13",
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0138",
"name":"D-Glucose to beta D-Glucose",
"metabolites":{
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"glc-D_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Artificial conversions",
"annotation":{
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0131",
"name":"methylglyoxal synthase",
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"g3p_c":-1.0,
"mthgxl_c":1.0,
"pi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Pyruvate metabolism",
"annotation":{
"ec-code":"4.2.3.3",
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0130",
"name":"fatty-acid--CoA ligase (vacc)",
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"atp_c":-1.0,
"coa_c":-1.0,
"ppi_c":1.0,
"vacc_c":-1.0,
"vacccoa_c":1.0
},
"lower_bound":-0.0,
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"gene_reaction_rule":"WBGene00009221 or WBGene00020343 or WBGene00018152 or WBGene00013575 or WBGene00022037 or WBGene00019920 or WBGene00016716 or WBGene00011173",
"subsystem":"Fatty acid metabolism",
"annotation":{
"ec-code":"6.2.1.3",
"kegg.reaction":"R00390",
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0137",
"name":"D-Glucose to alpha D-Glucose",
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"glc-D_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Artificial conversions",
"annotation":{
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0136",
"name":"synthesis of peptide with asparagine",
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"asn-L_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"N-Glycan biosynthesis",
"annotation":{
"sbo":"SBO:0000176"
}
},
{
"id":"RC00177",
"name":"ATP:L-methionine S-adenosyltransferase",
"metabolites":{
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"atp_c":-1.0,
"h2o_c":-1.0,
"met-L_c":-1.0,
"pi_c":1.0,
"ppi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00008205 or WBGene00015538 or WBGene00015540 or WBGene00006416",
"subsystem":"Cysteine and methionine metabolism",
"annotation":{
"ec-code":"2.5.1.6",
"kegg.reaction":"R00177",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00127",
"name":"ATP:AMP phosphotransferase",
"metabolites":{
"adp_c":2.0,
"amp_c":-1.0,
"atp_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00008458 or (WBGene00009531 or WBGene00002879)",
"subsystem":"Purine metabolism",
"annotation":{
"ec-code":"2.7.4.3",
"kegg.reaction":"R00127",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE5115",
"name":"ascr5 transport",
"metabolites":{
"ascr5_c":-1.0,
"ascr5_e":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Ascaroside biosynthesis",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC03346",
"name":"Nicotinate D-ribonucleotide phosphohydrolase",
"metabolites":{
"h2o_c":-1.0,
"nicrns_c":1.0,
"nicrnt_c":-1.0,
"pi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00017775 or WBGene00012423 or WBGene00022201",
"subsystem":"Nicotinate and nicotinamide metabolism",
"annotation":{
"ec-code":"3.1.3.5",
"kegg.reaction":"R03346",
"sbo":"SBO:0000176"
}
},
{
"id":"RC10059",
"name":"NADP+:L-tyrosine oxidoreductase (iodinating)",
"metabolites":{
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"i_c":-2.0,
"nadp_c":-2.0,
"nadph_c":2.0,
"tyr-L_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00015334",
"subsystem":"Tyrosine metabolism (indirect)",
"annotation":{
"ec-code":"1.22.1.1",
"kegg.reaction":"R10059",
"sbo":"SBO:0000176"
}
},
{
"id":"EX00376",
"name":"Retinal exchange",
"metabolites":{
"retinal_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RC06517",
"name":"acyl-CoA:sphingosine N-acyltransferase",
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"coa_c":1.0,
"dhcrm_ce_c":1.0,
"h_c":1.0,
"sphgn_ce_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00002043 or WBGene00002044 or WBGene00006505",
"subsystem":"Sphingolipid metabolism",
"annotation":{
"ec-code":"2.3.1.24",
"kegg.reaction":"R06517",
"sbo":"SBO:0000176"
}
},
{
"id":"RC06518",
"name":"N-acylsphingosine amidohydrolase",
"metabolites":{
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"dhcrm_ce_c":-1.0,
"h2o_c":-1.0,
"sphgn_ce_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00020947",
"subsystem":"Sphingolipid metabolism",
"annotation":{
"ec-code":"3.5.1.23",
"kegg.reaction":"R06518",
"sbo":"SBO:0000176"
}
},
{
"id":"RC06519",
"name":"sphingolipid delta-4 desaturase",
"metabolites":{
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"dhcrm_ce_c":-1.0,
"h2o_c":2.0,
"h_c":-1.0,
"nadp_c":1.0,
"nadph_c":-1.0,
"o2_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00017996 or WBGene00013197",
"subsystem":"Sphingolipid metabolism",
"annotation":{
"ec-code":"1.14.-.-",
"kegg.reaction":"R06519",
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0046",
"name":"dextrin phosphorylase",
"metabolites":{
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"g1p_c":1.0,
"pi_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00020696",
"subsystem":"Starch and sucrose metabolism",
"annotation":{
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"sbo":"SBO:0000176"
}
},
{
"id":"RCC0045",
"name":"Dextrin 6-alpha-D-glucanohydrolase",
"metabolites":{
"dxtrn2_c":-1.0,
"dxtrn3_c":0.8,
"glc-D-B_c":0.2,
"h2o_c":-0.2
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00011050",
"subsystem":"Starch and sucrose metabolism",
"annotation":{
"ec-code":"3.2.1.33",
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0044",
"name":"dextrin transglycosylase",
"metabolites":{
"dxtrn1_c":-1.0,
"dxtrn2_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00011050",
"subsystem":"Starch and sucrose metabolism",
"annotation":{
"ec-code":"2.4.1.25",
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0043",
"name":"glycogen phosphorylase",
"metabolites":{
"dxtrn1_c":0.5,
"g1p_c":0.5,
"glycogen_c":-1.0,
"pi_c":-0.5
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00020696",
"subsystem":"Starch and sucrose metabolism",
"annotation":{
"ec-code":"2.4.1.1",
"kegg.reaction":"R01821",
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0042",
"name":"beta-N-acetylglucosaminidase (acting on fnm2masn)",
"metabolites":{
"acgam_c":1.0,
"fm2masn_c":1.0,
"fnm2masn_c":-1.0,
"h2o_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00015767 or WBGene00012663 or WBGene00021766 or WBGene00013497",
"subsystem":"N-Glycan biosynthesis",
"annotation":{
"ec-code":"3.2.1.52",
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0041",
"name":"beta-N-acetylglucosaminidase (acting on nm2masn)",
"metabolites":{
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"h2o_c":-1.0,
"m2masn_c":1.0,
"nm2masn_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00015767 or WBGene00012663 or WBGene00021766 or WBGene00013497",
"subsystem":"N-Glycan biosynthesis",
"annotation":{
"ec-code":"3.2.1.52",
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0040",
"name":"beta-N-acetylglucosaminidase (acting on nm3masn)",
"metabolites":{
"acgam_c":1.0,
"h2o_c":-1.0,
"m3masn_c":1.0,
"nm3masn_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00015767 or WBGene00012663 or WBGene00021766 or WBGene00013497",
"subsystem":"N-Glycan biosynthesis",
"annotation":{
"ec-code":"3.2.1.52",
"sbo":"SBO:0000176"
}
},
{
"id":"RC08767",
"name":"4-hydroxybenzoyl-CoA formation",
"metabolites":{
"4cmcoa_c":-1.0,
"4hbzcoa_c":1.0,
"accoa_c":1.0,
"coa_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"nad_c":-1.0,
"nadh_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
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"annotation":{
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}
},
{
"id":"RC08766",
"name":"3-(4-hydroxyphenyl)lactate hydro-lyase (4-coumarate-forming)",
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"34hpl_c":-1.0,
"T4hcinnm_c":1.0,
"h2o_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Ubiquinone and other terpenoid-quinone biosynthesis",
"annotation":{
"ec-code":"4.2.1.-",
"kegg.reaction":"R08766",
"sbo":"SBO:0000176"
}
},
{
"id":"RC08761",
"name":"3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate,NADPH:oxygen oxidoreductase (26-hydroxylating)",
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"h2o_c":1.0,
"nadp_c":1.0,
"nadph_c":-1.0,
"o2_c":-1.0,
"thcholst_c":-1.0,
"thcholstoic_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000905",
"subsystem":"Primary bile acid biosynthesis",
"annotation":{
"ec-code":"1.14.13.15",
"kegg.reaction":"R08761",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01315",
"name":"Phosphatidylcholine 2-acylhydrolase",
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"h2o_c":-1.0,
"h_c":1.0,
"lpchol_c":1.0,
"pchol_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00019747 or WBGene00009801 or WBGene00012319 or WBGene00017026 or WBGene00019229 or WBGene00022233 or WBGene00011423 or WBGene00007419 or WBGene00044468",
"subsystem":"Glycerophospholipid metabolism",
"annotation":{
"ec-code":"3.1.1.4",
"kegg.reaction":"R01315",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00575",
"name":"hydrogen-carbonate:L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating)",
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"adp_c":2.0,
"atp_c":-2.0,
"cbp_c":1.0,
"gln-L_c":-1.0,
"glu-L_c":1.0,
"h2o_c":-1.0,
"h_c":2.0,
"hco3_c":-1.0,
"pi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00004259",
"subsystem":"Pyrimidine metabolism",
"annotation":{
"ec-code":"6.3.5.5",
"kegg.reaction":"R00575",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00570",
"name":"ATP:CDP phosphotransferase",
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"adp_c":1.0,
"atp_c":-1.0,
"cdp_c":-1.0,
"ctp_c":1.0
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"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00019899 or WBGene00021692 or WBGene00009119",
"subsystem":"Pyrimidine metabolism",
"annotation":{
"ec-code":"2.7.4.6",
"kegg.reaction":"R00570",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00571",
"name":"UTP:ammonia ligase (ADP-forming)",
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"adp_c":1.0,
"atp_c":-1.0,
"ctp_c":1.0,
"h_c":2.0,
"nh4_c":-1.0,
"pi_c":1.0,
"utp_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00012316",
"subsystem":"Pyrimidine metabolism",
"annotation":{
"ec-code":"6.3.4.2",
"kegg.reaction":"R00571",
"sbo":"SBO:0000176"
}
},
{
"id":"TCM1048",
"name":"Ethanol transport",
"metabolites":{
"etoh_c":-1.0,
"etoh_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC00573",
"name":"UTP:L-glutamine amido-ligase (ADP-forming)",
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"adp_c":1.0,
"atp_c":-1.0,
"ctp_c":1.0,
"gln-L_c":-1.0,
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"h2o_c":-1.0,
"h_c":2.0,
"pi_c":1.0,
"utp_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00012316",
"subsystem":"Pyrimidine metabolism",
"annotation":{
"ec-code":"6.3.4.2",
"kegg.reaction":"R00573",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01083",
"name":"N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming)",
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"amp_c":1.0,
"dcamp_c":-1.0,
"fum_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00011064",
"subsystem":"Purine metabolism",
"annotation":{
"ec-code":"4.3.2.2",
"kegg.reaction":"R01083",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01082",
"name":"(S)-malate hydro-lyase (fumarate-forming) (cytosolic)",
"metabolites":{
"fum_c":1.0,
"h2o_c":1.0,
"mal-L_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00001503",
"subsystem":"Citrate cycle (TCA cycle)",
"annotation":{
"ec-code":"4.2.1.2",
"kegg.reaction":"R01082",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00578",
"name":"L-aspartate:L-glutamine amido-ligase (AMP-forming)",
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"amp_c":1.0,
"asn-L_c":1.0,
"asp-L_c":-1.0,
"atp_c":-1.0,
"gln-L_c":-1.0,
"glu-L_c":1.0,
"h2o_c":-1.0,
"h_c":1.0,
"ppi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00003816 or WBGene00019730",
"subsystem":"Alanine, aspartate and glutamate metabolism",
"annotation":{
"ec-code":"6.3.5.4",
"kegg.reaction":"R00578",
"sbo":"SBO:0000176"
}
},
{
"id":"TCM5056",
"name":"Carnitine-acylcarnitine translocase (tmndnccrn)",
"metabolites":{
"tmndnccrn_c":-1.0,
"tmndnccrn_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000996 or WBGene00008320",
"subsystem":"Carnitine shuttle",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"EX00143",
"name":"\"5,10-Methylenetetrahydrofolate\" exchange",
"metabolites":{
"mlthf_e":-1.0
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"DMN1005",
"name":"Forssman hapten demand",
"metabolites":{
"forssman_ce_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Miscellaneous",
"annotation":{
"sbo":"SBO:0000628"
}
},
{
"id":"DMN1004",
"name":"Inositol 1,3,4,5,6-pentakisphosphate demand.",
"metabolites":{
"mi13456p_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Inositol phosphate metabolism",
"annotation":{
"sbo":"SBO:0000628"
}
},
{
"id":"DMN1007",
"name":"Inositol 1,3,4-trisphosphate demand",
"metabolites":{
"mi134p_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Inositol phosphate metabolism",
"annotation":{
"sbo":"SBO:0000628"
}
},
{
"id":"DMN1006",
"name":"D-Glucosaminylphosphatidylinositol demand",
"metabolites":{
"gpail_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Glycosylphosphatidylinositol(GPI)-anchor biosynthesis",
"annotation":{
"sbo":"SBO:0000628"
}
},
{
"id":"DMN1001",
"name":"Diiodotyrosine demand",
"metabolites":{
"35diotyr_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Miscellaneous",
"annotation":{
"sbo":"SBO:0000628"
}
},
{
"id":"EX00954",
"name":"Indole-3-acetate exchange",
"metabolites":{
"ind3ac_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"TCM5053",
"name":"Carnitine-acylcarnitine translocase (lnlccrn)",
"metabolites":{
"lnlccrn_c":-1.0,
"lnlccrn_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000996 or WBGene00008320",
"subsystem":"Carnitine shuttle",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"EX00956",
"name":"L-2-Aminoadipate exchange",
"metabolites":{
"L2aadp_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00483",
"name":"Tyramine exchange",
"metabolites":{
"tym_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"TCM5052",
"name":"Carnitine-acylcarnitine translocase (fa8p1n3crn)",
"metabolites":{
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"fa8p1n3crn_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000996 or WBGene00008320",
"subsystem":"Carnitine shuttle",
"annotation":{
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}
},
{
"id":"RC01227",
"name":"Guanosine 5-monophosphate phosphohydrolase",
"metabolites":{
"gmp_c":-1.0,
"gsn_c":1.0,
"h2o_c":-1.0,
"pi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00017775 or WBGene00012423 or WBGene00022201",
"subsystem":"Purine metabolism",
"annotation":{
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"kegg.reaction":"R01227",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00161",
"name":"ATP:FMN adenylyltransferase",
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"fmn_c":-1.0,
"h_c":-1.0,
"ppi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00011271",
"subsystem":"Riboflavin metabolism",
"annotation":{
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"kegg.reaction":"R00161",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01224",
"name":"5-methyltetrahydrofolate:NADP+ oxidoreductase",
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"h_c":-2.0,
"mlthf_c":-1.0,
"nadp_c":1.0,
"nadph_c":-1.0
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"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00015512",
"subsystem":"One carbon pool by folate",
"annotation":{
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"kegg.reaction":"R01224",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01220",
"name":"5,10-methylenetetrahydrofolate:NADP+ oxidoreductase",
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"mlthf_c":-1.0,
"nadp_c":-1.0,
"nadph_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00019492",
"subsystem":"One carbon pool by folate",
"annotation":{
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"kegg.reaction":"R01220",
"sbo":"SBO:0000176"
}
},
{
"id":"TCM5050",
"name":"Carnitine-acylcarnitine translocase (dlnlcgcrn)",
"metabolites":{
"dlnlcgcrn_c":-1.0,
"dlnlcgcrn_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000996 or WBGene00008320",
"subsystem":"Carnitine shuttle",
"annotation":{
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}
},
{
"id":"TCE5094",
"name":"octopamine secretion",
"metabolites":{
"octpmn_c":-1.0,
"octpmn_e":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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}
},
{
"id":"EX01326",
"name":"Hydrogen cyanide exchange",
"metabolites":{
"cyan_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
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}
},
{
"id":"RC01229",
"name":"GMP:diphosphate 5-phospho-alpha-D-ribosyltransferase",
"metabolites":{
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"gua_c":-1.0,
"ppi_c":1.0,
"prpp_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00020557 or WBGene00013690",
"subsystem":"Purine metabolism",
"annotation":{
"ec-code":[
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"2.4.2.8"
],
"kegg.reaction":"R01229",
"sbo":"SBO:0000176"
}
},
{
"id":"RM00472",
"name":"malate synthase",
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"coa_m":1.0,
"glx_m":-1.0,
"h2o_m":-1.0,
"h_m":1.0,
"mal-L_m":1.0
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00001564",
"subsystem":"Glyoxylate and dicarboxylate metabolism",
"annotation":{
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"kegg.reaction":"R00472",
"sbo":"SBO:0000176"
}
},
{
"id":"EX00002",
"name":"ATP exchange",
"metabolites":{
"atp_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RC01795",
"name":"L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating)",
"metabolites":{
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"h2o_c":1.0,
"o2_c":-1.0,
"phe-L_c":-1.0,
"thbpt_c":-1.0,
"tyr-L_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000240",
"subsystem":"Phenylalanine metabolism",
"annotation":{
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"kegg.reaction":"R01795",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01794",
"name":"5,6,7,8-tetrahydrobiopterin:NADP+ oxidoreductase",
"metabolites":{
"dhbpt_c":-1.0,
"h_c":-1.0,
"nadp_c":1.0,
"nadph_c":-1.0,
"thbpt_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00011398",
"subsystem":"Folate biosynthesis",
"annotation":{
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"kegg.reaction":"R01794",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01793",
"name":"5,6,7,8-tetrahydrobiopterin:NAD+ oxidoreductase",
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"h_c":-1.0,
"nad_c":1.0,
"nadh_c":-1.0,
"thbpt_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00011398",
"subsystem":"Folate biosynthesis",
"annotation":{
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"kegg.reaction":"R01793",
"sbo":"SBO:0000176"
}
},
{
"id":"EX00007",
"name":"O2 exchange",
"metabolites":{
"o2_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00559",
"name":"Deoxyadenosine exchange",
"metabolites":{
"dad-2_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00009",
"name":"Phosphate exchange",
"metabolites":{
"pi_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RC01799",
"name":"CTP:phosphatidate cytidyltransferase",
"metabolites":{
"cdpdag_c":1.0,
"ctp_c":-1.0,
"h_c":-1.0,
"pa_pl_c":-1.0,
"ppi_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00016384",
"subsystem":"Glycerophospholipid metabolism",
"annotation":{
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"kegg.reaction":"R01799",
"sbo":"SBO:0000176"
}
},
{
"id":"EX00794",
"name":"D-Sorbitol exchange",
"metabolites":{
"sbt-D_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"TCM0222",
"name":"dADP and dCDP transport",
"metabolites":{
"dadp_c":-1.0,
"dadp_m":1.0,
"dcdp_c":1.0,
"dcdp_m":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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}
},
{
"id":"TCM0221",
"name":"dUTP and dGDP transport",
"metabolites":{
"dgdp_c":1.0,
"dgdp_m":-1.0,
"dutp_c":-1.0,
"dutp_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM0220",
"name":"dATP and dCDP transport",
"metabolites":{
"datp_c":-1.0,
"datp_m":1.0,
"dcdp_c":1.0,
"dcdp_m":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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}
},
{
"id":"TCM0224",
"name":"(S)-3-Hydroxybutanoate transport",
"metabolites":{
"S3hb_c":-1.0,
"S3hb_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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}
},
{
"id":"RM04138",
"name":"3-Methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)",
"metabolites":{
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"3mgcoa_m":1.0,
"adp_m":1.0,
"atp_m":-1.0,
"h_m":1.0,
"hco3_m":-1.0,
"pi_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00009319 and WBGene00008514",
"subsystem":"Valine, leucine and isoleucine degradation",
"annotation":{
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"kegg.reaction":"R04138",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE1130",
"name":"Melibiose transport",
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"melib_c":1.0,
"melib_e":-1.0
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
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}
},
{
"id":"TCE1132",
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},
{
"id":"TCE1133",
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"pap_c":1.0,
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"lower_bound":-1000.0,
"upper_bound":1000.0,
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}
},
{
"id":"RM00383",
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"h_m":1.0,
"ppa_m":1.0,
"ppcoa_m":-1.0
},
"lower_bound":-0.0,
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"gene_reaction_rule":"",
"subsystem":"Propanoate metabolism",
"annotation":{
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"kegg.reaction":"R00383",
"sbo":"SBO:0000176"
}
},
{
"id":"TCM1085",
"name":"L-Serine transport",
"metabolites":{
"ser-L_c":-1.0,
"ser-L_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
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},
{
"id":"TCM0137",
"name":"dUDP and dCTP transport",
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"lower_bound":-0.0,
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}
},
{
"id":"TCM0135",
"name":"L-Valine transport",
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"val-L_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
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}
},
{
"id":"TCM0134",
"name":"Formaldehyde transport",
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"fald_c":1.0,
"fald_m":-1.0
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"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM0132",
"name":"L-Isoleucine transport",
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"ile-L_c":-1.0,
"ile-L_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
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"annotation":{
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}
},
{
"id":"TCM0131",
"name":"dTTP and dUDP transport",
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"lower_bound":-0.0,
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}
},
{
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"name":"dADP and dATP transport",
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"datp_m":1.0
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"lower_bound":-0.0,
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"gene_reaction_rule":"",
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}
},
{
"id":"TCM0139",
"name":"Sulfite and Fumarate transport",
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"fum_c":-1.0,
"fum_m":1.0,
"so3_c":1.0,
"so3_m":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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}
},
{
"id":"RMC0089",
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"h2o_m":-1.0,
"h_m":1.0,
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"1.1.1.211",
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"R02685",
"R01778",
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},
{
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"5.3.3.8",
"4.2.1.17",
"1.1.1.211",
"1.1.1.35",
"2.3.1.16"
],
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"R02685",
"R01778",
"R00391"
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},
{
"id":"RMC0087",
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"crn_m":1.0,
"occoa_m":1.0,
"occrn_m":-1.0
},
"lower_bound":-0.0,
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"subsystem":"Carnitine shuttle",
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}
},
{
"id":"TCE0662",
"name":"Sodium transport",
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"na1_e":-1.0
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"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
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}
},
{
"id":"TCE0660",
"name":"Methylglyoxal transport",
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"lower_bound":-0.0,
"upper_bound":1000.0,
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}
},
{
"id":"EX05519",
"name":"L-Allo-threonine exchange",
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}
},
{
"id":"EX01194",
"name":"Phosphatidylinositol exchange",
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"lower_bound":-0.0,
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},
{
"id":"EX05684",
"name":"Selenite exchange",
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"lower_bound":-0.0,
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},
{
"id":"EX01755",
"name":"Thiocyanate exchange",
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"tcynt_e":-1.0
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
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"annotation":{
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},
{
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"lower_bound":-0.0,
"upper_bound":1000.0,
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},
{
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"h2o_c":-1.0,
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"o2_c":-1.0
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"kegg.reaction":"R02529",
"sbo":"SBO:0000176"
}
},
{
"id":"RC02038",
"name":"CTP:ethanolamine-phosphate cytidylyltransferase",
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"ctp_c":-1.0,
"ethamp_c":-1.0,
"h_c":-1.0,
"ppi_c":1.0
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"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00016531 or WBGene00021352",
"subsystem":"Glycerophospholipid metabolism",
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}
},
{
"id":"RC02521",
"name":"4-Hydroxyphenylpyruvate:oxygen oxidoreductase (hydroxylating,decarboxylating)",
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"hgentis_c":1.0,
"o2_c":-1.0
},
"lower_bound":-0.0,
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"gene_reaction_rule":"WBGene00016294 or WBGene00001993",
"subsystem":"Ubiquinone and other terpenoid-quinone biosynthesis",
"annotation":{
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},
{
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"name":"CDP-diacylglycerol:phosphatidylglycerol 3-phosphatidyltransferase",
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"cmp_c":1.0,
"h_c":1.0,
"pglyc_c":-1.0
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"lower_bound":-1000.0,
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"gene_reaction_rule":"WBGene00017763",
"subsystem":"Glycerophospholipid metabolism",
"annotation":{
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"kegg.reaction":"R02030",
"sbo":"SBO:0000176"
}
},
{
"id":"RC02037",
"name":"S-Adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase",
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"amet_c":-1.0,
"ethamp_c":-1.0,
"h_c":1.0,
"methamp_c":1.0
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"lower_bound":-0.0,
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}
},
{
"id":"RC02035",
"name":"6-Phospho-D-glucono-1,5-lactone lactonohydrolase",
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"h2o_c":-1.0,
"h_c":1.0
},
"lower_bound":-0.0,
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"gene_reaction_rule":"WBGene00013301",
"subsystem":"Pentose phosphate pathway",
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},
{
"id":"EX01996",
"name":"Acetylcholine exchange",
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
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},
{
"id":"TCE5099",
"name":"Release of molybdate",
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
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},
{
"id":"TCE5098",
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"lower_bound":-1000.0,
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"gene_reaction_rule":"",
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},
{
"id":"EX06341",
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
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},
{
"id":"TCE5349",
"name":"3-Hydroxyanthranilate transport",
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"lower_bound":-1000.0,
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},
{
"id":"TCE5348",
"name":"Orotate transport",
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"orot_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
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}
},
{
"id":"TCE5347",
"name":"2-Oxoadipate transport",
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"akg_c":1.0,
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},
{
"id":"RC02326",
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},
{
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"name":"Tryptamine transport",
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"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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},
{
"id":"TCE5344",
"name":"trans-4-Hydroxycinnamate transport",
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"oh1_e":-1.0
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"gene_reaction_rule":"",
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},
{
"id":"RC02323",
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"sbo":"SBO:0000176"
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},
{
"id":"TCE5342",
"name":"Phosphoenolpyruvate transport",
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"lower_bound":-1000.0,
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"gene_reaction_rule":"",
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},
{
"id":"TCE5341",
"name":"Quinolinate transport",
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"so4_c":-1.0,
"so4_e":1.0
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"lower_bound":-1000.0,
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},
{
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"name":"Homogentisate transport",
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"hgentis_e":1.0
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"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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},
{
"id":"RC02147",
"name":"guanosine:phosphate alpha-D-ribosyltransferase",
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"pi_c":-1.0,
"r1p_c":1.0
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"lower_bound":-1000.0,
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"sbo":"SBO:0000176"
}
},
{
"id":"RC07641",
"name":"hydrogen-carbonate:ammonia amido-ligase (ADP-forming, carbamate-phosphorylating)",
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"atp_c":-2.0,
"cbp_c":1.0,
"h_c":2.0,
"hco3_c":-1.0,
"nh4_c":-1.0,
"pi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00004259",
"subsystem":"Pyrimidine metabolism",
"annotation":{
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"kegg.reaction":"R07641",
"sbo":"SBO:0000176"
}
},
{
"id":"RC02142",
"name":"XMP:pyrophosphate phosphoribosyltransferase",
"metabolites":{
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"prpp_c":-1.0,
"xan_c":-1.0,
"xmp_c":1.0
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00013690",
"subsystem":"Purine metabolism",
"annotation":{
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"kegg.reaction":"R02142",
"sbo":"SBO:0000176"
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},
{
"id":"TCE0450",
"name":"Pyridoxal transport",
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"pydx_e":-1.0
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"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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}
},
{
"id":"RC03321",
"name":"beta-D-Glucose 6-phosphate ketol-isomerase",
"metabolites":{
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"g6p-B_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00013597",
"subsystem":"Glycolysis / Gluconeogenesis",
"annotation":{
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"kegg.reaction":"R03321",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE5307",
"name":"7alpha,12alpha-Dihydroxycholest-4-en-3-one transport",
"metabolites":{
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"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0,
"xoldiolone_c":-1.0,
"xoldiolone_e":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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}
},
{
"id":"EX03917",
"name":"5alpha-Dihydrotestosterone exchange",
"metabolites":{
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
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},
{
"id":"TCE5304",
"name":"5,10-Methylenetetrahydrofolate secretion",
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"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"mlthf_c":-1.0,
"mlthf_e":1.0,
"pi_c":1.0
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"EX03284",
"name":"L-3-Amino-isobutanoate exchange",
"metabolites":{
"3aib_e":-1.0
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RC03038",
"name":"L-Alanine:tRNA(Ala) ligase (AMP-forming)",
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"ala-L_c":-1.0,
"alatrna_c":1.0,
"amp_c":1.0,
"atp_c":-1.0,
"ppi_c":1.0,
"trnaala_c":-1.0
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000197",
"subsystem":"Aminoacyl-tRNA biosynthesis",
"annotation":{
"ec-code":"6.1.1.7",
"kegg.reaction":"R03038",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE0401",
"name":"androsterone glucuronide transport",
"metabolites":{
"adp_c":1.0,
"andrstrnglc_c":-1.0,
"andrstrnglc_e":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RM01616",
"name":"4-Coumarate:CoA ligase (AMP-forming)",
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"4cmcoa_m":1.0,
"T4hcinnm_m":-1.0,
"amp_m":1.0,
"atp_m":-1.0,
"coa_m":-1.0,
"ppi_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00022849",
"subsystem":"Ubiquinone and other terpenoid-quinone biosynthesis",
"annotation":{
"ec-code":"6.2.1.12",
"kegg.reaction":"R01616",
"sbo":"SBO:0000176"
}
},
{
"id":"RC04208",
"name":"2-(Formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming)",
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"adp_c":1.0,
"air_c":1.0,
"atp_c":-1.0,
"fpram_c":-1.0,
"h_c":2.0,
"pi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00018174",
"subsystem":"Purine metabolism",
"annotation":{
"ec-code":"6.3.3.1",
"kegg.reaction":"R04208",
"sbo":"SBO:0000176"
}
},
{
"id":"RC04209",
"name":"1-(5-phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate carboxy-lyase",
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"5aizc_c":1.0,
"air_c":-1.0,
"co2_c":-1.0,
"h_c":1.0
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"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00015116",
"subsystem":"Purine metabolism",
"annotation":{
"ec-code":"4.1.1.21",
"kegg.reaction":"R04209",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00963",
"name":"Uridine 5-monophosphate phosphohydrolase",
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"h2o_c":-1.0,
"pi_c":1.0,
"ump_c":-1.0,
"uri_c":1.0
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"lower_bound":-0.0,
"upper_bound":1000.0,
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"ec-code":"3.1.3.5",
"kegg.reaction":"R00963",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00961",
"name":"IDP phosphohydrolase",
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"h2o_c":-1.0,
"h_c":1.0,
"idp_c":-1.0,
"imp_c":1.0,
"pi_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00044355 or WBGene00017244) or WBGene00003254 or WBGene00010697",
"subsystem":"Purine metabolism",
"annotation":{
"ec-code":"3.6.1.6",
"kegg.reaction":"R00961",
"sbo":"SBO:0000176"
}
},
{
"id":"RC04073",
"name":"Peptide-L-aspartate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)",
"metabolites":{
"akg_c":-1.0,
"co2_c":1.0,
"o2_c":-1.0,
"pepasp3oh_c":1.0,
"pepasp_c":-1.0,
"succ_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00010703",
"subsystem":"Protein modification by hydroxylation",
"annotation":{
"ec-code":"1.14.11.16",
"kegg.reaction":"R04073",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00965",
"name":"orotidine-5-phosphate carboxy-lyase (UMP-forming)",
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"co2_c":1.0,
"h_c":-1.0,
"orot5p_c":-1.0,
"ump_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00011559",
"subsystem":"Pyrimidine metabolism",
"annotation":{
"ec-code":"4.1.1.23",
"kegg.reaction":"R00965",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00964",
"name":"ATP:uridine 5-phosphotransferase",
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"atp_c":-1.0,
"h_c":1.0,
"ump_c":1.0,
"uri_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00007089 or WBGene00008948",
"subsystem":"Pyrimidine metabolism",
"annotation":{
"ec-code":"2.7.1.48",
"kegg.reaction":"R00964",
"sbo":"SBO:0000176"
}
},
{
"id":"RC04866",
"name":"S-adenosyl-L-methionine:histone-L-lysine N6-methyltransferase (acting on monomethylated residues)",
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"Nmelys_c":-1.0,
"ahcys_c":1.0,
"amet_c":-1.0,
"h_c":1.0
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"lower_bound":-0.0,
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"gene_reaction_rule":"(WBGene00011729 or WBGene00003040 or (WBGene00016603 or WBGene00019584) or WBGene00004782 or WBGene00019883 or WBGene00018023 or WBGene00003220 or WBGene00021515 or (WBGene00021474 or WBGene00010067 or WBGene00012302 or WBGene00010120 or WBGene00022512) or WBGene00016313 or WBGene00004781) or (WBGene00019690 or WBGene00020006 or WBGene00021282 or WBGene00008062 or WBGene00022431 or WBGene00008206)",
"subsystem":"Histone modification",
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"kegg.reaction":"R04866",
"sbo":"SBO:0000176"
}
},
{
"id":"RC04867",
"name":"S-adenosyl-L-methionine:histone-L-lysine N6-methyltransferase (acting on dimethylated residues)",
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"Ntmelys_c":1.0,
"ahcys_c":1.0,
"amet_c":-1.0,
"h_c":1.0
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00011729 or WBGene00003040 or (WBGene00016603 or WBGene00019584) or WBGene00004782 or WBGene00019883 or WBGene00018023 or WBGene00003220 or WBGene00021515 or (WBGene00021474 or WBGene00010067 or WBGene00012302 or WBGene00010120 or WBGene00022512) or WBGene00016313 or WBGene00004781) or (WBGene00019690 or WBGene00020006 or WBGene00021282 or WBGene00008062 or WBGene00022431 or WBGene00008206)",
"subsystem":"Histone modification",
"annotation":{
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"kegg.reaction":"R04867",
"sbo":"SBO:0000176"
}
},
{
"id":"DMN0064",
"name":"5-Hydroxyeicosatetraenoate demand",
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"5HETE_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Arachidonic acid metabolism",
"annotation":{
"sbo":"SBO:0000628"
}
},
{
"id":"RM01923",
"name":"Palmitoyl-CoA:L-carnitine O-palmitoyltransferase II",
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"crn_m":1.0,
"pmtcoa_m":1.0,
"pmtcrn_m":-1.0
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00011122",
"subsystem":"Fatty acid metabolism",
"annotation":{
"ec-code":"2.3.1.21",
"kegg.reaction":"R01923",
"sbo":"SBO:0000176"
}
},
{
"id":"RM02016",
"name":"NADPH:oxidized-thioredoxin oxidoreductase",
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"nadp_m":1.0,
"nadph_m":-1.0,
"trdox_m":-1.0,
"trdrd_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00015553",
"subsystem":"Pyrimidine metabolism",
"annotation":{
"ec-code":"1.8.1.9",
"kegg.reaction":"R02016",
"sbo":"SBO:0000176"
}
},
{
"id":"DMN0059",
"name":"glutaurine demand",
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"glutaur_c":-1.0
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Taurine and hypotaurine metabolism",
"annotation":{
"sbo":"SBO:0000628"
}
},
{
"id":"DMN0058",
"name":"tmao and urea demand for osmotic balancing",
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"tmao_c":-1.0,
"urea_c":-2.0
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"lower_bound":-0.0,
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"gene_reaction_rule":"",
"subsystem":"Miscellaneous",
"annotation":{
"sbo":"SBO:0000628"
}
},
{
"id":"TCM1287",
"name":"CO2 transport",
"metabolites":{
"co2_c":-1.0,
"co2_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC01639",
"name":"ATP:D-xylulose 5-phosphotransferase",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"h_c":1.0,
"xu5p-D_c":1.0,
"xylu-D_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00011147",
"subsystem":"Pentose and glucuronate interconversions",
"annotation":{
"ec-code":"2.7.1.17",
"kegg.reaction":"R01639",
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0234",
"name":"ascr2 synthesis (lumped with hydrolysis)",
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"ascr7coa_c":-1.0,
"co2_c":1.0,
"coa_c":1.0,
"h2o_c":-2.0,
"h_c":1.0,
"nad_c":-1.0,
"nadh_c":1.0
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00017123 and WBGene00000991",
"subsystem":"Ascaroside biosynthesis",
"annotation":{
"sbo":"SBO:0000176"
}
},
{
"id":"DMN0055",
"name":"1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate demand",
"metabolites":{
"pail34p_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Inositol phosphate metabolism",
"annotation":{
"sbo":"SBO:0000628"
}
},
{
"id":"DMN0054",
"name":"1-Phosphatidyl-1D-myo-inositol 3-phosphate demand",
"metabolites":{
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},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Inositol phosphate metabolism",
"annotation":{
"sbo":"SBO:0000628"
}
},
{
"id":"RCC0232",
"name":"ascr-coa (ascr7) hydrolysis",
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"ascr7coa_c":-1.0,
"coa_c":1.0,
"h2o_c":-1.0,
"h_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Ascaroside biosynthesis",
"annotation":{
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}
},
{
"id":"RCC0233",
"name":"ascr-coa (ascr18) hydrolysis",
"metabolites":{
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"ascr18coa_c":-1.0,
"coa_c":1.0,
"h2o_c":-1.0,
"h_c":1.0
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Ascaroside biosynthesis",
"annotation":{
"sbo":"SBO:0000176"
}
},
{
"id":"RC00369",
"name":"L-Alanine:glyoxylate aminotransferase",
"metabolites":{
"ala-L_c":-1.0,
"glx_c":-1.0,
"gly_c":1.0,
"pyr_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00020382 or WBGene00011767",
"subsystem":"Alanine, aspartate and glutamate metabolism",
"annotation":{
"ec-code":"2.6.1.44",
"kegg.reaction":"R00369",
"sbo":"SBO:0000176"
}
},
{
"id":"RC04666",
"name":"3-Ureidoisobutyrate amidohydrolase",
"metabolites":{
"3aib-D_c":1.0,
"3uib_c":-1.0,
"co2_c":1.0,
"h2o_c":-1.0,
"h_c":-2.0,
"nh4_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00017440",
"subsystem":"Pyrimidine metabolism",
"annotation":{
"ec-code":"3.5.1.6",
"kegg.reaction":"R04666",
"sbo":"SBO:0000176"
}
},
{
"id":"TCM1078",
"name":"trans-4-Hydroxy-L-proline transport",
"metabolites":{
"4hpro-LT_c":-1.0,
"4hpro-LT_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC03814",
"name":"linoleoyl-CoA desaturase",
"metabolites":{
"ficytb_c":2.0,
"focytb_c":-2.0,
"h2o_c":2.0,
"lnlccoa_c":-1.0,
"lnlncgcoa_c":1.0,
"o2_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00001395",
"subsystem":"Biosynthesis of unsaturated fatty acids",
"annotation":{
"ec-code":"1.14.19.3",
"kegg.reaction":"R03814",
"sbo":"SBO:0000176"
}
},
{
"id":"TCM1075",
"name":"L-Phenylalanine transport",
"metabolites":{
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"phe-L_m":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM1077",
"name":"Dihydroxyacetone phosphate transport",
"metabolites":{
"dhap_c":1.0,
"dhap_m":-1.0
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM1076",
"name":"Guanine transport",
"metabolites":{
"gua_c":-1.0,
"gua_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RM00705",
"name":"3-Oxopropanoate:NAD+ oxidoreductase (decarboxylating, CoA-acetylating)",
"metabolites":{
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"co2_m":1.0,
"coa_m":-1.0,
"msa_m":-1.0,
"nad_m":-1.0,
"nadh_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000114",
"subsystem":"Propanoate metabolism",
"annotation":{
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"1.2.1.27"
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"kegg.reaction":"R00705",
"sbo":"SBO:0000176"
}
},
{
"id":"TCM1070",
"name":"L-Asparagine transport",
"metabolites":{
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"asn-L_m":1.0
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"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC05795",
"name":"ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 3-phosphotransferase",
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"atp_c":-1.0,
"h_c":1.0,
"pail34p_c":1.0,
"pail4p_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00009552",
"subsystem":"Inositol phosphate metabolism",
"annotation":{
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"kegg.reaction":"R05795",
"sbo":"SBO:0000176"
}
},
{
"id":"RM00706",
"name":"3-Oxopropanoate:NADP+ oxidoreductase (decarboxylating, CoA-acetylating)",
"metabolites":{
"accoa_m":1.0,
"co2_m":1.0,
"coa_m":-1.0,
"msa_m":-1.0,
"nadp_m":-1.0,
"nadph_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000114",
"subsystem":"Propanoate metabolism",
"annotation":{
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"kegg.reaction":"R00706",
"sbo":"SBO:0000176"
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},
{
"id":"TCM1043",
"name":"Succinate and Fumarate transport",
"metabolites":{
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"fum_m":-1.0,
"succ_c":-1.0,
"succ_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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}
},
{
"id":"TCM1044",
"name":"Riboflavin transport",
"metabolites":{
"ribflv_c":-1.0,
"ribflv_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM1045",
"name":"Succinate and L-Malate transport",
"metabolites":{
"mal-L_c":-1.0,
"mal-L_m":1.0,
"succ_c":1.0,
"succ_m":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM1285",
"name":"L-Malate and Citrate transport",
"metabolites":{
"cit_c":-1.0,
"cit_m":1.0,
"mal-L_c":1.0,
"mal-L_m":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00010780 or WBGene00021345",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC01768",
"name":"hypoxanthine:NAD+ oxidoreductase",
"metabolites":{
"h2o_c":-1.0,
"h_c":1.0,
"hxan_c":-1.0,
"nad_c":-1.0,
"nadh_c":1.0,
"xan_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00010083",
"subsystem":"Purine metabolism",
"annotation":{
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"kegg.reaction":"R01768",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01769",
"name":"Hypoxanthine:oxygen oxidoreductase",
"metabolites":{
"h2o2_c":1.0,
"h2o_c":-1.0,
"hxan_c":-1.0,
"o2_c":-1.0,
"xan_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00010083",
"subsystem":"Purine metabolism",
"annotation":{
"ec-code":"1.17.3.2",
"kegg.reaction":"R01769",
"sbo":"SBO:0000176"
}
},
{
"id":"TCM5059",
"name":"2-Oxobutanoate transport (cytosol/mitochondria)",
"metabolites":{
"2obut_c":-1.0,
"2obut_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE0735",
"name":"L-Cysteine transport",
"metabolites":{
"cys-L_c":1.0,
"cys-L_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCE9072",
"name":"Stachyose transport",
"metabolites":{
"stachyose_c":-1.0,
"stachyose_e":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RCC0128",
"name":"fatty-acid--CoA ligase (Rtotal)",
"metabolites":{
"Rtotal_c":-1.0,
"Rtotalcoa_c":1.0,
"amp_c":1.0,
"atp_c":-1.0,
"coa_c":-1.0,
"ppi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00009221 or WBGene00020343 or WBGene00018152 or WBGene00013575 or WBGene00022037 or WBGene00019920 or WBGene00016716 or WBGene00011173",
"subsystem":"Fatty acid metabolism",
"annotation":{
"ec-code":"6.2.1.3",
"kegg.reaction":"R00390",
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0129",
"name":"fatty-acid--CoA ligase (Rtotal)",
"metabolites":{
"Rtotal3_c":-1.0,
"Rtotal3coa_c":1.0,
"amp_c":1.0,
"atp_c":-1.0,
"coa_c":-1.0,
"ppi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00009221 or WBGene00020343 or WBGene00018152 or WBGene00013575 or WBGene00022037 or WBGene00019920 or WBGene00016716 or WBGene00011173",
"subsystem":"Fatty acid metabolism",
"annotation":{
"ec-code":"6.2.1.3",
"kegg.reaction":"R00390",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE0743",
"name":"cAMP transport",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"camp_c":-1.0,
"camp_e":1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC01168",
"name":"L-histidine ammonia-lyase (urocanate-forming)",
"metabolites":{
"his-L_c":-1.0,
"nh4_c":1.0,
"urcan_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00009813",
"subsystem":"Histidine metabolism",
"annotation":{
"ec-code":"4.3.1.3",
"kegg.reaction":"R01168",
"sbo":"SBO:0000176"
}
},
{
"id":"RM00410",
"name":"succinyl-CoA:acetoacetate CoA-transferase",
"metabolites":{
"aacoa_m":1.0,
"acac_m":-1.0,
"succ_m":1.0,
"succoa_m":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00007330",
"subsystem":"Synthesis and degradation of ketone bodies",
"annotation":{
"ec-code":"2.8.3.5",
"kegg.reaction":"R00410",
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0120",
"name":"Acyl-CoA:L-carnitine O-acyltransferase I (cis-11,12-methyleneoctadecanoyl-CoA)",
"metabolites":{
"coa_c":1.0,
"crn_c":-1.0,
"fa19c11coa_c":-1.0,
"fa19c11crn_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00012907 or WBGene00021703 or WBGene00019644 or WBGene00008629 or WBGene00020911",
"subsystem":"Carnitine shuttle",
"annotation":{
"ec-code":"2.3.1.21",
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0121",
"name":"Acyl-CoA:L-carnitine O-acyltransferase I (Fatty acyl [C15:iso] CoA)",
"metabolites":{
"coa_c":1.0,
"crn_c":-1.0,
"fa15p0isocoa_c":-1.0,
"fa15p0isocrn_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00012907 or WBGene00021703 or WBGene00019644 or WBGene00008629 or WBGene00020911",
"subsystem":"Carnitine shuttle",
"annotation":{
"ec-code":"2.3.1.21",
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0122",
"name":"Acyl-CoA:L-carnitine O-acyltransferase I (Fatty acyl [C17:iso] CoA)",
"metabolites":{
"coa_c":1.0,
"crn_c":-1.0,
"fa17p0isocoa_c":-1.0,
"fa17p0isocrn_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00012907 or WBGene00021703 or WBGene00019644 or WBGene00008629 or WBGene00020911",
"subsystem":"Carnitine shuttle",
"annotation":{
"ec-code":"2.3.1.21",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01167",
"name":"L-histidine carboxy-lyase (histamine-forming)",
"metabolites":{
"co2_c":1.0,
"h_c":-1.0,
"his-L_c":-1.0,
"hista_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000239 or WBGene00001839 or WBGene00006562",
"subsystem":"Histidine metabolism",
"annotation":{
"ec-code":"4.1.1.28",
"kegg.reaction":"R01167",
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0124",
"name":"merged fatty acid elongation (C18 to C24)",
"metabolites":{
"co2_c":3.0,
"coa_c":3.0,
"h2o_c":3.0,
"h_c":-9.0,
"lgnccoa_c":1.0,
"malcoa_c":-3.0,
"nadp_c":6.0,
"nadph_c":-6.0,
"stcoa_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00001239 and WBGene00002891 and WBGene00020517 and WBGene00000198",
"subsystem":"Fatty acid elongation",
"annotation":{
"ec-code":[
"2.3.1.199",
"1.1.1.330",
"4.2.1.134",
"1.3.1.93"
],
"kegg.reaction":[
"R10825",
"R10826",
"R10827",
"R10828"
],
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0125",
"name":"beta oxidation of very long chain fatty acid",
"metabolites":{
"accoa_c":3.0,
"coa_c":-3.0,
"h2o2_c":3.0,
"h2o_c":-3.0,
"h_c":3.0,
"lgnccoa_c":-1.0,
"nad_c":-3.0,
"nadh_c":3.0,
"o2_c":-3.0,
"stcoa_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00008167 or WBGene00008564 or WBGene00008565 or WBGene00008566 or WBGene00008567 or WBGene00019060 or WBGene00010336) and (WBGene00000991 or WBGene00017123) and WBGene00013284",
"subsystem":"Peroxisomal fatty acid beta oxidation",
"annotation":{
"ec-code":[
"1.3.3.6",
"4.2.1.17",
"1.1.1.211",
"1.1.1.35",
"2.3.1.16"
],
"kegg.reaction":[
"R00388",
"R02685",
"R01778",
"R00391"
],
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0126",
"name":"Beta oxidation of stcoa (peroxisomal)",
"metabolites":{
"accoa_c":1.0,
"coa_c":-1.0,
"h2o2_c":1.0,
"h2o_c":-1.0,
"h_c":1.0,
"nad_c":-1.0,
"nadh_c":1.0,
"o2_c":-1.0,
"pmtcoa_c":1.0,
"stcoa_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00008167 or WBGene00008564 or WBGene00008565 or WBGene00008566 or WBGene00008567 or WBGene00019060 or WBGene00010336) and (WBGene00000991 or WBGene00017123) and WBGene00013284",
"subsystem":"Peroxisomal fatty acid beta oxidation",
"annotation":{
"ec-code":[
"1.3.3.6",
"4.2.1.17",
"1.1.1.211",
"1.1.1.35",
"2.3.1.16"
],
"kegg.reaction":[
"R00388",
"R02685",
"R01778",
"R00391"
],
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0127",
"name":"fatty-acid--CoA ligase (Rtotal6)",
"metabolites":{
"Rtotal6_c":-1.0,
"Rtotal6coa_c":1.0,
"amp_c":1.0,
"atp_c":-1.0,
"coa_c":-1.0,
"ppi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00009221 or WBGene00020343 or WBGene00018152 or WBGene00013575 or WBGene00022037 or WBGene00019920 or WBGene00016716 or WBGene00011173",
"subsystem":"Fatty acid metabolism",
"annotation":{
"ec-code":"6.2.1.3",
"kegg.reaction":"R00390",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01890",
"name":"CTP:choline-phosphate cytidylyltransferase",
"metabolites":{
"cdpchol_c":1.0,
"cholp_c":-1.0,
"ctp_c":-1.0,
"h_c":-1.0,
"ppi_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00017241",
"subsystem":"Glycerophospholipid metabolism",
"annotation":{
"ec-code":"2.7.7.15",
"kegg.reaction":"R01890",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01896",
"name":"xylitol dehydrogenase (D-xyulose-forming)",
"metabolites":{
"h_c":1.0,
"nad_c":-1.0,
"nadh_c":1.0,
"xylt_c":-1.0,
"xylu-D_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00011003 or WBGene00011004",
"subsystem":"Pentose and glucuronate interconversions",
"annotation":{
"ec-code":"1.1.1.14",
"kegg.reaction":"R01896",
"sbo":"SBO:0000176"
}
},
{
"id":"EX11135",
"name":"androsterone glucuronide exchange",
"metabolites":{
"andrstrnglc_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"SNK0029",
"name":"cis-retinyl ester demand",
"metabolites":{
"retpalm-cis-11_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Retinol metabolism",
"annotation":{
"sbo":"SBO:0000632"
}
},
{
"id":"SNK0028",
"name":"all trans retinyl ester demand",
"metabolites":{
"retpalm_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Retinol metabolism",
"annotation":{
"sbo":"SBO:0000632"
}
},
{
"id":"RC06521",
"name":"Sphingosine 1-phosphate phosphohydrolase",
"metabolites":{
"h2o_c":-1.0,
"pi_c":1.0,
"sphings_ce_c":1.0,
"sphs1p_ce_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00008749 or WBGene00018756 or WBGene00020895",
"subsystem":"Sphingolipid metabolism",
"annotation":{
"ec-code":"3.1.3.4",
"kegg.reaction":"R06521",
"sbo":"SBO:0000176"
}
},
{
"id":"RC06520",
"name":"Sphinganine 1-phosphate phosphohydrolase",
"metabolites":{
"h2o_c":-1.0,
"pi_c":1.0,
"sph1p_ce_c":-1.0,
"sphgn_ce_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00008749 or WBGene00018756 or WBGene00020895",
"subsystem":"Sphingolipid metabolism",
"annotation":{
"ec-code":"3.1.3.4",
"kegg.reaction":"R06520",
"sbo":"SBO:0000176"
}
},
{
"id":"RC06522",
"name":"Ceramide 1-phosphate phosphohydrolase",
"metabolites":{
"crm_ce_c":1.0,
"crmp_ce_c":-1.0,
"h2o_c":-1.0,
"pi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00008749 or WBGene00018756 or WBGene00020895",
"subsystem":"Sphingolipid metabolism",
"annotation":{
"ec-code":"3.1.3.4",
"kegg.reaction":"R06522",
"sbo":"SBO:0000176"
}
},
{
"id":"EXC0052",
"name":"RNA component of bacterial diet exchange",
"metabolites":{
"rna_BAC_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RCC0055",
"name":"fatty-acid--CoA ligase (dodecanoate)",
"metabolites":{
"amp_c":1.0,
"atp_c":-1.0,
"coa_c":-1.0,
"ddca_c":-1.0,
"ddcacoa_c":1.0,
"ppi_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00009221 or WBGene00020343 or WBGene00018152 or WBGene00013575 or WBGene00022037 or WBGene00019920 or WBGene00016716 or WBGene00011173",
"subsystem":"Fatty acid metabolism",
"annotation":{
"ec-code":"6.2.1.3",
"kegg.reaction":"R00390",
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0056",
"name":"fatty-acid--CoA ligase (tetradecanoate)",
"metabolites":{
"amp_c":1.0,
"atp_c":-1.0,
"coa_c":-1.0,
"ppi_c":1.0,
"tdcoa_c":1.0,
"ttdca_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00009221 or WBGene00020343 or WBGene00018152 or WBGene00013575 or WBGene00022037 or WBGene00019920 or WBGene00016716 or WBGene00011173",
"subsystem":"Fatty acid metabolism",
"annotation":{
"ec-code":"6.2.1.3",
"kegg.reaction":"R00390",
"sbo":"SBO:0000176"
}
},
{
"id":"EXC0051",
"name":"Protein component of bacterial diet exchange",
"metabolites":{
"protein_BAC_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RCC0050",
"name":"D-bifunctional protein",
"metabolites":{
"cholcoads_c":-1.0,
"cholcoaone_c":1.0,
"h2o_c":-1.0,
"h_c":1.0,
"nad_c":-1.0,
"nadh_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000988 or WBGene00000991 or WBGene00017123",
"subsystem":"Primary bile acid biosynthesis",
"annotation":{
"ec-code":[
"4.2.1.107",
"1.1.1.35"
],
"kegg.reaction":[
"R04813",
"R04812"
],
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0051",
"name":"poly(ADP-ribose) glycohydrolase (PARG)",
"metabolites":{
"adprib_c":1.0,
"h2o_c":-1.0,
"polyadprib_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00004051 or WBGene00004052",
"subsystem":"Nicotinate and nicotinamide metabolism",
"annotation":{
"ec-code":"3.2.1.143",
"sbo":"SBO:0000176"
}
},
{
"id":"EXC0054",
"name":"Peptidoglycan subunit of bacteria exchange",
"metabolites":{
"peptido_BAC_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RCC0053",
"name":"UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific); beta-D-glucuronoside glucuronosohydrolase",
"metabolites":{
"glcur_c":1.0,
"h2o_c":-1.0,
"h_c":1.0,
"udp_c":1.0,
"udpglcur_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00015371 or WBGene00016959 or WBGene00017334 or WBGene00018789 or WBGene00019235 or WBGene00019379 or WBGene00007072 or WBGene00020594 or WBGene00020593 or WBGene00020592 or WBGene00019232 or WBGene00019233 or WBGene00008097 or WBGene00013901 or WBGene00007422 or WBGene00013900 or WBGene00019515 or WBGene00007073 or WBGene00019516 or WBGene00007885 or WBGene00007455 or WBGene00007650 or WBGene00016762 or WBGene00015692 or WBGene00015695 or WBGene00015694 or WBGene00021709 or WBGene00013903 or WBGene00011340 or WBGene00021464 or WBGene00018543 or WBGene00007946 or WBGene00009255 or WBGene00044286 or WBGene00017315 or WBGene00017332 or WBGene00017333 or WBGene00017329 or WBGene00013905 or WBGene00017331 or WBGene00017336 or WBGene00017959 or WBGene00008485 or WBGene00008486 or WBGene00021372 or WBGene00015141 or WBGene00011006 or WBGene00015965 or WBGene00007070 or WBGene00013906 or WBGene00011564 or WBGene00015369 or WBGene00018931 or WBGene00020182 or WBGene00012013 or WBGene00011452 or WBGene00011453 or WBGene00009450 or WBGene00011238 or WBGene00013904 or WBGene00007402 or WBGene00018206 or WBGene00010904 or WBGene00015449 or WBGene00015577 or WBGene00008583 or WBGene00015739 or WBGene00019234 or WBGene00020587) and (WBGene00013693)",
"subsystem":"Pentose and glucuronate interconversions",
"annotation":{
"ec-code":[
"2.4.1.17",
"3.2.1.31"
],
"kegg.reaction":[
"R01383",
"R01478"
],
"sbo":"SBO:0000176"
}
},
{
"id":"RC01301",
"name":"4-Hydroxybenzoyl-CoA hydrolase",
"metabolites":{
"4hbz_c":1.0,
"4hbzcoa_c":-1.0,
"coa_c":1.0,
"h2o_c":-1.0,
"h_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Ubiquinone and other terpenoid-quinone biosynthesis",
"annotation":{
"ec-code":"3.1.2.23",
"kegg.reaction":"R01301",
"sbo":"SBO:0000176"
}
},
{
"id":"EXC0058",
"name":"Phosphatidylethanolamine (bacteria) exchange",
"metabolites":{
"pe_BAC_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EXC0059",
"name":"Phosphatidylglycerol (bacteria) exchange",
"metabolites":{
"pg_BAC_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RCC0058",
"name":"Acyl-CoA:L-carnitine O-acyltransferase I (Dodecanoyl-CoA )",
"metabolites":{
"coa_c":1.0,
"crn_c":-1.0,
"ddcacoa_c":-1.0,
"ddcrn_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00012907 or WBGene00021703 or WBGene00019644 or WBGene00008629 or WBGene00020911",
"subsystem":"Carnitine shuttle",
"annotation":{
"ec-code":"2.3.1.21",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00782",
"name":"L-Cysteine hydrogen-sulfide-lyase (deaminating, pyruvate-forming)",
"metabolites":{
"cys-L_c":-1.0,
"h2o_c":-1.0,
"h2s_c":1.0,
"nh4_c":1.0,
"pyr_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00007533 or WBGene00009048 or WBGene00022856",
"subsystem":"Cysteine and methionine metabolism",
"annotation":{
"ec-code":"4.4.1.1",
"kegg.reaction":"R00782",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00549",
"name":"riboflavin kinase",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"fmn_c":1.0,
"h_c":1.0,
"ribflv_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00011224",
"subsystem":"Riboflavin metabolism",
"annotation":{
"ec-code":"2.7.1.26",
"kegg.reaction":"R00549",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00548",
"name":"riboflavin-5-phosphate phosphohydrolase (acid optimum)",
"metabolites":{
"fmn_c":-1.0,
"h2o_c":-1.0,
"pi_c":1.0,
"ribflv_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"((WBGene00009146 or WBGene00014076 or WBGene00007328 or WBGene00007331) or (WBGene00020471 or WBGene00015161 or WBGene00011262) or WBGene00022379 or WBGene00008531) or (WBGene00206373 or WBGene00008802 or WBGene00008801 or WBGene00022246 or WBGene00004020 or WBGene00016152 or WBGene00004023 or WBGene00018696 or WBGene00011879 or WBGene00022181)",
"subsystem":"Riboflavin metabolism",
"annotation":{
"ec-code":"3.1.3.2",
"kegg.reaction":"R00548",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01092",
"name":"ATP:D-galactose 1-phosphotransferase",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"gal1p_c":1.0,
"gal_c":-1.0,
"h_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00006461",
"subsystem":"Galactose metabolism",
"annotation":{
"ec-code":"2.7.1.6",
"kegg.reaction":"R01092",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01093",
"name":"galactitol:NAD+ 1-oxidoreductase",
"metabolites":{
"gal_c":-1.0,
"galt_c":1.0,
"h_c":-1.0,
"nad_c":1.0,
"nadh_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00012722",
"subsystem":"Galactose metabolism",
"annotation":{
"ec-code":"1.1.1.21",
"kegg.reaction":"R01093",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01095",
"name":"galactitol:NADP+ 1-oxidoreductase",
"metabolites":{
"gal_c":-1.0,
"galt_c":1.0,
"h_c":-1.0,
"nadp_c":1.0,
"nadph_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00012722",
"subsystem":"Galactose metabolism",
"annotation":{
"ec-code":"1.1.1.21",
"kegg.reaction":"R01095",
"sbo":"SBO:0000176"
}
},
{
"id":"TCM1096",
"name":"O-Acetylcarnitine and L-Carnitine transport",
"metabolites":{
"acrn_c":-1.0,
"acrn_m":1.0,
"crn_c":1.0,
"crn_m":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM1095",
"name":"\"Adenosine 3',5'-bisphosphate\" transport",
"metabolites":{
"pap_c":-1.0,
"pap_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM1091",
"name":"S-Adenosyl-L-homocysteine transport",
"metabolites":{
"ahcys_c":-1.0,
"ahcys_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM1098",
"name":"(S)-3-Methyl-2-oxopentanoate transport",
"metabolites":{
"3mop_c":-1.0,
"3mop_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC01234",
"name":"Guanosine 3,5-cyclic phosphate 5-nucleotidohydrolase",
"metabolites":{
"35cgmp_c":-1.0,
"gmp_c":1.0,
"h2o_c":-1.0,
"h_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00011433 or WBGene00011146 or WBGene00008443 or WBGene00016328",
"subsystem":"Purine metabolism",
"annotation":{
"ec-code":"3.1.4.17",
"kegg.reaction":"R01234",
"sbo":"SBO:0000176"
}
},
{
"id":"RC06238",
"name":"GDP-D-mannose:D-Man-alpha-(1->3)-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol alpha-6-mannosyltransferase",
"metabolites":{
"gdp_c":1.0,
"gdpmann_c":-1.0,
"h_c":1.0,
"m1mpdol_c":-1.0,
"m2mpdol_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00017282",
"subsystem":"N-Glycan biosynthesis",
"annotation":{
"ec-code":"2.4.1.257",
"kegg.reaction":"R06238",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01230",
"name":"Xanthosine-5-phosphate:ammonia ligase (AMP-forming)",
"metabolites":{
"amp_c":1.0,
"atp_c":-1.0,
"gmp_c":1.0,
"h_c":2.0,
"nh4_c":-1.0,
"ppi_c":1.0,
"xmp_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00010912",
"subsystem":"Purine metabolism",
"annotation":{
"ec-code":"6.3.5.2",
"kegg.reaction":"R01230",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01231",
"name":"Xanthosine-5-phosphate:L-glutamine amido-ligase (AMP-forming)",
"metabolites":{
"amp_c":1.0,
"atp_c":-1.0,
"gln-L_c":-1.0,
"glu-L_c":1.0,
"gmp_c":1.0,
"h2o_c":-1.0,
"h_c":2.0,
"ppi_c":1.0,
"xmp_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00010912",
"subsystem":"Purine metabolism",
"annotation":{
"ec-code":"6.3.5.2",
"kegg.reaction":"R01231",
"sbo":"SBO:0000176"
}
},
{
"id":"RM08761",
"name":"3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate,NADPH:oxygen oxidoreductase (26-hydroxylating)",
"metabolites":{
"h2o_m":1.0,
"nadp_m":1.0,
"nadph_m":-1.0,
"o2_m":-1.0,
"thcholst_m":-1.0,
"thcholstoic_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000905",
"subsystem":"Primary bile acid biosynthesis",
"annotation":{
"ec-code":"1.14.13.15",
"kegg.reaction":"R08761",
"sbo":"SBO:0000176"
}
},
{
"id":"RM08767",
"name":"4-hydroxybenzoyl-CoA formation",
"metabolites":{
"4cmcoa_m":-1.0,
"4hbzcoa_m":1.0,
"accoa_m":1.0,
"coa_m":-1.0,
"h2o_m":-1.0,
"h_m":1.0,
"nad_m":-1.0,
"nadh_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Ubiquinone and other terpenoid-quinone biosynthesis",
"annotation":{
"kegg.reaction":"R08767",
"sbo":"SBO:0000176"
}
},
{
"id":"RM08766",
"name":"3-(4-hydroxyphenyl)lactate hydro-lyase (4-coumarate-forming)",
"metabolites":{
"34hpl_m":-1.0,
"T4hcinnm_m":1.0,
"h2o_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Ubiquinone and other terpenoid-quinone biosynthesis",
"annotation":{
"ec-code":"4.2.1.-",
"kegg.reaction":"R08766",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01786",
"name":"ATP:alpha-D-glucose 6-phosphotransferase",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"g6p-A_c":1.0,
"glc-D-A_c":-1.0,
"h_c":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00008780 or WBGene00010416 or WBGene00022306",
"subsystem":"Glycolysis / Gluconeogenesis",
"annotation":{
"ec-code":"2.7.1.1",
"kegg.reaction":"R01786",
"sbo":"SBO:0000176"
}
},
{
"id":"RC01787",
"name":"D-sorbitol reductase",
"metabolites":{
"glc-D_c":-1.0,
"h_c":-1.0,
"nadp_c":1.0,
"nadph_c":-1.0,
"sbt-D_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00012722",
"subsystem":"Fructose and mannose metabolism",
"annotation":{
"ec-code":"1.1.1.21",
"kegg.reaction":"R01787",
"sbo":"SBO:0000176"
}
},
{
"id":"EX00565",
"name":"trimethylamine exchange",
"metabolites":{
"tma_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00818",
"name":"D-Glucarate exchange",
"metabolites":{
"glcr_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00811",
"name":"trans-4-Hydroxycinnamate exchange",
"metabolites":{
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},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00584",
"name":"Prostaglandin E2 exchange",
"metabolites":{
"prostge2_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00583",
"name":"Propylene glycol exchange",
"metabolites":{
"12ppd-R_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX05688",
"name":"Selenocysteine exchange",
"metabolites":{
"selcys_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX00588",
"name":"Choline phosphate exchange",
"metabolites":{
"cholp_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EXC0203",
"name":"sphingosylphosphorylcholine  exchange",
"metabolites":{
"spc_ce_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EXC0202",
"name":"Ceramide 1-phosphate exchange",
"metabolites":{
"crmp_ce_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
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}
},
{
"id":"EXC0201",
"name":"Sphingomyelin exchange",
"metabolites":{
"sphmyln_ce_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EXC0207",
"name":"Sphinganine exchange",
"metabolites":{
"sphgn_ce_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"EX01697",
"name":"Galactitol exchange",
"metabolites":{
"galt_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
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}
},
{
"id":"EXC0208",
"name":"Sphinganine 1-phosphate exchange",
"metabolites":{
"sph1p_ce_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RC10951",
"name":"ATP:1-phosphatidyl-1D-myo-inositol 5-phosphotransferase",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"h_c":1.0,
"pail5p_c":1.0,
"pail_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00004089",
"subsystem":"Inositol phosphate metabolism",
"annotation":{
"ec-code":"2.7.1.150",
"kegg.reaction":"R10951",
"sbo":"SBO:0000176"
}
},
{
"id":"EX06424",
"name":"tetradecanoate (n-C14:0) exchange",
"metabolites":{
"ttdca_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RC01431",
"name":"xylitol:NADP+ oxidoreductase",
"metabolites":{
"h_c":-1.0,
"nadp_c":1.0,
"nadph_c":-1.0,
"xyl-D_c":-1.0,
"xylt_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00012722",
"subsystem":"Pentose and glucuronate interconversions",
"annotation":{
"ec-code":"1.1.1.21",
"kegg.reaction":"R01431",
"sbo":"SBO:0000176"
}
},
{
"id":"TCM0124",
"name":"Phosphatidylserine (bacteria) transport",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0,
"ps_BAC_c":-1.0,
"ps_BAC_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM0125",
"name":"dUDP and dCDP transport",
"metabolites":{
"dcdp_c":1.0,
"dcdp_m":-1.0,
"dudp_c":-1.0,
"dudp_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM0126",
"name":"dUTP and ATP transport",
"metabolites":{
"atp_c":1.0,
"atp_m":-1.0,
"dutp_c":-1.0,
"dutp_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM0127",
"name":"dGTP and dCDP transport",
"metabolites":{
"dcdp_c":1.0,
"dcdp_m":-1.0,
"dgtp_c":-1.0,
"dgtp_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM0121",
"name":"dADP and dCDP transport",
"metabolites":{
"dadp_c":1.0,
"dadp_m":-1.0,
"dcdp_c":-1.0,
"dcdp_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"EX00101",
"name":"\"5,6,7,8-Tetrahydrofolate\" exchange",
"metabolites":{
"thf_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"TCM0128",
"name":"dTDP and dCDP transport",
"metabolites":{
"dcdp_c":-1.0,
"dcdp_m":1.0,
"dtdp_c":1.0,
"dtdp_m":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"TCM0129",
"name":"Inosine transport",
"metabolites":{
"ins_c":-1.0,
"ins_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RC01818",
"name":"D-mannose 6-phosphate 1,6-phosphomutase",
"metabolites":{
"man1p_c":-1.0,
"man6p_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00009925",
"subsystem":"Fructose and mannose metabolism",
"annotation":{
"ec-code":"5.4.2.8",
"kegg.reaction":"R01818",
"sbo":"SBO:0000176"
}
},
{
"id":"RMC0098",
"name":"Beta oxidation of eicosapentanoic acid (mitochondrial)",
"metabolites":{
"accoa_m":2.0,
"coa_m":-2.0,
"fa16p4n3coa_m":1.0,
"fad_m":-1.0,
"fadh2_m":1.0,
"h2o_m":-2.0,
"h_m":2.0,
"nad_m":-2.0,
"nadh_m":2.0,
"tmndnccoa_m":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(WBGene00020812 or WBGene00019406 or WBGene00020366 or WBGene00017125) and (WBGene00001153 or WBGene00007130) and ((WBGene00001155 or WBGene00001156) or (WBGene00020347 or WBGene00001150) or WBGene00001152) and ((WBGene00020347 or WBGene00001150) or (WBGene00007129 or WBGene00010035 or WBGene00001157 or WBGene00001158 or WBGene00019978)) and (WBGene00015125 or WBGene00009952)",
"subsystem":"Mitochondrial fatty acid beta oxidation",
"annotation":{
"ec-code":[
"1.3.8.7",
"5.3.3.8",
"4.2.1.17",
"1.1.1.211",
"1.1.1.35",
"2.3.1.16"
],
"kegg.reaction":[
"R00392",
"R03224",
"R02685",
"R01778",
"R00391"
],
"sbo":"SBO:0000176"
}
},
{
"id":"RMC0099",
"name":"Acyl-CoA:L-carnitine O-acyltransferase II (intermediary fatty acyl [C8:1]-CoA)",
"metabolites":{
"coa_m":-1.0,
"crn_m":1.0,
"fa8p1n3coa_m":1.0,
"fa8p1n3crn_m":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00011122",
"subsystem":"Carnitine shuttle",
"annotation":{
"ec-code":"2.3.1.21",
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0033",
"name":" prenyl protein peptidase; Ste24 endopeptidase (acting on geranyl-geranyl moiety)",
"metabolites":{
"h2o_c":-1.0,
"pepd_c":1.0,
"protSgerC_c":1.0,
"protSger_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00001405 or WBGene00001406",
"subsystem":"Terpenoid backbone biosynthesis",
"annotation":{
"ec-code":[
"3.4.24.84",
"3.4.22.-"
],
"sbo":"SBO:0000176"
}
},
{
"id":"RMC0092",
"name":"Beta oxidation of intermediary fatty acid C14:2 (mitochondrial)",
"metabolites":{
"accoa_m":3.0,
"coa_m":-3.0,
"fa14p2n6coa_m":-1.0,
"fad_m":-2.0,
"fadh2_m":2.0,
"h2o_m":-3.0,
"h_m":2.0,
"nad_m":-3.0,
"nadh_m":3.0,
"nadp_m":1.0,
"nadph_m":-1.0,
"occoa_m":1.0
},
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{
"id":"RMC0093",
"name":"Beta oxidation of eicosatrieonic acid (mitochondrial)",
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{
"id":"RMC0090",
"name":"Beta oxidation of vaccenic acid (mitochondrial)",
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{
"id":"RMC0091",
"name":"Beta oxidation of linoleic acid (mitochondrial)",
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{
"id":"RMC0096",
"name":"Beta oxidation of eicosatetraeonic acid (mitochondrial)",
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{
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"name":"Beta oxidation of intermediary fatty acid C16:4 (mitochondrial)",
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{
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{
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{
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},
{
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"sbo":"SBO:0000176"
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},
{
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"amet_c":-1.0,
"h_c":1.0,
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"lower_bound":-0.0,
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},
{
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"name":"Nicotinate D-ribonucleotide exchange",
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},
{
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},
{
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},
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},
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},
{
"id":"RC02029",
"name":"Phosphatidylglycerophosphate phosphohydrolase",
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"pi_c":1.0
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},
{
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"sbo":"SBO:0000176"
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},
{
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"kegg.reaction":"R02024",
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},
{
"id":"RC04361",
"name":"Acyl-CoA:1-alkyl-sn-glycero-3-phosphate 2-O-acyltransferase",
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"akgp_c":-1.0,
"coa_c":1.0
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"kegg.reaction":"R04361",
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},
{
"id":"TCE5417",
"name":"Lactate and urate transport",
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"urate_c":1.0,
"urate_e":-1.0
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{
"id":"TCE5416",
"name":"L-3-Amino-isobutanoate transport",
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"subsystem":"Transport",
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},
{
"id":"TCE5414",
"name":"Xanthosine transport",
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"xtsn_e":-1.0
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{
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"name":"tetradecanoate (n-C14:0) transport",
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},
{
"id":"TCE5412",
"name":"Thymidine transport",
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"thymd_e":-1.0
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"lower_bound":-1000.0,
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},
{
"id":"TCE5358",
"name":"(S)-3-Methyl-2-oxopentanoate transport",
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{
"id":"RC07168",
"name":"5-methyltetrahydrofolate:NAD+ oxidoreductase",
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"h_c":-2.0,
"mlthf_c":-1.0,
"nad_c":1.0,
"nadh_c":-1.0
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"lower_bound":-1000.0,
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"subsystem":"One carbon pool by folate",
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"kegg.reaction":"R07168",
"sbo":"SBO:0000176"
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},
{
"id":"TCE5354",
"name":"Tyramine transport",
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"tym_e":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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}
},
{
"id":"RC02335",
"name":"UDP-N-acetyl-D-glucosamine:chitin 4-beta-N-acetylglucosaminyl-transferase",
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"h_c":1.0,
"uacgam_c":-1.0,
"udp_c":1.0
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"lower_bound":-0.0,
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"gene_reaction_rule":"WBGene00000496 or WBGene00000497",
"subsystem":"Amino sugar and nucleotide sugar metabolism",
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"kegg.reaction":"R02335",
"sbo":"SBO:0000176"
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},
{
"id":"TCE5356",
"name":"Anthranilate transport",
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"anth_e":-1.0
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"lower_bound":-1000.0,
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"gene_reaction_rule":"",
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}
},
{
"id":"TCE5357",
"name":"N-Carbamoyl-beta-alanine transport",
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"cala_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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}
},
{
"id":"TCE5350",
"name":"4-Trimethylammoniobutanoate transport",
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"na1_c":-1.0,
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"lower_bound":-1000.0,
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}
},
{
"id":"RC02331",
"name":"ATP:dUDP phosphotransferase",
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"adp_c":1.0,
"atp_c":-1.0,
"dudp_c":-1.0,
"dutp_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00019899 or WBGene00021692 or WBGene00009119",
"subsystem":"Pyrimidine metabolism",
"annotation":{
"ec-code":"2.7.4.6",
"kegg.reaction":"R02331",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE5352",
"name":"4-Acetamidobutanoate transport",
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"4aabutn_e":-1.0
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}
},
{
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"name":"Ethanolamine phosphate transport",
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"ethamp_e":-1.0
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"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
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"sbo":"SBO:0000185"
}
},
{
"id":"EX02505",
"name":"2-Phenylacetamide exchange",
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"pad_e":-1.0
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"lower_bound":-0.0,
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"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RC08174",
"name":"Stearoyl-CoA thioesterase",
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"coa_c":1.0,
"h2o_c":-1.0,
"h_c":1.0,
"ocdca_c":1.0,
"stcoa_c":-1.0
},
"lower_bound":-0.0,
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"subsystem":"Biosynthesis of unsaturated fatty acids",
"annotation":{
"ec-code":"3.1.2.2",
"kegg.reaction":"R08174",
"sbo":"SBO:0000176"
}
},
{
"id":"RC08177",
"name":"Linoleoyl-CoA hydrolase",
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"h2o_c":-1.0,
"h_c":1.0,
"lnlc_c":1.0,
"lnlccoa_c":-1.0
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"lower_bound":-0.0,
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"subsystem":"Biosynthesis of unsaturated fatty acids",
"annotation":{
"ec-code":"3.1.2.2",
"kegg.reaction":"R08177",
"sbo":"SBO:0000176"
}
},
{
"id":"RC03315",
"name":"ATP:pseudouridine 5'-phosphotransferase; pseudouridine kinase",
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"atp_c":-1.0,
"h_c":1.0,
"psd5p_c":1.0,
"psduri_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00020765",
"subsystem":"Pyrimidine metabolism",
"annotation":{
"ec-code":"2.7.1.83",
"kegg.reaction":"R03315",
"sbo":"SBO:0000176"
}
},
{
"id":"RM02480",
"name":"Cytochrome c apocytochrome-c-lyase",
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"focytC_m":1.0,
"pheme_m":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00011527 and (WBGene00017121 or WBGene00013854)",
"subsystem":"Iron metabolism",
"annotation":{
"ec-code":"4.4.1.17",
"kegg.reaction":"R02480",
"sbo":"SBO:0000176"
}
},
{
"id":"RM02488",
"name":"Glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating)",
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"co2_m":1.0,
"etfox_m":-1.0,
"etfrd_m":1.0,
"glutcoa_m":-1.0,
"h_m":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00010052",
"subsystem":"Lysine degradation",
"annotation":{
"ec-code":"1.3.8.6",
"kegg.reaction":"R02488",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE1158",
"name":"NMN transport",
"metabolites":{
"nmn_c":1.0,
"nmn_e":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
"sbo":"SBO:0000185"
}
},
{
"id":"RMC0074",
"name":"sulfinic acid oxidation",
"metabolites":{
"3sala_m":-1.0,
"Lcyst_m":1.0,
"h2o2_m":-1.0,
"h2o_m":1.0,
"h_m":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Taurine and hypotaurine metabolism",
"annotation":{
"sbo":"SBO:0000176"
}
},
{
"id":"RMC0075",
"name":"thioredoxin peroxidase",
"metabolites":{
"h2o2_m":-1.0,
"h2o_m":2.0,
"trdox_m":1.0,
"trdrd_m":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00006434 or WBGene00011110",
"subsystem":"Reactive oxygen species degradation",
"annotation":{
"ec-code":"1.11.1.15",
"sbo":"SBO:0000176"
}
},
{
"id":"RMC0077",
"name":"Sulfide:quinone oxidoreductase",
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"q_m":-1.0,
"qh2_m":1.0,
"s_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00008538",
"subsystem":"Sulfur metabolism",
"annotation":{
"ec-code":"1.8.5.-",
"sbo":"SBO:0000176"
}
},
{
"id":"RC00174",
"name":"ATP:pyridoxal 5-phosphotransferase",
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"adp_c":1.0,
"atp_c":-1.0,
"h_c":1.0,
"pydx5p_c":1.0,
"pydx_c":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00019008",
"subsystem":"Vitamin B6 metabolism",
"annotation":{
"ec-code":"2.7.1.35",
"kegg.reaction":"R00174",
"sbo":"SBO:0000176"
}
},
{
"id":"EX02188",
"name":"Peptidyl-L-lysine exchange",
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"peplys_e":-1.0
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
"sbo":"SBO:0000627"
}
},
{
"id":"RC02531",
"name":"Lactaldehyde:NAD+ 1-oxidoreductase",
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"lald-D_c":-1.0,
"mthgxl_c":1.0,
"nad_c":-1.0,
"nadh_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00012722",
"subsystem":"Pyruvate metabolism",
"annotation":{
"ec-code":"1.1.1.21",
"kegg.reaction":"R02531",
"sbo":"SBO:0000176"
}
},
{
"id":"RC03005",
"name":"ATP:nicotinamide-nucleotide adenylyltransferase",
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"dnad_c":1.0,
"h_c":-1.0,
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"ppi_c":1.0
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"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00012295 or WBGene00009176",
"subsystem":"Nicotinate and nicotinamide metabolism",
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"2.7.7.18"
],
"kegg.reaction":"R03005",
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}
},
{
"id":"RC03004",
"name":"Deaminido NAD diphosphatase",
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"h2o_c":-1.0,
"h_c":2.0,
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"lower_bound":-0.0,
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"subsystem":"Nicotinate and nicotinamide metabolism",
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"kegg.reaction":"R03004",
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0134",
"name":"(S) 3-hydroxybutyryl-CoA hydrolase",
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"S3hb_c":1.0,
"coa_c":1.0,
"h2o_c":-1.0,
"h_c":1.0
},
"lower_bound":-0.0,
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"subsystem":"Butanoate metabolism (indirect)",
"annotation":{
"ec-code":"3.1.2.4",
"sbo":"SBO:0000176"
}
},
{
"id":"RC03552",
"name":"Acetyl-CoA:histone acetyltransferase",
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"Nlys_c":-1.0,
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"h_c":1.0
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"lower_bound":-1000.0,
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"kegg.reaction":"R03552",
"sbo":"SBO:0000176"
}
},
{
"id":"TCE0416",
"name":"3-Methylimidazoleacetic acid transport",
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},
{
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"gene_reaction_rule":"",
"subsystem":"Transport",
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}
},
{
"id":"RC03956",
"name":"Glutathione:poly(4-glutamyl-cysteinyl)glycine 4-glutamylcysteinyltransferase",
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"gthrd_c":-1.0,
"pchltn_c":1.0
},
"lower_bound":-1000.0,
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"gene_reaction_rule":"WBGene00003960",
"subsystem":"Metal detoxification",
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"kegg.reaction":"R03956",
"sbo":"SBO:0000176"
}
},
{
"id":"RC03954",
"name":"xanthurenate formation",
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"h_c":1.0,
"xanate_c":1.0
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"lower_bound":-0.0,
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"gene_reaction_rule":"",
"subsystem":"Tryptophan metabolism",
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"sbo":"SBO:0000176"
}
},
{
"id":"RC09319",
"name":"glycoprotein 6-alpha-L-fucosyltransferase (acting on nm2masn)",
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"h_c":1.0,
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},
"lower_bound":-0.0,
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"gene_reaction_rule":"WBGene00001508",
"subsystem":"N-Glycan biosynthesis",
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"kegg.reaction":"R09319",
"sbo":"SBO:0000176"
}
},
{
"id":"RC03778",
"name":"Octanoyl-CoA:acetyl-CoA C-acyltransferase",
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"coa_c":-1.0,
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"subsystem":"Peroxisomal fatty acid beta oxidation",
"annotation":{
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"kegg.reaction":"R03778",
"sbo":"SBO:0000176"
}
},
{
"id":"EX00111",
"name":"Dihydroxyacetone phosphate exchange",
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"lower_bound":-0.0,
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}
},
{
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"name":"Folate exchange",
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}
},
{
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"fad_m":-1.0,
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"lower_bound":-1000.0,
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"subsystem":"Butanoate metabolism",
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"R10575"
],
"sbo":"SBO:0000176"
}
},
{
"id":"RC00978",
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"nadp_c":-1.0,
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"ura_c":1.0
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"lower_bound":-1000.0,
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"gene_reaction_rule":"WBGene00016103",
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"kegg.reaction":"R00978",
"sbo":"SBO:0000176"
}
},
{
"id":"RM01025",
"name":"choline:acceptor 1-oxidoreductase",
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"chol_m":-1.0,
"fad_m":-1.0,
"fadh2_m":1.0
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"lower_bound":-1000.0,
"upper_bound":1000.0,
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"subsystem":"Glycine, serine and threonine metabolism",
"annotation":{
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"kegg.reaction":"R01025",
"sbo":"SBO:0000176"
}
},
{
"id":"RM05052",
"name":"L-erythro-4-hydroxyglutamate:2-oxoglutarate aminotransferase",
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"akg_m":-1.0,
"e4hglu_m":-1.0,
"glu-L_m":1.0
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"lower_bound":-0.0,
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"gene_reaction_rule":"WBGene00016652 or WBGene00015778",
"subsystem":"Arginine and proline metabolism",
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"kegg.reaction":"R05052",
"sbo":"SBO:0000176"
}
},
{
"id":"RM05051",
"name":"L-erythro-4-Hydroxyglutamate:NAD+ oxidoreductase",
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"nad_m":-1.0,
"nadh_m":1.0
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000112",
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"kegg.reaction":"R05051",
"sbo":"SBO:0000176"
}
},
{
"id":"RM00716",
"name":"N6-(L-1,3-Dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)",
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"h2o_m":1.0,
"h_m":-1.0,
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"nadp_m":1.0,
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"saccrp-L_m":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00019819",
"subsystem":"Lysine degradation",
"annotation":{
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"kegg.reaction":"R00716",
"sbo":"SBO:0000176"
}
},
{
"id":"RM00713",
"name":"Succinate-semialdehyde:NAD+ oxidoreductase",
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"h_m":2.0,
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"sucsal_m":-1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000113",
"subsystem":"Alanine, aspartate and glutamate metabolism",
"annotation":{
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"kegg.reaction":"R00713",
"sbo":"SBO:0000176"
}
},
{
"id":"RM00710",
"name":"Acetaldehyde:NAD+ oxidoreductase",
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"acald_m":-1.0,
"h2o_m":-1.0,
"h_m":2.0,
"nad_m":-1.0,
"nadh_m":1.0
},
"lower_bound":-0.0,
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"gene_reaction_rule":"(WBGene00000107 or WBGene00000108 or WBGene00000110) or WBGene00000115",
"subsystem":"Glycolysis / Gluconeogenesis",
"annotation":{
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"kegg.reaction":"R00710",
"sbo":"SBO:0000176"
}
},
{
"id":"RM00711",
"name":"Acetaldehyde:NADP+ oxidoreductase",
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"acald_m":-1.0,
"h2o_m":-1.0,
"h_m":2.0,
"nadp_m":-1.0,
"nadph_m":1.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00000111",
"subsystem":"Glycolysis / Gluconeogenesis",
"annotation":{
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"kegg.reaction":"R00711",
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0200",
"name":"Ascarylose synthesis ",
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"ctp_c":-1.0,
"g1p_c":-1.0,
"h2o_c":1.0,
"h_c":-2.0,
"nad_c":1.0,
"nadh_c":-1.0,
"nadp_c":1.0,
"nadph_c":-1.0,
"pi_c":2.0
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"lower_bound":-0.0,
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"gene_reaction_rule":"",
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"annotation":{
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"4.2.1.45",
"1.17.1.1",
"5.1.3.-",
"1.1.1.-"
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"kegg.reaction":[
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"R02426",
"R03392",
"R08708",
"R08709"
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"sbo":"SBO:0000176"
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},
{
"id":"EX03479",
"name":"5-Formyltetrahydrofolate exchange",
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
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},
{
"id":"RCC0207",
"name":"ascr3 synthesis",
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"ascr3coa_c":1.0,
"h2o2_c":1.0,
"o2_c":-1.0
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"lower_bound":-0.0,
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"subsystem":"Ascaroside biosynthesis",
"annotation":{
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},
{
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"ascr1coa_c":1.0,
"ascr3coa_c":-1.0,
"coa_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"nad_c":-1.0,
"nadh_c":1.0
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"gene_reaction_rule":"WBGene00017123 and WBGene00000991 and WBGene00013284",
"subsystem":"Ascaroside biosynthesis",
"annotation":{
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},
{
"id":"TCM1069",
"name":"\"5,10-Methylenetetrahydrofolate\" transport",
"metabolites":{
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"mlthf_m":1.0
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"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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},
{
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},
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},
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},
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},
{
"id":"RC04300",
"name":"4-(2-Aminoethyl)-1,2-benzenediol:oxygen oxidoreductase(deaminating)(flavin-containing)",
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"lower_bound":-0.0,
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}
},
{
"id":"RM03991",
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}
},
{
"id":"RM03990",
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"1.3.8.9"
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}
},
{
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"name":"beta-D-Fructose 1,6-bisphosphate 1-phosphohydrolase",
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"kegg.reaction":"R04780",
"sbo":"SBO:0000176"
}
},
{
"id":"RCC0115",
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}
},
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}
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{
"id":"RCC0117",
"name":"Acyl-CoA:L-carnitine O-acyltransferase I (Palmitoleyl-CoA)",
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}
},
{
"id":"RC01938",
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"h2o_c":-1.0,
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"nh4_c":1.0
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"lower_bound":-0.0,
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"ec-code":"1.5.1.-",
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}
},
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"subsystem":"Pyrimidine metabolism",
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"sbo":"SBO:0000176"
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},
{
"id":"RCC0110",
"name":"Acyl-CoA:L-carnitine O-acyltransferase I (linoleic CoA)",
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{
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}
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}
},
{
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}
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}
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{
"id":"RM03663",
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"lower_bound":-0.0,
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"ec-code":"6.1.1.3",
"kegg.reaction":"R03663",
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}
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{
"id":"RM03662",
"name":"L-Serine:tRNA(Ser) ligase (AMP-forming)",
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"subsystem":"Aminoacyl-tRNA biosynthesis",
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"kegg.reaction":"R03662",
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}
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"id":"RM03661",
"name":"L-proline:tRNA(Pro) ligase (AMP-forming)",
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"subsystem":"Aminoacyl-tRNA biosynthesis",
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"kegg.reaction":"R03661",
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}
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{
"id":"RM03660",
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}
},
{
"id":"DMN0048",
"name":"dihydrobiopterin demand",
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}
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"id":"RM03664",
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"lower_bound":-0.0,
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"kegg.reaction":"R03664",
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}
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"id":"RC01334",
"name":"phosphoglycolate phosphatase",
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"h2o_c":-1.0,
"pi_c":1.0
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"lower_bound":-0.0,
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"subsystem":"Glyoxylate and dicarboxylate metabolism",
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"kegg.reaction":"R01334",
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}
},
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"id":"RC01844",
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"h_c":1.0,
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"sedh_c":-1.0
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"kegg.reaction":"R01844",
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}
},
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"id":"RC01843",
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"sbo":"SBO:0000176"
}
},
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"id":"SNK0036",
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}
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},
{
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"dhcrm_ce_c":-1.0,
"h2o_c":2.0,
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"sbo":"SBO:0000176"
}
},
{
"id":"RCC0063",
"name":"long chain fatty acid elongation (Stearidonoyl-CoA to Icosatetraenoyl-CoA)",
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"coa_c":1.0,
"eicostetcoa_c":1.0,
"h2o_c":1.0,
"h_c":-3.0,
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"strdnccoa_c":-1.0
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"subsystem":"Biosynthesis of unsaturated fatty acids",
"annotation":{
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"1.1.1.330",
"4.2.1.134",
"1.3.1.93"
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"kegg.reaction":[
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"R10826",
"R10827",
"R10828"
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"sbo":"SBO:0000176"
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},
{
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"name":"OMEGA3-fatty acid desaturase",
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"o2_c":-1.0
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},
{
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},
{
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"1.1.1.330",
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}
},
{
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},
{
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}
},
{
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}
},
{
"id":"RC00554",
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},
{
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},
{
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},
{
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},
{
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},
{
"id":"TCM1082",
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"lower_bound":-1000.0,
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}
},
{
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},
"lower_bound":-0.0,
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}
},
{
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"name":"L-Threonine transport",
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},
{
"id":"TCE0453",
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}
},
{
"id":"RC01201",
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}
},
{
"id":"RC01206",
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},
{
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},
{
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},
{
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},
{
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{
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},
{
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{
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},
{
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},
{
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},
{
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},
{
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},
{
"id":"TCE2003",
"name":"Histone-L-Lysine transport",
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"Nlys_c":1.0,
"Nlys_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport",
"annotation":{
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},
{
"id":"TCE2005",
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"gene_reaction_rule":"",
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},
{
"id":"EX00314",
"name":"pyridoxine exchange/defecation",
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"gene_reaction_rule":"",
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"annotation":{
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},
{
"id":"TCE0459",
"name":"Iodide and Chloride transport",
"metabolites":{
"cl_c":1.0,
"cl_e":-1.0,
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"i_e":2.0
},
"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
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"annotation":{
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}
},
{
"id":"RC01318",
"name":"Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase",
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"coa_c":1.0,
"lpchol_c":-1.0,
"pchol_c":1.0
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"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"WBGene00020115",
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},
{
"id":"EX00777",
"name":"Retinoate exchange",
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"lower_bound":-0.0,
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"gene_reaction_rule":"",
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},
{
"id":"EX04677",
"name":"5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide exchange",
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},
{
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},
{
"id":"EXC0210",
"name":"Sphingosine 1-phosphate exchange",
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},
{
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},
{
"id":"EXC0213",
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},
{
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"gene_reaction_rule":"",
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},
{
"id":"EXC0216",
"name":"globoside  exchange",
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"lower_bound":-0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Exchange with the environment",
"annotation":{
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}
},
{
"id":"RM00161",
"name":"ATP:FMN adenylyltransferase",
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"lower_bound":-0.0,
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"gene_reaction_rule":"WBGene00011271",
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},
{
"id":"RC01310",
"name":"Phosphatidylcholine phosphatidohydrolase",
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"h_c":1.0,
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"pchol_c":-1.0
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"kegg.genes":"CELE_B0285.8",
"sbo":"SBO:0000243",
"uniprot":"P46558",
"wormbase":"WBGene00000511"
}
},
{
"id":"WBGene00002043",
"name":"hyl-1",
"annotation":{
"kegg.genes":"CELE_C09G4.1",
"sbo":"SBO:0000243",
"uniprot":"G5ED45",
"wormbase":"WBGene00002043"
}
},
{
"id":"WBGene00017975",
"name":"F32B5.1",
"annotation":{
"kegg.genes":"CELE_F32B5.1",
"sbo":"SBO:0000243",
"uniprot":"O01854",
"wormbase":"WBGene00017975"
}
},
{
"id":"WBGene00015512",
"name":"mthf-1",
"annotation":{
"kegg.genes":"CELE_C06A8.1",
"sbo":"SBO:0000243",
"uniprot":[
"G8JXY2",
"Q17693"
],
"wormbase":"WBGene00015512"
}
},
{
"id":"WBGene00001239",
"name":"elo-1",
"annotation":{
"kegg.genes":"CELE_F56H11.4",
"sbo":"SBO:0000243",
"uniprot":"G5EEE5",
"wormbase":"WBGene00001239"
}
}
],
"id":"iCEL1314",
"name":"iCEL1314",
"compartments":{
"c":"cytosol",
"e":"extracellular space",
"m":"mitochondria"
},
"version":"1"
}